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Nipah Virus Unveiled: A Review Article

Advances in Bioscience and Biotechnology 2024年第3期15卷 161-173页

作者： Munama Magdum md. Abir Tazim Chowdhury Mahmuda Khandaker Razdip Datta md. Naheed Rayhan md. siffat uddin md. Junayed Imam Bhuiyan md. Ahaduzzaman md. Abdullah Al-Mahammud Kabir Mohammad Zishan uddin md. Estiak Ullah Sahid Subrata Saha Department of Community Medicine Shaheed Monsur Ali Medical College Dhaka Bangladesh Department of Cardiothoracic and Vascular Surgery Evercare Hospital Dhaka Bangladesh Department of Microbiology Shaheed Monsur Ali Medical College Dhaka Bangladesh Department of Anesthesia Dhaka Dental College & Hospital Dhaka Bangladesh Department of Cardiothoracic Anesthesia Evercare Hospital Dhaka Bangladesh Department of Medicine Times Multicare Hospital Ltd. Dhaka Bangladesh Barking Havering and Redbridge University Hospitals NHS Trust Romford UK

Nipah virus (NiV) is a highly infectious zoonotic pathogen that poses a significant threat to human and animal health. First identified in Malaysia in 1998, NiV has since caused several outbreaks in Southeast Asia, with sporadic cases reported in Bangladesh and India. The virus is primarily transmitted to humans through direct contact with infected animals, primarily fruit bats, or through the consumption of contaminated fruits and their juices. NiV infection presents a wide spectrum of clinical features, ranging from mild respiratory illness to severe encephalitis, with a high case fatality rate. The incubation period typically ranges from 4 to 14 days, during which patients develop fever, headache, myalgia, and respiratory symptoms such as cough and sore throat. As the disease progresses, neurological signs become prominent, including altered consciousness, seizures, and focal deficits. Severe cases may exhibit acute respiratory distress syndrome and multi organ failure. Laboratory findings often include lymphocytopenia, thrombocytopenia, and elevated liver enzymes. Diagnosis of NiV infection requires specialized laboratory testing, including reverse transcription-polymerase chain reaction (RT-PCR) and serological assays. Currently, no specific antiviral treatment exists for NiV infection, and management primarily focuses on supportive care. Prevention and control strategies encompass public health interventions, surveillance, and raising awareness among healthcare providers and the general population. The emergence and re-emergence of NiV highlight the urgent need for continued research, improved diagnostic capabilities, and the development of effective vaccines and therapeutics to mitigate the impact of this deadly virus.

关键词： Nipah Virus Zoonotic Pathogen Outbreaks Surveillance

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