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Versatile effects of galectin-1 protein-containing lipid bilayer coating for cardiovascular applications

Bioactive Materials 2024年第12期42卷 207-225页

作者： md lemon hasan Ju Ro Lee Khandoker Asiqur Rahaman Dae Hyeok Yang Yoon Ki Joung Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Hwarangno 14-gil 5Seongbuk-guSeoul02792Republic of Korea Division of Bio-Medical Science&Technology University of Science and Technology(UST)113 GwahangnoYuseong-guDaejeon34113Republic of Korea Center for Systems Biology Massachusetts General Hospital Research InstituteBostonMA02114USA Department of Radiology Massachusetts General HospitalHarvard Medical SchoolBostonMA02114USA Institute of Cell and Tissue Engineering College of MedicineThe Catholic University of KoreaSeoul06591Republic of Korea KHU-KIST Department of Conversing Science and Technology Graduate SchoolKyung Hee UniversitySeoulRepublic of Korea

Modulating inflammatory cells in an implantation site leads to severe complications and still unsolved challenges for blood-contacting medical *** by the role of galectin-1(Gal-1)in selective functions on multiple cells and immunomodulatory processes,we prepared a biologically target-specific surface coated with the lipid bilayer containing Gal-1(Gal-1-SLB)and investigate the proof of the biological ***,lipoamido-dPEG-acid was deposited on a gold-coated substrate to form a self-assembled monolayer and then conjugated dioleoylphosphatidylethanolamine(DOPE)onto that to produce a lower leaflet of the supported lipid bilayer(SLB)before fusing membrane-derived vesicles extracted from B16-F10 *** Gal-1-SLB showed the expected anti-fouling activity by revealing the resistance to protein adsorption and bacterial *** vitro studies showed that the Gal-1-SLB can promote endothelial function and inhibit smooth muscle cell ***,Gal-1-SLB presents potential function for endothelial cell migration and angiogenic *** vitro macrophage culture studies showed that the Gal-1-SLB attenuated the LPS-induced inflammation and the production of macrophage-secreted inflammatory ***,the implanted Gal-1-SLB reduced the infiltration of immune cells at the tissue-implant interface and increased markers for M2 polarization and blood vessel formation in *** straightforward surface coating with Gal-1 can be a useful strategy for modulating the vascular and immune cells around a blood-contacting device.

关键词： Galectin-1 protein Supported lipid bilayer Macrophage Cardiovascular devices Inflammation

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CUSTOMER EQUITY: MAKING MARKETING STRATEGY FINANCIALLY ACCOUNTABLE

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Systems Science and Systems Engineering 2004年第4期13卷 405-422页

作者： Ashwin ARAVINDAKSHAN Roland T. RUST Katherine N. lemon Valerie A. ZEITHAML Department of Marketing R.H. Smith School of Business University of Maryland College Park MD 20742Department of Marketing R.H. Smith School of Business University of Maryland College Park MD 20742Marketing Department Carroll School of Management Fulton Hall 444140 Commonwealth Ave Chestnut Hill MA 02467Kenan-Flagler Business School University of CB #3490 Chapel Hill NC 27599-3490

The article presents an overview of the literature on customer equity and how customer equity provides an opportunity for marketers to make marketing strategy financially accountable. Traditionally, Return on Investment (ROI) models have been used to evaluate the financial expenditures required by the strategies as well as the financial returns gained by them. However in addition to requiring lengthy longitudinal data, these models also have the disadvantage of not evaluating the effect of the strategies on a firm’s customer equity. The dominance of customer-centered thinking over product-centered thinking calls for a shift from product-based strategies to customer-based strategies. Hence, it is important to evaluate a firm’s marketing strategies in terms of the drivers of its customer equity. The article summarizes a unified strategic framework that enables competing marketing strategy options to be traded off on the basis of projected financial return, which is operationalized as the change in a firm’s customer equity relative to the incremental expenditure necessary to produce the change.

关键词： Customer equity return on marketing brand equity customer value relationship marketing marketing strategy customer lifetime value customer satisfaction measurement

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Protective effect of lemongrass oil against dexamethasone induced hyperlipidemia in rats:possible role of decreased lecithin cholesterol acetyl transferase activity

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Asian Pacific Journal of Tropical Medicine 2011年第8期4卷 658-660页

作者： VR Santhosh Kumar md Naseeruddin Inamdar Nayeemunnisa GL Viswanatha Department of Pharmacology Al-Ameen College of PharmacyHosur RoadBangaloreIndia Department of Pharmacology PES College of PharmacyHanumanthanagarBangaloreIndia

Objective:To evaluate the anti-hyperlipidemic activity of lemongrass oil against in dexamethasone induced hyperlipidemia in ***:Administration of dexamethasone was given at 10 mg/kg,*** the adult rats for 8 d induces hyperlipidemia characterized by marked increase in serum cholesterol and triglyceride levels along with increase in atherogenic ***:lemongrass oil(100 and 200 mg/kg,po.) treatment has showed significant inhibition against dexamethasone hyperlipidemia by maintaining the serum levels of cholesterol, triglycerides and atherogenic index near to the normal levels and the antihyperlipidemic effect of the lemongross oil was comparable with atorvastatin 10 mg/kg,*** possible mechanism may be associated with decrease in lecithin cholesterol acetyl transferase(LCAT) ***:These results suggested that lemon gross oil possess significant antihyperlipidemic activity.

关键词： lemongrass oil Hvperlipidemia Dexametliasone Lipid-lowering activity

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Assessment of Physico-Chemical and Microbial Quality of Sugarcane Juice Sold by Street Vendors in Three Regions of Bangladesh

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Food and Nutrition Sciences 2024年第4期15卷 263-276页

作者： Nargis Akter Khan md. Murtaja Reza Linkon Munni Akter md. Alamgir Hossain md. Mahbubur Rahman Tayeba Khan md. Abdul Alim md. Esrafil Department of Food Technology and Nutritional Science Mawlana Bhashani Science and Technology University Tangail Bangladesh Department of Biotechnology and Genetic Engineering Mawlana Bhashani Science and Technology University Tangail Bangladesh

Sugar cane juice is a popular refreshing drink in most part of Bangladesh. It has great taste and health benefits;also it is available most of the public places at reasonable prices which consumed by road side customers including general public, shopping personals, tourists, students. In our country, street vendors crushing sugarcane between roller crusher and sold without any heat treatment or preservative, also served with or without added ice and lemon juice. The study aimed to identify and compare the physico-chemical and microbial quality of sugarcane juice. The chemical qualities of juices including moisture, PH, ash, total soluble solid, total sugar, reducing sugar and titrable acidity were found slightly different in Mymensingh, Gazipur and Narayangonj areas. The highest and lowest value of moisture, ash, PH, total soluble solids, total sugar, reducing sugar and titrable acidity were found in 84.33% - 79.26% (Gazipur-Mymensingh), 0.57% - 0.04% (Mymensingh-Gazipur), 5.9 - 2.9 (Gazipur-Narayangonj), 17.48% - 4.98% (Mymensingh-Narayangonj), 21.9% - 6.56% (Mymensingh-Gazipur), 3.7 - 2.1 (Gazipur-Mymensingh) and 0.523% - 0.007% (Narayangonj-Gazipur) respectively. For microbiological analysis, the total viable count of sugar cane juice in Mymensingh, Gazipur and Narayangonj were ranged from 0.6 × 105 - 43.6 × 105 cfu/ml, 4.6 × 105 - 21.6 × 105 cfu/ml and 3.6 × 105 - 36.6 × 105 cfu/ml respectively, where the permitted value is 1.0 × 104 cfu/ml, whereas the total coliform count was ranged from 0.4 × 105 - 6.4 × 105 cfu/ml, 0.6 × 105 - 8.4 × 105 cfu/ml and 0.00 - 8.4 × 105 cfu/ml, where the permitted value is 100 cfu/ml and total fungal count was ranged from 5.5 × 105 - 56.5 × 105 cfu/ml, 21.5 × 105 - 54.5 × 105 cfu/ml and 32.5 × 105 - 68.5 × 105 cfu/

关键词： Sugarcane Street Vendors Microbial Quality Reducing Sugar

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