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Ne.AB family of ne.ronal calcium-binding prote.ns in he.lth and dise.se

Ne.ral Re.e.e.ation Re.e.rch 2025年第5期20卷 1236-1243页

作者： Dione. Bue.o Michae. K.e.Schafe. Sude.a Wang Michae. J.Schmeisse. Axe. methne. Institute.for Mole.ular medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany De.artment of Ane.the.iology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute.of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The.N-te.minal e.-hand calcium-binding prote.ns 1–3(Ne.AB1–3) constitute.a family of pre.ominantly ne.ronal prote.ns characte.ize. by the.pre.e.ce.of at le.st one.e.-hand calcium-binding domain and a functionally le.s we.l characte.ize. C-te.minal antibiotic biosynthe.is monooxyge.ase.domain. All thre. family membe.s we.e.initially discove.e. due.to the.r inte.actions with othe. prote.ns. Ne.AB1 associate. with synaptotagmin-1, a critical ne.ronal prote.n involve. in membrane.trafficking and synaptic ve.icle.e.ocytosis. Ne.AB2 inte.acts with pre.ominantly striatal G-prote.n-couple. re.e.tors, while.Ne.AB3 partne.s with amyloid-β A4 pre.ursor prote.n-binding family A membe.s 2 and 3, ke. re.ulators of amyloid-β production. This de.onstrate. the.capacity of the.family for inte.actions with various classe. of prote.ns. Ne.AB prote.ns e.hibit distinct subce.lular localizations: Ne.AB1 is found in the.nucle.s and cytosol, Ne.AB2 re.ide. in e.dosomes and the.plasma membrane. and Ne.AB3 is pre.e.t in the.e.doplasmic re.iculum and Golgi apparatus. The.antibiotic biosynthe.is monooxyge.ase.domain, an e.olutionarily ancie.t compone.t, is akin to atypical he.0} oxyge.ase. in prokaryote. but is not we.lcharacte.ize. in ve.te.rate.. Prokaryotic antibiotic biosynthe.is monooxyge.ase.domains typically form dimers, sugge.ting that calcium-mediate. conformational change. in Ne.AB prote.ns may induce.antibiotic biosynthe.is monooxyge.ase.domain dimerization, pote.tially activating some e.zymatic prope.tie.. Howe.e., the.substrate.for this e.zymatic activity re.ains unce.tain. Alte.native.y, calcium-mediate. conformational change. might influe.ce.prote.n inte.actions or the.subce.lular localization of Ne.AB prote.ns by controlling the.availability of prote.n–prote.n inte.action domains situate. be.we.n the.e. hands and the.antibiotic biosynthe.is monooxyge.ase.domain. This re.ie. summarize. what is known about ge.omic organization, tissue.e.pre.sion, intrace.lular localization, inte.ac

关键词： calcium e. hand mitochondria ne.vous syste. signal transduction

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Mixe. Inte.e. Program for e.Walle. Se.urity Base. on Suspicious Transaction De.e.tion

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e.gine.ring(科研) 2025年第1期17卷 155-167页

作者： Pacôme Brou Kadokan Coulibaly Siaho Diomande Laboratoire.de. Scie.ce. Te.hnologique. de.lInformation e. de.la Communication Ecole Suprieure Africaine des Technologies de lInformation et de la Communication (ESATIC) Abidjan Cte dIvoire

With the.rise.of digital transactions, e.Walle.s have.be.ome prime targe.s for fraudule.t activity. e.rly de.e.tion of suspicious transactions is the.e.ore.crucial to prote.t use.s and maintain trust in the.e.syste.s. This article.propose. a mathe.atical mode. base. on a Mixe. Inte.e. Program (MIP) to ide.tify and block suspicious transactions. This mathe.atical approach is de.igne. to analyze.e.Walle. transactions in re.l time by combining inte.e. and continuous de.ision variable., offe.ing gre.te. fle.ibility in mode.ing fraud de.e.tion constraints. It conside.s paramete.s such as transaction cost, ge.graphical location, type.of de.ice.use. for the.transaction, IP addre.s and othe. pote.tial fraud indicators. Assigning suspicion score. to e.ch transaction e.able. the.mode. to ide.tify risks that be.ome habitual be.avior and mark the. as suspicious. Te.ts carrie. out on 10,000 digital transactions show that using PMNe.significantly improve. the.de.e.tion of fraudule.t transactions by ide.tifying the.most critical anomalie. in te.ms of accuracy, adaptability and ope.ational e.ficie.cy. The.mode. also offe.s gre.te. accuracy, re.ucing the.numbe. of false.positive. and false.ne.ative., e.abling faste. inte.ve.tion to block truly suspicious transactions.

关键词： e.Walle. PMNe Digital Transaction Suspicion Score Suspicious Transaction

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Coarse.to Fine. The.Role.of Se.e.e.Plastic De.ormation in Advancing Titanium-Base. medical Implants - A Compre.e.sive.Re.ie.

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Journal of Wuhan Unive.sity of Te.hnology(Mate.ials Scie.ce. 2025年第1期40卷 295-306页

作者： Dragana R Mihajlović Bojan I međo Ivana Lj Cvijović-Alagić Ve.jko R Djokić Faculty of Te.hnology and metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia vinča Institute.of Nucle.r Sci-e.ce.-National Institute.of the.Re.ublic of Se.bia University of Belgrade11001BeogradSerbia Innovation Ce.tre.of the.Faculty of Te.hnology and metallurgy Karnegijeva 411120 BelgradeSerbia

This pape. de.cribe. se.e.e.plastic de.ormation(SPD)proce.ure.,which are.utilize. to form an ultrafine.graine. structure.in metallic *** the.SPD proce.s,a solid mate.ial sample.is subje.te. to ve.y high loads without a significant change.in sample.*** the.pre.e.t work,the.high-pre.sure.torsion(HPT)proce.s,as one.of the.SPD te.hnique.,which achie.e. a high de.re. of de.ormation and e.sure. re.ine.0}nt of the.microstructure.will be.discusse. in more.*** that grain size.control is acce.te. as a method to obtain mate.ials with de.ire. characte.istics,an ove.vie. of the.prope.tie. of ultrafine.graine. titanium-base. biomate.ials to be.use. in medicine.is ***,particular atte.tion is de.icate. to the.influe.ce. of HPT proce.s paramete.s,primarily hydrostatic pre.sure.and numbe. of re.olutions during torsion,on the.grain size.and physical and mechanical characte.istics(modulus of e.asticity,microhardne.s,and te.sile.prope.tie.),corrosion re.istance.and biocompatibility of the.titanium-base. biomate.ials.A re.ie. of the.lite.ature.indicate. that titanium-base. mate.ials obtaine. by the.SPD proce.s show improve. mechanical and physical prope.tie. without losing biocompatibility and corrosion re.istance.which sugge.ts that the.e.methods of obtaining implants are.something that should be.furthe. de.e.ope. in the.future.

关键词： high-pre.sure.torsion proce.s ultrafine.graine. titanium-base. mate.ials e.e.troche.ical anodization physical prope.tie. mechanical prope.tie.

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Solar wind transport into magne.osphe.e.cause. by magne.ic re.onne.tion at high latitude.magne.opause.during northward IMF: Cluste.-DSP conjunction obse.vations

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Scie.ce.China(Te.hnological Scie.ce.) 2008年第10期51卷 1677-1684页

作者： M. DUNLOP e. LUCe. H. Rme C. M. CARR Ruthe.ford Apple.on Laboratory Didcot United Kingdom Impe.ial Colle.e.of Scie.ce Technology and Medicine London United Kingdom Ce.R BP4346 31028 Toulouse Cedex 4 France

An e.e.t of Cluste.-Double.Star conjunction obse.vations of magne.ic re.onne.-tion at high latitude.magne.opause.nightside.of both cusps and solar wind trans-port into magne.osphe.e.cause. by such re.onne.tion proce.s has be.n inve.ti-gate.. During northward IMF, Cluste./SC1 obse.ve. acce.e.ate. flows and ion he.ting associate. with magne.ic re.onne.tion at high latitude.magne.opause.nightside.of southe.n cusp. And Double.Star obse.ve. cold de.se.solar wind plasma transporte. into dayside.magne.osphe.e. The.analysis on such conjunction obse.vations shows that: (1) during northward IMF, magne.ic re.onne.tion occurs at high latitude.nightside.of southe.n cusp, accompanie. by acce.e.ate. flows that are.obse.ve. by Cluste./SC1; (2) the.dire.tion of the.acce.e.ate. flows, with its sunward compone.t Vx, dawnward compone.t Vy, northward compone.t Vz, is quite.consiste.t with the.the.re.ical anticipation unde. the.condition of northward IMF with dawnward compone.t By; (3) re.onne.tion can he.t plasma more.in par-alle. dire.tion than in pe.pe.dicular dire.tion, to a le.e. of about 4 ke.; (4) with re.onne.tion taking place.at high latitude.magne.opause.nightside.of the.southe.n cusp, TC-1 obse.ve. cold and de.se.plasma transporte. into magne.osphe.e. (5) by re.onne.tion at high latitude.magne.opause.nightside.of both cusps, solar wind flux tube.can be.capture. by magne.osphe.e.and pulle. into dayside.magne.o-sphe.e. This e.e.t pre.e.ts furthe. obse.vational e.ide.ce.for magne.ic re.onne.-tion at high latitude.magne.opause.nightside.of both cusps as an important mech-anism of sol-ar w-ind transport into magne.osphe.e.

关键词： transport proce.s magne.ic re.onne.tion solar wind-magne.osphe.e inte.actions

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Inte.actions be.we.n rode.ts and we.ds in a lowland rice.agro-e.osyste.:the.ne.d for an inte.rate. approach to manage.1}nt

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Inte.rative.Zoology 2019年第4期14卷 396-409页

作者： Nyo me HTWe.Grant R.SINGLe.ON David e.JOHNSON Plant Prote.tion Division Department of AgricultureMinistry of AgricultureLivestock and IrrigationMyanmar Inte.national Rice.Re.e.rch Institute DAPO Box 7777Metro ManilaPhilippines Natural Re.ource. Institute University of GreenwichChatham MaritimeKentUK

Rode.ts and we.ds are.important pe.ts to rice.crops in Southe.st *** inte.action be.we.n the.e.2 major pe.ts is poorly *** te.pe.ate.ce.e.l syste.s,se.ds of grass we.ds can be.an important food source.for rode.ts and we.d cove. along crop margins provide. important re.uge.for *** 2012 and 2013,a re.licate. study(n=4)in Bago,Myanmar compare. 4 tre.tments(rode.ts and we.ds;no rode.ts and we.ds;rode.ts and no we.ds;no rode.ts and no we.ds)e.ch of 0.25 ha in transplante. *** we.e.manage. with hand we.ding in the.we. se.son,and hand we.ding and he.bicide. in the.dry *** fe.ce. we.e.installe. to e.clude.*** e.amine. the.we.d cove. and re.ative.abundance.of we.d spe.ie.,rode.t damage.rode.t population dynamics and rice.yie.d loss cause. by rode.ts and *** dominant rode.t spe.ie. was Bandicota *** the.dry se.son,Cype.us difformis was dominant at the.tille.ing stage.and e.hinochloa crus-galli was the.dominant we.d spe.ie. at the.booting *** the.we. se.son ***-galli was a dominant we.d throughout the.*** by rode.ts was highe. in the.dry *** we.e.large. e.onomic be.e.its for be.t we.d manage.0}nt and e.fe.tive.rode.t control in the.dry se.son(258 US$/ha)than in the.we. se.son(30 US$/ha).Concurre.t control of we.ds in and around rice.fie.ds combine. with coordinate. community trapping of rode.ts during the.e.rly tille.ing stage.and ripe.ing stage.of rice.are.re.ommende. manage.0}nt options.

关键词： Bandicota be.gale.sis Myanmar rice rode.ts we.ds

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Unde.re.re.e.tation of active.histone.modification marks in e.olutionarily young ge.e.

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Inse.t Scie.ce 2017年第2期24卷 174-186页

作者： Daqi Yu We.we. Shi Yong e. Zhang State.Ke. Laboratory of Inte.rate. manage.1}nt of Pe.t Inse.ts and Rode.ts & Ke. Laboratory of the.Zoological Syste.atics ande.olution Institute of Zoology Chinese Academy of Sciences Beijing 100101 China

It is known that e.olutionarily ne. ge.e. can rapidly e.olve.e.se.tial role. in fundamental biological proce.se.. Ne.e.the.e.s, the.unde.lying mole.ular mechanism of how the. acquire.the.t nove. transcriptional patte.n is le.s characte.ize. e.ce.t for the.role.ofcis-re.ulatory e.olution. e.ige.e.ic modification offe.s an alte.native.possibility. He.e. we.e.amine. how histone.modifications have.change. among diffe.e.t ge.e.age.groups in Drosophila melanogaste. by inte.rative.analyse. of an update. ne. ge.e.datase. and publishe. e.ige.omic data. We.found a robust patte.n across various datase.s whe.e.both the.cove.age.and inte.sity of active.histone.modifications, histone.3 lysine.4 trimethylation and lysine.36 trimethylation, incre.se. with e.olutionary age. Such a te.poral corre.ation is ne.ative.and much we.ke. for the.re.re.sive.histone.mark, lysine.9 trimethylation, which is e.pe.te. give. its major association with he.e.ochromatin. By furthe. comparison with ne.ghboring old ge.e., the.de.le.ion of active.marks of ne. ge.e. could be.only partially e.plaine. by the.local e.ige.e.ic conte.t. All the.e.data are.consiste.t with the.obse.vation that olde. ge.e. be.r re.ative.y highe. e.pre.sion le.e.s and sugge.t that the.e.olution of histone.modifications could be.implicate. in transcriptional e.olution afte. ge.e.birth.

关键词： Drosophila H3K4me3 H3K36me3 H3K9me3 e.ige.e.ic e.olution ne.ge.e.e.olution

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Pe.FORmanCe.SIMULATION OF Ve.ICLe. e.UIPPe. WITH TRACTION DRIVe.CVTS

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Chine.e.Journal of mechanical e.gine.ring 2005年第3期18卷 405-410页

作者： Zhang Xianjie.William e. Toble. Zhang Yi Zou Zhanjiang Ford Re.e.rch Laboratory Ford Motor Company Dearborn USA MI 48128 De.artment of mechanical e.gine.ring University of Michigan-Dearborn Dearborn USA MI 48128

A compute. mode. for the.pe.formance.simulation of ve.icle. e.uippe. with traction drive.continuously variable.transmission （CVT） is pre.e.te.. The.mode. inte.rate. the.traction drive.CVT subsyste. into an e.isting ove.all ve.icle.syste.. The.characte.istics of e.gine.output torque.are.formulate. using ne.ral ne.works, and torque.conve.te. is mode.e. using lookup table.. Compone.t inputs and outputs are.couple. in the.dynamic e.uations and inte.face. in the.powe.train syste.. The.mode. simulation can provide.e.aluation of ve.icle.pe.formance.in drivability, fue. e.onomy and e.ission le.e.s for various drive.range. prior to the.prototyping of the.ve.icle. As a de.ign tool, the.mode. assists e.gine.rs in unde.standing the.e.fe.t ofpowe.train compone.ts on ve.icle.pe.formance.and making de.isions in the.se.e.tion of ke. de.ign paramete.s. The.mode. is imple.3}nte. in the.MATLAB/Simulink e.vironment. The.pe.formance.simulation of a te.t ve.icle.is include. as a numerical e.ample.to illustrate.the.e.fe.tive.e.s of the.mode..

关键词： Traction drive.Mode.ing Ve.icle.simulation

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Optimal De.p Canonically Corre.ate. Autoe.code.-e.able. Pre.iction Mode. for Customer Churn Pre.iction

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Compute.s, Mate.ials & Continua 2022年第11期73卷 3757-3769页

作者： Olfat M.Mirza GJose.Mose. R.Raje.de. e.Laxmi Lydia Se.fe.ine.Kadry Che.dchai me-e.d Orawit Thinnukool De.artment of Compute. Scie.ce College of Computers and Information SystemsUmm Al-Qura UniversityMakkahSaudi Arabia De.artment of Compute. Scie.ce.e.gine.ring Malla Reddy Engineering College500100India De.artment of Compute. Scie.ce.e.gine.ring Lendi Institute of Engineering&TechnologyDenkada535005India De.artment of Compute. Scie.ce.and e.gine.ring Vignan’s Institute of Information TechnologyVisakhapatnam530049India De.artment of Applie. Data Scie.ce Noroff University CollegeNorway Program in Statistics and Information manage.1}nt Faculty of ScienceMaejo UniversityChiang Mai50290Thailand De.artment of Mode.n manage.0}nt and Information Te.hnology College of Arts Media and TechnologyChiang Mai UniversityChiang Mai50200Thailand

Pre.e.tly,customer re.e.tion is e.se.tial for re.ucing customer churn in te.e.ommunication *** churn pre.iction(CCP)is important to pre.ict the.possibility of customer re.e.tion in the.quality of *** risks of customer churn also ge. e.se.tial,the.rise.of machine.le.rning(ML)mode.s can be.e.ploye. to inve.tigate.the.characte.istics of customer ***,de.p le.rning(DL)mode.s he.p in pre.iction of the.customer be.avior base. characte.istic *** the.DL mode.s ne.e.sitate.hype.paramete. mode.ling and e.fort,the.proce.s is difficult for re.e.rch communitie. and busine.s *** this vie.,this study de.igns an optimal de.p canonically corre.ate. autoe.code. base. pre.iction(ODCCAe.)mode. for compe.itive.customer de.e.de.t application *** addition,the.O-DCCAe. method purpose. for de.e.mining the.churning nature.of the.*** O-DCCAe. te.hnique.e.compasse. pre.roce.sing,classification,and hype.paramete. ***,the.DCCAe.mode. is e.ploye. to classify the.churne.s or ***,the.hype.paramete. optimization of the.DCCAe.te.hnique.occurs utilizing the.de.r hunting optimization algorithm(DHOA).The.e.pe.imental e.aluation of the.O-DCCAe. te.hnique.is carrie. out against an own datase. and the.outcomes highlighte. the.be.te.ment of the.pre.e.te. O-DCCAe. approach on e.isting approache..

关键词： Churn pre.iction customer re.e.tion de.p le.rning machine.le.rning archimede. optimization algorithm

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rHBsAg 结合载脂蛋白 H 的机理研究

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中华微生物学和免疫学杂志 1997年第3期17卷 160-163页

作者：杨旭 Pe.p.,me 湖南医科大学附二院肝病研究中心

用酶免疫测定、配体印迹、酶水解、化学修饰等方法研究ｒＨＢｓＡｇ结合ａｐｏＨ的机理。实验结果表明，ｒＨＢｓＡｇ结合ａｐｏＨ是不依赖于Ｃａ＋＋、Ｍｇ＋＋等二价阳离子的，其最适ｐＨ在６．５～８．０。切除ａｐｏＨ上的神经氨酸... 详细信息

用酶免疫测定、配体印迹、酶水解、化学修饰等方法研究ｒＨＢｓＡｇ结合ａｐｏＨ的机理。实验结果表明，ｒＨＢｓＡｇ结合ａｐｏＨ是不依赖于Ｃａ＋＋、Ｍｇ＋＋等二价阳离子的，其最适ｐＨ在６．５～８．０。切除ａｐｏＨ上的神经氨酸和Ｎ－糖苷键，ａｐｏＨ结合力无变化，说明糖基不是ａｐｏＨ结合ｒＨＢｓＡｇ所必需的。化学修饰ａｐｏＨ的精氨酸残基对ａｐｏＨ的结合力无影响。然而，修饰其中几个赖氨酸残基即可减弱直至完全破坏ａｐｏＨ的结合力，说明赖氨酸残基与ａｐｏＨ结合ｒＨＢｓＡｇ有关。由于ａｐｏＨ与脂蛋白，特别是ＣＭ和ＨＤＬ结合，ＨＢＶ有可能通过ａｐｏＨ，结合ＣＭ、ＨＤＬ等，在脂蛋白代谢过程中进入肝细胞。

关键词：受体载脂蛋白H 乙型肝炎表面抗原

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Gamma induce. change. in Makrofol/CdSe.nanocomposite.films

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Chine.e.Physics B 2022年第9期31卷 547-553页

作者： Ali A.Alhazime M.me.Barakat Radiyah A.Bahare.h e.M.Mahrous Saad Aldawood S.Abd e. Aal S.A.Nouh Physics De.artment Faculty of ScienceTaibah UniversityMedinaSaudi Arabia De.artment of Physics Faculty of ScienceTaibah UniversityYanbuSaudi Arabia De.artment of Physics Faculty of ScienceAlexandria UniversityAlexandriaEgypt Physics De.artment College of ScienceJeddah UniversityJeddahSaudi Arabia De.artment of Physics and Astronomy College of ScienceP.O.BOX 2455King Saud UniversitySaudi Arabia Ce.te. of Radiation Re.e.rch and Te.hnology Egyptian Atomic AuthorityNasr CityCairoEgypt Qassim Unive.sity P.B.6644Buraidah 51452QassimSaudi Arabia Physics De.artment Faculty of ScienceAin Shams UniversityCairoEgypt

We.applie. an e.-situ casting proce.ure.to pre.are.a nanocomposite.NCP)from Makrofol polycarbonate.PC)and CdSe.*** CdSe.nanoparticle. we.e.pre.are. by a the.molysis proce.ure.in the.pre.e.ce.of N_(2) gas *** re.ine.0}nt of x-ray data illustrate. that the.CdSe.adopts a cubic zinc ble.d structure.of 6.057 A lattice.paramete. and 2 nm typical grain *** from the.pre.are. NCP we.e.e.pose. to γ dosage.(20 kGy-250 kGy).The.modifications induce. in the.NCP films owing to γ dosage. have.be.n ***γirradiation(50 kGy-250 kGy)cause. crosslinks that re.uce.the.optical bandgap from 4.15 e. to 3.81 e.,associate. with an incre.se.in die.e.tric paramete.s and re.ractive.*** is attribute. to an incre.se.in the.mass fraction of the.disorde.e. re.ions as spe.ifie. by x-ray *** PC-CdSe.NCP was found to have.a re.ction to color modification which make. it suitable.for sale.ble.re.roduction on a printing pre.s.

关键词： gamma nanocomposite x-ray dfraction UV spe.tra color change.

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