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<i>Citrobacter rodentium</i>, a Gut Pathogen: The Yin and the Yang of Its Pathophysiology, Immunity and Clinical Manifestation in Mice

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Advances in Microbiology 2018年第9期8卷 699-718页

作者： Tania Rahman md. ferdous Seraj md. Monirul Islam Department of Biochemistry and Molecular Biology Bio21 Molecular Science and Biotechnology Institute University of Melbourne Melbourne Australia School of Civil Environmental and Chemical Engineering RMIT University Melbourne Australia Fiona Elsey Cancer Research Institute Ballarat Technology Park Central Ballarat Australia

Pathogenic strains of E. coli including enteropathogenic E. coli (EPEC), enterohemorrhagic E. coli (EHEC), enterotoxigenic E. coli (ETEC) are principle causes for diarrhoea in many parts of the globe. Citrobacter rodentium (C. rodentium), a gram negative bacterium, is a murine pathogen that also utilizes type III secretion system and similar virulence factors to EPEC and EHEC and forms comparable attaching/effacing lesions in the intestines as EPEC and EHEC. The infection caused by C. rodentium in mice is usually self-limiting and results in only minor systemic effects with higher mortality in some susceptible mouse strains. All these characteristics have made the bacteria a commonly used model to study host immune responses to pathogenic E. coli infection. In this review, we focus on the impact of virulence factors of the pathogen;different immune components involved in the immune response and summarize their role during C. rodentium infection.

关键词： Citrobacter rodentium Attaching and Effacing Pathogen Locus of Enterocyte Effacement Transmissible Murine Colonic Hyperplasia Colitis Mucosal Immune Response

Available Approaches of Remediation and Stabilisation of Metal Contamination in Soil: A Review

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American Journal of Plant Sciences 2018年第10期9卷 2033-2052页

作者： Tania Rahman md. ferdous Seraj Department of Biochemistry and Molecular Biology University of Dhaka Dhaka Bangladesh Department of Environmental Science and Management North South University Dhaka Bangladesh School of Civil Environmental and Chemical Engineering RMIT University Melbourne Australia

Anthropogenic activities, such as mining of natural resources, manufac-turing industries, modern agricultural practices and energy production have resulted in the release of heavy metals with resultant harmful im-pacts in some natural environments. Toxic heavy metals are harmful to living organisms even at low concentrations. Therefore, heavy metal contaminated sites should be remediated as heavy metals do not decompose into less harmful substances and are retained in the soil. Conventional methods are used for remediation of heavy metal contaminated soils such as heavy metal extraction, immobilization and removal of soils to landfill produce large quantities of toxic products including insoluble hydroxides and are rarely cost effective. The advent of bioremediation technologies like biosparging, bioventing and bioaugmentation has provided an alternative to conventional methods for remediating heavy metal contaminated soils. A subset of bacteria found in the rhizosphere has been found to increase the tolerance of plants to heavy metals in soil. These bacteria commonly known as plant growth promoting rhizobacteria or Plant Growth Promoting Rhizobacteria (PGPR) are showing promise as a bioremediation technique for the stabilisation and remediation of heavy metal contami-nated sites. PGPR can improve plant growth via a variety of mechanism including fixing atmospheric N to improve N status and making plants more tolerant of heavy metals. Scattered literature is harnessed to review the principles, advantages and disadvantages of the available technologies for remediating heavy metal contaminated soils and is presented.

关键词： In Situ Bioremediation Ex Situ Bioremediation Phytoremediation Rhizoremediation Plant Growth Promoting Rhizobacteria (PGPR)

Performance Improvement of CIGS Solar Cell: A Simulation Approach by SCAPS-1D

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Energy and Power Engineering 2023年第8期15卷 291-306页

作者： md. ferdous Wahid md. Nuralam Howlader Nazmul Ahasan md. Mizanur Rahman Department of Electrical and Electronic Engineering Hajee Mohammad Danesh Science and Technology University Dinajpur Bangladesh

Thin-film solar cells possess the distinct advantage of being cost-effective and relatively simple to manufacture. Nevertheless, it is of utmost importance to enhance their overall performance. In this research work, copper indium gallium selenide (CIGS)-based ultra-thin solar cell (SC) configuration (Ag/ZnO/ZnSe/CIGS/Si/Ni) has been designed and examined using SCAPS-1D. The numerical calculations revealed that this new design resulted in a substantial improvement in SC performance. This study explores the utilization of two absorber layers, CIGS and Si, both with a total of 2 μm thickness, to enhance device performance while reducing material costs, observing an increase in key SC parameters as the Si absorber layer thickness is increased, reaching a maximum efficiency of 29.13% when CIGS and Si thicknesses are set at 0.4 μm and 1.6 μm, respectively with doping absorber doping density of 1014 cm-3. Furthermore, we analyze the impact of variation in absorber and buffer layer thickness, as well as doping concentration, surface recombination velocity (SRV), electron affinity, series-shunt resistance, and temperature, on optimized CIGS SC parameters such as short-circuit current density (JSC), open circuit voltage (VOC), fill factor (FF), and power conversion efficiency (PCE). The findings yielded by the investigation offer significant elucidation regarding the fabrication of economically viable and highly efficient non-hazardous CIGS ultra-thin SC.

关键词： Thin-Flim CIGS-Based Solar Cell Non-Toxic Solar Cell SCAPS-1D Numerical Simulation Renewable Energy

Primary Sites of Gastric Carcinoma with Metastatic Spread Detected by Transabdominal Hydrosonography: Experience of 76 Cases in Bangladesh

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Open Journal of Radiology 2016年第4期6卷 251-257页

作者： Akm Golam Kabir Showkat Araydah md. Abdullah Yusuf md. ferdous Mian Department of Neuroradiology & Imaging National Institute of Neurosciences & Hospital Dhaka Bangladesh Department of Microbiology National Institute of Neurosciences & Hospital Dhaka Bangladesh Department of Neurology National Institute of Neurosciences & Hospital Dhaka Bangladesh

Background: Metastasis is frequently occurred among the gastric carcinoma patients. Objectives: The purpose of the present study was to detect the different primary sites of gastric carcinoma by ultrasonography with the metastatic spread. Methodology: This cross-sectional study was carried in the department of Radiology and Imaging of Dhaka Medical College, Dhaka from July 2009 to June 2011 for a period of two (2) years. Clinically suspected gastric carcinoma patients attended at indoor and outdoor Surgery department of Dhaka Medical College Hospital, Dhaka were selected as study population. All the patients were examined by ultrasonography of upper abdomen and or Ba-meal X-ray. Detailed clinical history and relevant points in clinical examination and investigations were noted. The sonographic findings were noted. The extent of tumour infiltration and metastasis was assessed in all patients with suspected gastric malignancy. All these patients were properly follow up and collect the endoscopic biopsy and/or surgical resection biopsy reports. In all patients who underwent operation the extent of tumour infiltration and metastasis was looked for and was noted. Results: A total number of 76 patients were included in this study. Among 76 patients, 3 unwilling to take part in the study, 4 patients refused to undergo endoscopy or surgery, 5 patients were unfit for the same and in 4 cases, and histopathological reports were not available. Ultimately 60 patients were evaluated finally. The commonest site of involvement of gastric carcinoma as determined by ultrasound was the antrum 13 out of 23 cases (56.52%). Among them metastatic para-aortic lymph nodes were seen in seven patients and hepatic metastases was detected in five patients’ ascites was seen in eleven patients. Conclusion: In conclusion, the most common site of gastric carcinoma is the antral part of stomach and majority are metastasized in peritoneum.

关键词： Gastric Carcinoma Metastasis Ultrasonography Primary Sites

Investigation on Lanthanum Fluoride as a Novel Cathode Buffer Material Layer for the Enhancement of Stability and Performance of Organic Solar Cell

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Optics and Photonics Journal 2014年第10期4卷 280-287页

作者： md. Shahinul Islam md. Golam Saklayen md. ferdous Rahman Hartmut Baerwolff Abu Bakar md. Ismail Department of Applied Physics & Electronic Engineering Rajshahi University Rajshahi Bangladesh Department of Electronics and Telecommunication Engineering Begum Rokeya University Rangpur Bangladesh Department of Analog & Optoelectronics Cologne University of Applied Sciences Cologne Germany

This article presents the investigation on very thin Lanthanum Fluoride (LaF3) layer as a new cathode buffer layer (CBL) for organic solar cell (OSC). OSCs were fabricated with poly(3-hexylthiophene) (P3HT) and phenyl-C61-butyric acid methyl ester (PCBM) polymer blend at 1:1 ratio. Electron-beam evaporation at room temperature was used to deposit 3 and 5 nm thick LaF3 layer. A very smooth surface of LaF3 with an average roughness of 0.2 nm has been observed by the Atomic Force Microscope (AFM) that is expected to prevent diffusion of cathode metal ion through it and thereby enhance the lifetime and stability of OSC. Huge enhancement of JSC and VOC was also observed for 3 nm-thick LaF3 CBL. Several excellent features of the LaF3 layer such as, transporting electron through tunneling, blocking of holes to the cathode, minimizing recombination, protecting the photoactive polymer from ambient oxygen, and reducing degradation/oxidation of any low work function layer at the cathode interface, might have contributed to the performance enhancement of OSC. The experimental findings indicate the promise of LaF3 to be an excellent CBL material for OSC.

关键词： Organic Semiconductor Photoactive Polymer Organic Solar Cell Bulk Heterojunction Solar Cells Cathode Buffer Layer Lanthanum Fluoride Spin Coating E-Beam Evaporation

Dissecting Emerging Aspects of Regulatory Circuitry in Man and Mice: Regulatory T Cell Biology

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Advances in Bioscience and Biotechnology 2018年第9期9卷 443-468页

作者： Tania Rahman md. ferdous Seraj Annelise Casellato Department of Biochemistry and Molecular Biology Bio21 Molecular Science and Biotechnology Institute University of Melbourne Melbourne Australia Department of Microbiology and Immunology University of Melbourne at the Peter Doherty Institute for Infection and Immunity Melbourne Australia School of Civil Environmental and Chemical Engineering RMIT University Melbourne Australia Departamento de Química Inorganica Instituto de Química Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil

Regulatory T cells (Treg), a component of adaptive immunity, are well known for their immunosuppressive roles and their ability to maintain the balance between the immunological and pathological reactions. Treg have been shown to provide protective responses and their depletion has resulted severe pathology in some pathogen infections. The work presented here has unravelled the potential of regulatory cells in the immune system including different repertoir of Treg cell subsets, markers to distinguish them, Treg suppression mechanisms in the pathogenesis of various infections and summarize different mouse models depleting Tregs. These findings would help set up future avenues of research to elucidate a key mechanism of action of these cells and provide new therapeutic insights for pathogenesis and also for broader antibacterial/antiviral/antiproliferative immunity.

关键词： Regulatory T Cells Foxp3 tTreg pTreg IL-10 TGF-β Helios Neuropilin-1

Performance Enhancement of CZTS Solar Cell with CuSbS₂ Back Surface Field: A Numerical Simulation Approach

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Engineering（科研） 2023年第9期15卷 497-513页

作者： md. ferdous Wahid Nowshad Ahmed md. Shahriar Rahman Abdullah Al Mamun md. Nuralam Howlader md. Motiur Rahman Tareq Department of Electrical and Electronic Engineering Hajee Mohammad Danesh Science and Technology University Dinajpur Bangladesh

Copper Zinc Tin Sulfide (CZTS) solar cell (SC) has garnered significant attention from researchers in recent years owing to its affordability, less toxic earth abundant constituents, remarkable conversion efficiency and promising prospects for the bulk manufacture of thin film solar cells. Moreover, CZTS exhibits a high absorption coefficient and possesses an optimal adjustable direct band gap, making it a promising candidate for various photovoltaic applications. Hence, in this study, a new configuration (CuSbS2/CZTS/CdS/i-ZnO/ Al: ZnO) is introduced for CZTS SC, which was simulated using SCAPS-1D. The utilization of CuSbS2 as the back surface field (BSF) and CdS as the buffer layer was investigated to enhance the performance of CZTS SC. Moreover, a comparative numerical analysis was carried out to contrast the SC configurations of CZTS/CdS/i-ZnO/Al: ZnO and CuSbS2/CZTS/CdS/i-ZnO/Al: ZnO. In this study, the impact on SC parameters such as open circuit voltage (Voc), short- circuit current density (Jsc), Fill-factor (FF), and Power Conversion Efficiency (PCE) by varying thickness, doping density, defect density of absorber and buffer layer, thickness and doping density of BSF, and operating temperature have been thoroughly investigated. The optimum structure consists of i-ZnO and Al: ZnO for the window layer, CdS for the buffer layer, CZTS for the absorber layer, and BSF layers with thicknesses of 50 nm, 200 nm, 50 nm, 2000 nm, and 50 nm, respectively. The designed SC with a BSF layer had a PCE of 28.76%, JSC of 32.53 mA/cm2, Voc of 1.01233 V, and FF of 87.35%. The structure without a BSF layer has a PCE of 24.21%, Voc of 0.898 V, JSC of 31.56 mA/cm2, and FF of 85.32%. Furthermore, an analysis of temperature, quantum efficiency (QE), C- V characteristics and the J-V curve was conducted, revealing the potential of CuSbS2 as a BSF and CdS

关键词： Solar Cell CZTS BSF Defect Density Doping Concentration SCAPS-1D

Numerical Simulation for Enhancing Performance of MoS₂ Hetero-Junction Solar Cell Employing Cu₂O as Hole Transport Layer

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Materials Sciences and Applications 2023年第9期14卷 458-472页

作者： md. ferdous Wahid Ushna Das Bidesh Kumer Paul Shuvo Paul md. Nuralam Howlader md. Sazedur Rahman Department of Electrical and Electronic Engineering Hajee Mohammad Danesh Science and Technology University Dinajpur Bangladesh

The paper reported the design and thorough analysis of a thin-film solar cell (TFSC) based on molybdenum disulfide (MoS2) with an integrated Copper(I) Oxide (Cu2O) hole transport layer (HTL), employing the one-dimensional Solar Cell Capacitance Simulator (SCAPS-1D) software. By varying crucial parameters such as absorber layer thickness, doping density, and bulk defect density, as well as HTL thickness, doping concentration, and electron affinity, defect density at ZnO/absorber and absorber/Cu2O interfaces, and operating temperature, we explored key photovoltaic measures including open circuit voltage (Voc), short-circuit current density (Jsc), fill-factor (FF), and power conversion efficiency (PCE) of the hetero-junction solar cell. The study demonstrated an efficiency of 18.87% for the MoS2 solar cell without HTL, while the proposed solar cell (SC) utilizing Cu2O HTL and optimized device structure exhibited a remarkable PCE of 26.70%. The outcomes derived from the present study offer valuable insights for the progress of a highly efficient and economically viable MoS2 hetero-junction TFSC.

关键词： Solar Cell Thin Film SCAPS-1D Hetero-Junction HTL Defect Density

Synergistic enhancement of photocatalytic and antimicrobial efficacy of nitrogen and erbium co-doped ZnO nanoparticles

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Journal of Rare Earths 2024年第5期42卷 859-868,I0002页

作者： Sudipta Mondal Moniruzzaman Jamal Sikder Ashikuzzaman Ayon md.Jannatul ferdous Anik md.Muktadir Billah Department of Materials and Metallurgical Engineering Bangladesh University of Engineering and TechnologyDhaka1000Bangladesh School of Materials Engineering Purdue UniversityWest LafayetteIN47907USA Department of Materials Science and Engineering University of CaliforniaBerkeleyCA94720USA Department of Materials Science and Engineering Northwestern UniversityEvanstonI28USA

Using the chemical co-precipitation approach,a series of nitrogen(N) and erbium(Er) co-doped ZnO nanoparticles(NPs) was effectively synthesized to enhance the photocatalytic and antibacterial *** characterization techniques,including X-ray diffraction(XRD),X-ray photoelectron spectro scopy(XPS),scanning electron microscopy(SEM),UV-vis,and photoluminescence(PL) spectroscopy,were carried out to validate the evaluated photocatalytic and antibacterial *** analysis confirms the pure wurtzite ZnO phase without the presence of any secondary *** analysis confirms the succe ssful incorporation of nitrogen and erbium into the ZnO *** optical bandgap of ZnO calculated from UV-vis spectroscopy shows a redshift after Er-N co-doping,with the lowest bandgap of 3.215 eV calculated for Zn_(0.97)Er_(0.03)N_(0.01)O_(0.99) *** images demonstrate the formation of nanorods after N-Er co-doping,followed by gradually increase d rod diameter and length after N-Er ***,the photocatalytic activities of ZnO samples we re measured by their ability to facilitate the photodegradation of Rhodamine B under UV *** with 1 mol% N doping exhibits 88% photodegradation of RhB under UV light within 360 min,and the photodegradation and antibacterial activity are greatly improved with Er *** fact,3 mol% Er-1 mol% N doped ZnO NPs demonstrate the highest photocatalytic activity,with approximately 96% degradation after 360 min,as well as superior antibacterial activity against Staphylococcus aureus(Gram-positive bacteria) and Pseudomonas aeruginosa(Gram-negative bacteria) with the highest zone of inhibition(ZOI) of 16 nm,due to nanorod formation,increased reactive oxygen species(ROS),and decreased electron-hole recombination,as validated by SEM,XPS,and PL spectroscopy.

关键词： Chemical co-precipitation Co-doping Bandgap Photocatalysis Rare earths Antimicrobial