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Cyclophilin D as a potential therapeutic target of liver ischemia/reperfusion injury by mediating crosstalk between apoptosis and autophagy

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慢性疾病与转化医学:英文版 2023年第3期9卷 238-249页

作者： Mengjiao Yang Zhihui Wang Jin Xie mdreyad‐ul‐ferdous Siying Li Yongfeng Song Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Shandong Key Laboratory of Endocrinology and Lipid Metabolism JinanShandongChina Shandong Institute of Endocrine and Metabolic Diseases JinanShandongChina Department of Endocrinology Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinanShandongChina Department of Endocrinology and Metabolism Central Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina

Background:Liver ischemia/reperfusion(I/R)injury is a complex and multifactorial pathophysiological *** is well recognized that the membrane permeability transition pore(mPTP)opening of mitochondria plays a crucial role in cell death after I/R *** D(CypD)is a critical positive regulator of ***,the effect of CypD on the pathogenesis of liver I/R injury and whether CypD is a potential therapeutic target are still ***:We constructed liver-specific CypD knockout and AAV8-peptidyl prolyl isomerase F(PPIF)overexpression ***,a 70%liver I/R injury model was established in mice,with 90 min of ischemia and 6 h of *** liver function was detected by the level of serum glutamic pyruvic transaminase(alanine transaminase)and glutamic oxaloacetic transaminase(aspartate aminotransferase),the liver damage score and degree of necrosis were measured by hematoxylin and eosin(H&E)staining of liver *** oxygen species(ROS)staining,apoptosis,and autophagy-related molecules were used to detect apoptosis and autophagy during liver I/***:The liver-specific knockout of CypD alleviated necrosis and dysfunction in liver I/R injury,by reducing the excessive production of ROS,and inhibiting cell apoptosis and *** the contrary,overexpression of CypD exacerbated I/R-induced liver ***:We found that the downregulation of CypD expression alleviated liver I/R injury by reducing apoptosis and autophagy through caspase-3/Beclin1 crosstalk;in contrast,the upregulation of CypD expression aggravated liver I/R ***,interfering with the expression of CypD seems to be a promising treatment for liver I/R injury.

关键词： apoptosis autophagy cyclophilin D ischemia/reperfusion necrosis reactive oxygen species

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SeqCor:correct the effect of guide RNA sequences in clustered regularly interspaced short palindromic repeats/Cas9 screening by machine learning algorithm

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Journal of Genetics and Genomics 2020年第11期47卷 672-680页

作者： Xiaojian Liu Yuanyuan Yang Yan Qiu md reyad-ul-ferdous Qiurong Ding Yi Wang CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Ministry of Education Key Laboratory of Contemporary Anthropology Department of Anthropology and Human GeneticsSchool of Life SciencesFudan UniversityShanghai 200438China Human Phenome Institute Fudan UniversityShanghai 200438China

Clustered regularly interspaced short palindromic repeats(CRISPR)/Cas9-based screening using various guide RNA(g RNA)libraries has been executed to identify functional components for a wide range of phenotypes with regard to numerous cell types and *** data from public CRISPR/Cas9-based screening experiments,we found that the sequences of g RNAs in the library influence CRISPR/Cas9-based *** building a standard strategy for correcting results of all g RNA libraries is impractical,we developed Seq Cor,an open-source programming bundle that enables researchers to address the result bias potentially triggered by the composition of g RNA sequences via the organization of g RNA in the library used in CRISPR/Cas9-based ***,Seq Cor completely computerizes the extraction of sequence features that may influence single-guide RNA knockout efficiency using a machine learning *** together,we have developed a software program bundle that ought to be beneficial to the CRISPR/Cas9-based screening platform.

关键词： SeqCor CRISPR/Cas9-based screening Machine learning

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Synergistic enhancement of photocatalytic and antimicrobial efficacy of nitrogen and erbium co-doped ZnO nanoparticles

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Journal of Rare Earths 2024年第5期42卷 859-868,I0002页

作者： Sudipta Mondal Moniruzzaman Jamal Sikder Ashikuzzaman Ayon md Jannatul ferdous Anik md Muktadir Billah Department of Materials and Metallurgical Engineering Bangladesh University of Engineering and TechnologyDhaka1000Bangladesh School of Materials Engineering Purdue UniversityWest LafayetteIN47907USA Department of Materials Science and Engineering University of CaliforniaBerkeleyCA94720USA Department of Materials Science and Engineering Northwestern UniversityEvanstonI28USA

Using the chemical co-precipitation approach,a series of nitrogen(N) and erbium(Er) co-doped ZnO nanoparticles(NPs) was effectively synthesized to enhance the photocatalytic and antibacterial *** characterization techniques,including X-ray diffraction(XRD),X-ray photoelectron spectro scopy(XPS),scanning electron microscopy(SEM),UV-vis,and photoluminescence(PL) spectroscopy,were carried out to validate the evaluated photocatalytic and antibacterial *** analysis confirms the pure wurtzite ZnO phase without the presence of any secondary *** analysis confirms the succe ssful incorporation of nitrogen and erbium into the ZnO *** optical bandgap of ZnO calculated from UV-vis spectroscopy shows a redshift after Er-N co-doping,with the lowest bandgap of 3.215 eV calculated for Zn_(0.97)Er_(0.03)N_(0.01)O_(0.99) *** images demonstrate the formation of nanorods after N-Er co-doping,followed by gradually increase d rod diameter and length after N-Er ***,the photocatalytic activities of ZnO samples we re measured by their ability to facilitate the photodegradation of Rhodamine B under UV *** with 1 mol% N doping exhibits 88% photodegradation of RhB under UV light within 360 min,and the photodegradation and antibacterial activity are greatly improved with Er *** fact,3 mol% Er-1 mol% N doped ZnO NPs demonstrate the highest photocatalytic activity,with approximately 96% degradation after 360 min,as well as superior antibacterial activity against Staphylococcus aureus(Gram-positive bacteria) and Pseudomonas aeruginosa(Gram-negative bacteria) with the highest zone of inhibition(ZOI) of 16 nm,due to nanorod formation,increased reactive oxygen species(ROS),and decreased electron-hole recombination,as validated by SEM,XPS,and PL spectroscopy.

关键词： Chemical co-precipitation Co-doping Bandgap Photocatalysis Rare earths Antimicrobial

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Multi-species probiotics enhance survival,growth,intestinal microbiota and disease resistance of rohu(Labeo rohita)larvae

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Water Biology and Security 2024年第1期3卷 71-79页

作者： Zannatul ferdous md Kabir Hossain md Hadiuzzaman SMRafiquzzaman KM Abdul Halim Tanvir Rahman md Ali Reza Faruk Zulhisyam Abdul Kari md Shahjahan Laboratory of Fish Ecophysiology Department of Fisheries ManagementBangladesh Agricultural UniversityMymensingh2202Bangladesh Department of Aquaculture Bangladesh Agricultural UniversityMymensingh2202Bangladesh Department of Fisheries Matshoy BhabanDhakaBangladesh Department of Fisheries Biology&Aquatic Environment Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur1706Bangladesh Department of Agricultural Sciences Faculty of Agro-Based IndustryUniversiti Malaysia KelantanJeli Campus17600JeliKelantanMalaysia

Multi-strain probiotics provide the most dependable approaches to improve health,immune response,and disease resistance in farmed *** the present study,we examined the effects of multi-species probiotics on the survival,growth,immune response,and disease resistance of rohu(Labeo rohita)*** hatched larvae from the day of first feeding(average weight of 0.003 g)were reared with multi-species probiotics having a combination of Bacillus subtilis(109 colony forming units(cfu)/mL)and Lactobacillus spp.(Lactobacillus plantarum,Lactobacillus buchneri-1011 cfu/mL)in water containing doses of 0(control-C),0.5 mL/L(treatment 1-T1),and 1.0 mL/L(treatment 2-T2)in triplicates for 90 *** the experiment,a challenge test was performed to assess the fish's resistance to pathogenic Aeromonas *** higher survival was recorded in larvae of treated groups(87%in T2 and 79%in T1)compared to the control(62%).Significantly higher growth performance(weight gain and specific growth rate—SGR)was shown by the probiotic-treated larval groups compared to the *** supplementation resulted in significantly higher counts of total viable colony(TVC)and lactic acid bacteria(LAB)in the *** immunological parameters(mucosal fold fattening,goblet cell abundance,expansion of lamina propria and enterocytes)of the gut were significantly better in probiotic-treated *** liver of treated fish showed irregular shape nuclei turning into regular shape and reducing spaces between the hepatic ***-treated fish had the highest post-challenge survival rate(90%)against *** *** erythrocytes of challenged fish treated with probiotics had significantly lower frequencies of various nuclear and cellular *** findings suggest that multi-species probiotic supplements could improve the survival,growth,health status,and immune response of rohu in the early stages of its development.

关键词： Aquaculture Disease resistance Immunity Labeo rohita Probiotics

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Characteristics of Multi-Objective Linear Programming Problem and Multi-Objective Linear Fractional Programming Problem Taking Maximum Value of Multi-Objective Functions

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Applied Mathematics 2024年第1期15卷 22-32页

作者： Samsun Nahar md. Asadujjaman Khadiza Begum Mahede-ul-Hassan md. Abdul Alim Department of Basic Sciences and Humanities University of Asia Pacific Dhaka Bangladesh Department of Mathematics University of Dhaka Dhaka Bangladesh Computer Science and Engineering Department Prime University Dhaka Bangladesh Department of Mathematics and Statistics Bangladesh University of Business and Technology Dhaka Bangladesh Department of Mathematics Bangladesh University of Engineering and Technology Dhaka Bangladesh

In this paper, a new statistical averaging technique is proposed for finding an optimal solution to a multi-objective linear fractional programming problem (MOLFPP) and multi-objective linear programming problem (MOLPP) by using new arithmetic averaging method and new geometric averaging method. It is significantly noticeable same characteristics among all the technique while taking maximum or minimum among all optimized values for multi-objective functions using simplex algorithm. The characteristics provided from the problems are verified by the numerical examples.

关键词： MOLPP MOLFPP New Arithmetic Averaging Method New Geometric Averaging Method

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The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy

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Genes & Diseases 2024年第1期11卷 321-334页

作者： md Rakibul Alam md Mizanur Rahman Zhiguo Li Department of Toxicology and Cancer Biology College of MedicineUniversity of KentuckyLexingtonKY 40506USA Department of Medicine(Nephrology) Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6E2H7Canada

Exosomes are small membrane vesicles containing microRNA,RNA,DNA fragments,and proteins that are transferred from donor cells to recipient *** cells release exo-somes to reprogram the factors associated with the tumor microenvironment(TME)causing tu-mor metastasis and immune *** evidence revealed that cancer cell-derived exosomes carry immune inhibitory molecule program death ligand 1(PD-L1)that binds with re-ceptor program death protein 1(PD-1)and promote tumor progression by escaping immune ***,some FDA-approved monoclonal antibodies are clinicallyused for cancer treatment by blocking PD-1/PD-L1 *** notable treatment outcomes,some pa-tients show poor drug *** PD-L1 plays a vital role in lowering the treatment response,showing resistance to PD-1/PD-L1 blockage therapy through recapitulating the ef-fect of cell surface *** enhance therapeutic response,inhibition of exosomal PD-L1 is *** signaling is the central regulator of tumorigenesis and can regulate exosome biogenesis and secretion by modulating Rab GTPase family and membrane fusion ***-mune checkpoints are also connected with calcium signaling and calcium channel blockers like amlodipine,nifedipine,lercanidipine,diltiazem,and verapamil were also reported to suppress cellular PD-L1 ***,to enhance the PD-1/PD-L1 blockage therapy response,the reduction of exosomal PD-L1 secretion from cancer cells is in our therapeutic *** this review,we proposed a therapeutic strategy by targeting calcium signaling to inhibit the expression of PD-L1-containing exosome levels that could reduce the anti-PD-1/PD-L1 therapy resistance and increase the patient's drug response rate.

关键词： Calcium signaling CD8^(+)T cells Exosomal PD-L1 Exosomes biogenesis Immunosuppression Immunotherapy

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Dynamic Hand Gesture-Based Person Identification Using Leap Motion and Machine Learning Approaches

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Computers, Materials & Continua 2024年第4期79卷 1205-1222页

作者： Jungpil Shin md.AlMehedi Hasan md.Maniruzzaman Taiki Watanabe Issei Jozume School of Computer Science and Engineering The University of AizuAizuwakamatsuFukushima965-8580Japan Department of Computer Science&Engineering Rajshahi University of Engineering&TechnologyRajshahi6204Bangladesh

Person identification is one of the most vital tasks for network security. People are more concerned about theirsecurity due to traditional passwords becoming weaker or leaking in various attacks. In recent decades, fingerprintsand faces have been widely used for person identification, which has the risk of information leakage as a resultof reproducing fingers or faces by taking a snapshot. Recently, people have focused on creating an identifiablepattern, which will not be reproducible falsely by capturing psychological and behavioral information of a personusing vision and sensor-based techniques. In existing studies, most of the researchers used very complex patternsin this direction, which need special training and attention to remember the patterns and failed to capturethe psychological and behavioral information of a person properly. To overcome these problems, this researchdevised a novel dynamic hand gesture-based person identification system using a Leap Motion sensor. Thisstudy developed two hand gesture-based pattern datasets for performing the experiments, which contained morethan 500 samples, collected from 25 subjects. Various static and dynamic features were extracted from the handgeometry. Randomforest was used to measure feature importance using the Gini Index. Finally, the support vectormachinewas implemented for person identification and evaluate its performance using identification accuracy. Theexperimental results showed that the proposed system produced an identification accuracy of 99.8% for arbitraryhand gesture-based patterns and 99.6% for the same dynamic hand gesture-based patterns. This result indicatedthat the proposed system can be used for person identification in the field of security.

关键词： Person identification leap motion hand gesture random forest support vector machine

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Random fractal-based computational design of an ice-ray (IR) lattice shell structure

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Frontiers of Architectural Research 2024年第2期13卷 406-424页

作者： Iasef md Rian Department of Architecture Xi'an Jiaotong-Liverpool UniversitySuzhou 215123China

Chinese ice-ray (IR) lattices, known for their intricate and visually fascinating random patterns as decorative elements in traditional 18th-century Chinese window design, exhibit underlying stiffness as latticed window fences. Such unique patterns represent a new morphology within the family of stochastic lattices. However, the latent structural potential within the random patterns of ice-ray lattices remains largely unexplored, particularly in the context of lattice shell design. This study systematically studies the geometric qualities of ice-ray lattice patterns and develops an algorithm to model these patterns for ice-ray lattice shell design. Subsequently, it assesses the structural feasibility and effectiveness of these lattice shells in comparison to conventional gridshells. The practicality of constructing random lattice shells using digital fabrication tools is also explored. Employing fractal geometry as a foundational framework, this research not only offers insights into the potential of ice-ray lattices for innovative lattice shell design but also introduces a new structural morphology to the field, expanding the possibilities of incorporating stochastic patterns in lattice shell design. ultimately, it opens up new opportunities for innovative lattice shell designs, emphasizing the potential of stochastic patterns in structural applications.

关键词： Ice-ray pattern Fractals Random Lattice shells Computational design Digital fabrication

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Seasonal influence of freshwater discharge on spatio-temporal variations in primary productivity, sea surface temperature, and euphotic zone depth in the northern Bay of Bengal

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Acta Oceanologica Sinica 2024年第6期43卷 1-14页

作者： Hafez Ahmad Felix Jose md.Simul Bhuyan md.Nazrul Islam Padmanava Dash Geosystems Research Institute/Department of Geosciences Mississippi State UniversityStarkville 39759USA Department of Oceanography University of ChittagongChittagong 4331Bangladesh Department of Marine&Earth Sciences Florida Gulf Coast UniversityFort Myers 33965USA Bangladesh Oceanographic Research Institute Cox’s Bazar 4730Bangladesh Faculty of Marine Sciences&Fisheries Institute of Marine SciencesUniversity of ChittagongChittagong 4331Bangladesh Department of Geography and Environment Jahangirnagar UniversityDhaka 1342Bangladesh Department of Geosciences Mississippi State UniversityStarkville 39759USA

Ocean productivity is the foundation of marine food web,which continuously removes atmospheric carbon dioxide and supports life at sea and on ***-temporal variability of net primary productivity(NPP),sea surface temperature(SST),sea surface salinity(SSS),mixed layer depth(MLD),and euphotic zone depth(EZD) in the northern B ay of Bengal(BoB) during three monsoon seasons were examined in this study based on remote sensing data for the period 2005 to *** compare the NPP distribution between the coastal zones and open BoB,the study area was divided into five zones(Z1-Z5).Results suggest that most productive zones Z2 and Zl are located at the head bay area and are directly influenced by freshwater discharge together with riverine sediment and nutrient *** Z1-Z5,the NPP ranges from 5 315.38 mg/(m~2·d) to 346.7 mg/(m~2·d)(carbon,since then the same).The highest monthly average NPP of 5 315.38 mg/(m~2·d) in February and 5 039.36 mg/(m~2·d) in June were observed from Z2,while the lowest monthly average of 346.72 mg/(m~2·d) was observed in March from Z4,which is an oceanic *** values vary from 6-154 m for the study area,and it has an inverse correlation with NPP *** is deeper during the summer season and shallower during the wintertime,with a corresponding increase in *** the year,monthly SST shows slight fluctuation for the entire study area,and statistical analysis shows a significant correlation among NPP,and EZD,overall positive between NPP and MLD,whereas no significant correlation among SSS,and SST for the northern ***-term trends in SST and productivity were significantly po sitive in head bay zones but negatively productive in the open *** findings in this study on the distribution of NPP,SST,SSS,MLD,and EZD and their seasonal variability in five different zones of BoB can be used to further improve the management of marine resources and overall environmental condition in response to climate change

关键词： chlorophyll a sea surface temperature euphotic zone depth primary productivity Ganges-Brahmaputra ocean color Bay of Bengal monsoon

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Potential role of tubulin glutamylation in neurodegenerative diseases

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Neural Regeneration Research 2024年第6期19卷 1191-1192页

作者： Abdullah md.Sheikh Shatera Tabassum Department of Laboratory Medicine Shimane University Faculty of Medicine

The differentiation of neuronal stem cells into mature neurons is a complex process that involves both structural and functional changes. As cells undergo differentiation, there are notable functional changes, including the expression of various transcription factors, cytokines, and neurotransmitiers. Additionally, structural changes occur as the cells develop various processes from the cell body and establish synaptic contacts with other cells.

关键词： POLARITY

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