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The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy

Genes & Diseases 2024年第1期11卷 321-334页

作者： md Rakibul Alam md mizanur rahman Zhiguo Li Department of Toxicology and Cancer Biology College of MedicineUniversity of KentuckyLexingtonKY 40506USA Department of Medicine(Nephrology) Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6E2H7Canada

Exosomes are small membrane vesicles containing microRNA,RNA,DNA fragments,and proteins that are transferred from donor cells to recipient *** cells release exo-somes to reprogram the factors associated with the tumor microenvironment(TME)causing tu-mor metastasis and immune *** evidence revealed that cancer cell-derived exosomes carry immune inhibitory molecule program death ligand 1(PD-L1)that binds with re-ceptor program death protein 1(PD-1)and promote tumor progression by escaping immune ***,some FDA-approved monoclonal antibodies are clinicallyused for cancer treatment by blocking PD-1/PD-L1 *** notable treatment outcomes,some pa-tients show poor drug *** PD-L1 plays a vital role in lowering the treatment response,showing resistance to PD-1/PD-L1 blockage therapy through recapitulating the ef-fect of cell surface *** enhance therapeutic response,inhibition of exosomal PD-L1 is *** signaling is the central regulator of tumorigenesis and can regulate exosome biogenesis and secretion by modulating Rab GTPase family and membrane fusion ***-mune checkpoints are also connected with calcium signaling and calcium channel blockers like amlodipine,nifedipine,lercanidipine,diltiazem,and verapamil were also reported to suppress cellular PD-L1 ***,to enhance the PD-1/PD-L1 blockage therapy response,the reduction of exosomal PD-L1 secretion from cancer cells is in our therapeutic *** this review,we proposed a therapeutic strategy by targeting calcium signaling to inhibit the expression of PD-L1-containing exosome levels that could reduce the anti-PD-1/PD-L1 therapy resistance and increase the patient's drug response rate.

关键词： Calcium signaling CD8^(+)T cells Exosomal PD-L1 Exosomes biogenesis Immunosuppression Immunotherapy

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Thornthwaite moisture index and depth of suction change under current and future climate‒An Australian study

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1761-1775页

作者： md Rajibul Karim Bikash Devkota md mizanur rahman Hoang Bao Khoi Nguyen UniSA STEM University of South AustraliaMawson Lakes CampusMawson LakesSouth Australia5095Australia

Climate change is one of the major global challenges and it can have a significant influence on the behaviour and resilience of geotechnical *** changes in moisture content in soil lead to effective stress changes and can be accompanied by significant volume changes in reactive/expansive *** volume change leads to ground movement and can exert additional stresses on structures founded on or within a shallow depth of such *** change is likely to amplify the ground movement potential and the associated problems are likely to *** effect of atmospheric boundary interaction on soil behaviour has often been correlated to Thornthwaite moisture index(TMI).In this study,the long-term weather data and anticipated future projections for various emission scenarios were used to generate a series of TMI maps for *** changes in TMI were then correlated to the depth of suction change(H s),an important input in ground movement *** all climate scenarios considered,reductions in TMI and increases in H s values were observed.A hypothetical design scenario of a footing on expansive soil under current and future climate is *** is observed that a design that might be considered adequate under the current climate scenario,may fail under future scenarios and accommodations should be made in the design for such events.

关键词： Climate change Future prediction Thornthwaite moisture index(TMI) Characteristic surface movement Infrastructure resilience

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Textile dyeing wastewater negatively influences the hematological profile and reproductive health of male Swiss albino mice

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Asian pacific Journal of Reproduction 2024年第4期13卷 169-177页

作者： Taimur Islam Nusrat Binte Rafique Mohosina Mou Dipu Roy Robius Sani Sadi Ziban Chandra Das Anup Kumar Talukder Minhaz Ahmed mizanur rahman Golam Haider Department of Pathobiology Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Department of Gynecology Obstetrics and Reproductive HealthBangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Department of Agroforestry and Environment Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Department of Physiology and Pharmacology Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh

Objective:To determine the effects of textile dyeing industrial wastewater on the hematological parameters and reproductive health including histoarchitecture of male gonad(testes)of ***:Twenty-four Swiss albino mice at 4-weeks old were divided into four groups(n=6 per group).Mice of group 1 supplied with normal drinking water were served as the control *** of group 2,3 and 4 were supplied normal drinking water mixed with textile dyeing wastewater at 5%,10% and 20% concentration,*** completing 24 weeks of treatment,different hematological profile,weight of testes,gonadosomatic index(GSI),sperm concentration and morphology were ***,histopathological changes in testes were ***:Hematocrit value and hemoglobin concentrations were decreased in all groups of wastewater-treated mice compared to the control ***,weight of testes,GSI and sperm concentration were decreased significantly in wastewater-treated mice in comparison to the control *** percentage of morphologically healthy epididymal sperm was significantly reduced in wastewater-treated *** examination revealed degenerative changes in seminiferous tubules,a smaller number of spermatogenic cells,elongation of seminiferous tubules and degenerative changes of seminiferous tubules in wastewater-treated ***:Textile dyeing wastewater has harmful effects on hematological profile and reproductive health of male mice.

关键词： Textile dyeing wastewater Gonads Hematology Histopathology Mice

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Capturing transition and non-transition flows with a new shear stress transport model

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Chinese Journal of Aeronautics 2023年第3期36卷 121-136页

作者： md mizanur rahman School of Mechanical Engineering Hangzhou Dianzi UniversityHangzhou 310018China

A new Shear Stress Transport(SST)k-ω model is devised to integrate salient features of both the non-transitional SST k-ω model and correlation-based γ-Re_(θ) transition *** exceptionally simplified approach is applied to extend the New SST(NSST)model capabilities toward transition/non-transition ***’s stress-intensity factor R_(b)=|-uv|/k can be parameterized with the wall-distance dependent Reynolds number Re_(y)=√ky/v;however,as the Re_(y)is replaced by a“flow-structure-adaptive”parameter R_(μ)=v_(T)/v,the resulting R_(b)is capable of capturing various transition phenomena *** prospective stress-intensity parameter R_(b)=R_(b)(Re_(y),R_(μ))is incorporated in the constitutive relations for eddy-viscosity v_(T) and production term P_(k).The proposed formulation is intrinsically plausible,having a dramatic impact on the prediction of bypass,separation-induced and natural transitions together with non-transitional *** extra viscous-production term P_(k)^(lim) is added with the k-equation to ensure proper generation of k at the viscous sublayer when computing separation-induced transition over a Low-Reynolds Number(LRN)*** demonstrate that the NSST k-ω model maintains an excellent consistency with both SST k-ω and γ-Re_(θ) models.

关键词： γ-Re_(θ)model Non-transition Stress-intensity parameter SST model Transition

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Cyclic liquefaction screening of sand with non-plastic fines:Critical state approach

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Geoscience Frontiers 2020年第2期11卷 429-438页

作者： md.mizanur rahman TGSitharam Natural and Built Environments Research Centre(NBERC) School of Natural and Built EnvironmentsUniversity of South AustraliaMawson LakesSA 5095Australia Department of Civil Engineering Indian Institute of Science(IISc)BangaloreIndia

There have been significant advances in the application of critical state,CS,in liquefaction potential *** was done by comparing state parameter,j with estimated characteristic cyclic stress ratio,CSR due to an earthquake.A cyclic resistance ratio,CRR curve,which can be determined from cyclic liquefaction tests,separates historical liquefied and non-liquefied data points(j,CSR).On the other hand,the concepts of equivalent granular state parameter,j*,which was developed for sands with fines,can be used in lieu j to provide a unifying framework for characterizing the undrained response of sands with non/low plasticity fines,irrespective of fines content(fc).The present work combines these two propositions,and by merely substituting j*for j into the aforementioned CS approach to capture the influence of fc.A series of static and cyclic triaxial tests were conducted,separately and independently of the concept of j*,for sand with up to fc of 30%.The clean sand was collected from Sabarmati river belt at Ahmedabad city in India which was severely affected during the Bhuj earthquake,*** experimental data gave a single relation for CRR and j*which was then used to assess liquefaction potential for a SPT based case study,where fc varies along the *** prediction matched with the field observation.

关键词： Critical state State parameter Liquefaction Sands Fines Constitutive model

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CFD study of turbulent jet impingement on curved surface

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Chinese Journal of Chemical Engineering 2016年第5期24卷 588-596页

作者： Javad Taghinia md mizanur rahman Timo Siikonen Aalto University School of EngineeringDepartment of Applied MechanicsFI-00076Finland Hong Kong University of Science and Technology Department of Civil and Environmental EngineeringClear Water BayHong KongChina

The heat transfer and flow characteristics of air jet impingement on a curved surface are investigated with computational fluid dynamics(CFD)*** first applied model is a one-equation SGS model for large eddy simulation(LES)and the second one is the SST-SAS hybrid *** models are utilized to study the flow physics in impinging process on a curved surface for different jet-to-surface(h/B)distances at two Reynolds numbers namely,2960 and 4740 based on the jet exit velocity(U_e)and the hydraulic diameter(2B).The predictions are compared with the experimental data in the literature and also the results from RANS k-ε*** show that both models can produce relatively good ***,one-equation model(OEM)produced more accurate results especially at impingement region at lower jet-to-surface *** terms of heat transfer,the OEM also predicted better at different jet-to-surface *** is also observed that both models show similar performance at higher h/B ratios.

关键词： Jet impingement Curved surface RAST one-equation model Large eddy simulation Heat transfer

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Self-centring segmental retaining walls—A new construction system for retaining walls

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Frontiers of Structural and Civil Engineering 2021年第4期15卷 980-1000页

作者： Mehdi JAVADI Reza HASSANLI md mizanur rahman md Rajibul KARIM UniSA STEM University of South AustraliaMawson Lakes5095Australia

This paper reports on an experimental study on a new self-centring retaining wall *** post-tensioned segmental retaining walls(PSRWs)were experimentally *** of the walls was constructed using seven T-shaped concrete segments with a dry *** walls were tested under incrementally increasing cyclic lateral *** effect of the wall height,levels of post-tensioning(PT)force,and bonded versus unbonded condition of PT reinforcement on the structural behavior of the PSRWs was *** results showed that such PSRWs are structurally adequate for water retaining *** to the results,increasing the wall height decreases initial strength but increases the deformation capacity of the *** larger deformation capacity and ductility of PSRW make it a suitable structural system for fluctuating loads or deformation,e.g.,*** was also found that increasing the PT force increases the wall’s stiffness;however,reduces its *** residual drift and the extent of damage of the unbonded PSRWs were significantly smaller than those of the bonded *** suggest that this newly developed self-centring retaining wall can be a suitable structural system to retain lateral *** to its unique deformation capacity and self-centring behavior,it can potentially be used for seawall application.

关键词： retaining wall segmental precast concrete unbonded post-tensioning water retaining wall seawall

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Behaviour of self-centring shear walls——A state of the art review

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Frontiers of Structural and Civil Engineering 2023年第1期17卷 53-77页

作者： Mehdi JAVADI Reza HASSANLI md mizanur rahman md Rajibul KARIM UniSA STEM University of South AustraliaAdelaide 5095Australia

The application of unbonded post-tensioning (PT) in structural walls has led to the development of advanced self-centring (rocking) shear wall systems that has significant advantages, including accelerated construction due to the incorporation of prefabricated elements and segmental construction for different materials (e.g., concrete, masonry, and timber), reduced residual drifts, and little damage upon extreme seismic and wind loads. Concrete, masonry, and timber are often used for the construction of unbonded PT structural wall systems. Despite extensive research since the 1980s, there are no well-established design guidelines available on the shear wall configuration with the required energy dissipation system, joint’s locations and acceptance criteria for shear sliding, confinement, seismic performance factors, PT loss, PT force range and residual drifts of shear walls subjected to lateral loads. In this research a comprehensive state-of-the-art literature review was performed on self-centring shear wall system. An extensive study was carried out to collect a database of 100 concrete, masonry, and self-centring shear wall tests from the literature. The established database was then used to review shear walls’ configurations, material, and components to benchmark requirements applicable for design purposes. The behaviour of concrete, masonry and timber shear walls were compared and critically analysed. The general behaviour, force-displacement performance of the walls, ductility, and seismic response factors, were critically reviewed and analysed for different self-centring wall systems to understand the effect of different parameters including configurations of the walls, material used for construction of the wall (concrete, masonry, timber) and axial stress ratio. The outcome of this research can be used to better understand the behaviour of self-centring wall system in order to develop design guidelines for such walls.

关键词： self-centring shear walls rocking walls energy dissipation seismic performance factors PT loss residual drift

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Can picnic influence floral diversity and vitality of trees in Bhawal National Park of Bangladesh?

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Forestry Studies in China 2009年第3期11卷 148-157页

作者： md. mizanur rahman Harald VACIK Institute of Silviculture Department of Forest and Soil Sciences University of Natural Resources and Applied Life Sciences Vienna A-1190 Austria

We examined the impact of picnic activities on forest diversity, structure, regeneration and vitality of tree species in the Bhawal National Park of Bangladesh. The study area was classified as a non-used, occasionally used and frequently used area on the basis of the intensity of the picnic activities. A total of 43 plant species were enumerated in the whole study area. The highest plant species richness （41 species） was observed in the non-used area whereas the lowest species richness （11 species） in the frequently used area. The diversity index decreased with the increase of picnic intensity whereas the concentration of dominance increased. Density of all plant groups except mature trees, and the basal area of the mature trees showed a declining trend from the non-used to frequently used area. The frequently used area exhibited very poor regeneration. Tree vitality decreased with the increase of picnic intensity. The relevance of our study as a basis for further research to determine the impact of tourism on biodiversity in Bangladesh is discussed.

关键词： species richness diversity index concentration of dominance regeneration intensity

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Direct and Indirect Effects of Socioeconomic Factors on Age at First Marriage in Slum Areas,Bangladesh

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Chinese Journal of Population,Resources and Environment 2009年第3期7卷 79-82页

作者： Shamima Akter md.mizanur rahman Department of Population Science and Human Resource Development University of Rajshahi

This article attempts to examine the influence of some selected predictor variables on female age at first marriage in slum areas of Bangladesh.A path and multiple classification analysis(MCA) approach have been *** thought that respondent's educational level and the mass media such as watching television have a significant direct impact on age at marriage,while the types of family and occupational status have an indirect effect on age at marriage.

关键词： age at first marriage slum areas MCA and path analysis

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