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Development and Evaluation of Stable Paracetamol Loaded Solid Dispersion with Enhanced Analgesic and Hepatoprotective Property

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Pharmacology & Pharmacy 2023年第4期14卷 123-143页

作者： Ashim Kumar Milon Kumar Ghosh Mst. Boby Aktar Bithy md. Rafiqul Islam Khan md. monimul huq Mir Imam Ibne Wahed Ranjan Kumar Barman Laboratory of Pharmaceutics Department of Pharmacy Faculty of Science University of Rajshahi Rajshahi Bangladesh Department of Pharmacy Faculty of Biological Sciences Islamic University Kushtia Bangladesh Department of Statistics Faculty of Science University of Rajshahi Rajshahi Bangladesh

Paracetamol (PCM) is enlisted in the WHO model list as an essential medicine for pain and palliative care, but at overdose, it causes hepatic damage. This study was designed to assess the analgesic efficacy and hepatoprotective property of a solid dispersion (SD) loaded with PCM. A number of PCM loaded formulations (PSDs) were fabricated using silica alone or in combination with polyethylene glycol and/or Na-citrate followed by in-vitro dissolution profiling. Selected PSDs with improved dissolution profile were subjected to solid-state characterization (DSC, PXRD, FTIR, and SEM), stability study along with investigation of in-vivo analgesic efficacy and effect on hepatocytes. Among these, PSD10 showed a rapid and significantly higher in-vitro drug release than pure PCM. This improvement was distinct to other PSDs also. Solid-state characterization of PSD10 authenticated the conversion of crystalline PCM to amorphous form upon formulation. Subsequent oral administration of PSD10 in Swiss albino mice showed 1.44-fold greater analgesic efficacy than pure PCM at dose 30 mg/kg. Besides, at acute toxic dose, liver histology of PSD10 mice was comparable with NC mice indicating hepatic protection upon formulation, whereas the PCM mice showed extensive hepatic necrosis which was also endorsed by significantly higher values of SGPT, SGOT, and ALP than PSD10 mice. Finally, an accelerated stability study of PSD10 performed according to the guideline of ICH noticed no remarkable deviation in its dissolution performance as well as crystalline nature. Thus, this newly developed PSD10 may be a safe and promising alternative for pain management and palliative care.

关键词： Paracetamol Solid Dispersion Dissolution Analgesic Activity Hepatocyte Particle Surface Property Stability

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Complete separation of the urinary tract from proximal rectum during PSARP surgery: our experience with the novel technique

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World Journal of Pediatric Surgery 2024年第1期7卷 66-69页

作者： md.Samiul Hasan md.Nazmul Islam Refoyez Mahmud Umama huq Ashrarur Rahman Pediatric Surgery Bangladesh Shishu Hospital and InstituteDhakaBangladesh

Anorectal malformation(ARM)is a frequently occurring surgical condition in neonates,with a prevalence of 1 in 4000 live births.'In boys with this anomaly,the rectum and urinary tract share a common wall for some distance,often ending up in fistulous *** goals of definite reconstruction are to separate the rectum from the urinary tract without injuring the urethra and mobilizing the rectum to the perineum within the muscle *** the rectum and the urinary tract is the most critical part of this operation and is associated with a significant risk of urinary tract injury.2-5 The original procedure described by Pena and Devries involves multiple stay sutures on the rectal mucosa just above the fistula,lifting the mucosa and continuing a submucosal dissection up to the prostate,where the entire thickness of the intestine can be separated from the urinary tract.

关键词： urinary rectum intestine

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Design and Optimization of Photonic Crystal Fiber for Liquid Sensing Applications

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Photonic Sensors 2016年第3期6卷 279-288页

作者： md. Faizul huq ARIF Kawsar AHMED Sayed ASADUZZAMAN md. Abul Kalam AZAD Department of Information and Communication Technology (ICT) Mawlana Bhashani Science and TechnologyUniversity (MBSTU) Tangail-1902 Bangladesh Department of Material and Metallurgical Engineering (MME) Bangladesh University of Engineering and TechnologyUniversity (BUET) Dkaka-l O00 Bangladesh

This paper proposes a hexagonal photonic crystal fiber （H-PCF） structure with high relative sensitivity for liquid sensing; in which both core and cladding are microstructures. Numerical investigation is carried out by employing the full vectorial finite element method （FEM）. The analysis has been done in four stages of the proposed structure. The investigation shows that the proposed structure achieves higher relative sensitivity by increasing the diameter of the innermost ring air holes in the cladding. Moreover, placing a single channel instead of using a group of tiny channels increases the relative sensitivity effectively. Investigating the effects of different parameters, the optimized structure shows significantly higher relative sensitivity with a low confinement loss.

关键词： Photonic crystal fiber (PCF) liquid sensor microstructure core sensitivity confinement loss

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Mobility Issue on Octagonal Structured ZigBee Network Using Riverbed

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International Journal of Communications, Network and System Sciences 2016年第3期9卷 55-66页

作者： Nazrul Islam md. Jaminul Haque Biddut md. Faizul huq Arif Mohammad Motiur Rahman md. Syfur Rahman Department of Information and Communication Technology (ICT) Mawlana Bhashani Science and Technology University Santosh Tangail Bangladesh Department of Computer Science and Engineering (CSE) Mawlana Bhashani Science and Technology University Santosh Tangail Bangladesh Education Management Information System (EMIS) Cell Directorate of Secondary and Higher Education Ministry of Education Dhaka Bangladesh

Wireless Sensor Network (WSN) is a special type of communication medium through distributed sensor nodes. Popular wireless sensor nodes like ZigBee have splendid interoperability after IEEE 802.15.4 standardization in the domain of wireless personal area network (WPAN). ZigBee has another great feature mobility that makes the ZigBee network more versatile. The mobility feature of ZigBee mobile nodes has a greater impact on network performance than fixed nodes. This impact sometimes turns into more severe because of network structure and mobility model. This study mainly focuses on the performance analysis of the ZigBee mobile node under Random and Octagonal mobility management model with the Tree routing method. The Riverbed academic modeler is used to design, implement and simulate the ZigBee network under certain conditions. This study also presents a competitive performance analysis based on ZigBee mobile nodes transmitter and receiver characteristics under the observation of the mobility model. This indicates that Octagonal mobility model exhibits better performance than the Random mobility model. This study will constitute a new way for further designing and planning a reliable and efficient ZigBee network.

关键词： WSN ZigBee Network Mobility Octagonal Structure Riverbed

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Photonic Crystal Fiber Based Sensor for Detecting Binary Liquid Mixture

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Optics and Photonics Journal 2017年第11期7卷 221-234页

作者： md. Faizul huq Arif md. Jaminul Haque Biddut md. Shaiful Islam Babu H M Mostafizur Rahman md. Mahbubur Rahman Busrat Jahan Moshrefa Sultana Chaity Shah Mostafa Khaled Institute of Information Technology (IIT) University of Dhaka Dhaka Bangladesh Automation and Robotics Faculty of Electrical Engineering and Information Technology (EEIT) TU Dortmund University Dortmund Germany Department of Computer Science and Engineering World University of Bangladesh Dhaka Bangladesh School of Information Technology BAC International Study Centre Dhaka Bangladesh Department of Computer Science and Engineering Feni University Feni Bangladesh Institute of Information Technology (IIT) Jahangirnagar University Dhaka Bangladesh

Detection of liquid mixture of different volume ratio is very important in industrial purposes. The paper reports a sensing mechanism of binary liquid mixture for different volume fraction, based on the measurement of refractive index of the mixture. Here, a highly sensitive liquid filled core Photonic Crystal Fiber structure has been proposed to detect liquid mixture solution. Numerical investigation of the proposed structure is carried out by employing full vectorial Finite Element Method (FEM).

关键词： Binary Liquid Mixture Photonic Crystal Fiber Refractive Index Sensitivity Confinement Loss

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Macro and Micro Nutrient Supply to Soil and Plants from Sugar Mill Mud

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Agricultural Sciences 2019年第2期10卷 164-172页

作者： Ishrat Jahan Sanchary Kazi md. Jahangir Kabir Shah Muhammad Imamul huq Department of Soil and Environmental Sciences University of Barishal Barishal Bangladesh Department of Soil Water and Environment University of Dhaka Dhaka Bangladesh Vice Chancellor University of Barishal Barishal Bangladesh

The effects of sugar mill mud application on the availability of nutrients for plant uptake were investigated. Mill mud generated from conventional sugar mill operations was applied in three different rates and a leafy vegetable, locally called “PuiShak” or Indian spinach (Basellarubra L.) was grown for 60 days as a test crop in a pot culture experiment. Crop yield and essential nutrients like N, P, K and Zn uptake concentration was determined to come up with an inference that higher doses of mill mud application impose better effect on root and shoot uptake of these elements. A little infraction was observed for nitrogen uptake by plants for the maximum dose.

关键词： Nutrient Supply Soil-Plant System Mill Mud

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Release of Arsenic from Arsenic Removal Water Filter Sludge in Soil and Its Uptake by Red Amaranth

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Open Journal of Soil Science 2013年第8期3卷 342-346页

作者： Sajal Roy Shah Muhammad Imamul huq md. Abul Kashem Khan Towhid Osman Bangladesh-Australia Centre for Environmental Research Department of Soil Water and Environment University of Dhaka Dhaka Bangladesh. Department of Soil Science University of Chittagong Chittagong Bangladesh

There is a major concern among scientists over the elevated levels of arsenic (As) in drinking water in Bangladesh and some parts of India. Investigating the release of As from water filter sludge in soil and its uptake by plants may provide information about the management of As contaminated filter sludge. In this macrocosm study, iron based sludge con- taining granular ferric hydroxide (GFH) was mixed with air dried silt loam surface soil at rate of 0 (control, no sludge), 1.5 and 2.5 t?ha?1 and red amaranth (Amaranthus tricolor L.) plants were grown for 45 days. Addition of filter sludge did not affect the height, fresh weight and dry matter yield of amaranth. However, the highest concentration of As and Fe were found both in shoots and roots of amaranth grown in the pot of the highest rate of sludge treated soil. The con- centration of As, Fe and S was higher in the roots than that in the shoots of Amaranth. Translocation of As, S and Fe in- creased with the rates of sludge application. Elevated concentration of As in sludge treated plants is a sign of environ- mental hazard and should be taken into consideration.

关键词： Arsenic Accumulation Concentration Red Amaranth Translocation

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Optimization of ZigBee Network Parameters for the Improvement of Quality of Service

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Journal of Computer and Communications 2018年第6期6卷 1-14页

作者： Sun Maung Shafia Shiraje Atiqul Islam Mohammad Mobarak Hossain Shamsun Nahar md. Faizul huq Arif Department of Computer Science and Engineering (CSE) World University of Bangladesh (WUB) Dhaka Bangladesh

Network enabled digital technologies are offering new and exciting opportunities to increase the connectivity of devices for the purpose of home and office automation. ZigBee (IEEE 802.15.4) is such a digital wireless technology that is used for personal area networks. In this paper, an office automation network using the combination of fixed and mobile IEEE 802.15.4 has been deployed and analyzed. The QoS parameters of the network as the performance metrics like throughput, MAC delay and data dropped rate have been investigated. Finally the network has been finalized with the optimized QoS parameters.

关键词： ZigBee Quality of Service WSN Riverbed

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Nutrient dynamics in the Sundarbans mangrove estuarine system of Bangladesh under different weather and tidal cycles

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Ecological Processes 2013年第1期2卷 300-312页

作者： Shak md.Bazlur Rahaman Lipton Sarder md.Sayadur Rahaman Alokesh Kumar Ghosh Sudhin Kumar Biswas SM Shahjahan Siraj Khandaker Anisul huq Abul Farah md.Hasanuzzaman Shikder Saiful Islam Fisheries and Marine Resource Technology Discipline Khulna UniversityKhulna 9208Bangladesh Chemistry Department Comilla UniversityComilla 3500Bangladesh

Introduction:Seasonal and tidal variations in nutrient concentration and water quality were investigated in the western Sundarbans of Bangladesh during the post-monsoon,winter and monsoon seasons during 2010–***:Water collected from the surface,middle and bottom layers at six locations of the Kholpetua-Arpangashia river system during high and low tides was analyzed for temperature,salinity,pH,dissolved oxygen(DO),total dissolved solids(TDS),electrical conductivity(EC)and dissolved nutrients(NO3–N,PO4–P,SO4 and NH3–N).Results:The study revealed that nutrient concentrations were influenced by seasonal *** nutrient levels during post-monsoon,winter and monsoon seasons,respectively,were in the following ranges:nitrate(0.06–0.40,0.06–0.46 and 0.08–0.46 mg/L);phosphate(0.09–0.18,0.05–0.42 and 0.10–0.16 mg/L);sulphate(58.71–86.14,68.68–119.01 and 78.15–136.47 mg/L)and ammonia(0.02–0.08,0.02–0.04 and 0.26–0.38 mg/L).Increased levels of PO4–P,SO4 and NH3–N and lower DO and salinity were recorded during the monsoon *** of the experimental sites showed higher NO3–N content during monsoon,whereas few elevated concentrations were observed during post-monsoon and winter *** and low tidal waters contained mean nutrient levels in the following ranges:nitrate(0.05–0.46 and 0.04–0.40 mg/L);phosphate(0.05–0.42 and 0.07–0.18 mg/L);sulphate(63.63–125.36 and 58.71–136.47 mg/L)and ammonia(0.02–0.38 and 0.02–0.37 mg/L)without following any distinct fluctuation *** western part of the Sundarbans receives less freshwater input during the monsoon season than other areas of the ecosystem,which reduces the variability of nutrient levels and water quality ***:This study provides considerable advances in understanding the seasonality of nutrient distribution with possible tidal *** data generated from this study will guide continuing efforts to support a sound management for coastal mangrove ecosystems.

关键词： Sundarbans Monsoon Post-monsoon Nitrate Phosphate Sulphate Ammonia Aquatic ecosystem Water quality River

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Outcomes of Layered versus Mass Closure in Transverse Incision during Emergency Laparotomy in Children

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Journal of Biosciences and Medicines 2020年第8期8卷 180-193页

作者： Khandoker Moynul Hasan Shahnoor Islam md. Ashraf Ul huq Muhammed Moinul huque Shah md. Rezaul Karim Mohammad Shafiul Azam md. Iqbal Hossain Talukder Sharmin Ara Begum Mohammad Kamrul Ahsan A. K. M. Shahidur Rahman Department of Pediatric Surgery Dhaka Medical College Hospital (DMCH) Dhaka Bangladesh Department of Pediatric Urology Dhaka Medical College Hospital (DMCH) Dhaka Bangladesh Department of Surgery Sheikh Hasina Medical College Hospital Habiganj Bangladesh Department of Urology National Institute of Kidney Diseases and Urology (NIKDU) Dhaka Bangladesh Department of Surgery Sheikh Hasina Medical College Hospital Tangail Bangladesh Department of Anesthesiology National Institute of Traumatology and Orthopedic Rehabilitation (NITOR) Dhaka Bangladesh Holy Family Red Crescent Medical College Hospital (HFRCMCH) Dhaka Bangladesh Department of Nephrology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh

Background: The value of laparotomy closure technique may be measured by the incidence of early and late wound complications. The best laparotomy closure technique should be less time consuming, easy and cost-effective, while preventing both early and late complications. Objective: To compare the outcomes of layered versus mass closure in transverse incision during emergency laparotomy in children. Methods: This prospective comparative study was conducted at Department of Pediatric Surgery, Dhaka Medical College Hospital (DMCH), Dhaka, Bangladesh from July 2016 to June 2018. A total of 60 pediatric age cases that underwent laparotomy were included in this study. Cases were randomly allocated into two groups;30 patients were in Group A (Layered closure) and 30 patients were in Group B (Mass closure). The outcome variables were time required for wound closure, wound infection, wound dehiscence and incisional hernia. Data were analyzed and compared by statistical tests. Results: The mean age of Group A and Group B patients were 31.08 ± 30.25 months and 34.70 ± 42.73 months respectively (p = 0.706). The ratio between male and female subject was 1.1:1 in Group A and 3.3:1 in Group B. The common diseases of the study patients who underwent laparotomy were intussusceptions, intestinal obstruction due to bands and adhesion, perforated appendix and perforation of small intestine due to blunt trauma respectively. Mean wound closure time was significantly less in mass closure group [28.20 ± 2.17 minutes in layered closure group and 18.80 ± 1.67 minutes in mass closure group, (p ≤ 0.001)]. Wound infection rate, incidence of superficial wound dehiscence, and incisional hernia were relatively less in mass closure group, however, the differences were not statistically significant (p = 0.053, p = 0.095 and p = 0.301 respectively). There was no complete wound dehiscence in Group A, but that was in 1 (3.3%) patient i

关键词： Laparotomy Layered Closure Mass Closure

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