检索结果-南通市图书馆

Cyclophilin D as a potential therapeutic target of liver ischemia/reperfusion injury by mediating crosstalk between apoptosis and autophagy

引用

慢性疾病与转化医学:英文版 2023年第3期9卷 238-249页

作者： Mengjiao Yang Zhihui Wang Jin Xie mdreyad‐ul‐ferdous Siying Li Yongfeng Song Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Shandong Key Laboratory of Endocrinology and Lipid Metabolism JinanShandongChina Shandong Institute of Endocrine and Metabolic Diseases JinanShandongChina Department of Endocrinology Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinanShandongChina Department of Endocrinology and Metabolism Central Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina

Background:Liver ischemia/reperfusion(I/R)injury is a complex and multifactorial pathophysiological *** is well recognized that the membrane permeability transition pore(mPTP)opening of mitochondria plays a crucial role in cell death after I/R *** D(CypD)is a critical positive regulator of ***,the effect of CypD on the pathogenesis of liver I/R injury and whether CypD is a potential therapeutic target are still ***:We constructed liver-specific CypD knockout and AAV8-peptidyl prolyl isomerase F(PPIF)overexpression ***,a 70%liver I/R injury model was established in mice,with 90 min of ischemia and 6 h of *** liver function was detected by the level of serum glutamic pyruvic transaminase(alanine transaminase)and glutamic oxaloacetic transaminase(aspartate aminotransferase),the liver damage score and degree of necrosis were measured by hematoxylin and eosin(H&E)staining of liver *** oxygen species(ROS)staining,apoptosis,and autophagy-related molecules were used to detect apoptosis and autophagy during liver I/***:The liver-specific knockout of CypD alleviated necrosis and dysfunction in liver I/R injury,by reducing the excessive production of ROS,and inhibiting cell apoptosis and *** the contrary,overexpression of CypD exacerbated I/R-induced liver ***:We found that the downregulation of CypD expression alleviated liver I/R injury by reducing apoptosis and autophagy through caspase-3/Beclin1 crosstalk;in contrast,the upregulation of CypD expression aggravated liver I/R ***,interfering with the expression of CypD seems to be a promising treatment for liver I/R injury.

关键词： apoptosis autophagy cyclophilin D ischemia/reperfusion necrosis reactive oxygen species

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Local Macroscopic Conservative(LoMaC)Low Rank Tensor Method with the Discontinuous Galerkin Method for the Vlasov Dynamics

引用

Communications on Applied Mathematics and Computation 2024年第1期6卷 550-575页

作者： Wei Guo Jannatul ferdous Ema Jing-Mei Qiu Department of Mathematics and Statistics Texas Tech UniversityLubbockTX70409USA Department of Mathematical Sciences University of DelawareNewarkDE19716USA

In this paper,we propose a novel Local Macroscopic Conservative(LoMaC)low rank tensor method with discontinuous Galerkin(DG)discretization for the physical and phase spaces for simulating the Vlasov-Poisson(VP)*** LoMaC property refers to the exact local conservation of macroscopic mass,momentum,and energy at the discrete *** recently developed LoMaC low rank tensor algorithm(arXiv:2207.00518)simultaneously evolves the macroscopic conservation laws of mass,momentum,and energy using the kinetic flux vector splitting;then the LoMaC property is realized by projecting the low rank kinetic solution onto a subspace that shares the same macroscopic *** paper is a generalization of our previous work,but with DG discretization to take advantage of its compactness and flexibility in handling boundary conditions and its superior accuracy in the long *** algorithm is developed in a similar fashion as that for a finite difference scheme,by observing that the DG method can be viewed equivalently in a nodal *** the nodal DG method,assuming a tensorized computational grid,one will be able to(i)derive differentiation matrices for different nodal points based on a DG upwind discretization of transport terms,and(ii)define a weighted inner product space based on the nodal DG grid *** algorithm can be extended to the high dimensional problems by hierarchical Tucker(HT)decomposition of solution tensors and a corresponding conservative projection *** a similar spirit,the algorithm can be extended to DG methods on nodal points of an unstructured mesh,or to other types of discretization,e.g.,the spectral method in velocity *** numerical results are performed to showcase the efficacy of the method.

关键词： Hierarchical Tucker(HT)decomposition Conservative SVD Energy conservation Discontinuous Galerkin(DG)method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synergistic enhancement of photocatalytic and antimicrobial efficacy of nitrogen and erbium co-doped ZnO nanoparticles

引用

Journal of Rare Earths 2024年第5期42卷 859-868,I0002页

作者： Sudipta Mondal Moniruzzaman Jamal Sikder Ashikuzzaman Ayon Md Jannatul ferdous Anik Md Muktadir Billah Department of Materials and Metallurgical Engineering Bangladesh University of Engineering and TechnologyDhaka1000Bangladesh School of Materials Engineering Purdue UniversityWest LafayetteIN47907USA Department of Materials Science and Engineering University of CaliforniaBerkeleyCA94720USA Department of Materials Science and Engineering Northwestern UniversityEvanstonI28USA

Using the chemical co-precipitation approach,a series of nitrogen(N) and erbium(Er) co-doped ZnO nanoparticles(NPs) was effectively synthesized to enhance the photocatalytic and antibacterial *** characterization techniques,including X-ray diffraction(XRD),X-ray photoelectron spectro scopy(XPS),scanning electron microscopy(SEM),UV-vis,and photoluminescence(PL) spectroscopy,were carried out to validate the evaluated photocatalytic and antibacterial *** analysis confirms the pure wurtzite ZnO phase without the presence of any secondary *** analysis confirms the succe ssful incorporation of nitrogen and erbium into the ZnO *** optical bandgap of ZnO calculated from UV-vis spectroscopy shows a redshift after Er-N co-doping,with the lowest bandgap of 3.215 eV calculated for Zn_(0.97)Er_(0.03)N_(0.01)O_(0.99) *** images demonstrate the formation of nanorods after N-Er co-doping,followed by gradually increase d rod diameter and length after N-Er ***,the photocatalytic activities of ZnO samples we re measured by their ability to facilitate the photodegradation of Rhodamine B under UV *** with 1 mol% N doping exhibits 88% photodegradation of RhB under UV light within 360 min,and the photodegradation and antibacterial activity are greatly improved with Er *** fact,3 mol% Er-1 mol% N doped ZnO NPs demonstrate the highest photocatalytic activity,with approximately 96% degradation after 360 min,as well as superior antibacterial activity against Staphylococcus aureus(Gram-positive bacteria) and Pseudomonas aeruginosa(Gram-negative bacteria) with the highest zone of inhibition(ZOI) of 16 nm,due to nanorod formation,increased reactive oxygen species(ROS),and decreased electron-hole recombination,as validated by SEM,XPS,and PL spectroscopy.

关键词： Chemical co-precipitation Co-doping Bandgap Photocatalysis Rare earths Antimicrobial

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Identification of Software Bugs by Analyzing Natural Language-Based Requirements Using Optimized Deep Learning Features

引用

Computers, Materials & Continua 2024年第3期78卷 4379-4397页

作者： Qazi Mazhar ul Haq Fahim Arif Khursheed Aurangzeb Noor ul Ain Javed Ali Khan Saddaf Rubab Muhammad Shahid Anwar Department of Computer Science and Engineering and International Bachelor’s Program in Informatics Yuan Ze UniversityZhongliTaoyuan320315Taiwan Department of Computer Science National University of PakistanRawalpindiPunjab46000Pakistan Department of Computer Software Engineering MCSNational University of Sciences and TechnologyIslamabad44000Pakistan Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia Department of Computer Science School of PhysicsEngineering and Computer ScienceUniversity of HertfordshireHatfieldAL109ABUK Department of Computer Engineering College of Computing and InformaticsUniversity of SharjahSharjah27272United Arab Emirates Department of AI and Software Gachon UniversitySeongnam-SI13120South Korea

Software project outcomes heavily depend on natural language requirements,often causing diverse interpretations and issues like ambiguities and incomplete or faulty *** are exploring machine learning to predict software bugs,but a more precise and general approach is *** bug prediction is crucial for software evolution and user training,prompting an investigation into deep and ensemble learning ***,these studies are not generalized and efficient when extended to other ***,this paper proposed a hybrid approach combining multiple techniques to explore their effectiveness on bug identification *** methods involved feature selection,which is used to reduce the dimensionality and redundancy of features and select only the relevant ones;transfer learning is used to train and test the model on different datasets to analyze how much of the learning is passed to other datasets,and ensemble method is utilized to explore the increase in performance upon combining multiple classifiers in a *** National Aeronautics and Space Administration(NASA)and four Promise datasets are used in the study,showing an increase in the model’s performance by providing better Area Under the Receiver Operating Characteristic Curve(AUC-ROC)values when different classifiers were *** reveals that using an amalgam of techniques such as those used in this study,feature selection,transfer learning,and ensemble methods prove helpful in optimizing the software bug prediction models and providing high-performing,useful end mode.

关键词： Natural language processing software bug prediction transfer learning ensemble learning feature selection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Robust design of sliding mode control for airship trajectory tracking with uncertainty and disturbance estimation

引用

Journal of Systems Engineering and Electronics 2024年第1期35卷 242-258页

作者： WASIM Muhammad ALI Ahsan CHOUDHRY Mohammad Ahmad SHAIKH Inam ul Hasan SALEEM Faisal Department of Aeronautics and Astronautics Engineering Institute of Space TechnologyIslamabad 44000Pakistan Department of Electrical Engineering University of Engineering and TechnologyTaxila 47080Pakistan Department of Measurements and Control Systems Silesian University of TechnologyGliwice 44-101Poland The Joint Doctoral School Silesian University of TechnologyGliwice 44-100Poland

The robotic airship can provide a promising aerostatic platform for many potential *** applications require a precise autonomous trajectory tracking control for *** has a nonlinear and uncertain *** is prone to wind disturbances that offer a challenge for a trajectory tracking control *** paper addresses the airship trajectory tracking problem having time varying reference path.A lumped parameter estimation approach under model uncertainties and wind disturbances is opted against distributed *** uses extended Kalman filter(EKF)for uncertainty and disturbance *** estimated parameters are used by sliding mode controller(SMC)for ultimate control of airship trajectory *** comprehensive algorithm,EKF based SMC(ESMC),is used as a robust solution to track airship *** proposed estimator provides the estimates of wind disturbances as well as model uncertainty due to the mass matrix variations and aerodynamic model *** stability and convergence of the proposed method are investigated using the Lyapunov stability *** simulation results show that the proposed method efficiently tracks the desired *** method solves the stability,convergence,and chattering problem of SMC under model uncertainties and wind disturbances.

关键词： airship chattering extended Kalman filter(EKF) model uncertainties estimation sliding mode controller(SMC)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Re-analysis of temperature dependent neutron capture rates and stellar β-decay rates of 95-98Mo

引用

Chinese Physics C 2024年第9期48卷 146-153页

作者： Abdul Kabir Jameel-Un Nabi Muhammad Tahir Abdul Muneem Zain ul Abideen Space and Astrophysics Research lab National Centre of GIS and Space Applications Department of Space Science Institute of Space Technology University of Wah Faculty of Engineering Sciences GIK Institute of Engineering Sciences and Technology

The neutron capture rates and temperature dependent stellar beta decay rates of Mo isotopes are investigated within the framework of the statistical code TALYS v1.96 and the proton neutron quasi particle random phase approximation（pn-QRPA） *** Maxwellian average cross-section（MACS） and neutron capture rates for the95-98Mo（n,γ）96-99Mo radiative capture process are analyzed within the framework of the statistical code TALYS v1.96 based on the phenomenological nuclear level density model and gamma strength *** present model-based computations for the MACS are comparable to the existing measured *** sensitivity of stellar weak interaction rates to various densities and temperatures is investigated within the framework of the pn-QRPA *** attention is paid to the impact of thermally filled excited states in the decaying nuclei(95-98Mo) on electron emission and positron capture ***,we compare the neutron capture rates and stellar beta decay *** is found that neutron capture rates are higher than stellar beta decay rates at both lower and higher temperatures.

关键词： capture rates cross-section decay rates nuclear level density TALYS

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Deep Learning Based Efficient Crowd Counting System

引用

Computers, Materials & Continua 2024年第6期79卷 4001-4020页

作者： Waleed Khalid Al-Ghanem Emad ul Haq Qazi Muhammad Hamza Faheem Syed Shah Amanullah Quadri Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityRiyadh12372Saudi Arabia Centre of Excellence in Cybercrime and Digital Forensics Naif Arab University for Security SciencesRiyadh14812Saudi Arabia Center of Excellence for Information Assurance(COEIA) King Saud UniversityRiyadh12372Saudi Arabia

Estimation of crowd count is becoming crucial nowadays,as it can help in security surveillance,crowd monitoring,and management for different *** is challenging to determine the approximate crowd size from an image of the crowd’s *** in this research study,we proposed a multi-headed convolutional neural network architecture-based model for crowd counting,where we divided our proposed model into two main components:(i)the convolutional neural network,which extracts the feature across the whole image that is given to it as an input,and(ii)the multi-headed layers,which make it easier to evaluate density maps to estimate the number of people in the input image and determine their number in the *** employed the available public benchmark crowd-counting datasets UCF CC 50 and ShanghaiTech parts A and B for model training and testing to validate the model’s *** analyze the results,we used two metrics Mean Absolute Error(MAE)and Mean Square Error(MSE),and compared the results of the proposed systems with the state-of-art models of crowd *** results show the superiority of the proposed system.

关键词： Crowd counting EfficientNet multi-head attention convolutional neural network transfer learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aldosterone synthase inhibitor“Baxdrostat”for resistant hypertension:A clinical approach or futuristic idea?

引用

Chronic Diseases and Translational Medicine 2024年第2期10卷 146-148页

作者： Muhammad Osama Siddiqui Ayaan Ahmed Qureshi Arooba Siddiqui Noor ul ain Liaquat National Hospital and Medical College KarachiSindhPakistan Karachi Medical and Dental College KarachiSindhPakistan

The American College of Cardiology/American Heart Association defines resistant hypertension(RH)as a clinical blood pressure(BP)reading of>130/80 mmHg in patients taking three antihypertensive drugs,including a renin–angiotensin system inhibitor,a calcium channel blocker(CCB),and a diuretic at well-tolerated doses.1,2 It is reported from multiple population-based surveys that in the United States,there is an approximately 12%–15%prevalence of RH among adults diagnosed with hypertension.2 A prospective study demonstrates that 20%of people diagnosed with RH had primary hyperaldosteronism.3,4 In addition to the classic three antihypertensive drugs,spironolactone and mineralocorticoid are also administered for ***,with respect to the safety profile of spironolactone,it has been reported to have several side effects such as low testosterone production,menstrual irregularities,and excessively raised serum potassium levels,leaving the drug unfit for the longitudinal therapeutic purpose of treating RH.

关键词： hypertension drugs hypertensive

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CapsNet-FR: Capsule Networks for Improved Recognition of Facial Features

引用

Computers, Materials & Continua 2024年第5期79卷 2169-2186页

作者： Mahmood ul Haq Muhammad Athar Javed Sethi Najib Ben Aoun Ala Saleh Alluhaidan Sadique Ahmad Zahid farid Department of Computer System Engineering University of Engineering&TechnologyPeshawar25000Pakistan College of Computer Science and Information Technology Al-Baha UniversityAlaqiq65779-7738Saudi Arabia REGIM-Lab:Research Groups in Intelligent Machines National School of Engineers of Sfax(ENIS)University of SfaxSfax3038Tunisia Department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh84428Saudi Arabia EIAS:Data Science and Blockchain Laboratory College of Computer and Information SciencesPrince Sultan UniversityRiyadh11586Saudi Arabia Department of Computer Sciences Bahria University Karachi CampusKarachi541004Pakistan Department of Electrical Engineering Abasyn UniversityPeshawar25000Pakistan

Face recognition (FR) technology has numerous applications in artificial intelligence including biometrics, security,authentication, law enforcement, and surveillance. Deep learning (DL) models, notably convolutional neuralnetworks (CNNs), have shown promising results in the field of FR. However CNNs are easily fooled since theydo not encode position and orientation correlations between features. Hinton et al. envisioned Capsule Networksas a more robust design capable of retaining pose information and spatial correlations to recognize objects morelike the brain does. Lower-level capsules hold 8-dimensional vectors of attributes like position, hue, texture, andso on, which are routed to higher-level capsules via a new routing by agreement algorithm. This provides capsulenetworks with viewpoint invariance, which has previously evaded CNNs. This research presents a FR model basedon capsule networks that was tested using the LFW dataset, COMSATS face dataset, and own acquired photos usingcameras measuring 128 × 128 pixels, 40 × 40 pixels, and 30 × 30 pixels. The trained model outperforms state-ofthe-art algorithms, achieving 95.82% test accuracy and performing well on unseen faces that have been blurred orrotated. Additionally, the suggested model outperformed the recently released approaches on the COMSATS facedataset, achieving a high accuracy of 92.47%. Based on the results of this research as well as previous results, capsulenetworks perform better than deeper CNNs on unobserved altered data because of their special equivarianceproperties.

关键词： CapsNet face recognition artificial intelligence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Design of an Efficient and Provable Secure Key Exchange Protocol for HTTP Cookies

引用

Computers, Materials & Continua 2024年第7期80卷 263-280页

作者： Waseem Akram Khalid Mahmood Hafiz Burhan ul Haq Muhammad Asif Shehzad Ashraf Chaudhry Taeshik Shon Graduate School of Engineering Science and Technology National Yunlin University of Science and TechnologyYunlin64002TaiwanChina Future Technology Research Center National Yunlin University of Science and TechnologyYunlin64002TaiwanChina Department of Computer Science Lahore Garrison UniversityLahore54920Pakistan Department of Computer Science and Information Technology College of EngineeringAbu Dhabi UniversityAbu Dhabi69911United Arab Emirates Department of Software Engineering Faculty of Engineering and ArchitectureNisantasi UniversityIstanbul34398Turkey Department of Cybersecurity Ajou UniversitySuwon16499Republic of Korea

Cookies are considered a fundamental means of web application services for authenticating various Hypertext Transfer Protocol(HTTP)requests andmaintains the states of clients’information over the *** cookies are exploited to carry client patterns observed by a *** client patterns facilitate the particular client’s future visit to the corresponding ***,security and privacy are the primary concerns owing to the value of information over public channels and the storage of client information on the *** protocols have been introduced that maintain HTTP cookies,but many of those fail to achieve the required security,or require a lot of resource *** this article,we have introduced a lightweight Elliptic Curve Cryptographic(ECC)based protocol for authenticating client and server transactions to maintain the privacy and security of HTTP *** proposed protocol uses a secret key embedded within a *** proposed protocol ismore efficient and lightweight than related protocols because of its reduced computation,storage,and communication ***,the analysis presented in this paper confirms that proposed protocol resists various known attacks.

关键词： Cookies authentication protocol impersonation attack ECC

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：