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胶质瘤分级的MRI扩散峰度研究

国际医学放射学杂志 2012年第4期 376-376页

作者： S.V. Cauter J. Veraart J. Sijbers R.R. Peeters U. Himmelreich F.d. Keyzer 唐光健 department of Radiology University Hospitals of LeuvenHerestraat 49 3000 Leuven Belgium

摘要目的评估MRI扩散峰度参数对胶质瘤分级的正确性。材料与方法此项前瞻性研究由机构审查委员会批准,所有病人均签署知情同意书。对照17例高级别胶质瘤与11例低级别胶质瘤实性部分的扩散参数--平均扩散度(md.、节段性各向异性(FA)、平... 详细信息

摘要目的评估MRI扩散峰度参数对胶质瘤分级的正确性。材料与方法此项前瞻性研究由机构审查委员会批准,所有病人均签署知情同意书。对照17例高级别胶质瘤与11例低级别胶质瘤实性部分的扩散参数--平均扩散度(md.、节段性各向异性(FA)、平均峰度、径向与轴向峰度(P<0.05为差异有统计学意义

关键词：低级别胶质瘤平均参数值峰度高级别胶质瘤 MRI

Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer

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Hepatoma Research 2018年第1期4卷 31-40页

作者： Tao-Yang Chen Geng-Sun Qian Chun-Sun Fan Yan Sun Jin-Bing Wang Pei-Xin Lu Xue-Feng Xue Yan Wu Qi-Nan Zhang Yan Jin Yi-Qian Wu Yu Gan Jian-Quan Lu Thomas W.Kensler John d.Groopman Hong Tu department of Etiology Qidong Liver Cancer InstituteQidong People’s HospitalQidong 226200JiangsuChina State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200032China Environmental Health and Engineering Bloomberg School of Public HealthJohns Hopkins UniversityBaltimoreMD 21205USA

Qidong hepatitis B virus (HBV) infection cohort (QBC) is a prospective community-based study designed to investigate causative factors of primary liver cancer (PLC) in Qidong, China, where both PLC and HBV infection are highly endemic. Residents aged 20-65 years, living in seven townships of Qidong, were surveyed using hepatitis B surface antigen (HBsAg) serum test and invited to participate in QBC from June 1991 to december 1991. A total of 852 and 786 participants were enrolled in HBsAg-positive and HBsAg-negative sub-cohorts in May 1992, respectively. All participants were actively followed up in person, received HBsAg, alanine aminotransferase, alpha-fetoprotein tests and upper abdominal ultrasonic examination, and donated blood and urine samples once or twice a year. The total response rate was 99.6%, and the number of incident PLC was 201 till the end of February 2017. The ratio of incidence rates was 12.32 [95% confidence interval (CI): 7.16-21.21, P d with HBsAg-negative arm. The relative risk of PLC was 13.25 (95%CI: 6.67-26.33, P d 28.05 (95% CI: 13.87-56.73, P d the HBsAg+/HBeAg+ group, respectively, as compared to the HBsAg-/HBeAg- group. A series of novel PLC-related mutations including A2159G, A2189C and G2203W at the C gene, A799G, A987G and T1055A at the P gene of HBV genome were identified by using samples from the cohort. The mutation in HBV basal core promoter region of HBV genome has an accumulative effect on the occurrence of PLC. In addition, the tripartite relationship of aflatoxin exposure, P53 mutation and PLC was also investigated. QBC will be used to develop dynamic prediction model for PLC risk by using its long-term follow-up information and serial blood samples. This model is expected to improve the efciency of PLC screening in HBV infection individuals.

关键词： Prospective cohort hepatitis B virus primary liver cancer

继发于小的胰腺内分泌肿瘤的胰管狭窄:分泌血清素的表现?

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国际医学放射学杂志 2010年第6期 573-573页

作者： Ch.J.Shi S.S.Siegelman S.Kawamoto C.L.Wolfgang R.d.Schulick A.Maitra 何岸苇 department of Pathology Johns Hopkins Medical Institutions401 N BroadwayWeinberg 2242BaltimoreMD 21231

目的为了确定胰腺内分泌肿瘤产生血清素是否与胰管狭窄有关,狭窄与CT影像所显示的肿瘤大小不成比例。材料与方法该研究经学院医学伦理委员会批准,免除病人签署知情同意书。回顾6例病人的临床及影像学结果。对切除胰腺组织的大体和组织... 详细信息

目的为了确定胰腺内分泌肿瘤产生血清素是否与胰管狭窄有关,狭窄与CT影像所显示的肿瘤大小不成比例。材料与方法该研究经学院医学伦理委员会批准,免除病人签署知情同意书。回顾6例病人的临床及影像学结果。对切除胰腺组织的大体和组织学结果也进行评价。福尔马林固定

关键词：胰腺免疫反应胰管狭窄内分泌血清素 5-羟色胺

多形性胶质母细胞瘤区域性dTI派生的张量指标的诊断作用:p,q,L,Cl,Cp,Cs,RA,Rd,Ad,平均扩散系数和部分各向异性的同时评估

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国际医学放射学杂志 2013年第3期 304-304页

作者： d.Cortez-Conradis R.Favila K.Isaac-Olive M.Martinez-Lopez C.Rios E.Roldan-Valadez 林江南 Section of Research and Innovation in MRI Magnetic Resonance UnitMedica Sur Clinic & Foundation

目的将较少用于诊断的近12个扩散张量成像(dTI)变量用于对脑肿瘤进行评估。目的是对过去10年报道的张量指标进行综合评估。方法对14例多形性胶质母细胞瘤(GBM)和28例对照组进行回顾性病例对照研究。根据传统颅脑MR序列和dTI的后处理影... 详细信息

目的将较少用于诊断的近12个扩散张量成像(dTI)变量用于对脑肿瘤进行评估。目的是对过去10年报道的张量指标进行综合评估。方法对14例多形性胶质母细胞瘤(GBM)和28例对照组进行回顾性病例对照研究。根据传统颅脑MR序列和dTI的后处理影像计算正常白质(NAWM),邻近和远处的水肿,环状强化区和囊变区的平均扩散率(md.,部分各向异性(FA),纯各向同性扩散(p),纯各向异性扩散(q),总扩散张量(L),线性张量(Cl),平面张量(Cp),球形张量(Cs),相对各向异性(RA),放射状扩散(Rd)和轴向扩散系数(Ad)。进行ANOVA和AUROC分析。结果所有指标在ANOVA分析中均显示差异具有统计学意义(Pd和Cp,q是环状强化区最好的生物标志物,所有指标Pmd.为公认的脑损伤生物标志物,已被其他指标超过。RA结合Cs、Cl和CP,可能成为脑肿瘤评估的新指标。dTI张量指标在肿瘤各区域表现出不同的临床适用性。要点①dTI派生的张量指标可定性肿瘤的不同区域。②新的诊断试验功效评估须遵循初级STARd。③多形性胶质母细胞瘤的每个肿瘤区域用不同的张量指标进行检测。④FA和md.不是肿瘤浸润最好的生物标志物。⑤某些张量指标的诊断作用可被交换应用。

关键词：脑肿瘤扩散张量成像 MRI 敏感度和特异度统计学论题

LFA-1 antagonist (BIRT377) similarly reverses peripheral neuropathic pain in male and female mice with underlying sex divergent peripheral immune proinflammatory phenotypes

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Neuroimmunology and Neuroinflammation 2019年第7期6卷 12-43页

作者： Shahani Noor Melody S.Sun Arden G.Vanderwall Mara A.Havard Jacob E.Sanchez Nathan W.Harris Monique V.Nysus Jeffrey P.Norenberg Harrison T.West Carsten R.Wagner Lauren L.Jantzie Nikolaos Mellios Erin d.Milligan department of Neurosciences School of MedicineUniversity of New MexicoAlbuquerqueNM 87131USA department of Anesthesiology and Critical Care University of New MexicoAlbuquerqueNM 87131USA department of Pediatrics and Neurology Johns Hopkins University School of MedicineBaltimoreMD 21205-2196USA department of Radiopharmaceutical Sciences College of PharmacyNew Mexico Center for Isotopes in MedicineUniversity of New MexicoAlbuquerqueNM 87131USA department of Medicinal Chemistry University of MinnesotaCollege of PharmacyMinneapolisMN 55455USA

Aim:The majority of preclinical studies investigating aberrant glial-neuroimmune actions underlying neuropathic pain have focused on male rodent ***,studies have shown peripheral immune cells play a more prominent role than glial cells in mediating pathological pain in ***,we compared the onset and duration of allodynia in males and females,and the anti-allodynic action of a potentially novel therapeutic drug(BIRT377)that not only antagonizes the action of lymphocyte function-associated antigen-1(LFA-1)to reduce cell migration in the periphery,but may also directly alter the cellular inflammatory ***:Male and female mice were subjected to peripheral nerve injury chronic constriction injury(CCI)applying two methods,using either 4-0 or 5-0 chromic gut suture material,to examine potential sex differences in the onset,magnitude and duration of *** sensitivity before and after CCI and application of intravenous BIRT377 was *** and spinal tissues were analyzed for protein(multiplex electrochemiluminescence technology)and mRNA expression(quantitative real-time PCR).The phenotype of peripheral T cells was determined using flow ***:Sex differences in proinflammatory CCL2 and IL-1βand the anti-inflammatory IL-10 were observed from a set of cytokines analyzed.A profound proinflammatory T cell(Th17)response in the periphery and spinal cord was also observed in neuropathic ***377 reversed pain,reduced IL-1βand TNF,and increased IL-10 and transforming growth factor(TGF)-β1,also an anti-inflammatory cytokine,in both ***,female-derived T cell cytokines are transcriptionally regulated by BIRT377,as demonstrated by reducing proinflammatory IL-17A production with concurrent increases in IL-10,TGF-β1 and the anti-inflammatory regulatory T cell-related factor,***:This study supports that divergent peripheral immune and neuroimmune responses during neuropathy exists between males and

关键词： Neuropathic pain glia neuroimmune peripheral immune T cells

A history of high-power laser research and development in the United Kingdom

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High Power Laser Science and Engineering 2021年第2期9卷 41-126页

作者： Colin N.danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth david Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker dangor Laurence devereux Peter E.dyer Anthony dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin denis R.Hall david C.Hanna Wayne Harris david I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull david Hunt dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.d.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin david Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng david Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins dave Willford Trevor Winstone AWE Aldermaston ReadingUK Oxford Centre for High Energy density Science Department of PhysicsClarendon LaboratoryUniversity of OxfordOxfordUK Centre for Intertial Fusion Studies Blackett LaboratoryImperial College LondonLondonUK Formerly of Electrox LetchworthUK Formerly of Central Laser Facility Rutherford LaboratoryDidcotUK Formerly of Ferranti defence Systems LincolnUK Leonardo EdinburghUK Retired AWEReadingUK Formerly of AWE ReadingUK Formerly of Laser Lines Ltd BanburyUK Formerly of Optilas Ltd Milton KeynesUK Retired Pro-Lite TechnologyCranfieldUK Specialised Imaging Ltd PitstoneUK Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK Magna-Power Electronics Ltd ReadingUK deBe Lasers Needham Laser TechnologiesWhitchurchUK Blackett Laboratory Imperial College LondonLondonUK SPIE Europe CardiffUK Professor Emeritus(Physics) University of HullKingston upon HullUK Kentech Instruments Ltd WallingfordUK department of Physics Clarendon LaboratoryUniversity of OxfordOxfordUK Professor Emeritus Department of PhysicsUniversity of StrathclydeGlasgowUK department of Physics Durham UniversityDurhamUK Professor Emeritus(Photonics) Heriot-Watt UniversityEdinburghUK Professor Emeritus University of SouthamptonSouthamptonUK Optical Surfaces Ltd KenleyUK JEH Lasers Ltd RugbyUK Scottish Universities Physics Alliance Department of PhysicsUniversity of StrathclydeGlasgowUK ITER Organization Saint-Paul-lez-DuranceFrance Manx Precision Optics Ltd BallasallaUK Laser Lines Ltd BanburyUK Elliot Scientific Ltd MetroTest Scientific GroupHarpendenUK Centre for Plasma Physics Queen’s University BelfastBelfastUK Retired Founderand former MDRofin-Sinar UK LtdHullUK Heraeus Noblelight Ltd CambridgeUK Mirli Books ChelmsfordUK M Squared Lasers Ltd GlasgowUK University of Hertfordshire HatfieldUK E&EO UK Ltd Barton-upon-HumberUK department of Physics University of YorkYorkUK IC Optical Systems Ltd BeckenhamUK Laser Micromachining Ltd St AsaphUK MBdA UK Ltd Brist

The first demonstration of laser action in ruby was made in 1960 by *** of Hughes Research Laboratories,*** laboratories worldwide began the search for lasers using different materials,operating at different *** the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of *** historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years.

关键词： high-power lasers history United Kingdom

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Correction: Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1860-1860页

作者： Qi Zhang Bridget Riley-Gillis Lina Han Yannan Jia Alessia Lodi Haijiao Zhang Saravanan Ganesan Rongqing Pan Sergej N.Konoplev Shannon R.Sweeney Jeremy A.Ryan Yulia Jitkova Kenneth dunner Jr Shaun E.Grosskurth Priyanka Vijay Sujana Ghosh Charles Lu Wencai Ma Stephen Kurtz Vivian R.Ruvolo Helen Ma Connie C.Weng Cassandra L.Ramage Natalia Baran Ce Shi Tianyu Cai Richard Eric davis Venkata L.Battula Yingchang Mi Jing Wang Courtney d.diNardo Michael Andreeff Jeffery W.Tyner Aaron Schimmer Anthony Letai Rose Ann Padua Carlos E.Bueso-Ramos Stefano Tiziani Joel Leverson Relja Popovic Marina Konopleva department of Leukemia The University of Texas MD Anderson Cancer Center Houston TX USA Institute of Hematology Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China department of Hematology The First Hospital Affiliated Harbin Medical University Harbin China AbbVie Inc. North Chicago IL USA department of Nutritional Sciences Department of Pediatrics Department of Oncology Dell Medical School The University of Texas at Austin Austin TX 78712 USA department of Cell Developmental & Cancer Biology Division of Hematology & Medical Oncology Knight Cancer Institute Oregon Health & Science University Portland OR USA Université de Paris Institut de la Recherche Saint-Louis (IRSL) Inserm Unit 1131 Paris France dana-Farber Cancer Institute Boston MA USA department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA Princess Margaret Cancer Center Toronto ON Canada High Resolution Electron Microscopy Facility The University of Texas MD Anderson Cancer Center Houston TX USA department of Bioinformatics & Computational Biology The University of Texas MD Anderson Cancer Center Houston TX USA department of Lymphoma & Myeloma Research The University of Texas MD Anderson Cancer Center Houston TX USA

Correction to:Signal Transduction and Targeted Therapy(2022)7:1–13,https://***/10.1038/s41392-021-00870-3 In the original version of this article,given name of 4th author Yannan Jia was incorrectly published as Yanan *** original article has been *** Access This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source.

关键词： myeloid Therapy resistance