检索结果-南通市图书馆

Autophagy as a targeted therapeutic approach for skin cancer:Evaluating natural and synthetic molecular interventions

引用

Cancer Pathogenesis and Therapy 2024年第4期2卷 231-245页

作者： md.Liakot Ali Amdad Hossain Roky S.M.Asadul Karim Azad Abdul Halim Shaikat Jannatul Naima Meem Emtiajul Hoque Abu Mohammed Fuad Ahasan Mohammed Murshedul Islam md.Saifur Rahaman Arif md.saqline mostaq md.Zihad Mahmud Mohammad Nurul Amin mdAshiq Mahmud Department of Pharmacy University of ChittagongChattogram 4331Bangladesh Pratyasha Health Biomedical Research Center Dhaka 1230Bangladesh Department of Pharmacy International Islamic University ChittagongChattogram 4318Bangladesh Department of Pharmacy Daffodil International UniversityDhaka 1216Bangladesh Department of Pharmacy BGC Trust University BangladeshChattogram 4381Bangladesh School of Basic Pharmaceutical and Toxicological Sciences College of PharmacyUniversity of Louisiana at MonroeMonroeLA 71209-0497USA Pioneer Dental College and Hospital Dhaka 1229Bangladesh

Skin cancer,a prevalent malignancy worldwide,poses significant health concerns owing to its increasing ***,a natural cellular process,is a pivotal event in skin cancer and has advantageous and detrimental *** duality has prompted extensive investigations into medical interventions targeting autophagy modulation for their substantial therapeutic *** systematic review aimed to investigate the relationship between skin cancer and autophagy and the contribution and mechanism of autophagy modulators in skin *** outlined the effectiveness and safety of targeting autophagy as a promising therapeutic strategy for the treatment of skin *** comprehensive review identified a diverse array of autophagy modulators with promising potential for the treatment of skin *** of these compounds demonstrates efficacy through distinct physiological mechanisms that have been elucidated in ***,findings from a literature search indicated that none of the natural,synthetic,or semisynthetic compounds exhibited notable adverse effects in either human or animal ***,this review offers novel mechanistic and therapeutic perspectives on the targeted modulation of autophagy in skin cancer.

关键词： Autophagy Skin cancer Autophagy inducers Autophagy inhibitors Nature-derived compounds Synthetic compounds

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Copper and Mercury in Food, Biological and Pharmaceutical Samples: Spectrophotometric Estimation as Cu(DDTC)<sub>2</sub>

引用

American Journal of Analytical Chemistry 2014年第13期5卷 838-850页

作者： Mohammad Nasir Uddin Nur mostaq Shah Mohammad Amzad Hossain md. Muzahidul Islam Department of Chemistry University of Chittagong Chittagong Bangladesh

An alternative spectrophotometric method was optimized and validated for the estimation of mercury using diethyldithiocarbamate (DDTC), a common reagent, widely used for the preconcentration and isolation of metal ions in complex matrices followed by their estimation by varied techniques. Diethyldithiocarbamate forms yellow Cu(DDTC)2 with copper and white Hg(DDTC)2 with mercury (having d10 system) which are extracted in CCl4. The UV-visible spectrum of Cu(DDTC)2 is very stable at pH 5.0 and has a maximum absorption (λmax) at 435 nm. Hg(DDTC)2 is more stable than Cu(DDTC)2. Estimation of mercury is based on a quantitative displacement of Cu(II) of Cu(DDTC)2 with the addition of mercury followed by the measurement of reduced absorbance. Primarily, method was optimized and validated for the estimation of copper. Therefore, simultaneous determination of Cu(II) and Hg(II) in mixture is proposed fractionating the extract. The molar specific coefficient (ε) for the mercury was 1.4 × 104 mol﹣1·L·cm﹣1 and for copper was 3.16 × 105 mol﹣1·L·cm﹣1 at 435 nm. The detection limits of Cu2+ and Hg2+ were 0.023 μg·mL﹣1 and 0.029 μg·mL﹣1, respectively. The calibration curve shows good linearity of 0.02 - 12.0 and 0.02 - 15.0 μg·mL﹣1 for the Cu2+ and Hg2+ determination, respectively. Proposed technique was applied to food, biological and pharmaceutical samples for the determination of Cu(II) and Hg(II).

关键词： Copper Mercury Diethyldithiocarbamate Spectrophotometric Method Food Biological Pharmaceutical Samples

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：