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unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： bismark Gatica-Garcia Michael J.bannon Irma Alicia Martínez-Dávila Luis O.Soto-Rojas David Reyes-Corona Lourdes escobedo Minerva Maldonado-berny me Gutierrez-Castillo Armando J.espadas-Alvarez Manuel A.Fernandez-Parrilla Juan u.Mascotte-Cruz CP Rodríguez-Oviedo Irais e.Valenzuela-Arzeta Claudia Luna-Herrera Francisco e.Lopez-Salas Jaime Santoyo-Salazar Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de medicina para la educación y Desarrollo y la Investigación Científica de Iztacala(Red meDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico Departamento de biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico escuela Nacional de medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de biología Molecular y biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

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Air traffic monitoring using optimized ADS-b CubeSat constellation

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Astrodynamics 2024年第1期8卷 189-208页

作者： Ghulam Jaffer Rameez AMalik elias Aboutanios Nazish Rubab Ronnie Nader Hans u.eichelberger Guy A.e.Vandenbosch Interdisciplinary Centre for Security Reliability and Trust(SnT)University of LuxembourgLuxembourg1855Luxembourg

The primary technique used for air traffic surveillance is ***,nowadays,its role in surveillance is gradually being replaced by the recently adopted Automatic Dependent Surveillance-broadcast(ADS-b).ADS-b offers a higher accuracy,lower power consumption,and longer range than radar,thus providing more safety to *** coverage of terrestrial radar and ADS-b is confined to continental parts of the globe,leaving oceans and poles uncovered by real-time surveillance *** study presents an optimized Low-earth Orbit(LeO)-based ADS-b constellation for global air traffic surveillance over intercontinental trans-oceanic flight *** optimization algorithm is based on performance evaluation parameters,i.e.,coverage time,satellite availability,and orbit stability(precession and perigee rotation),and communication *** results indicate that the constellation provides ample coverage in the simulated global oceanic *** constellation is a feasible and cost-effective solution for global air supervision,which can supplement terrestrial ADS-b and radar systems.

关键词： constellation automatic dependent surveillance-broadcast (ADS-b) air traffic surveillance precession perigee rotation.

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epidemiologic investigation of pediatric distal humerus fractures: An American insurance claims database study

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World Journal of Orthopedics 2024年第1期15卷 52-60页

作者： Kyle Jay Klahs Jake e Dertinger Grant T mello Kevin Thapa Alexis b Sandler e'Stephan J Jesus Garcia Nata Parnes Department of Orthopaedic Surgery Texas Tech University Health Sciences-El PasoEl PasoTX 79905United States medical School California Health Sciences University College of Osteopathic MedicineClovisCA 93611United States undergraduate School Binghampton UniversityVestalNY 13902United States Department of Orthopaedic Surgery William Beaumont Army Medical CenterFort BlissTX 79918United States Department of Orthopaedic Surgery Carthage Area HospitalCarthageNY 13619United States

bACKGROuND Distal humerus elbow fractures are one of the most common traumatic fractures seen in pediatric patients and present as three main types:Supracondylar(SC),lateral condyle(LC),and medial epicondyle(me)*** To evaluate the epidemiology of pediatric distal humerus fractures(SC,LC,and me)from an American insurance claims *** A retrospective review was performed on patients 17 years and younger with the ICD 9 and 10 codes for SC,LC and me fractures based on the IbM Truven MarketScan®Commercial and IbM Truven MarketScan medicare Supplemental *** from 2015 to 2020 were queried for treatments,patient age,sex,length of hospitalization,and *** A total of 1133 SC,154 LC,and 124 me fractures were *** fractures had the highest percentage of operation at 83%,followed by LC(78%)and me fractures(41%).Male patients were,on average,older than female patients for both SC and me *** In the insurance claims databases used,SC fractures were the most reported,followed by LC fractures,and finally me *** was identified to be a factor for how a pediatric distal humerus fractures,with patients with SC and LC fractures being younger than those with me *** peak age per injury per sex was similar to reported historic central tendencies,despite reported trends for younger physiologic development.

关键词： Supracondylar humerus fracture Lateral condyle fracture medial epicondyle fracture Pediatric elbow Truven epidemiology

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城市与自然之间嘉兴种子艺术中心

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室内设计与装修 2024年第2期 24-27页

作者： b.L.u.e.建筑设计事务所 b.L.u.e.建筑设计事务所

种子艺术中心位于嘉兴市南湖区,距离市中心东侧10 km,处在城市与自然的过渡边界。项目定位为地产配套设施,近期作为附近社区的展示中心与零售空间,未来则活用为周边共享的邻里中心。艺术中心周围一半是农场与公园,一半是住宅与商业街,... 详细信息

种子艺术中心位于嘉兴市南湖区,距离市中心东侧10 km,处在城市与自然的过渡边界。项目定位为地产配套设施,近期作为附近社区的展示中心与零售空间,未来则活用为周边共享的邻里中心。艺术中心周围一半是农场与公园,一半是住宅与商业街,不同方位面向不同的景观与氛围,形成多元、生动的场所感。四周道路交会,人流聚集于此,是整个片区最具活力的核心点位。

关键词：邻里中心场所感嘉兴市南湖区配套设施商业街展示中心项目定位零售空间

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exploring the effects of dietary inulin in rainbow trout fed a high‑starch,100%plant‑based diet

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Journal of Animal Science and biotechnology 2024年第2期15卷 713-732页

作者： Raphaël Defaix Jep Lokesh Laura Frohn Mickael Le bechec Thierry Pigot Vincent Veron Anne Surget Sandra biasutti Frederic Terrier Sandrine Skiba-Cassy Jerome Roy Stephane Panserat Karine Ricaud universite de Pau et Des Pays de L’Adour E2S UPPAINRAENUMEASaint‑Pee‑Sur‑NivelleFrance universite de Pau et Des Pays de L’Adour E2S UPPACNRSIMT Mines AlesIPREMPauFrance universite de Pau et Des Pays de L’Adour E2S UPPAIUT des Pays de l’AdourDepartement Genie BiologiqueMont de MarsanFrance.

background High dietary carbohydrates can spare protein in rainbow trout(Oncorhynchus mykiss)but may affect growth and ***,a prebiotic,could have nutritional and metabolic effects,along with anti-inflammatory properties in teleosts,improving growth and *** tested this hypothesis in rainbow trout by feeding them a 100%plant-based diet,which is a viable alternative to fishmeal and fish oil in aquaculture *** a two-factor design,we examined the impact of inulin(2%)as well as the variation in the carbohydrates(CHO)/plant protein ratio on rainbow *** assessed the influence of these factors on zootechnical parameters,plasma metabolites,gut microbiota,production of short-chain fatty acids and lactic acid,as well as the expression of free-fatty acid receptor genes in the mid-intestine,intermediary liver metabolism,and immune markers in a 12-week feeding *** The use of 2%inulin did not significantly change the fish intestinal microbiota,but interestingly,the high CHO/protein ratio group showed a change in intestinal microbiota and in particular the beta diversity,with 21 bacterial genera affected,including Ralstonia,bacillus,and 11 lactic-acid producing *** were higher levels of butyric,and valeric acid in groups fed with high CHO/protein diet but not with *** high CHO/protein group showed a decrease in the expression of pro-inflammatory cytokines(il1b,il8,and tnfa)in liver and a lower expression of the genes coding for tight-junction proteins in mid-intestine(tjp1a and tjp3).However,the 2%inulin did not modify the expression of plasma immune ***,inulin induced a negative effect on rainbow trout growth performance irrespective of the dietary *** With a 100%plant-based diet,inclusion of high levels of carbohydrates could be a promising way for fish nutrition in aquaculture through a protein sparing effect whereas the supplementation of 2%inulin does not appear to improve the use of CHO wh

关键词： Aquaculture Fish nutrition Gut microbiota Immune markers Intermediary metabolism Inulin Prebiotic Rainbow trout Short-chain fatty acids

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Highly Defective Dark TiO_(2) Modified with Pt: effects of Precursor Nature and Preparation method on Photocatalytic Properties

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Transactions of Tianjin university 2024年第2期30卷 198-209页

作者： e.D.Fakhrutdinova O.A.Reutova T.A.bugrova I.Yu.Ovsyuk L.S.Kibis O.A.Stonkus D.b.Vasilchenko O.V.Vodyankina V.A.Svetlychnyi National Research Tomsk State university TomskRussia 634050 Novosibirsk State university NovosibirskRussia 630090 boreskov Institute of Catalysis NovosibirskRussia 630090 Nikolaev Institute of Inorganic Chemistry NovosibirskRussia 630090

The study focused on the modification with platinum of dark defective titania obtained via pulsed laser ablation. both the method of Pt introduction and the nature of the Pt precursor were varied. All samples exhibited similar phase compositions, specific surface areas, and Pt contents. High-resolution transmission electron microscopy coupled with pulsed CO adsorption revealed increased dispersity when photoreduction and the hydroxonitrate complex (me _(4) N) _(2) [Pt _(2) (OH) _(2) (NO _(3) ) _(8) ] were used. The sample featured a high content of single-atom species and subnano-sized Pt clusters. The X-ray photoelectron spectroscopy results showed that the photoreduction method facilitated the appearance of a larger number of Pt ^(2+) states, which appeared owing to the strong metal-support interaction (SMSI) eff ect of the transfer of electron density from the electron-saturated defects on the TiO _(2) surface to Pt ^(4+) . In the hydrogen evolution reaction, samples with a significant fraction of the Pt ^(2+) ionic component, capable of generating short-lived Pt^(0) single-atom sites under irradiation due to the SMSI eff ect, exhibited the highest photocatalytic activity. The 0.5Pt(C)/TiO_(2) -Ph sample exhibited the highest hydrogen yield with a quantum efficiency of 0.53, retaining its activity even after 8 h of operation.

关键词： Dark(black)TiO_(2) Pulsed laser ablation Platinum reduction method Precursor type Photocatalysis Hydrogen evolution reaction

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Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

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Light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra b.Anantharaman Jason Lynch Christopher e.Stevens Christopher Munley Chentao Li Jin Hou Hao Zhang Andrew Torma Thomas Darlington Francis Coen Kevin Li Arka Majumdar PJames Schuck Aditya Mohite Hayk Harutyunyan Joshua R.Hendrickson Deep Jariwala Department of electrical and Systems engineering University of PennsylvaniaPhiladelphiaPA19104USA KbR Inc. BeavercreekOH45431USA Air Force Research Laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of Chemical and biomolecular engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of mechanical engineering Columbia UniversityNew YorkNY10027USA Department of electrical and Computer engineering University of WashingtonSeattleWA98195USA

excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D HOIPs)are capable of forming hybrid light-matter states known as exciton-polaritons(e–Ps)when the excitonic medium is confined in an optical *** the case of 2D HOIPs,they can self-hybridize into e–Ps at specific thicknesses of the HOIP crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized e–Ps in 2D HOIPs,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOIP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized e–P *** e–Ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy e–Ps to lower energy e–***,we also demonstrate that e–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in e–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

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Jigsaw-Sketch: a fast and accurate algorithm for finding top-k elephant flows in high-speed networks

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Science China(Information Sciences) 2024年第4期67卷 113-130页

作者： boyu ZHANG He HuANG Yu-e SuN Yang Du Dan WANG School of Computer Science and Technology Soochow University School of Rail Transportation Soochow University

Finding top-k elephant flows in high-speed networks is one of the most fundamental network measurement tasks. It is more challenging than per-flow size estimation since the IDs and sizes of top-k flows must be tracked simultaneously. Most existing studies only record the IDs of a small number of elephant flows to fit their estimators in the extremely limited high-speed on-chip memory. However, these solutions need too many memory accesses when a packet arrives to track the elephant flows with high accuracy, which limits their practicability. Therefore, this paper proposes Jigsaw-Sketch, a new algorithm to find the top-k elephant flows with much fewer memory accesses while achieving high memory efficiency and accuracy. In this design, we propose a novel two-stage jigsaw storage scheme, which can capture the candidate top-k flows from massive network steams efficiently, and further find the top-k elephant flows with high memory efficiency and only a few memory accesses for each packet. extensive experimental results based on real network traces show that Jigsaw-Sketch improves the packet processing throughput by at least 86%, while achieving smaller memory footprints and higher accuracy compared to the SOTA.

关键词： sketch top-$k$ network measurement elephant flow high-speed networks

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夏洛的网(三)

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疯狂英语（初中天地） 2024年第4期 54-56页

作者： e.b.White 不详

作为一只猪,威尔伯似乎只能接受任人宰割的命运了,但夏洛却承诺要救威尔伯。这是一场关于信任、勇气、拯救与自我拯救的对话,一起读读吧!

关键词：威尔伯自我拯救夏洛的网读读

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Magnetoresistivity studies for biPb-2223 phase added by baSnO3 nanoparticles

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Journal of Advanced Ceramics 2017年第2期6卷 100-109页

作者： Mai me.bARAKAT Khulud HAbANJAR Department of Physics Faculty of Science Alexandria University Alexandria Egypt Department of Physics Faculty of Science Beirut Arab University Beirut Lebanon

Co-precipitation method and conventional solid-state reaction technique were used to synthesize baSnO3 nanoparticles and (baSnO3) x /bi1.6Pb0.4Sr2Ca2Cu3O10+δ (0 ≤ x ≤ 1.50 wt%) samples, respectively. X-ray powder diffraction (XRD), scanning electron microscopy (SeM), and electrical resistivity data were used to characterize biPb-2223 phase added by baSnO3 nanoparticles. The relative volume fraction and superconducting transition temperature Tc of biPb-2223 phase were enhanced by increasing baSnO3 addition up to 0.50 wt%. These parameters were decreased with further increase of x. The resistive transition broadening under different applied DC magnetic fields (0.29–4.40 kG) was analyzed through thermally activated flux creep (TAFC) model and Ambegaokar–Halperin (AH) theory. Improvements of the derived flux pinning energy u, critical current density Jc (0) estimated from AH parameter C(b), and upper critical magnetic field bc2 (0), were recorded by adding baSnO3 nanoparticles up to 0.50 wt%, beyond which these parameters were suppressed. The magnetic field dependence of the flux pinning energy and critical current density decreased as a power-law relation, which indicated the single junction sensitivity between the superconducting grains to the applied magnetic field. Furthermore, the increase in the applied magnetic field did not affect the electronic thermal conductivity κe above the superconducting transition temperature and suppressed it below Tc.

关键词： biPb-2223 baSnO 3 nanoparticles flux pinning energy critical current density

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