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Autophagy as a targeted therapeutic approach for skin cancer:Evaluating natural and synthetic molecular interventions

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Cancer Pathogenesis and Therapy 2024年第4期2卷 231-245页

作者： md.Liakot Ali Amdad Hossain Roky S.M.Asadul Karim Azad Abdul Halim Shaikat Jannatul Naima Meem Emtiajul Hoque Abu Mohammed Fuad Ahasan Mohammed Murshedul Islam md.saifur rahaman arif md.Saqline Mostaq md.Zihad Mahmud Mohammad Nurul Amin mdAshiq Mahmud Department of Pharmacy University of ChittagongChattogram 4331Bangladesh Pratyasha Health Biomedical Research Center Dhaka 1230Bangladesh Department of Pharmacy International Islamic University ChittagongChattogram 4318Bangladesh Department of Pharmacy Daffodil International UniversityDhaka 1216Bangladesh Department of Pharmacy BGC Trust University BangladeshChattogram 4381Bangladesh School of Basic Pharmaceutical and Toxicological Sciences College of PharmacyUniversity of Louisiana at MonroeMonroeLA 71209-0497USA Pioneer Dental College and Hospital Dhaka 1229Bangladesh

Skin cancer,a prevalent malignancy worldwide,poses significant health concerns owing to its increasing ***,a natural cellular process,is a pivotal event in skin cancer and has advantageous and detrimental *** duality has prompted extensive investigations into medical interventions targeting autophagy modulation for their substantial therapeutic *** systematic review aimed to investigate the relationship between skin cancer and autophagy and the contribution and mechanism of autophagy modulators in skin *** outlined the effectiveness and safety of targeting autophagy as a promising therapeutic strategy for the treatment of skin *** comprehensive review identified a diverse array of autophagy modulators with promising potential for the treatment of skin *** of these compounds demonstrates efficacy through distinct physiological mechanisms that have been elucidated in ***,findings from a literature search indicated that none of the natural,synthetic,or semisynthetic compounds exhibited notable adverse effects in either human or animal ***,this review offers novel mechanistic and therapeutic perspectives on the targeted modulation of autophagy in skin cancer.

关键词： Autophagy Skin cancer Autophagy inducers Autophagy inhibitors Nature-derived compounds Synthetic compounds

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Frame Length Dependency for Fundamental Frequency Extraction in Noisy Speech

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Journal of Signal and Information Processing 2024年第1期15卷 1-17页

作者： md. saifur Rahman Any Chowdury Nargis Parvin Arpita Saha Moinur Rahman Department of Information and Communication Technology Comilla University Cumilla Bangladesh Department of Computer Science and Engineering Bangladesh Army International University of Science and Technology (BAIUST) Cumilla Bangladesh Department of Information Technology University of Information Technology and Sciences (UITS) Dhaka Bangladesh

The fundamental frequency plays a significant part in understanding and perceiving the pitch of a sound. The pitch is a fundamental attribute employed in numerous speech-related works. For fundamental frequency extraction, several algorithms have been developed which one to use relies on the signal’s characteristics and the surrounding noise. Thus, the algorithm’s noise resistance becomes more critical than ever for precise fundamental frequency estimation. Nonetheless, numerous state-of-the-art algorithms face struggles in achieving satisfying outcomes when confronted with speech recordings that are noisy with low signal-to-noise ratio (SNR) values. Also, most of the recent techniques utilize different frame lengths for pitch extraction. From this point of view, This research considers different frame lengths on male and female speech signals for fundamental frequency extraction. Also, analyze the frame length dependency on the speech signal analytically to understand which frame length is more suitable and effective for male and female speech signals specifically. For the validation of our idea, we have utilized the conventional autocorrelation function (ACF), and state-of-the-art method BaNa. This study puts out a potent idea that will work better for speech processing applications in noisy speech. From experimental results, the proposed idea represents which frame length is more appropriate for male and female speech signals in noisy environments.

关键词： Pitch Estimation Fundamental Frequency BaNa ACF Frame Length

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A Critical Review of Community Resilience Building Framework: Contexts of Climate Change and Disasters in Bangladesh

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Journal of Geoscience and Environment Protection 2024年第9期12卷 315-334页

作者： Abdul Alim Shaikh Mousumi Halder Muhammad Ramzan Ali Ruhul Amin md.saifur Rahman md. Kamruzzaman Khulna University Khulna Bangladesh Climate Change Program Christian Commission for Development in Bangladesh (CCDB) Dhaka Bangladesh International Rescue Committee-UK Coxs Bazar Bangladesh Tropical and International Forestry Technical University Dresden Cotta Bau Pienner Strae 7 01737 Tharandt Germany Forestry and Wood Technology Discipline Khulna University Khulna Bangladesh

The concept of community resilience in the contexts of climate change and disasters draws increasing attention and interest from practitioners and researchers in recent development discourse. This paper provides a critical review of six selected frameworks of community resilience building operationalized in Bangladesh over the span of years. In other words, this study aims to contribute to the understanding of resilience through a systematic analysis of the dimensions and indicators of community resilience frameworks. The analysis shows that comprehensive and effective community resilience frameworks should incorporate the missing components linked to fundamental elements of good governance, economic growth, environmental sustainability, social transformation, and capacity development. The paper concludes by highlighting a few other areas of grave concern that need more appropriate attention, considering the severe threats posed by climate change and natural disasters in line with sustainable development goals. Finally, this study recommends further research regarding the effectiveness of these frameworks in different climatic and disaster contexts that can lead the concept into a new dimension of community resilience and sustainability.

关键词： Community Resilience Resilience Building Framework Resilience Indicators Climate Change Disaster Bangladesh

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A Systematic Review Towards Big Data Analytics in Social Media

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Big Data Mining and Analytics 2022年第3期5卷 228-244页

作者： md.saifur Rahman Hassan Reza School of Electrical Engineering and Computer Science University of North DakotaGrand ForksND 58202USA

The recent advancement in internet 2.0 creates a scope to connect people worldwide using society 2.0 and web 2.0 *** new era allows the consumer to directly connect with other individuals,business corporations,and the *** are open to sharing opinions,views,and ideas on any topic in different formats out *** creates the opportunity to make the"Big Social Data"handy by implementing machine learning approaches and social data *** study offers an overview of recent works in social media,data science,and machine learning to gain a wide perspective on social media big data *** explain why social media data are significant elements of the improved data-driven decision-making *** propose and build the"Sunflower Model of Big Data"to define big data and bring it up to date with technology by combining 5 V’s and 10 *** discover the top ten social data analytics to work in the domain of social media platforms.A comprehensive list of relevant statistical/machine learning methods to implement each of these big data analytics is discussed in this work."Text Analytics"is the most used analytics in social data analysis to *** create a taxonomy on social media analytics to meet the need and provide a clear ***,techniques,and supporting data type are also discussed in this research *** a result,researchers will have an easier time deciding which social data analytics would best suit their needs.

关键词： big data social media big data analytics social media analytics text analytics image analytics audio analytics video analytics predictive analytics descriptive analytics prescriptive analytics diagnostic analytics

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Rural Resilience: A Comprehensive Study on Water Supply, Sanitation, Disease Patterns, and Hygiene Practices in Munshiganj, Bangladesh

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Journal of Environmental Protection 2024年第1期15卷 63-75页

作者： Jubayer Hoque Rifat Islam md. Mustafizur Rahman md. Golam Rabbani md. Selim Reja saifur Rahman Soykat Saim Raiyan md. Shafiqul Ahsan Emon Sakil Khan Department of Environmental Science and Disaster Management Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalgnj Bangladesh Department of Political Science Bangabandhu Sheikh Mujibur Rahman Science and Technology University GopalgnjBangladesh Department of Statistics Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalgnj Bangladesh

This research project investigates the current status of water supply, sanitation, and hygiene practices in Munshiganj District, Bangladesh. Data collection involved a structured questionnaire and a reconnaissance survey. Findings reveal that 30% of individuals rely on surface water (hand-tube wells, rivers, and ponds), prioritized as canal > river > pond, while 70% depend on groundwater (subterranean electric motor, deep tube-well). Drinking water is generally sufficient, with 95% reporting adequacy throughout the year. About 45% use hand tube-well water, 28% use deep tube-well water, and 11% use supply tap water for various purposes. Bathing trends include underground water through electric motor > pond > hand tube-well water > river, while for cooking, the order is underground water through electric motor > pond > hand tube-well water > river. Toilet water supply ranks as supply tap water > hand tube-well water > deep tube-well water. Although sanitation awareness is high, some lack knowledge of good hygiene practices. After defecating, handwashing methods include soap, ash, soil, or water. Children’s waste disposal varies, with some discarding it in open areas. Approximately 40% suffer from diseases like Diarrhoea due to unsafe water, primarily affecting children and elders. Training exists, but a significant portion lacks sanitation education. Dry skin or exposure to cold water may cause temporary irritation. Local government involvement in sanitation efforts is less active compared to non-governmental organizations. Results emphasize the need to enhance community awareness of safe water supplies and sanitation practices. .

关键词： Water Supply Sanitation Practices Hygiene Awareness Groundwater Dependency Community Health Intervention

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Rural Resilience: A Comprehensive Study on Water Supply, Sanitation, Disease Patterns, and Hygiene Practices in Munshiganj, Bangladesh

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Journal of Environmental Protection（环境保护） 2024年第1期

作者： Jubayer Hoque Rifat Islam md.Mustafizur Rahman md.Golam Rabbani md.Selim Reja saifur Rahman Soykat Saim Raiyan md.Shafiqul Ahsan Emon Sakil Khan

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Low Altitude Satellite Constellation for Futuristic Aerial-Ground Communications

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Computer Modeling in Engineering & Sciences 2023年第8期136卷 1053-1089页

作者： saifur Rahman Sabuj Mohammad Saadman Alam Majumder Haider md Akbar Hossain Al-Sakib Khan Pathan Department of Electronic Engineering Hanbat National UniversityDaejeon34158South Korea Department of Electrical and Electronic Engineering Brac UniversityDhaka1212Bangladesh School of Business and Digital Technologies Manukau Institute of TechnologyManukau2241New Zealand Department of Computer Science and Engineering United International UniversityDhaka1212Bangladesh

This paper discusses the significance and prospects of low altitude small satellite aerial vehicles to ensure smooth aerial-ground communications for next-generation broadband *** achieve the generic goals of fifthgeneration and beyondwireless networks,the existing aerial network architecture needs to be *** detailed architecture of low altitude aerial networks and the challenges in resource management have been illustrated in this ***,we have studied the coordination between promising communication technologies and low altitude aerial networks to provide robust network *** talk about the techniques that can ensure userfriendly control and monitoring of the low altitude aerial networks to bring forth wireless broadband connectivity to a new *** the end,we highlight the future research directions of aerial-ground communications in terms of access technologies,machine learning,compressed sensing,and quantum communications.

关键词： Aerial-terrestrial network cognitive radio network cooperative communication high altitude platform low altitude platform low earth orbit satellite constellation unmanned aerial vehicle

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Broadband mechanoresponsive liquid metal sensors

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npj Flexible Electronics 2022年第1期6卷 718-725页

作者： md.saifur Rahman Julia E.Huddy Andrew B.Hamlin William J.Scheideler Thayer School of Engineering Dartmouth CollegeHanoverNH 03755USA

Stretchable electronics have the fundamental advantage of matching the complex geometries of the human body,providing opportunities for real-time biomechanical *** report a method for high-frequency AC-enhanced resistive sensing that leverages deformable liquid metals to improve low-power detection of mechanical stimuli in wearable *** fundamental mechanism of this enhancement is geometrical modulation of the skin effect,which induces current crowding at the surface of a liquid metal *** combination with DC sensing,this method quantitatively pinpoints mechanical modes of deformation such as stretching in-plane and compression out-of-plane that are traditionally impossible to *** we explore this method by finite element simulations then employ it in a glove to detect hand gestures and tactile forces as well as a respiratory sensor to measure ***,this AC sensor uses lower power(100X)than DC sensors,enabling a new generation of energy-efficient wearables for haptics and biomedical sensing.

关键词： wear deformation liquid

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Blockchain-Based Certificate Authentication System with Enabling Correction

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Journal of Computer and Communications 2023年第3期11卷 73-82页

作者： md. Mijanur Rahman md. Tanzinul Kabir Tonmoy saifur Rahman Shihab Riya Farhana Department of Computer Science and Engineering Southeast University Dhaka Bangladesh

Blockchain has proven to be an emerging technology in the digital world, changing the way everyone thinks about data security and bringing efficiency to several industries. It has already been applied to a wide range of applications, from financial services and supply chain management to voting systems and identity verification. An organization must verify its candidates before selecting them. Choosing an unqualified candidate can ruin an organization’s reputation. In this paper, a blockchain-based academic certificate authentication system will be used to ensure authenticity and make the assertion of the decentralized system secure. However, the system will generate, authenticate and make corrections on academic certificates. Ultimately, some blockchain-based authentication systems already exist, they can’t correct any errors that occur during generation. A blockchain-based certificate authentication system was built using blockchain technology. Where admin could generate, authenticate and correct the certificate if necessary. The admin can also check how many times a certificate has been modified. Other users can only check the authenticity of the certificates. We’re using two blockchains to enable corrections. Blockchain technology can successfully implement a certificate authentication system. This system will eliminate doubts about the authenticity of certificates, provide fast responses, and ensure reliable and secure storage. The proposed system will help in many ways, such as providing a user-friendly university admission, and smooth job hiring process, etc. In conclusion, our proposed system can permanently eradicate certificate forgeries and create and promote trust in society.

关键词： Blockchain Certificate Authentication Certificate Correction Secure Certification Eliminate Forging

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Structural and Mechanical Properties of Alumina-Zirconia (ZTA) Composites with Unstabilized Zirconia Modulation

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Materials Sciences and Applications 2021年第11期12卷 542-560页

作者： md. Abdul Gafur md. Al-Amin md. saifur Rahman Sarker md. Zahangir Alam Pilot Plant & Process Development Centre Bangladesh Council of Scientific and Industrial Research Dhaka Bangladesh Department of Applied Chemistry and Chemical Engineering Dhaka University Dhaka Bangladesh Kurigram Govt. College Kurigram Rangpur Bangladesh

Zirconia toughened alumina (ZTA) ceramics are very promising materials for structural and biomedical applications due to their high hardness, fracture toughness, strength, corrosion and abrasion resistance and excellent biocompatibility. The effect of unstabilized ZrO2 on the density, fracture toughness, microhardness, flexural strength and microstructure of some Zirconia-toughened alumina (ZTA) samples was investigated in this work. The volume percentage of unstabilized ZrO2 was varied from 0% - 20% whereas sintering time and sintering temperature were kept constant at 2 hours and 1580°C. The samples were fabricated from nanometer-sized (α-Al2O3: 150 nm, monoclinic ZrO2: 30 - 60 nm) powder raw materials by the conventional mechanical mixing process. Using a small amount of sintering aid (0.2 wt% MgO) almost 99.2% of theoretical density, 8.54 MPam? fracture toughness, 17.35 GPa Vickers microhardness and 495.67 MPa flexural strength were found. It was observed that the maximum flexural strength and fracture toughness was obtained for 10 vol% monoclinic ZrO2 but maximum Vickers microhardness was achieved for 5 vol% ZrO2 although the maximum density was found for 20 vol% ZrO2. It is assumed that this was happened due to addition of denser component, phase transformation of monoclinic ZrO2 and the changes of grain size of α-Al2O3 and ZrO2.

关键词： Zirconia Toughened Alumina (ZTA) Mechanical Properties Toughening XRD SEM Grain Size

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