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Target specificity of selective bioactive compounds in blocking α-dystroglycan receptor to suppress Lassa virus infection: an in silico approach

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The Journal of Biomedical Research 2021年第6期35卷 459-473页

作者： Adittya Arefin Tanzila Ismail Ema Tamnia Islam MdSaddam Hossen Tariqul Islam Salauddin Al Azad MdNasir Uddin Badal MdAminul Islam Partha Biswas Nafee Ul Alam Enayetul Islam Maliha Anjum Afsana Masud mdshaikh kamran Ahsab Rahman Parag Kumar Paul Wolfson Institute for Biomedical Research Division of MedicineUniversity College LondonLondon WC1E6AEUK Department of Biochemistry and Microbiology North South UniversityDhaka 1229Bangladesh Faculty of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhouZhejiang 310018China Faculty of Pharmacy International Islamic University MalaysiaKuantanPahang 25200Malaysia School of Biotechnology Jiangnan UniversityWuxiJiangsu 214122China Department of Biomedical Technology Tampere UniversityTampere 33014Finland Department of Genetic Engineering and Biotechnology Jashore University of Science and TechnologyJashore 7408Bangladesh Department of Genetic Engineering and Biotechnology University of ChittagongChittagong 4331Bangladesh Applied Statistics and Data Science Jahangirnagar UniversityDhaka 1342Bangladesh Department of Mathematics and Natural Sciences Brac UniversityDhaka 1212Bangladesh Department of Electrical and Electronic Engineering United International UniversityDhaka 1212Bangladesh.

Lassa hemorrhagic fever,caused by Lassa mammarenavirus(LASV)infection,accumulates up to 5000 deaths every ***,there is no vaccine available to combat this *** this study,a library of 200 bioactive compounds was virtually screened to study their drug-likeness with the capacity to block theα-dystroglycan(α-DG)receptor and prevent LASV *** rigorous absorption,distribution,metabolism,and excretion(ADME)and quantitative structure-activity relationship(QSAR)profiling,molecular docking was conducted with the top ligands against theα-DG *** compounds chrysin,reticuline,and 3-caffeoylshikimic acid emerged as the top three ligands in terms of binding ***-docking analysis revealed that interactions with Arg76,Asn224,Ser259,and Lys302 amino acid residues of the receptor protein were important for the optimum binding affinity of *** dynamics simulation was performed comprehensively to study the stability of the protein-ligand ***-depth assessment of root-mean-square deviation(RMSD),root mean square fluctuation(RMSF),polar surface area(PSA),B-Factor,radius of gyration(Rg),solvent accessible surface area(SASA),and molecular surface area(MolSA)values of the protein-ligand complexes affirmed that the candidates with the best binding affinity formed the most stable protein-ligand *** authenticate the potentialities of the ligands as target-specific drugs,an in vivo study is underway in real time as the continuation of the research.

关键词： LASV infection α-dystroglycan receptor bioactive compounds target specificity molecular docking molecular dynamic simulations

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Novel Fractal-Based Features for Low-Power Appliances in Non-Intrusive Load Monitoring

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Computers, Materials & Continua 2024年第7期80卷 507-526页

作者： Anam Mughees Muhammad kamran Department of Electrical Engineering University of Engineering and Technology(UET)Lahore54890Pakistan Department of Electrical Engineering Government College UniversityFaisalabad38000Pakistan Department of Electrical Engineering and Technology Muhammad Nawaz Sharif University of Engineering&Technology(MNS UET)Multan60000Pakistan

Non-intrusive load monitoring is a method that disaggregates the overall energy consumption of a building to estimate the electric power usage and operating status of each appliance *** studies have mostly concentrated on the identification of high-power appliances like HVAC systems while overlooking the existence of low-power ***-power consumer appliances have comparable power consumption patterns,which can complicate the detection task and can be mistaken as *** research tackles the problem of classification of low-power appliances and uses turn-on current transients to extract novel features and develop unique appliance signatures.A hybrid feature extraction method based on mono-fractal and multi-fractal analysis is proposed for identifying low-power *** dimension,Hurst exponent,multifractal spectrum and the Hölder exponents of switching current transient signals are extracted to develop various‘turn-on’appliance signatures for *** classifiers,i.e.,deep neural network,support vector machine,decision trees,and K-nearest neighbours have been optimized using Bayesian optimization and trained using the extracted *** simulated results showed that the proposed method consistently outperforms state-of-the-art feature extraction methods across all optimized classifiers,achieving an accuracy of up to 96%in classifying low-power appliances.

关键词： Nonintrusive load monitoring multi-fractal analysis appliance classification switching transients

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Experimental investigation into effects of the natural polymer and nanoclay particles on the EOR performance of chemical flooding in carbonate reservoirs

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Petroleum Science 2024年第2期21卷 951-961页

作者： Amir Mohammad Zamani Ashkan Moslemi kamran Hassani Department of Petroleum Engineering Islamic Azad University Science and Research BranchTehranIran Institute of Petroleum Engineering University of TehranTehranIran

This paper aims to investigate the tragacanth gum potential as a natural polymer combined with natural clay mineral(montmorillonite,kaolinite,and illite)nanoparticles(NPs)to form NP-polymer suspension for enhanced oil recovery(EOR)in carbonate *** gravimetric analysis(TGA)tests were conducted initially in order to evaluate the properties of tragacanth ***,scanning electron microscopy(SEM)and energy-dispersive X-ray(EDX)tests were used to detect the structure of clay *** various scenarios,the effects of natural NPs and polymer on the wettability alteration,interfacial tension(IFT)reduction,viscosity improvement,and oil recovery were investigated through contact angle system,ring method,Anton Paar viscometer,and core flooding tests,*** entire experiment was conducted at 25,50,and 75℃,*** to the experimental results,the clay minerals alone did not have a significant effect on viscosity,but the addition of minerals to the polymer solution leads to the viscosity enhancement remarkably,resulting mobility ratio *** clay NPs,the combination of natural polymer and kaolinite results in increased viscosity at all *** wettability alteration was also observed in the case of natural polymer and illite *** in combination with natural polymer showed an ability in reducing ***,the results of displacement experiments revealed that the combination of natural polymer and kaolinite could be the best option for EOR due to its substantial ability to improve the recovery factor.

关键词： Chemical flooding Tragacanth gum Clay nanoparticle Wettability IFT

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A Framework to Assess Possible Sources of Stakeholder Exploitation:A Developing Country Case

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International Journal of Disaster Risk Science 2024年第1期15卷 32-44页

作者： kamran Shafique Syed Shams Tapan Sarker School of Business University of Southern QueenslandSpringfeldQLD 4300Australia Business School University of QueenslandSt LuciaQLD 4072Australia

Solving complex post-disaster reconstruction challenges requires the altruistic involvement of heterogeneous stakeholder ***,small,more organized groups,such as government parastatals,private developers,and contractors often exploit large,unorganized groups,such as affected communities,leaving them more vulnerable to future *** on data collected from a case study in Pakistan,this study proposed a framework to assess,anticipate,and mitigate the exploitation of vulnerable stakeholders in post-disaster reconstruction *** framework draws on influential management theories and utilizes reciprocal relationships between stakeholder attributes(power,legitimacy,and urgency),participation,and *** study also argued for non-binary treatment of stakeholder *** framework will allow practitioners to address issues around the exploitation of stakeholder interests in future post-disaster reconstruction projects.

关键词： Collective action Pakistan Post-disaster reconstruction-Stakeholder participation Stakeholder exploitation

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Leveraging machine learning for early recurrence prediction in hepatocellular carcinoma:A step towards precision medicine

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World Journal of Gastroenterology 2024年第5期30卷 424-428页

作者： Abhimati Ravikulan kamran Rostami epartment of Gastroenterology Palmerston North HospitalPalmerston North 4442New Zealand

The high rate of early recurrence in hepatocellular carcinoma(HCC)post curative surgical intervention poses a substantial clinical hurdle,impacting patient outcomes and complicating postoperative *** advent of machine learning provides a unique opportunity to harness vast datasets,identifying subtle patterns and factors that elude conventional prognostic *** learning models,equipped with the ability to analyse intricate relationships within datasets,have shown promise in predicting outcomes in various medical *** the context of HCC,the application of machine learning to predict early recurrence holds potential for personalized postoperative care *** editorial comments on the study carried out exploring the merits and efficacy of random survival forests(RSF)in identifying significant risk factors for recurrence,stratifying patients at low and high risk of HCC recurrence and comparing this to traditional COX proportional hazard models(CPH).In doing so,the study demonstrated that the RSF models are superior to traditional CPH models in predicting recurrence of HCC and represent a giant leap towards precision medicine.

关键词： Machine learning Artificial intelligence Hepatocellular carcinoma Hepatology Early recurrence Liver resection

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Facile synthesis of samarium and cerium doped double perovskite cobaltite with enhanced dielectric response

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Journal of Rare Earths 2024年第7期42卷 1317-1327,I0005页

作者： Yasir Abbas M.kamran M.Anis-ur-Rehman Applied Thermal Physics Laboratory Department of PhysicsCOMSATS University IslamabadIslamabad 45550Pakistan

The investigation of Sm-Ce doping on structure,conduction,and dielectric response of Bi_(2)Ca_(2-2x)Sm_(x)CexCoO_(6)(x=0.000,0.025,0.050,0.075)(BCSCCO)are *** the specimens were synthesized by a facile synthesis technique named the co-precipitation route.X-ray diffraction(XRD)reveals that BCSCCO crystallizes into one phase with space group P21/*** crystallite size,dislocation density,lattice parameters,lattice strain,unit cell volume,and bulk density were determined using XRD *** structural properties of Bi_(2)Ca_(2)CoO_(6)were examined using calculations based on the density functional *** and experimental values discrepancy is less than 1%.A scanning electron microscope was used for performing a microstructural *** SEM images demonstrate the homogeneous distribution of grains with a range of sizes(0.054-0.090μm).The alternating current(ac)conductivity,dielectric permittivity,and tangent loss were also studied as a function of frequency(20 Hz-3 MHz)at different temperatures(100-500℃).All synthesized samples were examined using non-linear Debye's function to determine their spreading factor and relaxation *** specimen with the lowest crystallite size(∼23 nm)exhibits a high dielectric permittivity(∼3.80×10^(6)).The conduction mechanism was examined in the studied samples with the use of Jonscher's power *** power law indicates that the BCSCCO(x=0.000,0.025)follows correlated barrier hopping,whereas the x=0.050 and 0.075 compositions follow non-overlapping polaron *** studied specimen Bi_(2)Ca_(1.9)0Sm_(0.05)0Ce_(0.05)_(0)CoO_(6)with the highest density(∼5.65 g/cm^(3))displays a high electrical conductivity(∼46.1 S/cm).These findings correspond to those published for ceramics made from calcium cobaltite using solid-state reactions(5.0-26.0 S/cm).

关键词： Bismuth calcium samarium cerium cobaltite (BCSCCO) Spreading factor Conduction mechanism Rare earths

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Pro and anti-inflammatory diets as strong epigenetic factors in inflammatory bowel disease

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World Journal of Gastroenterology 2024年第27期30卷 3284-3289页

作者： Adele Rostami Kristen White kamran Rostami Digestive Health Clinic Palmerston North 4410New Zealand Digestive Health Clinic&Kōtare Wellness Ltd Palmerston North 4410New Zealand Department of Gastroenterology Palmerston North HospitalPalmerston North 4442New Zealand

Inflammatory bowel disease(IBD)is the consequence of a complex interplay between environmental factors,like dietary habits,that alter intestinal microbiota in response to luminal antigens in genetically susceptible *** represents an auspicious area for the discovery of how environmental factors influence the pathogenesis of inflammation,prognosis,and response to ***,it relates to gene expression control in response to environmental *** increasing number of patients with IBD globally is indicative of the negative effects of a food supply rich in trans and saturated fats,refined su-gars,starches and additives,as well as other environmental factors like seden-tarism and excess bodyweight,influencing the promotion of gene expression and increasing DNA hypomethylation in *** many genetic variants are now associated with Crohn's disease(CD),new therapeutic strategies targeting modi-fiable environmental triggers,such as the implementation of an anti-inflammatory diet that involves the removal of potential food antigens,are of growing interest in the current ***,as a strong epigenetic factor in the pathogenesis of inflammatory disorders like IBD,provides novel insights into the pathophysio-logy of intestinal and extraintestinal inflammatory disorders.

关键词： Inflammatory bowel disease Epigenetic Anti-inflammatory diet Immunogenetics Microbiome Polymeric diet Elemental diet

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Purity-dependent Lorenz number,electron hydrodynamics and electron-phonon coupling in WTe_(2)

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 153-158页

作者： Wei Xie Feng Yang Liangcai Xu Xiaokang Li Zengwei Zhu kamran Behnia Wuhan National High Magnetic Field Center and School of Physics Huazhong University of Science and TechnologyWuhan 430074China Laboratoire de Physique et d’Etude des Matériaux(ESPCI-CNRS-Sorbonne Université)PSL University Paris 75005France

We present a study of electrical and thermal transport in Weyl semimetal WTe_(2)down to 0.3 *** Wiedemann-Franz law holds below 2 K and a downward deviation starts *** deviation is more pronounced in cleaner samples,as expected in the hydrodynamic picture of electronic transport,where a fraction of electron-electron collisions conserve *** are the dominant heat carriers and their mean-free-path does not display a Knudsen *** is presumably a consequence of weak anharmonicity,as indicated by the temperature dependence of the specific *** momentum exchange between phonons and electrons leads to quantum oscillations of the phononic thermal ***-Grüneisen picture of electron-phonon scattering breaks down at low temperature when Umklapp ph-ph collisions cease to be a sink for electronic flow of *** with semi-metallic Sb shows that normal ph-ph collisions are amplified by *** both semimetals,at cryogenic temperature,e-ph collisions degrade the phononic flow of energy but not the electronic flow of momentum.

关键词： thermal conductivity Wiedemann-Franz law electron hydrodynamics electron-phonon coupling

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Hepatocellular carcinoma presenting as an extrahepatic mass:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2241-2252页

作者： Wei Kelly Wu Krutika Patel Chandrasekhar Padmanabhan kamran Idrees Department of Surgery Vanderbilt University Medical CenterNashvilleTN 37232United States Department of Pathology Microbiology and ImmunologyVanderbilt University Medical CenterNashvilleTN 37232United States Division of Surgical Oncology and Endocrine Surgery Department of SurgeryVanderbilt University Medical CenterNashvilleTN 37232United States

BACKGROUND Hepatocellular carcinoma(HCC)is a primary liver tumor generally diagnosed based on radiographic *** disease is typically associated with increased tumor diameter,multifocality,and vascular *** report a case of a patient who presented with extrahepatic HCC metastasis to a portocaval lymph node with occult hepatic primary on computed tomography(CT).We review the literature for cases of extrahepatic HCC presentation without known hepatic lesions and discuss strategies to differentiate between metastatic and ectopic *** SUMMARY A 67-year-old male with remotely treated hepatis C was referred for evaluation of an enlarging portocaval,mixed cystic-solid *** CT evaluations demonstrated steatosis,but no cirrhosis or liver *** ultrasound demonstrated a normal-appearing pancreas,biliary tree,and *** needle aspiration yielded atypical *** differential diagnosis included duodenal or pancreatic cyst,lymphoproliferative cyst,stromal or mesenchymal lesions,nodal involvement from gastrointestinal or hematologic malignancy,or duodenal gastrointestinal stromal *** review by a multidisciplinary tumor board,the patient underwent open surgical resection of a 5.2 cm×5.5 cm retroperitoneal mass with pathology consistent with moderately-differentiated *** resonance imaging(MRI)subsequently demonstrated a 1.2 cm segment VIII hepatic lesion with late arterial enhancement,fatty sparing,and intrinsic T1 *** fetoprotein was 23.3 ng/*** patient was diagnosed with HCC with portocaval nodal ***:We surveyed the literature for HCC presenting as extrahepatic masses without history of concurrent or prior intrahepatic *** identified 18 cases of extrahepatic HCC ultimately found to represent metastatic lesions,and 30 cases of extrahepatic HCC found to be primary,ectopic *** Hepatocellular carcinoma can seldomly present with extrahepatic metastasis in the setting of

关键词： Extrahepatic Metastasis Portocaval Lymph node Case report

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AI-Driven Energy Optimization in UAV-Assisted Routing for Enhanced Wireless Sensor Networks Performance

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Computers, Materials & Continua 2024年第9期80卷 4085-4110页

作者： Syed kamran Haider Abbas Ahmed Noman Mujeeb Khan Ali Nauman Sung Won Kim College of Internet of Things(IoT)Engineering Hohai UniversityChangzhou213001China Department of Electrical and Electronics Engineering Beaconhouse International CollegeIslamabad44000Pakistan School of Computer Science and Engineering Yeungnam UniversityGyeongsan38428Republic of Korea

In recent advancements within wireless sensor networks(WSN),the deployment of unmanned aerial vehicles(UAVs)has emerged as a groundbreaking strategy for enhancing routing efficiency and overall network *** research introduces a sophisticated framework,driven by computational intelligence,that merges clustering techniques with UAV mobility to refine routing strategies in *** proposed approach divides the sensor field into distinct sectors and implements a novel weighting system for the selection of cluster heads(CHs).This system is primarily aimed at reducing energy consumption through meticulously planned routing and path *** a greedy algorithm for inter-cluster dialogue,our framework orchestrates CHs into an efficient communication *** comparative analysis,the proposed model demonstrates a marked improvement over traditional methods such as the cluster chain mobile agent routing(CCMAR)and the energy-efficient cluster-based dynamic algorithms(ECCRA).Specifically,it showcases an impressive 15%increase in energy conservation and a 20%reduction in data transmission time,highlighting its advanced ***,this paper investigates the impact of various network parameters on the efficiency and robustness of the WSN,emphasizing the vital role of sophisticated computational strategies in optimizing network operations.

关键词： UAV trajectory clustering next-generation wireless sensor network(NGWSN) energy efficiency mobile sink

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