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The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy

Genes & Diseases 2024年第1期11卷 321-334页

作者： md.Rakibul Alam md.Mizanur rahman Zhiguo Li Department of Toxicology and Cancer Biology College of MedicineUniversity of KentuckyLexingtonKY 40506USA Department of Medicine(Nephrology) Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6E2H7Canada

Exosomes are small membrane vesicles containing microRNA,RNA,DNA fragments,and proteins that are transferred from donor cells to recipient *** cells release exo-somes to reprogram the factors associated with the tumor microenvironment(TME)causing tu-mor metastasis and immune *** evidence revealed that cancer cell-derived exosomes carry immune inhibitory molecule program death ligand 1(PD-L1)that binds with re-ceptor program death protein 1(PD-1)and promote tumor progression by escaping immune ***,some FDA-approved monoclonal antibodies are clinicallyused for cancer treatment by blocking PD-1/PD-L1 *** notable treatment outcomes,some pa-tients show poor drug *** PD-L1 plays a vital role in lowering the treatment response,showing resistance to PD-1/PD-L1 blockage therapy through recapitulating the ef-fect of cell surface *** enhance therapeutic response,inhibition of exosomal PD-L1 is *** signaling is the central regulator of tumorigenesis and can regulate exosome biogenesis and secretion by modulating Rab GTPase family and membrane fusion ***-mune checkpoints are also connected with calcium signaling and calcium channel blockers like amlodipine,nifedipine,lercanidipine,diltiazem,and verapamil were also reported to suppress cellular PD-L1 ***,to enhance the PD-1/PD-L1 blockage therapy response,the reduction of exosomal PD-L1 secretion from cancer cells is in our therapeutic *** this review,we proposed a therapeutic strategy by targeting calcium signaling to inhibit the expression of PD-L1-containing exosome levels that could reduce the anti-PD-1/PD-L1 therapy resistance and increase the patient's drug response rate.

关键词： Calcium signaling CD8^(+)T cells Exosomal PD-L1 Exosomes biogenesis Immunosuppression Immunotherapy

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Mobility Issue on Octagonal Structured ZigBee Network Using Riverbed

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International Journal of Communications, Network and System Sciences 2016年第3期9卷 55-66页

作者： Nazrul Islam md. Jaminul Haque Biddut md. Faizul Huq Arif Mohammad Motiur rahman md. syfur rahman Department of Information and Communication Technology (ICT) Mawlana Bhashani Science and Technology University Santosh Tangail Bangladesh Department of Computer Science and Engineering (CSE) Mawlana Bhashani Science and Technology University Santosh Tangail Bangladesh Education Management Information System (EMIS) Cell Directorate of Secondary and Higher Education Ministry of Education Dhaka Bangladesh

Wireless Sensor Network (WSN) is a special type of communication medium through distributed sensor nodes. Popular wireless sensor nodes like ZigBee have splendid interoperability after IEEE 802.15.4 standardization in the domain of wireless personal area network (WPAN). ZigBee has another great feature mobility that makes the ZigBee network more versatile. The mobility feature of ZigBee mobile nodes has a greater impact on network performance than fixed nodes. This impact sometimes turns into more severe because of network structure and mobility model. This study mainly focuses on the performance analysis of the ZigBee mobile node under Random and Octagonal mobility management model with the Tree routing method. The Riverbed academic modeler is used to design, implement and simulate the ZigBee network under certain conditions. This study also presents a competitive performance analysis based on ZigBee mobile nodes transmitter and receiver characteristics under the observation of the mobility model. This indicates that Octagonal mobility model exhibits better performance than the Random mobility model. This study will constitute a new way for further designing and planning a reliable and efficient ZigBee network.

关键词： WSN ZigBee Network Mobility Octagonal Structure Riverbed

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OAM-based diffractive all-optical classification

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Advanced Photonics 2024年第1期6卷 6-7页

作者： md.Sadman Sakib rahman Aydogan Ozcan University of California Electrical and Computer Engineering DepartmentLos AngelesCaliforniaUnited States University of California Bioengineering DepartmentLos AngelesCaliforniaUnited States University of California California NanoSystems Institute(CNSI)Los AngelesCaliforniaUnited States

Object classification is an important aspect of machine *** practices in object classification entail the digitization of object information followed by the application of digital algorithms such as deep neural *** execution of digital neural networks is power-consuming,and the throughput is *** existing von Neumann digital computing paradigm is also less suited for the implementation of highly parallel neural network architectures.^(1)

关键词： consuming digit neural

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Adequate Closed Form Wave Solutions to the Generalized KdV Equation in Mathematical Physics

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Journal of Applied Mathematics and Physics 2024年第6期12卷 2069-2082页

作者： md. Munnu Miah md. Al Amin Meia md. Matiur rahman Sarker Ahammodullah Hasan Department of Mathematics Islamic University Kushtia Bangladesh Department of Mathematics Government Titumir College Dhaka Bangladesh Department of Pharmacy University of Asia Pacific Dhaka Bangladesh

In this paper, we consider the generalized Korteweg-de-Vries (KdV) equations which are remarkable models of the water waves mechanics, the shallow water waves, the quantum mechanics, the ion acoustic waves in plasma, the electro-hydro-dynamical model for local electric field, signal processing waves through optical fibers, etc. We determine the useful and further general exact traveling wave solutions of the above mentioned NLDEs by applying the exp(−τ(ξ))-expansion method by aid of traveling wave transformations. Furthermore, we explain the physical significance of the obtained solutions of its definite values of the involved parameters with graphic representations in order to know the physical phenomena. Finally, we show that the exp(−τ(ξ))-expansion method is convenient, powerful, straightforward and provide more general solutions and can be helping to examine vast amount of travelling wave solutions to the other different kinds of NLDEs.

关键词： The Generalized KdV Equation The exp(-τ(ξ)) -Expansion Method Travelling Wave Solitary Wave

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Quality of Service Analysis of Ethernet Network Based on Packet Size

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Journal of Computer and Communications 2016年第4期4卷 63-72页

作者： Nazrul Islam Chayan Chandra Bawn Jahid Hasan Asma Islam Swapna md. syfur rahman Department of Information and Communication Technology Mawlana Bhashani Science and Technology University Santosh Bangladesh Education Management Information System (EMIS) Cell Directorate of Secondary and Higher Education Ministry of Education Dhaka Bangladesh

Ethernet network, standardized by IEEE 802.3, is vastly installed in Local Area Network (LAN) for cheaper cost and reliability. With the emergence of cost effective and enhanced user experience needs, the Quality of Service (QoS) of the underlying Ethernet network has become a major issue. A network must provide predictable, reliable and guaranteed services. The required QoS on the network is achieved through managing the end-to-end delay, throughput, jitter, transmission rate and many other network performance parameters. The paper investigates QoS parameters based on packet size to analyze the network performance. Segmentation in packet size larger than 1500 bytes, Maximum Transmission Unit (MTU) of Ethernet, is used to divide the large data into small packets. A simulation process under Riverbed modeler 17.5 initiates several scenarios of the Ethernet network to depict the QoS metrics in the Ethernet topology. For analyzing the result from the simulation process, varying sized packets are considered. Hence, the network performance results in distinct throughput, end-to-end delay, packet loss ratio, bit error rate etc. for varying packet sizes.

关键词： QoS Ethernet Network Performance Analysis Packet Size Segmentation

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Rural Resilience: A Comprehensive Study on Water Supply, Sanitation, Disease Patterns, and Hygiene Practices in Munshiganj, Bangladesh

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Journal of Environmental Protection 2024年第1期15卷 63-75页

作者： Jubayer Hoque Rifat Islam md. Mustafizur rahman md. Golam Rabbani md. Selim Reja Saifur rahman Soykat Saim Raiyan md. Shafiqul Ahsan Emon Sakil Khan Department of Environmental Science and Disaster Management Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalgnj Bangladesh Department of Political Science Bangabandhu Sheikh Mujibur Rahman Science and Technology University GopalgnjBangladesh Department of Statistics Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalgnj Bangladesh

This research project investigates the current status of water supply, sanitation, and hygiene practices in Munshiganj District, Bangladesh. Data collection involved a structured questionnaire and a reconnaissance survey. Findings reveal that 30% of individuals rely on surface water (hand-tube wells, rivers, and ponds), prioritized as canal > river > pond, while 70% depend on groundwater (subterranean electric motor, deep tube-well). Drinking water is generally sufficient, with 95% reporting adequacy throughout the year. About 45% use hand tube-well water, 28% use deep tube-well water, and 11% use supply tap water for various purposes. Bathing trends include underground water through electric motor > pond > hand tube-well water > river, while for cooking, the order is underground water through electric motor > pond > hand tube-well water > river. Toilet water supply ranks as supply tap water > hand tube-well water > deep tube-well water. Although sanitation awareness is high, some lack knowledge of good hygiene practices. After defecating, handwashing methods include soap, ash, soil, or water. Children’s waste disposal varies, with some discarding it in open areas. Approximately 40% suffer from diseases like Diarrhoea due to unsafe water, primarily affecting children and elders. Training exists, but a significant portion lacks sanitation education. Dry skin or exposure to cold water may cause temporary irritation. Local government involvement in sanitation efforts is less active compared to non-governmental organizations. Results emphasize the need to enhance community awareness of safe water supplies and sanitation practices. .

关键词： Water Supply Sanitation Practices Hygiene Awareness Groundwater Dependency Community Health Intervention

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Assessment of Physico-Chemical and Microbial Quality of Sugarcane Juice Sold by Street Vendors in Three Regions of Bangladesh

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Food and Nutrition Sciences 2024年第4期15卷 263-276页

作者： Nargis Akter Khan md. Murtaja Reza Linkon Munni Akter md. Alamgir Hossain md. Mahbubur rahman Tayeba Khan md. Abdul Alim md. Esrafil Department of Food Technology and Nutritional Science Mawlana Bhashani Science and Technology University Tangail Bangladesh Department of Biotechnology and Genetic Engineering Mawlana Bhashani Science and Technology University Tangail Bangladesh

Sugar cane juice is a popular refreshing drink in most part of Bangladesh. It has great taste and health benefits;also it is available most of the public places at reasonable prices which consumed by road side customers including general public, shopping personals, tourists, students. In our country, street vendors crushing sugarcane between roller crusher and sold without any heat treatment or preservative, also served with or without added ice and lemon juice. The study aimed to identify and compare the physico-chemical and microbial quality of sugarcane juice. The chemical qualities of juices including moisture, PH, ash, total soluble solid, total sugar, reducing sugar and titrable acidity were found slightly different in Mymensingh, Gazipur and Narayangonj areas. The highest and lowest value of moisture, ash, PH, total soluble solids, total sugar, reducing sugar and titrable acidity were found in 84.33% - 79.26% (Gazipur-Mymensingh), 0.57% - 0.04% (Mymensingh-Gazipur), 5.9 - 2.9 (Gazipur-Narayangonj), 17.48% - 4.98% (Mymensingh-Narayangonj), 21.9% - 6.56% (Mymensingh-Gazipur), 3.7 - 2.1 (Gazipur-Mymensingh) and 0.523% - 0.007% (Narayangonj-Gazipur) respectively. For microbiological analysis, the total viable count of sugar cane juice in Mymensingh, Gazipur and Narayangonj were ranged from 0.6 × 105 - 43.6 × 105 cfu/ml, 4.6 × 105 - 21.6 × 105 cfu/ml and 3.6 × 105 - 36.6 × 105 cfu/ml respectively, where the permitted value is 1.0 × 104 cfu/ml, whereas the total coliform count was ranged from 0.4 × 105 - 6.4 × 105 cfu/ml, 0.6 × 105 - 8.4 × 105 cfu/ml and 0.00 - 8.4 × 105 cfu/ml, where the permitted value is 100 cfu/ml and total fungal count was ranged from 5.5 × 105 - 56.5 × 105 cfu/ml, 21.5 × 105 - 54.5 × 105 cfu/ml and 32.5 × 105 - 68.5 × 105 cfu/

关键词： Sugarcane Street Vendors Microbial Quality Reducing Sugar

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Frame Length Dependency for Fundamental Frequency Extraction in Noisy Speech

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Journal of Signal and Information Processing 2024年第1期15卷 1-17页

作者： md. Saifur rahman Any Chowdury Nargis Parvin Arpita Saha Moinur rahman Department of Information and Communication Technology Comilla University Cumilla Bangladesh Department of Computer Science and Engineering Bangladesh Army International University of Science and Technology (BAIUST) Cumilla Bangladesh Department of Information Technology University of Information Technology and Sciences (UITS) Dhaka Bangladesh

The fundamental frequency plays a significant part in understanding and perceiving the pitch of a sound. The pitch is a fundamental attribute employed in numerous speech-related works. For fundamental frequency extraction, several algorithms have been developed which one to use relies on the signal’s characteristics and the surrounding noise. Thus, the algorithm’s noise resistance becomes more critical than ever for precise fundamental frequency estimation. Nonetheless, numerous state-of-the-art algorithms face struggles in achieving satisfying outcomes when confronted with speech recordings that are noisy with low signal-to-noise ratio (SNR) values. Also, most of the recent techniques utilize different frame lengths for pitch extraction. From this point of view, This research considers different frame lengths on male and female speech signals for fundamental frequency extraction. Also, analyze the frame length dependency on the speech signal analytically to understand which frame length is more suitable and effective for male and female speech signals specifically. For the validation of our idea, we have utilized the conventional autocorrelation function (ACF), and state-of-the-art method BaNa. This study puts out a potent idea that will work better for speech processing applications in noisy speech. From experimental results, the proposed idea represents which frame length is more appropriate for male and female speech signals in noisy environments.

关键词： Pitch Estimation Fundamental Frequency BaNa ACF Frame Length

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Renewable Energy: Prospects and Challenges in Bangladesh

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Energy and Power Engineering 2024年第2期16卷 43-78页

作者： Abul Fattah Mohammad Masum Rabbani md. Masudur rahman Rahat Ahsan Habib md. Nazrul Islam Bangladesh Police Dhaka Bangladesh Department of Chemistry University of Dhaka Dhaka Bangladesh

Among expert scientists and politicians, there is increasing agreement that it is absolutely necessary to reduce the emission of greenhouse gas (GHG) to lessen the severity of climate change. Although little, renewable energy sources currently reduce GHG that are being emitted from the energy industries. According to the majority of long-term energy estimates, renewable energy will be a substantial addition to the supply of energy worldwide by the end of this century, as capacity of renewable energy is gradually increasing in the early decades. However, developing nations like Bangladesh are largely reliant on pricey imported energy supplies (coal, gas, and oil) that lay a heavy weight on the country’s economy. Also, air pollution growing in importance as a national and international environmental issue. Regarding the development of clean and sustainable energy, renewable energy sources seem to be among the most practical and efficient alternatives, in both Bangladesh and globally. The geographic advantages of Bangladesh allow for widespread usage of the majority of such renewable energy sources. The comparative potential and use of fossil fuels against renewable energy sources globally and in Bangladesh is explored in this review.

关键词： Renewable Energy Solar and Photovoltaics Hydropower Wind Energy Geothermal

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Effect of Trimetazidine on Functional Capacity in Patient with Ischaemic Cardiomyopathy (TOFCAPI)

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International Journal of Clinical Medicine 2024年第2期15卷 55-67页

作者： Mohsin Ahmed Golam Morshed Mahmood Hasan Khan md. Arifur rahman Muhammed Aminur Razzaque Shariful Islam Sayeedur rahman Khan Chowdhury md. Kudrat-E-Khuda Salahuddin Anis Shiblee md. Habibur rahman Department of Cardiology National Institute of Cardiovascular Diseases Dhaka Bangladesh Department of Cardiology Government Employee’s Hospital Dhaka Bangladesh Department of Cardiology Delta Hospital Ltd. Dhaka Bangladesh IPDI Foundation Dhaka Bangladesh

Objective: This study aimed to evaluate the efficacy of trimetazidine on exercise capacity via a six-minute walk test in patients with ischaemic cardiomyopathy and also evaluate the effect of trimetazidine on left ventricular function via echocardiography in the same population. Methods: This prospective observational study, conducted at the National Institute of Cardiovascular Diseases in Dhaka, Bangladesh, enrolled 200 patients with ischaemic cardiomyopathy and a depressed left ventricular ejection fraction (LVEF Results: In this study (n = 200) of ischaemic cardiomyopathy patients, the mean age was 58 years, with 76% of the patients being male. All study subjects received GDMT (Guideline-Directed Medical Therapy) for angina and heart failure. Those who received the modified released form of trimetazidine developed lesions during the 1st and 2nd follow-ups, during which the LVEF, LVIDd, and six-minute walk distance significantly improved (p Conclusion: The findings of the present study demonstrated that the addition of modified-release trimetazidine to GDMT can improve exercise capacity and left ventricular function in patients with ischaemic cardiomyopathy.

关键词： Bangladesh Heart Failure Exercise Capacity Trimetazidine Ischaemic Cardiomyopathy

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