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Outcome of Long Segment Transpedicular Screw Fixation in Unstable Thoracolumbar Spine Injury with Incomplete Neurological Deficit

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Journal of Biosciences and Medicines 2020年第3期8卷 166-187页

作者： Shah md. Rezaul Karim A. K. M. Shahidur Rahman Syed Abdus Sobhan md. shahidul islam akon Muhammad Akter Hossain Ashraf Ali Shah Newas md. Ruhul Quddus md. Moshiur Rahman Mollick Department of Surgery Sheikh Hasina Medical College Hospital Habiganj Bangladesh Department of Nephrology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Orthopaedic Surgery Dhaka Medical College Hospital (DMCH) Dhaka Bangladesh Department of Anatomy Chandpur Medical College Chandpur Bangladesh Department of Cardiology Abdul Malek Ukil Medical College Hospital Noakhali Bangladesh Department of Orthopaedic Surgery National Institute of Traumatology and Orthopedic Rehabilitation (NITOR) Dhaka Bangladesh Department of Biochemistry Pabna Medical College Pabna Bangladesh Department of Orthopaedic Surgery Sheikh Hasina Medical College Hospital Habiganj Bangladesh

Background: Long segment transpedicular screw fixation in thoracolumbar spine injury has gained popularity in the last decades as it provides immediate stability, prevents further risk of complications and allows early mobilization of patient. Objectives: Evaluation of clinical and functional outcome after long segment transpedicular screw fixation in unstable thoracolumbar spine injury with incomplete neurological deficit patients. Methods: This quasi experimental study was conducted at Dhaka Medical College and Hospital (DMCH), Dhaka, Bangladesh from January 2016 to December 2017. A total of twenty four (24) patients with traumatic unstable fracture of the thoracolumbar spine with incomplete neurological deficit underwent long segment transpedicular screw fixation were included in this study. Clinical and radiologic outcomes were assessed pre-operatively and post-operatively. Results: A total of 24 patients aged between 20 - 60 years of both sexes (Male-21, Female-03) were included in this study. Their mean (±SD) age was 33.12 (±8.57) years. Most of them were farmer [09 (37.5%)] and day labour [08 (33.33%)]. Motor vehicle accidents were the most common [16 (66.67%)] cause of injury and then fall from height [08 (33.33%)]. The most common level of injury involved was L1-10 (41.67%) patients, followed by L2-07 (29.17%), T12-05 (20.83%) and T11-02 (8.33%) of the study patients. Burst fracture was the commonest [22 (91.67%)] type of fracture followed by Chance fracture [02 (8.33%)]. Pre-operative mean (±SD) Cobb angle, Kyphotic deformation of vertebral body, Beck index and vertebral compression deformity were 21.83 ± 4.5 degrees, 22.09 ± 4.40 degrees, 0.78 ± 2.65 and 0.18 ± 0.93 mm respectively, after procedure which were significantly (p Conclusions: Long segment transpedicular screw fixation is an effective method of treatment in patients having thoracolumbar spine injury with incomplete neurological deficit.

关键词： Neurological Deficit Transpedicular Screw Fixation Unstable Thoracolumbar Spine Injury

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Red honeybush(Cyclopia genistoides)tea mitigates oxidative imbalance and hyperlipidemia,while improving glucose homeostasis in type 2 diabetic rats

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Food Science and Human Wellness 2023年第6期12卷 2029-2039页

作者： Xin Xiao Ochuko L.Erukainure md.shahidul islam Department of Biochemistry University of KwaZulu-NatalWestville CampusDurban 4000South Africa Department of Pharmacology University of the Free StateBloemfontein 9300South Africa

Red honeybush tea(RHT)is a tea product developed from Cyclopia *** is endemic to South *** refreshment,RHT has over the years been used traditionally in the treatment of various diseases including type 2 *** study investigated the in vivo antioxidant and anti-diabetic activity of RHT concentrated hot water extract in type 2 diabetes(T2D)model of rats.T2D was induced starting with feeding 10%fructose solution ad libitum for 2 weeks followed by a single intraperitoneal injection of streptozotocin(40 mg/kg body weight(BW)).Five weeks of treatment of RHT led to significant(Pmd. levels and enhanced level of GSH,activity of SOD,catalase,GR in most of organs(pancreas,liver,kidneys,and heart).Signifi cantly(P<0.05)improved morphological changes in the islets andβ-cells were observed in rats treated with *** data of this study suggest that RHT demonstrates an outstanding antioxidant and anti-diabetic effects in STZ-induced T2D model of rats.

关键词： Red honeybush tea(Cyclopia genistoides) Antioxidants Anti-diabetes Type 2 diabetes

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Glucagon-like-peptide-1 receptor agonists and the management of type 2 diabetes-backwards and forwards

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World Journal of Diabetes 2024年第3期15卷 326-330页

作者： Michael Horowitz Lu Cai md.shahidul islam Department of Medicine University of AdelaideAdelaide 5005Australia Pediatric Research Institute University of LouisvilleLouisvilleKY 40202United States Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa

This editorial is stimulated by the article by Alqifari et al published in the World Journal of Diabetes(2024).Alqifari et al focus on practical advice for the clinical use of glucagon-like-peptide-1(GLP-1)receptor agonists(GLP-1RAs)in the management of type 2 diabetes and this editorial provides complementary *** initially give a brief historical perspective of the development of GLP-1RAs stimulated by recognition of the‘incretin effect’,the substantially greater insulin increase to enteral when compared to euglycaemic intravenous glucose,and the identification of the incretin hormones,GIP and *** addition to stimulating insulin,GLP-1 reduces postprandial glucose levels by slowing gastric ***-1RAs were developed because native GLP-1 has a very short plasma *** majority of current GLP-1RAs are administered by subcutaneous injection once a *** are potent in glucose lowering without leading to hypoglycaemia,stimulate weight loss in obese individuals and lead to cardiovascular and renal *** landscape in relation to GLP-1RAs is broadening rapidly,with different formulations and their combination with other peptides to facilitate both glucose lowering and weight *** is a need for more information relating to the effects of GLP-1RAs to induce gastrointestinal symptoms and slow gastric emptying which is likely to allow their use to become more effective and personalised.

关键词： Glucagon-like-peptide-1 Glucose-dependent insulinotropic peptide Gastric emptying Type 2 diabetes

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Recent therapeutic targets for the prevention and management of diabetic complications

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World Journal of Diabetes 2023年第9期14卷 1330-1333页

作者： md.shahidul islam Lu Cai Michael Horowitz Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa Pediatric Research Institute University of LouisvilleLouisvilleKY 40202United States Department of Medicine University of AdelaideAdelaide 5005Australia

Diabetes and associated complications represent major global public health issues which are associated with impaired quality of life and premature *** some diabetic complications have decreased in the developed world,the majority are still prevalent,with an increasing trend in the developing *** used therapies are mainly‘glucocentric’,focusing on the optimization of glycemic control to prevent,delay or manage diabetes-associated complications-other common comorbidities,such as dyslipidemia and hypertension are often *** a number of novel therapeutic approaches have been reported recently,some of them have not received comparable attention in relation to either further studies or potential clinical *** editorial briefly discusses some recent therapeutic approaches to the prevention and management of diabetes and its associated complications,as well as potential directions for future research and development in this area.

关键词： Diabetic complications Oxidative stress Phytochemicals Zinc Silent information regulator 1 FOXO Micro RNA

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Whole Leea macrophylla ethanolic extract normalizes kidney deposits and recovers renal impairments in an ethylene glycol-induced urolithiasis model of rats

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Asian Pacific Journal of Tropical Medicine 2012年第7期5卷 533-538页

作者： Abu Nasim Nizami md.Atiar Rahman Nazim Uddin Ahmed md.shahidul islam Department of Biochemistry and Molecular Biology University of ChittagongChittagong-4331Bangladesh Department of Biochemistry School of BiochemistryGenetics and MicrobiologyUniversity of KwaZulu-NatalDurban 4000South Africa Bangladesh Council of Scientific and Industrial Research(BCSIR) Chittagong-4220Bangladesh

Objective:To investigate the antilithiatic effect of the whole Leea macrophylla(L macrophylla) Roxb(Leeaeeae) ethanol extract in ediylene glycol-induced urolithiasis model of ***: Forty two seven weeks old male wistar albino rats were randomly divided into two major groups namely:preventive(n=18) and therapeutic(n=24).Preventive group was further subdivided into 3 groups of 6 rats namely:preventive control(PC),preventive lithiatic control(PLC) and preventive lithiatic ***(PLLM).Similarly,therapeutic group was also subdivided into 4 groups of 6 rats namely:therapeutic control(TC),therapeutic lithiatic control(TLC).therapeutic lithitatic L macrophylla(TLLM) and therapeutic lithiatic cystone(TLCYS).The lithiasis was induced by 0.75%(v/v) ethylene glycol in the drinking water of all groups except the PC and TC *** urinary ionic parameters such as calcium,inorganic phosphate,oxalate,magnesium & creatinine and renal morphology were altered by ediylene glycol,which were partially recovered by 14 d preventive and almost fully recovered by 28 d therapeutic intervention trials with L macrophylla extract(500 mg/kg BW daily).Results:Significant difference on recovery was observed between preventive and dierapeutic interventional ***-urolithiatic effect of cystone was significantly(P<0.001) higher than extracts.L macrophylla extract was found nontoxic in the acute toxicity ***:The results of this study demonstrated very promising antiurolithiatic effect of *** extract with preventive and therapeutic treatments in this experimental condition.

关键词： Urolithiasis Ethylene glycol Leea macrophylla Urinary parameter Rats

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Potential therapeutic targets for the prevention of diabetic nephropathy:Glycyrrhetinic acid

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World Journal of Diabetes 2023年第12期14卷 1717-1720页

作者： Lu Cai Michael Horowitz md.shahidul islam Pediatric Research Institute Department of PediatricsUniversity of LouisvilleLouisvilleKY 40202United States Department of Medicine University of AdelaideAdelaide 5005Australia Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa

Uncontrolled hyperglycemia or poorly managed disease increases the propensityfor a number of diabetes-related complications targeting major organs includingthe heart, eyes, and kidney. Although the mechanisms by which diabetes inducescardiovascular diseases include oxidative stress and inflammation, when insulinresistance remains the key to the pathogenesis, as implicated in the two reviews inthis issue. This editorial mainly comments on the potential preventive applicationof glycyrrhetinic acid (or 18β-GA) in relation to diabetic nephropathy. The therapeuticor preventive effects of 18β-GA, as a hydrolytic product of glycy-rrhizicacid that is a component of licorice, have been appreciated in other disorders, buthave received much less attention in relation to diabetic complications. A study inthis issue has identified 18β-GA as a therapeutic for preventing diabeticnephropathy and provides evidence to support efficacy in cultured human renaltubule cells in vitro. Although it represents a pilot study, the observations supporta new therapeutic approach that warrants further ex-ploration.

关键词： Insulin resistance Diabetic cardiomyopathy Diabetic nephropathy Glycyrrhetinic acid Licorice Chinese herbal remedy

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Contribution of non-timber forest products to the livelihoods of the forest-dependent communities around the Khadimnagar National Park in northeastern Bangladesh

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Regional Sustainability 2021年第3期2卷 280-295页

作者： md.Habibur RAHMAN Bishwajit ROY md.shahidul islam Laboratory of Tropical Forest Resources and Environments Division of Forest and Biomaterials ScienceGraduate School of AgricultureKyoto UniversityKyoto606-8502Japan Bangladesh Institute of Social Research Trust LalmatiaDhaka1207Bangladesh Climate Change andSustainable Development Policies Faculty of ScienceUniversity of LisbonLisbon1749-016Portugal Research and Development Cell Bangladesh Knitwear Manufacturers and Exporters AssociationDhaka1000Bangladesh

Non-timber forest products(NTFPs)play a significant role in the improvement of the forest-dependent people’s livelihoodsaround the world,strengthening protection for the sustainable use of *** purpose of this research was to evaluate the influence of occupational category-wise(fuelwood collectors,farmers,small-scale businessmen,day labourers,and tea estate labourers)dependencyon NTFPsand the role of NTFPs on household income around the Khadimnagar National Park(KNP)in northeastern *** 2014,178purposively selected respondents from four villages(out of 22 villagesaround the KNP)were interviewed face-to-face using a semi-structured *** study observed that these forest-dependent communities utilized resources of the KNP mainly for domestic energy supply,household income,and house *** showed that income from NTFPs made a significant contribution to family *** data analysis indicated that small-scale businessmen earned relatively more income from NTFPs,followed by tea estate labourersand day *** study revealed significant negative relationships of the distance of households from the forest with the amount of NTFPs collected(P<0.01)and monthly income from NTFPs(P<0.01).Positive significant relationships were found between the amount of NTFPs collected and the time spent in NTFP collection(P<0.001),as well as betweenmonthly income from NTFPs and family size(P<0.001).The fuelwood collectors and farmers collected significantly greater amounts of NTFPs per trip(P<0.001)than other occupational *** households that were moderately to highly dependent on NTFPs collected significantly higher amounts of NTFPs pertrip(P<0.01)than the households that were moderately dependent and less dependent on *** dependence on KNP’sresources,community’sappreciation of the KNP’s ecosystem services for villagers’livelihoods,and community’s high levels of concern for forest conservation provided a foundation

关键词： Forest dependency Household income Non-timber forest products Forest sustainability Occupational categories Khadimnagar National Park

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Molecular methods for detection of pathogenic viruses of respiratory tract——A review

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Asian Pacific Journal of Tropical Biomedicine 2018年第5期8卷 237-244页

作者： md.shahidul Kabir Department of Microbiology Institutional Quality Assurance Cell Stamford University

Human respiratory system is harbored by a vast array of transient and normal microbial flora.A number of pathogenic viruses were diagnosed from samples in different occasions from mild to severe infections of respiratory *** methods were developed for detection of these viruses during last two *** acid amplification methods were introduced for rapid and accurate diagnosis of pathogenic *** detection systems were employed to identify a panel of pathogenic viruses,which requires specialized kits and instruments in some *** review summarizes different types of molecular approaches which were developed with time and applied for the detection of pathogenic viruses associated with infections of the respiratory system.

关键词： Respiratory system Virus Molecular method Detection

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Effect of Plant Extracts on Seed Borne Fungi of Jute

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American Journal of Plant Sciences 2018年第13期9卷 2580-2592页

作者： md. Abdul Ahad md. shahidul islam Nur Fatema Nupur Department of Plant Pathology Bangladesh Agricultural University Mymensingh Bangladesh Department of Plant Pathology Yunnan Agricultural University Kunming China Department of Fisheries Management Bangladesh Agricultural University Mymensingh Bangladesh

The aim of this study was to determine the prevalence of seed-borne fungal pathogens of jute and their control with plant extract. The experiment was carried out in seed pathology centre, Bangladesh Agricultural University to obtain relevant information about the health of jute seeds and find out the efficacy of extracts as seed-treater. Two varieties viz., Deshipat (Corchorus capsularis) and Tossapat (Corchorus olitorius) were selected for this study and jute seeds were collected from two different locations of Bangladesh. The major predominant identified fungi were Colletotrichum corchori, Macrophomina phaseolina, Fusarium spp., and Botryodiplodia theobromae. Least seed-borne fungi were found in the variety of Tossapat. Low germination of seeds was found related to high prevalence of seed-borne fungal infections. Highest seed-borne infection was obtained in the variety of Deshipat. In this study, we evaluated some major plant extracts such as garlic clove (Allium sativum), neem leaves (Azadirachta indica), allamanda leaves (Allamanda cathartica L.) and marigold leaves (Tagetes spp.) for observing the action of these plant extracts on seed borne fungi of Jute. The study revealed that the extract of Garlic (Allium sativum), and Biskatali (Polygonum hydropiper) increased the germination of seeds and garlic?(Allium sativum) extract was also found to be most effective in controlling the seed-borne infection among all the treatments. Although the inhibiting capacity of the extracts of Allamanda (Allamanda cathartica L.) and Biskatali (Polygonum hydropiper) was found to be similar and Biskatali extract was found to have the second position among all the treated plant extracts in inhibiting the growth of isolated fungal pathogens.

关键词： Botanical Treatment Medicinal Plant Bio-Control Seed Jute

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Sorbitol-based osmotic diarrhea:Possible causes and mechanism of prevention investigated in rats

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World Journal of Gastroenterology 2006年第47期12卷 7635-7641页

作者： md.shahidul islam Ei Sakaguchi Laboratory of Animal Nutri-tion Faculty of Agriculture Okayama University 1-1-1 Tsushima-naka Okayama City 700-8530 Japan

AIM: To study the possible causes of sorbitol (S)-based diarrhea and its mechanism of reduction by rice gruel (RG) in cecectomized rats. METHODS: S was dissolved either in distilled water or in RG (50 g/L) and ingested as a single oral dose (1.2 g/kg body mass, containing 0.5 g/L phenol red as a re-covery marker) by S (control) and S + RG groups (n = 7), respectively. This dose is over the laxative dose for hu-mans. Animals were sacrificed exactly 1 h after dose in-gestion, without any access to drinking water. The whole gastro-intestinal tract was divided into seven segments and sampled to analyze the S and marker remaining in its ***: Gastric-emptying and intestinal transit were comparatively slower in the S + RG group. Also, the S absorption index in the 3rd and last quarter of the small intestine (24.85 ± 18.88% vs 0.0 ± 0.0% and 39.09 ± 32.75% vs 0.0 ± 0.0%, respectively, P < 0.05) was sig-nificantly higher in the S + RG group than in the control group. The S absorption index and the intestinal fluid volume are inversely related to each other. CONCLUSION: The intestinal mal-absorption of S is the main reason for S-based osmotic diarrhea. Where RG en-hanced the absorption of S through passive diffusion, the degree of diarrhea was reduced in cecectomized rats.

关键词： Cecectomized rat Sorbitol Diarrhea Rice gruel Phenol red

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