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Ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry-characterized extract of Aerides odorata Lour alleviates paracetamol-induced hepatotoxicity in animal model evidenced by biochemical,molecular,and computational studies

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Animal Models and Experimental Medicine 2024年第4期7卷 497-522页

作者： A.M.Abu Ahmed md.Atiar Rahman Farjana Sharmen A.S.M.Ali Reza md.Shahidul Islam md.Mamunur Rashid md.khalid juhani rafi Tanvir Ahmed Siddiqui md.Muzahid Ahmed Ezaj Srabonti Saha md.Nazim Uddin Walla Alelwani Department of Genetic Engineering and Biotechnology University of ChittagongChittagongBangladesh Department of Biochemistry and Molecular Biology University of ChittagongChittagongBangladesh Department of Pharmacy International Islami University ChittagongChittagongBangladesh Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial ResearchDhakaBangladesh Department of Biochemistry College of ScienceUniversity of JeddahJeddahSaudi Arabia

Background:Many kinds of orchids have significant health benefits although ade-quate research on their biological functions is yet to be carried *** study inves-tigated the paracetamol-induced liver damage-protecting effect of epiphytic Aerides odorata methanol extract(AODE).Methods:The protective effects of AODE were studied by analyzing its effect on liver function parameters,messenger RNA(mRNA)expression,and tissue histopatho-logical *** results were confirmed by ligand-receptor interaction of molecular docking and multitarget interaction of network pharmacological ***:AODE significantly(p<0.05)minimized the dose-dependent increase in acid phosphatase,aspartate aminotransferase,alanine aminotransferase,alkaline phos-phatase,γ-glutamyl transferase,lactate dehydrogenase,and total bilirubin compared to the reference drug *** level decreased,and the antioxidant genes catalase(CAT),superoxide dismutase(SOD),β-actin,paraoxonase-1(PON1),and phosphofructokinase-1(PFK-1)were upregulated in AODE-treated paracetamol-intoxicated rats.A total of 376 compounds comprising phenols and flavonoids were identified using ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry(UPLC-qTOF-MS).The online toxicity assessment using SwissADME and admetSAR exhibited drug-like,nontoxic,and potential pharmaco-logical ***,in silico analysis showed that isoacteoside,one of the identified compounds,exhibited the best docking score(−11.42)with the liver pro-tein human pituitary adenylate cyclase-1(Protein Data Bank ID:3N94).Furthermore,network pharmacology analysis identified the top 10 hub genes,namely AKT1(protein kinase B),CTNNB1(catenin beta-1),SRC(proto-oncogene c-Src),TNF(tumor necrosis factor),EGFR(epidermal growth factor receptor),HSP90AA1(heat shock protein 90α),MAPK3(mitogen-activated protein kinase 3),STAT3(signal transducer and activator of transcription 3),CASP3(caspase protein),

关键词： Aerides odorata animal model mRNA expression PCM-induced hepatotoxicity UPLC-qTOF-MS

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IoT Task Offloading in Edge Computing Using Non-Cooperative Game Theory for Healthcare Systems

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1487-1503页

作者： Dinesh Mavaluru Chettupally Anil Carie Ahmed I.Alutaibi Satish Anamalamudi Bayapa Reddy Narapureddy Murali Krishna Enduri md Ezaz Ahmed School of Computing and Informatics Saudi Electronic UniversityRiyadhSaudi Arabia Department of Computer Engineering SRM University APGunturIndia College of Computer and Information Sciences Majmaah UniversityAl Majma’ahSaudi Arabia Department of Public Health College of Applied Medical SciencesKing Khalid UniversityAbhaSaudi Arabia

In this paper,we present a comprehensive system model for Industrial Internet of Things(IIoT)networks empowered by Non-Orthogonal Multiple Access(NOMA)and Mobile Edge Computing(MEC)*** network comprises essential components such as base stations,edge servers,and numerous IIoT devices characterized by limited energy and computing *** central challenge addressed is the optimization of resource allocation and task distribution while adhering to stringent queueing delay constraints and minimizing overall energy *** system operates in discrete time slots and employs a quasi-static approach,with a specific focus on the complexities of task partitioning and the management of constrained resources within the IIoT *** study makes valuable contributions to the field by enhancing the understanding of resourceefficient management and task allocation,particularly relevant in real-time industrial *** results indicate that our proposed algorithmsignificantly outperforms existing approaches,reducing queue backlog by 45.32% and 17.25% compared to SMRA and ACRA while achieving a 27.31% and 74.12% improvement in Qn ***,the algorithmeffectively balances complexity and network performance,as demonstratedwhen reducing the number of devices in each group(Ng)from 200 to 50,resulting in a 97.21% reduction in complexity with only a 7.35% increase in energy *** research offers a practical solution for optimizing IIoT networks in real-time industrial settings.

关键词： Internet of Things edge computing offloading NOMA

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Measurement and correlation of solubility of diosmin in four pure solvents and β-cyclodextrin solution at 298.15K to 333.15K

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Chinese Journal of Chemical Engineering 2015年第5期23卷 812-815页

作者： md.khalid Anwer Faiyaz Shakeel Department of Pharmaceutics College of Pharmacy Salman Bin Abdulaziz University Center of Excellence in Biotechnology Research King Saud University Department of Pharmaceutics College of Pharmacy King Saud University

The aim of present study was to measure and correlate the solubility of poorly water-soluble flavonoid diosmin in water, ethanol, isopropyl alcohol （IPA）, polyethylene glycol-400 （PEG-400） and β-cyclodextrin （β-CD） aqueous solution （0.02 mol·L^-1 ）. The solubility of diosmio was measured using the shake flask method from （298.15 to 333.15） K at atmospheric pressure. The experimental solubilities of diosmin were regressed by the modified Apelblat model with a relative deviation in the range of 0.048% to 5.940%. The correlation coefficients were observed in the range of 0.9957 to 0.9995. The solubility of diosmin was found to be increased with temperature in all sample matrices investigated. The mole fraction solubility of diosmin was found to be higher in 5-CD aqueous solution and PEG-400 as compared to water, ethanol and IPA. Based on solubility data of present study, diosmin was considered as practically insoluble in water, insoluble in ethanol ＆ IPA and soluble in PEG- 400 and β-CD aqueous solution.

关键词： Apelblat model Cyclodextrin Diosmin Solubility Thermodynamics

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Simulation and Modelling of Water Injection for Reservoir Pressure Maintenance

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Computers, Materials & Continua 2022年第9期72卷 5761-5776页

作者： Rishi Dewan Adarsh Kumar Mohammad khalid Imam Rahmani Surbhi Bhatia md Ezaz Ahmed Department of Physics University of Petroleum&Energy StudiesDehradun 248007UttarakhandIndia Department of Computer Science University of Petroleum&Energy StudiesDehradun 248007UttarakhandIndia College of Computing and Informatics Saudi Electronic UniversityRiyadh 11673Saudi Arabia Department of Information Systems College of Computer Science and Information TechnologyKing Faisal UniversityAl Hasa 36362Saudi Arabia

Water injection has shown to be one of the most successful,efficient,and cost-effective reservoir management *** re-injecting treated and filtered water into reservoirs,this approach can help maintain reservoir pressure,increase hydrocarbon output,and reduce the environmental *** goal of this project is to create a water injection model utilizing Eclipse reservoir simulation software to better understand water injection methods for reservoir pressure maintenance.A basic reservoir model is utilized in this *** simulation designs,the reservoir length,breadth,and thickness may be changed to different *** water-oil contact was discovered at 7000 feet,and the reservoir pressure was recorded at 3000 pounds per square inch at a depth of 6900 *** aquifer chosen was of the Fetkovich type and was linked to the reservoir in the j+*** porosity was estimated to be varied,ranging from 9%to 16%.The residual oil saturation was set to 25%and the irreducible water saturation was set at 20%.The vertical permeability was set at 50 md as a *** Volume Temperature(PVT)data was used to estimate the gas and water characteristics.

关键词： Eclipse water injection reservoir modeling simulation oil saturation

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Assessment of ecological risk for heavy metals in surface sediment of an urban river in a developing country

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International Journal of Sediment Research 2023年第6期38卷 834-846页

作者： md Saiful Islam md Humayun Kabir Mir Mohammad Ali md Towhidul Islam Asfia Niger md Humayun Kabir Zulhilmi Ismail Sujat Ahmed khalid A.Ibrahim Abubakr M.Idris Department of Soil Science Patuakhali Science and Technology University Department of Environmental Science and Resource Management Mawlana Bhashani Science and Technology University Department of Aquaculture Sher-e-Bangla Agricultural University Department of Soil Science Bangabandhu Sheikh Mujibur Rahman Agricultural University Centre for River and Coastal Engineering(CRCE) Universiti Teknologi Malaysia(UTM) Department of Water & Environmental Engineering Faculty of Civil EngineeringUniversiti Teknologi Malaysia(UTM) Environment Center for People & Environ(CPE) Department of Biology College of ScienceKing Khalid University Center for Environment and Tourism Studies and Research King Khalid University Department of Chemistry College of ScienceKing Khalid University Research Center for Advanced Materials Science(RCAMS) King Khalid University

The speed of increasing threats to the riverine water resources makes it more critical to protect the health of Old Brahmaputra River *** current study was done to investigate the concentrations,distributions,sources,and ecological risk of heavy metals in surface sediment from the Old Brahmaputra River,*** were collected from seven sites and analyzed with an inductively coupled plasma-mass spectrometer(ICP-MS).The results showed that mean concentrations(mg/kg) of heavy metals were in the order of nickel(Ni)(44.69)> chromium(Cr)(30.16)> lead(Pb)(19.31)>copper(Cu)(17.84)> cadmium(Cd)(3.94)> arsenic(As)(2.73).The contamination factor(CF),pollution load index(PLI),enrichment factor(EF),and geo-accumulation index(Igeo) indicated low to moderate *** unit analysis revealed that the studied metals from all stations posed low *** sediment of the study river was uncontaminated to moderately contaminated,posing a minimal ecological ***,Cr,Ni,and Pb originated from anthropogenic sources rather than geogenic sources,and caused the severity of *** this regard,pollutant-based intensive monitoring of heavy metals and holistic ecological risk assessments are required to maintain a sound and healthy aquatic environment in the river.

关键词： Heavy metals Sediment quality Ecological risk Old Brahmaputra river Source identification

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Automatic Real-Time Medical Mask Detection Using Deep Learning to Fight COVID-19

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Computer Systems Science & Engineering 2022年第9期42卷 1181-1198页

作者： Mohammad khalid Imam Rahmani Fahmina Taranum Reshma Nikhat md.Rashid Farooqi Mohammed Arshad Khan College of Computing and Informatics Saudi Electronic UniversityRiyadhSaudi Arabia Computer Science and Engineering Department Muffakham Jah College of Engineering and TechnologyOsmania UniversityHyderabadTelanganaIndia Department of Commerce and Business Management Maulana Azad National Urdu UniversityHyderabadTelanganaIndia Department of Accountancy College of Administrative and Financial SciencesSaudi Electronic UniversityRiyadSaudi Arabia

The COVID-19 pandemic is a virus that has disastrous effects onhuman lives globally;still spreading like wildfire causing huge losses to humanityand economies. There is a need to follow few constraints like social distancingnorms, personal hygiene, and masking up to effectively control the virus *** proposal is to detect the face frame and confirm the faces are properly covered with masks. By applying the concepts of Deep learning, the results obtainedfor mask detection are found to be effective. The system is trained using4500 images to accurately judge and justify its accuracy. The aim is to developan algorithm to automatically detect a mask, but the approach does not facilitatethe percentage of improper usage. Accuracy levels are as low as 50% if the maskis improperly covered and an alert is raised for improper placement. It can be usedat traffic places and social gatherings for the prevention of virus transmission. Itworks by first locating the region of interest by creating a frame boundary, thenfacial points are picked up to detect and concentrate on specific features. Thetraining on the input images is performed using different epochs until the artificialface mask detection dataset is created. The system is implemented using TensorFlow with OpenCV and Python using a Jupyter Notebook simulation environment. The training dataset used is collected from a set of diverse open-sourcedatasets with filtered images available at Kaggle Medical Mask Dataset by Mikolaj Witkowski, Kera, and Prajna Bhandary. To simulate MobilNetV2 classifier isused to load and pre-process the image dataset for building a fully connectedhead. The objective is to assess the accuracy of the identification, measuringthe efficiency and effectiveness of algorithms for precision, recall, and F1 score.

关键词： COVID-19 pandemic convolution neural network deep learning face detection facemask detection global health machine learning

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Machine Learning-Enabled Power Scheduling in IoT-Based Smart Cities

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Computers, Materials & Continua 2021年第5期67卷 2449-2462页

作者： Nabeela Awan Salman Khan Mohammad khalid Imam Rahmani Muhammad Tahir Nur Alam md Ryan Alturki Ihsan Ullah Department of Computer Science Government Girls Degree College MardanKPK23200Pakistan Department of Electrical Energy System UETPeshawar25000Pakistan Department of Computer Science College of Computing and InformaticsSaudi Electronic UniversityKSA Department of Smart Computing Kyungdong UniversityGlobal CampusGosung24764South Korea Department of Information Sciences College of Computer and Information SystemsUmm Al-Qura UniversityMakkahSaudi Arabia Robotics Engineering Daegu Gyeongbuk Institute of Science and TechnologySouth Korea

Recent advancements in hardware and communication technologies have enabled worldwide interconnection using the internet of things(IoT).The IoT is the backbone of smart city applications such as smart grids and green energy *** smart cities,the IoT devices are used for linking power,price,energy,and demand information for smart homes and home energy management(HEM)in the smart *** complex smart gridconnected systems,power scheduling and secure dispatch of information are the main research *** challenges can be resolved through various machine learning techniques and data *** this paper,we have proposed a particle swarm optimization based machine learning algorithm known as a collaborative execute-before-after dependency-based requirement,for the smart *** proposed collaborative execute-before-after dependencybased requirement algorithm works in two phases,analysis and assessment of the requirements of end-users and power distribution *** the rst phases,a xed load is adjusted over a period of 24 h,and in the second phase,a randomly produced population load for 90 days is evaluated using particle swarm *** simulation results demonstrate that the proposed algorithm performed better in terms of percentage cost reduction,peak to average ratio,and power variance mean ratio than particle swarm optimization and inclined block rate.

关键词： PSO IBR machine learning IoT smart cities CDBR

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Nigella sativa oil alleviates doxorubicin-induced cardiomyopathy and neurobehavioral changes in mice:In vivo and in-silico study

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Asian Pacific Journal of Tropical Biomedicine 2022年第7期12卷 312-322页

作者： md Jamir Anwar Sattam Khulaif Alenezi Faizul Azam Danish Mahmood Faisal Imam khalid Saad Alharbi Department of Pharmacology and Toxicology Unaizah College of PharmacyQassim UniversityAl-QassimSaudi Arabia Department of Pharmaceutical Chemistry&Pharmacognosy Unaizah College of PharmacyQassim UniversityAl-QassimSaudi Arabia Department of Pharmacology and Toxicology College of PharmacyKing Saud UniversityRiyadhSaudi Arabia Department of Pharmacology College of PharmacyJouf UniversitySakakahSaudi Arabia

Objective:To investigate the effect of Nigella sativa oil on cardiomyopathy and neurobehavioral changes induced by doxorubicin in ***:Swiss strain of albino female mice were divided into 6 groups of 5 animals in each:GroupⅠ(control group),groupⅡ(doxorubicin,10 mg/kg,i.v.),groupⅢ,Ⅳ,andⅤ(Nigella sativa oil;1.5,3,and 6 mL/kg,respectively),groupⅥ(Nigella sativa oil per se;6 mL/kg,p.o.).The duration of treatment was 15 d(10 days’pre-treatment and 5 days’post-treatment)and doxorubicin was administered on day 11th of the treatment *** Nigella sativa oil treatment,neurobehavioral tests,cardiac hypertrophy tests,and biochemical tests in serum and tissues were *** tests included assessment of anxiety-like behavior in the elevated plus maze,spontaneous alternation behavior in the cross maze,and depression-like behavior in modified forced swim *** tests included serum lactate dehydrogenase and creatinine kinase-MB,malondialdehyde and reduced glutathione in ***,molecular docking was used to estimate the affinity of the phytoconstituents of Nigella sativa oil with histone ***:Nigella sativa oil treatment significantly(P<0.001)restored doxorubicin-induced neurobehavioral changes,decreased lactate dehydrogenase and creatinine kinase-MB in the plasma,malondialdehyde contents in tissues,and increased reduced glutathione ***,no significant alteration was observed in Nigella sativa oil per se group as compared to the *** docking showed that Nigella sativa oil components had appreciable binding affinitiy with the protein cavities of HDAC1 and ***:The result shows that Nigella sativa oil exerts anxiolytic,antidepressant,and memory-enhancing effects in addition to cardioprotective effect against doxorubicin-induced cardiomyopathy in *** modulatory effect of Nigella sativa oil on oxidative stress could contribute to the cardioprotective effect and associated neuro

关键词： Nigella sativa oil Doxorubicin Cardiomyopathy Neurobehavioral changes Lactate dehydrogenase Creatinine kinase-MB Malondialdehyde Reduced glutathione Mice HDAC docking

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Potentiality of Different Seed Priming Agents to Mitigate Cold Stress of Winter Rice Seedling

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Phyton-International Journal of Experimental Botany 2021年第5期90卷 1491-1506页

作者： md.Parvez Anwar md.Ariful Islam khalid A.K.M.Mominul Islam Sabina Yeasmin Sharif Ahmed Adel Hadifa Ismail A.Ismail Akbar Hossain Ayman EL Sabagh Agro Innovation Laboratory Department of AgronomyBangladesh Agricultural UniversityMymensingh2202Bangladesh International Rice Research Institute Bangladesh OfficeDhaka1213Bangladesh Rice Research and Training Center Field Crops Research InstituteAgricultural Research CenterSakha33717Egypt Department of Biology College of ScienceTaif UniversityTaif21944Saudi Arabia Bangladesh Wheat and Maize Research Institute Dinajpur5200Bangladesh Department of Agronomy Faculty of AgricultureKafrelsheikh UniversityKafr Elsheikh33516Egypt

Seed priming has proved to be an effective pre-germination seed invigoration technique for different crops to improve seed and seedling performance under different abiotic *** Bangladesh,winter rice is very often exposed to cold waves just after sowing in the nursery bed resulting in poor seed germination and seedling emergence,yellowish and thin seedlings production,and a very low survival *** priming may mitigate the cold stress during seed germination and seedling emergence and helps in the quality seedling production of winter *** evaluate the efficacy of different seed priming techniques in increasing seedling emergence,growth,vigor and survivability of winter rice cultivars under cold stress,a pot experiment was conducted at the Department of Agronomy,Bangladesh Agricultural University during December 2018 to January *** experiment comprised two factors,(A)Winter rice variety namely,(i)BRRI dhan29 and (ii)BRRI dhan36;(B)Seed priming agent namely (i)Control(no priming),(ii)20000 ppm NaCl,(iii)30000 ppm NaCl,(iv)20000 ppm KCl,(v)30000 ppm KCl,(vi)20000 ppm CaCl2,(vii)30000 ppm CaCl2,(viii)50 ppm CuSO4,(ix)75 ppm CuSO_(4),(x)10000 ppm ZnSO4,(xi)15000 ppm ZnSO4,(xii)2 ppm Na2MoO4,(xiii)3 ppm Na2MoO4,(xiv)100 ppm PEG(Polyethylene glycol 4000)and (xv)150 ppm *** were sown on two different dates viz.,1st December and 1st January so that seedlings are exposed to cold stress at different *** experiment was laid out in a completely randomized design(CRD)with three *** indicated that(in most of the cases)seed priming has a positive impact on seedling emergence rate(%),root length,shoot length,root shoot ratio,root dry weight,shoot dry weight,seedling dry weight and survival rate(%).Among the priming agents,KCl and CaCl2 performed best;while priming with NaCl and PEG showed no advantages over no priming for both the sowing *** general,BRRI dhan36 performed better than BRRI dhan29 in terms of seedling growth because

关键词： Seed invigoration seedling emergence seedling mortality seedling growth low temperature stress

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喜来芝石中提取的腐植酸与阿司匹林的分子络合物及其表征

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腐植酸 2010年第4期 34-39页

作者： md.khalid Anwer Suraj P.Agarwal Asgar Ali Yasmin Sultana 黄静佳米雅综合大学药剂学院南德里110062 中国腐植酸工业协会北京100120

阿司匹林具有退热、消炎、止痛和抗血小板凝集的作用。乙酰水杨酸分子含一个羧基和一个酯基。酯基容易被水解,导致其药效降低,并会对人体产生副作用。本研究的目的是用冻干技术和溶剂挥发技术,以原料的物质的量比为1∶1和1∶2,制备阿司... 详细信息

阿司匹林具有退热、消炎、止痛和抗血小板凝集的作用。乙酰水杨酸分子含一个羧基和一个酯基。酯基容易被水解,导致其药效降低,并会对人体产生副作用。本研究的目的是用冻干技术和溶剂挥发技术,以原料的物质的量比为1∶1和1∶2,制备阿司匹林和腐植酸固态络合物。阿司匹林和腐植酸分子间相互作用通过差示扫描量热法(DSC)、X射线衍射(XRD)、傅里叶变换红外光谱学法(FT-IR)和扫描电子显微镜法(SEM)进行研究。用这些技术能清晰表明固态包合络合物的结构。对物质的量比为1∶2冻干络合物研究表明,阿司匹林的稳定性和溶出率显著提高。优选的冻干阿司匹林与腐植酸(1∶2)络合物对抑制鼠爪水肿和抗溃疡作用测得的最低值(0.63±0.10)与单纯的阿司匹林相比,有明显的降低,证明用其治疗具有非常显著的抗炎作用(P<0.05)。

关键词：阿司匹林喜来芝石腐植酸表征稳定性生物药效率

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