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Conservation and Utilization of Crop Genetic Resources in Malaysia： Mardi＇s Effort

Journal of Agricultural Science and Technology(A) 2015年第6期5卷 381-386页

作者： Mohd Shukor Nordin Mohd Shafie md Shah Mohd Norfaizal Mohd Ghazali Siti Nurzuraini abdul Rahman Salma Idris Mohd Shukri Mohd Ali Kulliyyah of Science International Islamic University Malaysia Kuantan Campus Kuantan 25200 Pahang Malaysia Strategic Resources Research Centre Malaysian Agricultural Research & Development Institute (MARD1) Headquarters Serdang43000 Selangor Malaysia

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Reversal of multidrug resistance and antitumor promoting activity of 3-oxo-6β-hydroxy-β-amyrin isolated from Pistacia integerrima

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BIOCELL 2021年第1期45卷 139-147页

作者： ABDUR RAUF SAUD BAWAZEER MUSLIM RAZA EMAN EL-SHARKAWY md.HABIBUR RAHMAN MOHAMED A.EL-ESAWI GHIAS UDDIN BINA SSIDDIQUI ANEES AHMED KHALIL JOSEPH MOLNAR AKOS CSONKA DIÁNA SZABÓ HAROON KHAN MOHAMMAD SMUBARAK TAIBI BEN HADDA MUDYAWATI KAMARUDDIN SEEMA PATEL Department of Chemistry University of SwabiAnbar23561Khyber Pakhtunkhwa Pakistan Department of Pharmaceutical Chemistry Faculty of PharmacyUmm Al-Qura UniversityMakkah24211Saudi Arabia State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China Chemical Departments Faculty of ScienceNorthern Borders UniversityArar91431Saudi Arabia Department of Pharmacy Southeast UniversityBanani-1213DhakaBangladesh Department of Global Medical Science Wonju College of MedicineYonsei UniversitySeoulSouth Korea Botany Department Faculty of ScienceTanta UniversityTanta31527Egypt Institute of Chemical Sciences University of PeshawarPeshawar25120Pakistan H.E.J.Research Institute of Chemistry International Center for Chemical and Biological SciencesUniversity of KarachiKarachi75270Pakistan University Institute of Diet and Nutritional Sciences Faculty of Allied Health SciencesThe University of LahoreLahore54000Pakistan Department of Medical Microbiology and Immunobiology Faculty of MedicineUniversity of SzegedSzeged6700Hungary Department of Oto-Rhino-Laryngology and Head-Neck Surgery Faculty of MedicineUniversity of SzegedSzeged6700Hungary Department of Pharmacy Abdul Wali Khan UniversityMardan23200Pakistan Department of Chemistry The University of JordanAmman11942Jordan LCM Laboratory Faculty of SciencesMohamed First UniversityOujda60000Morocco Institution of Health Science of Tahirah Al Baeti Bulukumba South Sulawesi92352Indonesia Bioinformatics and Medical Informatics Research Center San Diego State UniversitySan Diego92182USA

The bioactive triterpenoid 3-oxo-6-β-hydroxy-β-amyrin(1)has been isolated from multiple plant *** this study,chloroform fraction of Pistacia integerrima extract was processed for the isolation of the *** compound identity was confirmed by advanced spectroscopy technique.X-ray crystallography was applied for molecular structure *** addition,compound 1 was screen for its activity on reversal of mdR(multidrug resistance)mediated by P-gp(P-glycoprotein).This was accomplished by using rhodamine123 exclusion on multidrug-resistant human ABCB1 gene transfected mouse T-lymphoma cell *** revealed that mdR reversing effect was comparable to verapamil as positive control in *** of TPA-induced tumor promotion with 3-oxo-6β-hydroxy-β-amyrin led to reduction in the applied anti-tumor promotion *** chemo-preventive effect of 3-oxo-6β-hydroxy-β-amyrin was comparable to curcumin as positive control based on the reduction of immediate early tumor antigen *** docking by applying Autodock Vina 1 and i-GEmdOCK v 2.1 tools indicated that compound 1 gives good docking results,as determined by their fitness score and ***,results showed that compound 1 isolated from Pistacia integerrima precisely attached to a region where co-crystallized ligand for receptor previously *** findings may explain the use of Pistacia integerrima plant extracts as an anticancer agent in folk medicine.

关键词： Pistacia integerrima Anti-tumor properties X-ray crystallography POM Molecular docking

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COVID-19 Disease Complicated with Severe Pneumonia in a Patient with End Stage Renal Disease (ESRD): A Case Report from Bangladesh

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Advances in Infectious Diseases 2020年第3期10卷 101-109页

作者： md. Reaz Uddin Chowdhury Kazi Shanzida Akter Muhammad Zahangir Alam Muhammad Anwarul Kabir Sahedul Islam Bhuiyan Arifa Akram Sohel Rahman abdul Malek Ukil Medical College Noakhali Bangladesh Dedicated COVID-19 Hospital-Trauma Center Feni Bangladesh Brahmanbaria Medical College Brahmanbaria Bangladesh National Institute of Laboratory Medicine and Refferal Center Dhaka Bangladesh Institute of Epidemiology Disease Control and Research Dhaka Bangladesh

Background: Since 2019, the pandemic of Coronavirus disease 2019 (COVID-19) has spread very rapidly in China and Worldwide. COVID-19 is a highly contagious, infectious and rapidly spreading viral disease with an alarming case fatality rate up to 5%. Case Report: In this article, we report a case of 60 years old non diabetic, hypertensive woman infected with COVID-19 who has end stage renal disease (ESRD) on hemodialysis for last 18 months. COVID-19 patients with ESRD need isolation dialysis but most of them cannot be handled properly due to limited hemodialysis machine. With these unavailability and risk, we continue the treatment along with hemodialysis for controlling uraemia and fluid balance. With all effort this patient ended with an uneventful course with clinical improvement, improvement of all laboratory parameters and resolution of radiological findings but follow up RT-PCR cannot done due to changing guideline of discharge criteria of COVID-19 patient in Bangladesh.

关键词： ESRD Hemodialysis COVID-19 Pneumonia Corona Virus

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鸡抗马立克氏病毒免疫应答机制研究

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中国家禽 2012年第10期34卷 1-6页

作者： P.Parvizi M.F.abdul-Careem K.Haq N.Thanthrige-Don K.A.Schat S.Sharif 吕天星王颖田文霞加拿大圭尔夫大学美国康奈尔大学兽医学院纽约伊萨卡14853 山西农业大学动物科技学院

自100多年前鸡马立克病(md)首次报道以来,人们一直致力于病原体及其防控策略的研究。近几年来,由于马立克氏病毒(mdV)的不断进化,引起诸多地区屡次暴发md,如何改进预防措施显得刻不容缓,因此,必须了解病毒与宿主之间的相互作用。宿主的... 详细信息

自100多年前鸡马立克病(md)首次报道以来,人们一直致力于病原体及其防控策略的研究。近几年来,由于马立克氏病毒(mdV)的不断进化,引起诸多地区屡次暴发md,如何改进预防措施显得刻不容缓,因此,必须了解病毒与宿主之间的相互作用。宿主的免疫系统与病毒的入侵与扩散息息相关,主要通过两种机制应对病毒入侵,作为机体第一道免疫防线的天然防御机制包括可溶性因子的分泌以及巨噬细胞和自然杀伤细胞等免疫细胞的参与,天然免疫反应促使免疫系统形成特异的抵抗mdV的抗体和细胞免疫应答。除免疫系统外,遗传和表现遗传机制有助于鸡应答mdV感染。本文综述了目前对mdV诱导的免疫应答的理解以及免疫应答的遗传因子。

关键词：免疫应答马立克氏病疫苗鸡疱疹病毒遗传抗性

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Comparison of Serum Lipid Profile between Gestational Diabetes Mellitus and Pregnant Women with Normal Glucose Tolerance

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Journal of Biosciences and Medicines 2020年第6期8卷 148-159页

作者： Mahmudul Hossain A. K. M. Shahidur Rahman Samira Mahjabeen Mohona Zaman Mohaiminul Abedin Tahseen Mahmood md. Abdur Razzaque Ummul Khair Alam Department of Medicine Kurmitola General Hospital Dhaka Bangladesh Department of Nephrology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Endocrinology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Endocrinology Monno Medical College Hospital Manikganj Bangladesh Department of Anatomy Abdul Malek Ukil Medical College Noakhali Bangladesh Department of Endocrinology BRB Hospital Limited Dhaka Bangladesh Department of Dermatology Khwaja Yunus Ali Medical College and Hospital (KYAMCH) Sirajganj Bangladesh Department of Maternal and Child Health (MCH) National Institute of Preventive and Social Medicine (NIPSOM) Dhaka Bangladesh

Background: Aberrant lipid metabolism presumed to have important relationship with gestational diabetes mellitus (GDM), though previous studies revealed inconsistent results on this area. Objectives: To identify the difference of serum lipid profile between gestational diabetes mellitus (GDM) and pregnant woman with normal glucose tolerance (NGT). Methods: This cross sectional study was conducted from January 2017 to December 2017 at Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh with 31 GDM and equal number of NGT pregnant women diagnosed on the basis of WHO criteria-2013, during 24 - 40 weeks of gestation. Glucose was measured by glucose oxidase method and fasting serum lipid profile [Total cholesterol (TC), High Density Lipoprotein-cholesterol (HDL-C) and Triglyceride (TG)] was measured by enzymatic-colorimetric method. Data were analyzed and compared by statistical tests. Results: Among total sixty-two (62) study subjects, 31 were GDM (age: 27.52 ± 4.8 years, body mass index (BMI): 27.17 ± 3.3 kg/m2) and 31 were pregnant women with NGT (age: 24.94 ± 4.2 years, BMI: 25.43 ± 6.5 kg/m2). Mean age of GDM group was significantly higher than that of NGT group (p = 0.028). Women with GDM showed relatively higher BMI than NGT women but that was not statistically significant (p = 0.194). Fasting lipid profiles between GDM and NGT (GDM vs. NGT;total cholesterol: 194.21 ± 42.18 vs. 208.52 ± 42.18 mg/dl, p = 0.187;HDL-C: 47.50 ± 16.17 vs. 47.18 ± 11.71 mg/dl, p = 0.928;LDL-C: 109.25 ± 28.80 vs. 119.30 ± 34.76 mg/dl, p = 0.220 and triglyceride 204.78 ± 58.50 vs. 202.34 ± 79.18 mg/dl, p = 0.891) were not significantly different. The variations in all lipid fraction values were not statistically significant among GDM women when analyzed between BMI groups holding BMI cut-off at 23 kg/m2. No significant differences of any valu

关键词： Gestational Diabetes Mellitus (GDM) Normal Glucose Tolerance (NGT) Serum Lipid Profile

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Evaluation of Lipid Profile in Obese and Non-Obese Hypertensive Adult Patients Attended in Medicine Department of a Medical College Hospital of Bangladesh

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World Journal of Cardiovascular Diseases 2020年第8期10卷 520-544页

作者： md Reaz Uddin Chowdhury Kazi Shanzida Akter Sahedul Islam Bhuiyan Mainuddin Sohel Mahbub Majumder Arif Mohammad Sohan Mahfuzur Rahman Muhammad Anwarul Kabir Zaman Ahmed abdul Malek Ukil Medical College Noakhali Bangladesh Trauma Center Feni Bangladesh Brahmanbaria Medical College Brahmanbaria Bangladesh Cumilla Medical College Cumilla Bangladesh Ad-Din Akij Medical College Khulna Bangladesh

Background: By the dawn of this modern era of science, the prime challenge of physician is cardiovascular disease (CVD). The most important modifiable risk factors of CVDs are unhealthy diet, physical inactivity and tobacco use. The effects of unhealthy diet and physical inactivity include abnormal blood lipid, obesity and hypertension. We tried to evaluate and correlate the pattern of lipid profile in obese and non-obese hypertensive patients. Objectives: This study was conducted at medicine department of Cumilla Medical College Hospital. The principal aim was to evaluate the lipid profile in obese and non-obese adult hypertensive patients. Methodology: During this cross sectional analytical study, a total of 100 adult hypertensive patients were taken by purposive sampling. Among them 50 (group 1) patients were taken those were obese and 50 (group 2) patients taken those were non-obese according to BMI measurement on operational definition. Diagnosis of hypertension would be established with the help of ambulatory BP measurements two occasions few minutes apart. The staging of hypertension was done according to JNC7 Criteria. Morning blood samples were taken after 8 - 12 hours of fasting and lipid profiles were done on authentic laboratories. The laboratory values were interpreted according to the operational definition of dyslipidaemia. The ethical research and review committee approved the study protocol and signed informed consent was obtained from the participants. The statistics was analyzed using the IBM SPSS software of version 19.0. Statistical significance was set at p Results: Among the two groups, there were 56 (56%) males and 44 (44%) females. The mean age of group 1 (46.10 ± 11.09) was compared to that of group 2 (

关键词： Lipid Profile Dyslipidaemia Obese Non-Obese Hypertension

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线粒体DNA与LL-37多肽通过形成复合物逃避自噬识别从而促进动脉粥样硬化

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科学新闻 2016年第1期 68-68页

作者：张治业 Ping Meng Yajun Han Chuanbin Shen Bowen Li md.abdul Hakim Xuguang Zhang Qiumin Lu Mingqiang Rong 赖仞中国科学院昆明动物研究所

文章简介动脉粥样硬化是发生在动脉血管壁内膜中的一种慢性炎症疾病。近年来的研究表明动脉粥样硬化疾病的发病与多肽LL-37及自身DNA相关,但LL-37或自身DNA如何引起该疾病的发病尚不清楚。本研究表明多肽LL-37可以与线粒体DNA(mtDNA)形... 详细信息

文章简介动脉粥样硬化是发生在动脉血管壁内膜中的一种慢性炎症疾病。近年来的研究表明动脉粥样硬化疾病的发病与多肽LL-37及自身DNA相关,但LL-37或自身DNA如何引起该疾病的发病尚不清楚。本研究表明多肽LL-37可以与线粒体DNA(mtDNA)形成复合物(LL-37-mtDNA),而这种复合物是介导或促进人动脉粥样硬化疾病发病的主要原因。正常情况下,具有炎症刺激作用的mtDNA可通过

关键词：动脉粥样硬化动脉硬化自噬 LL-37 DNA 线粒体粒线体复合物多肽

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