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Global geoepidemiology of gastrointestinal surgery rates in Crohn’s disease

World Journal of Gastrointestinal Surgery 2024年第6期16卷 1835-1844页

作者： Simcha Weissman Muhammad Aziz Ayrton Bangolo Vignesh K Nagesh Htat Aung Midhun Mathew Lino Garcia Shiva A Chandar Praveena Karamthoti Harinder Bawa Aseel Alshimari Yabets Kejela Nazish Mehdi Chrishanti A Joseph Athri Kodali Rohan Kumar Priya Goyal Sanya Satheesha Fnu Nivedita Nicole Tesoro Tanni Sethi Gurpreet Singh Areej Belal Alina Intisar Hirra khalid Samuel Cornwell Suchith B Suresh Kareem Ahmed Karabo K Marole Om P Anand Rahat B Reshi Tej I Mehta Sameh Elias Joseph D Feuerstein Department of Medicine Hackensack Meridian Health Palisades Medical CenterNorth BergenNJ 07047United States Division of Gastroenterology and Hepatology University of Toledo Medical CenterToledoOH 43614United States Department of Medicine University of WashingtonSeattleWA 98195United States Department of Radiology Johns Hopkins University HospitalBaltimoreMD 21218United States Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215United States

BACKGROUND Data regarding the worldwide gastrointestinal surgery rates in patients with Crohn’s disease(CD)remains *** To systematically review the global variation in the rates of surgery in *** A comprehensive search analysis was performed using multiple electronic databases from inception through July 1,2020,to identify all full text,randomized controlled trials and cohort studies pertaining to gastrointestinal surgery rates in adult patients with *** included continent based demographic data,CD surgery rates over time,as well as the geoepidemiologic variation in CD surgery *** analyses were conducted using *** Twenty-three studies spanning four continents were *** median proportion of persons with CD who underwent gastrointestinal surgery in studies from North America,Europe,Asia,and Oceania were 30%(range:1.7%-62.0%),40%(range:0.6%-74.0%),17%(range:16.0%-43.0%),and 38%*** clear association was found regarding the proportion of patients undergoing gastrointestinal surgery over time in North America(R^(2)=0.035)and Europe(R^(2)=0.100).A moderate,negative association was seen regarding the proportion of patients undergoing gastrointestinal surgery over time(R^(2)=0.520)in *** There appears to be significant inter-continental variation regarding surgery rates in *** evidencebased guidelines accounting for the geographic differences in managing patients with CD is ***,as a paucity of data on surgery rates in CD exists outside the North American and European continents,future studies,particularly in less studied locales,are warranted.

关键词： Gastrointestinal surgery Crohn’s disease Geoepidemiology Inflammatory bowel disease Prevalence

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Assessment of Water Quality and Microbial Load of Dhaleshwari River Tangail, Bangladesh

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Advances in Microbiology 2017年第6期7卷 523-533页

作者： md. khalid Hassan Real Natasha Khanam md. Younus Mia Marufa Nasreen Department of Environmental Science and Resource Management Mawlana Bhashani Science and Technology University Tangail Bangladesh Department of Biotechnology and Genetic Engineering Mawlana Bhashani Science and Technology University Tangail Bangladesh

The present study was undertaken to investigate some water quality parameters (pH, BOD, DO and water temperature), anion concentration (PO43- , SO42- and NO3- ) and the availability of some selected microorganisms consisted of total coliform, fecal coliform (Escherichia coli) and Vibrio cholerae in the Dhaleshwari river during the period from April to June 2015. The water samples were collected from three different stations of the river namely Belta (St-1), Kendua (St-2) and Charabari (St-3) under the Porabari union at Tangail Sadar Upazilla. Water temperature varied from 29.5 oC in June to 31.7 oC in May with a highest mean 31.17 ± 0.47 in May. The pH of water was slightly alkaline in nature and ranged between 7.25 in June and 8.45 in April. Mean concentrations of BOD 0.87 ± 0.19, 1.12 ± 0.6 and 0.97 ± 0.67 were recorded in April, May and June respectively. Highest PO42- value 4.4 mg/l was found in May and lowest value of PO42- 1.74 mg/l was found in June. Mean sulfate values at different months of Dhaleshwaririver were 6.61 ± 1.78 mg/l, 7.61 ± 2.16 mg/l and 3.68 ± 0.23 mg/l respectively. Nitrate concentration in water samples varied from 0.51 mg/l in June to 3.66 mg/l in April. Total coliforms bacteria were found high in all water samples and values ranged from 11.05 × 108 - 19 × 1023 cfu/ml. The highest load of total coliforms bacteria was recorded at St-2 in May and the lowest was at St-1 in April. The highest concentration of (Escherichia coli counted in water sample was 6 × 1013 cfu/ml at St-2 during June, while lowest concentration was 5 × 105 cfu/ml at St-1 during May. The highest concentration of Vibrio cholerae was 9.66 × 1014 cfu/ml at St-1 during June, while lowest concentration was 4.2 × 108 cfu/ml at St-3 during April. The high number of total coliform, Escherichia coli and Vibrio cholerae indicated significant level of microbial pollution in Dhaleshwari river. The presence of pathogenic organisms may pose not only health hazards to the users of the ri

关键词： Bacteria Total Coliform Escherichia coli Vibrio cholerae

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喜来芝石中提取的腐植酸与阿司匹林的分子络合物及其表征

喜来芝石中提取的腐植酸与阿司匹林的分子络合物及其表征

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第八届全国绿色环保肥料（农药）新技术、新产品交流会

作者： md.khalid Anwer Suraj P.Agarwal Asgar Ali Yasmin Sultana 黄静佳米雅综合大学药剂学院中国腐植酸工业协会

阿司匹林具有退热、消炎和抗血小板凝集的作用。乙酰水杨酸分子含一个羧基和一个酯基。酯基容易被水解,导致其药效降低,并会对人体产生副作用。本研究的目的是用冻干技术和溶剂挥发技术,以原料的摩尔比为1:1和1:2,制备阿司匹林和腐植酸... 详细信息

阿司匹林具有退热、消炎和抗血小板凝集的作用。乙酰水杨酸分子含一个羧基和一个酯基。酯基容易被水解,导致其药效降低,并会对人体产生副作用。本研究的目的是用冻干技术和溶剂挥发技术,以原料的摩尔比为1:1和1:2,制备阿司匹林和腐植酸固态配合物。阿司匹林和腐植酸分子间相互作用通过差示扫描量热法(DSC)、X射线衍射(XRD)和扫描电子显微镜(SEM)法进行研究。用这些技术能清晰表明固态包内配合物的结构。对摩尔比为1:2冻干配合物研究表明阿司匹林的稳定性和溶出率显著提高。优选的冻干阿司匹林与腐植酸(1:2)配合物对抑制鼠爪水肿和抗溃疡作用测得的最低值(0.63±0.10)与单纯的阿司匹林相比,有明显的降低,证明用其治疗具有非常显著的抗炎作用(p<0.05)。

关键词：阿司匹林喜来芝石腐植酸表征稳定性生物利用度

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Repurposing of FDA-Approved drugs to predict new inhibitors against key regulatory genes in Mycobacterium tuberculosis

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BIOCELL 2021年第6期45卷 1569-1583页

作者： XINJUN YANG AFTAB ALAM NAIYAR IQBAL khalid RAZA Department of Pediatrics 3201 HospitalHanzhongChina Centre for Interdisciplinary Research in Basic Sciences Jamia Millia IslamiaNew DelhiIndia Department of Computer Science and Information Technology Maulana Azad National Urdu UniversityHyderabadIndia Department of Computer Science Jamia Millia IslamiaNew DelhiIndia

Tuberculosis(TB)disease has become one of the major public health concerns globally,especially in developing *** research studies have already been carried out for TB,but we are still struggling for a complete and quick cure for *** progress of Mycobacterium tuberculosis(MTB)strains resistant to existing drugs makes its cure and control very ***,it is the need of the hour to search for newer and effective drugs that can inhibit an increasing number of putative drug *** applied the drug repurposing concept to identify promising FDAapproved drugs against five key-regulatory genes(FurB,IdeR,KstR,MosR,and RegX3)of the *** FDA drugs were virtually screened using a structure-based approach by GOLD versions 5.2,and subjected to rigid docking followed by an induced-fit docking algorithm to enhance the accuracy and prioritize drugs for *** found 11 candidate drugs(including ZINC03871613,ZINC03871614,ZINC03871615 as top scorer candidate drugs)that were frequently present within the top 20 GoldScore ranks and showed promising ***,molecular dynamics simulation was performed to monitor the effect of the top scorer drugs on the structural stability of all the five targets,indicating that inhibitors preferentially bind to the active site of the *** work suggests that these known FDA-approved drugs open new application domains in the form of anti-tuberculosis agents.

关键词： Virtual screening Molecular docking md simulation PPI network

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Medical Image Enhancement Using Morphological Transformation

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Journal of Data Analysis and Information Processing 2016年第1期4卷 1-12页

作者： Raihan Firoz md. Shahjahan Ali M. Nasir Uddin Khan md. khalid Hossain md. Khairul Islam md. Shahinuzzaman Department of Applied Physics Electronics & Communication Engineering Islamic University Kushtia Bangladesh Institute of Electronics Atomic Energy Research Establishment Savar Dhaka Bangladesh

Medical imaging includes different modalities and processes to visualize the interior of human body for diagnostic and treatment purpose. However, one of the most common degradations in medical images is their poor contrast quality and noise. The existence of several objects and the close proximity of adjacent pixels values make the diagnostic process a daunting task. The idea of image enhancement techniques is to improve the quality of an image. In this study, morphological transform operation is carried out on medical images to enhance the contrast and quality. A disk shaped mask is used in Top-Hat and Bottom-Hat transform and this mask plays a vital role in the operation. Different types and sizes of medical images need different masks so that they can be successfully enhanced. The method shown in this study takes a mask of an arbitrary size and keeps changing its size until an optimum enhanced image is obtained from the transformation operation. The enhancement is achieved via an iterative exfoliation process. The results indicate that this method improves the contrast of medical images and can help with better diagnosis.

关键词： Medical Image Image Enhancement Morphological Transform Top-Hat Transform Bottom-Hat Transform MATLAB

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Development of Nanostructure Formation of Fe73.5Cu1Nb3Si13.5B9Alloy from Amorphous State on Heat Treatment

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World Journal of Nano Science and Engineering 2015年第4期5卷 107-114页

作者： md. khalid Hossain Jannatul Ferdous md. Manjurul Haque A. K. M. Abdul Hakim Institute of Electronics Atomic Energy Research Establishment Savar Dhaka Bangladesh Department of Applied Physics Electronics & Communication Engineering Islamic University Kushtia Bangladesh Department of Glass and Ceramic Engineering Bangladesh University of Engineering and Technology Dhaka Bangladesh

Iron-based amorphous alloys have attracted technological and scientific interests due to their excellent soft magnetic properties. The typical nanocrystalline alloy with the composition of Fe73.5Cu1Nb3Si13.5B9 known as FINEMENT has been studied for structural properties analysis. Recently, it is found that after proper annealing the amorphous alloy like Fe73.5Cu1Nb3Si13.5B9 has a transition to the nanocrystalline state, thus exhibiting good magnetic properties. The alloy in the form of ribbon of 10 mm width and 25mm thickness with the composition of Fe73.5Cu1Nb3Si13.5B9 was prepared by rapid quenching method. The prepared ribbon sample has been annealed for 30 min in a controlled way in the temperature range 490℃ - 680℃. By analyzing X-ray diffraction (XRD) patterns, various structural parameters such as lattice parameters, grain size and silicon content of the nanocrystalline Fe(Si) grains, crystallization behavior and nanocrystalline phase formation have been investigated. In the nanocrystalline state, Cu helps the nucleation of α-Fe(Si) grains while Nb controls their growth, Si and B has been used as glass forming materials. Thus on the residual amorphous, the nanometric Fe(Si) grains develops. From broadening of fundamental peaks, the optimum grain size has been determined in the range of 7 - 23 nm.

关键词： Fe Based Alloy Rapid Solidification Crystallization Behavior Nanocrystalline Phase Formation

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Study and Characterization of Soft Magnetic Properties of Fe73.5Cu1Nb3Si13.5B9Magnetic Ribbon Prepared by Rapid Quenching Method

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Materials Sciences and Applications 2015年第12期6卷 1089-1099页

Nanocrystalline Fe-based alloys offer a new opportunity for tailoring soft magnetic materials. Nanocrystalline alloy in the form of ribbon with the composition of Fe73.5Cu1Nb3Si13.5B9 was prepared by rapid quenching method for soft magnetic properties analysis. The rapidly quenched alloy has been annealed in a controlled way in the temperature range 490℃ to 680℃ and annealing time 1 min to 60 min. The study of the structural parameters has been investigated by means of XRD analysis. Magnetic properties were analyzed by measuring B-H loop and frequency dependence of initial permeability. Enhanced value of initial permeability by two orders of magnitude and very low value of relative loss factor of the order of 10–3 has been observed with the variation of annealing temperature and time. The initial permeability for the optimum annealed sample has been found 23,064 as compared with 360 for its amorphous counterpart. The initial permeability spectra show dispersion around 100 kHz. Magnetic hysteresis has been investigated by measuring B-H loops at various magnetic fields for different annealing temperature and time. The coercivity and remanence has been found to decrease significantly for optimized annealed condition compared to as-cast state. The core loss of the samples decreases with the annealing time which indicates the good magnetic property of soft magnetic materials.

关键词： Nanocrystalline Alloy Magnetic Property Hysteresis Loop Permeability Coercivity Remanence

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Performance Evaluation of a DS-CDMA System in a Rayleigh Fading Environment

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World Journal of Engineering and Technology 2016年第1期4卷 1-9页

作者： M. A. Rahman M. M. Alam md. khalid Hossain md. Khairul Islam Khan M. Nasir Uddin md. Shahinuzzaman Department of Applied Physics Electronics & Communication Engineering Islamic University Kushtia Bangladesh Institute of Electronics Atomic Energy Research Establishment Savar Bangladesh

This work represents the performance evaluation of DS-CDMA in a Rayleigh fading environment. Performance analysis was carried out for a DS-CDMA system to evaluate the signal-to-noise ratio (SNR), signal-to-interference ratio (SIR) and bit error rate (BER) for different modulation schemes like ASK, PSK and FSK. Results were evaluated at different data rates and were presented in terms of SNR, SIR and BER. Computer simulation was also carried out by using Matlab to evaluate the signal waveforms with and without addition white Gaussian noise (AWGN). Butterworth filtered waveform was given to get better signal quality. Decoded output waveforms were also evaluated to confirm the simulation.

关键词： DS-CDMA Rayleigh Fading Performance Analysis SNR BER ASK PSK FSK MATLAB AWGN

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Drought Tolerance in Mung Bean is Associated with the Genotypic Divergence, Regulation of Proline, Photosynthetic Pigment and Water Relation

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Phyton-International Journal of Experimental Botany 2023年第3期92卷 955-981页

作者： Mohammad rafiqul Islam Mohd Mostofa Kamal Mohammad Faruk Hossain Jamil Hossain Mohammad Golam Azam Mst Masuma Akhter MKamrul Hasan Ibrahim Al-Ashkar khalid FAlmutairi Ayman EL Sabagh md Atikur Rahman Muhammad Aamir Iqbal Mohammad Sohidul Islam Agronomy Division Regional Agricultural Research StationBangladesh Agricultural Research Institute(BARI)Pabna6600Bangladesh Chief Research Scientist New Edge MicrobialsLtd.Albury2641Australia Horticulture Research Centre Regional Agricultural Research StationBangladesh Agricultural Research Institute(BARI)Pabna6600Bangladesh Pulses Research Centre BARIPabna6600Bangladesh Agronomy Division Bangladesh Wheat and Maize Research InstituteDinajpur5200Bangladesh Department of Agronomy Hajee Mohammad Danesh Science and Technology UniversityDinajpur5200Bangladesh Department of Plant Production College of Food and AgricultureKing Saud UniversityRiyadh11451Saudi Arabia Department of Agronomy Faculty of AgricultureKafrelsheikh UniversityKafrelsheikh33156Egypt Grassland and Forage Division National Institute of Animal ScienceRural Development AdministrationCheonan31000Korea Department of Agronomy Faculty of AgricultureUniversity of Poonch RawalakotRawalakot12350Pakistan Department of Genetics and Plant Breeding Faculty of AgricultureBangladesh Agricultural UniversityMymensingh2202Bangladesh

Drought is one of the critical conditions for the growth and productivity of many crops including mung bean(Vigna radiata ***).Screening of genotypes for variations is one of the suitable strategies for evaluating crop adaptability and global food *** this context,the study investigated the physiological and biochemical responses of four drought tolerant(BARI Mung-8,BMX-08010-2,BMX-010015,BMX-08009-7),and four drought sensitive(BARI Mung-1,BARI Mung-3,BU Mung-4,BMX-05001)mung bean genotypes under wellwatered(WW)and water deficit(WD)*** WW treatment maintained sufficient soil moisture(22%±0.5%,i.e.,30%deficit of available water)by regularly supplying ***,the WD treatment was maintained throughout the growing period,and water was applied when the wilting symptom *** drought tolerant(DT)genotypes BARI Mung-8,BMX-08010-2,BMX-010015,BMX-08009-7 showed a high level of proline accumulation(2.52–5.99 mg g^(−1) FW),photosynthetic pigment(total chlorophyll 2.96–3.27 mg g^(−1) FW at flowering stage,and 1.62–2.38 mg g^(−1) FW at pod developing stage),plant water relation attributes including relative water content(RWC)(82%–84%),water retention capacity(WRC)(12–14)as well as lower water saturation deficit(WSD)(19%–23%),and water uptake capacity(WUC)(2.58–2.89)under WD condition,which provided consequently higher relative seed *** indicate that the tolerant genotypes gained better physiobiochemical attributes and adaptability in response to drought ***,the genotype BMX-08010-2 showed superiority in terms of those physio-biochemical traits,susceptibility index(SSI)and stress tolerance index(STI)to other *** on the physiological and biochemical responses,the BMX-08010-2 was found to be a suitable genotype for sustaining yield under drought stress,and subsequently,it could be recommended for crop improvement through hybridization *** addition,the identified traits can be used as markers to ide

关键词： Mung bean drought proline chlorophyll water status stress tolerance

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Zinc enhances the cell adhesion,migration,and self-renewal potential of human umbilical cord derived mesenchymal stem cells

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World Journal of Stem Cells 2023年第7期15卷 751-767页

作者： Iqra Sahibdad Shumaila khalid G Rasul Chaudhry Asmat Salim Sumreen Begum Irfan Khan Dr.Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological SciencesUniversity of KarachiKarachi 75270SindhPakistan Department of Biological Sciences Oakland UniversityRochesterMI 48309United States Stem Cell Research Laboratory(SCRL) Sindh Institute of Urology and Transplantation(SIUT)Karachi 74200SindhPakistan

BACKGROUND Zinc(Zn)is the second most abundant trace element after Fe,present in the human *** is frequently reported in association with cell growth and proliferation,and its deficiency is considered to be a major disease contributing *** To determine the effect of Zn on in vitro growth and proliferation of human umbilical cord(hUC)-derived mesenchymal stem cells(MSCs).METHODS hUC-MSCs were isolated from human umbilical cord tissue and characterized based on immunocytochemistry,immunophenotyping,and tri-lineage *** impact of Zn on cytotoxicity and proliferation was determined by MTT and Alamar blue *** determine the effect of Zn on population doubling time(PDT),hUC-MSCs were cultured in media with and without Zn for several *** in vitro scratch assay was performed to analyze the effect of Zn on the wound healing and migration capability of hUC-MSCs.A cell adhesion assay was used to test the surface adhesiveness of *** analysis of genes involved in the cell cycle,proliferation,migration,and selfrenewal of hUC-MSCs was performed by quantitative real-time polymerase chain *** protein expression of Lin28,a pluripotency marker,was analyzed by *** Zn at lower concentrations enhanced the rate of proliferation but at higher concentrations(>100μM),showed concentration dependent cytotoxicity in ***-MSCs treated with Zn exhibited a significantly greater healing and migration rate compared to untreated *** also increased the cell adhesion rate,and colony forming efficiency(CFE).In addition,Zn upregulated the expression of genes involved in the cell cycle(CDC20,CDK1,CCNA2,CDCA2),proliferation(transforming growth factorβ1,GDF5,hypoxia-inducible factor 1α),migration(CXCR4,VCAM1,VEGF-A),and self-renewal(OCT4,SOX2,NANOG)of *** of Lin28 protein was significantly increased in cells treated with *** Our findings suggest that zinc enhances the proliferat

关键词： Human umbilical cord Mesenchymal stem cells Zinc Cell proliferation In vitro expansion

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