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Research on the Development of Fibroin and Nano-Fiber from Silk Cocoons for Regenerated Tissue Engineering Applications by Electro-Spinning

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Advances in Nanoparticles 2024年第1期13卷 1-9页

作者： md kamrul hasan Xinbo Ding School of Textile Science and Engineering International Silk Institute Zhejiang Sci-Tech University Hangzhou China

In this paper, the main goal is to prepare silk fibroin nano-fiber, which is used for regenerated tissue applications. Silk scaffold nano-fibers made by electro-spinning technology can be used in regenerated tissue applications. The purpose of the research is to prepare a silk-fibroin nano-fiber solution for potential applications in tissue engineering. Using a degumming process, pure silk fibroin protein is extracted from silk cocoons. The protein solution for fibroin is purified, and the protein content is determined. The precise chemical composition, exact temperature, time, voltage, distance, ratio, and humidity all have a huge impact on degumming, solubility, and electro-spinning nano-fibers. The SEM investigates the morphology of silk fibroin nano-fibres at different magnifications. It also reveals the surface condition, fiber orientation, and fiber thickness of the silk fibroin nano-fiber. The results show that regenerated silk fibroin and nano-fiber can be used in silk fibroin scaffolds for various tissue engineering applications.

关键词： Silk fibroin Scaffold electro-spinning nano-fiber Tissue Engineering

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 85-94页

作者： Iffat Ara Rita Turcio Tasmia Islam md.Sabbir Hossain md.kamrul hasan Department of Biochemistry and Molecular Biology Tejgaon CollegeNational UniversityGazipur-1700Bangladesh Department of Pharmacy University of Naples Federico IIvia Domenico Montesano49-80131 Napoli NAItaly Department of Genetic Engineering and Biotechnology Jashore University of Science and TechnologyJashore-7408Bangladesh Department of Public Health North South UniversityDhaka-1229Bangladesh

Background:Licochalcone A(LCA)is a flavonoid derived from the roots of Glycyrrhiza uralensis *** DC and other related *** natural source has been extensively used in complementary medicine,especially traditional Chinese medicine,to treat various *** as a phenolic chalcone compound,LCA has gained significant attention in recent years due to its various pharmacological ***:The objective of this review article is to assess the anti-aging ralated pharmacological properties of ***:An exhaustive search of several scientific databases was conducted using various relevant keywords to write this review article on LCA,focusing on its therapeutic applications and anti-aging-related pharmacological *** inclusion and exclusion criteria were strictly followed to retrieve updated relevant ***:A collection of 292 papers were screened,and 131 were included in this review for an in-depth analysis of Licochalcone A,focusing on its anti-aging-related pharmacological activities and relevant mechanisms,and its toxicity and side ***,the potential of LCA as a pharmacological product is discussed,emphasizing its health benefits and potential as a pharmaceutical ***:These findings indicate that Licochalcone A is a promising natural therapeutic agent for anti-aging therapy and other ailments.

关键词： Licochalcone A Glycyrrhiza uralensis Chalcone Anti-aging Neuroprotective Antioxidant Skin protection Therapeutic agent

A Numerical Simulation of Air Flow in the Human Respiratory System Based on Lung Model

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Journal of Applied Mathematics and Physics 2023年第8期11卷 2205-2215页

作者： md. kamrul hasan Mahtab U. Ahmmed md. Samsul Arefin Department of Mathematics Khulna University of Engineering and Technology Khulna Bangladesh Department of Mathematics Jahangirnagar University Dhaka Bangladesh

The lung is an important organ that takes part in the gas exchange process. In the study of gas transport and exchange in the human respiratory system, the complicated process of advection and diffusion (AD) in airways of human lungs is considered. The basis of a lumped parameter model or a transport equation is modeled during the inspiration process, when oxygen enters into the human lung channel. The quantitative measurements of oxygen are detached and the model equation is solved numerically by explicit finite difference schemes. Numerical simulations were made for natural breathing conditions or normal breathing conditions. The respiratory flow results for the resting conditions are found strongly dependent on the AD effect with some contribution of the unsteadiness effect. The contour of the flow rate region is labeled and AD effects are compared with the variation of small intervals of time for a constant velocity when breathing is interrupted for a negligible moment.

关键词： Lumped Model Lumped Model Channel Mass Flow Rate Ideal Law of Gas 2D Advection Diffusion Equation Finite Difference Scheme

N-Myc Inhibition: Advances in Neuroblastoma Treatment

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CellBio 2017年第3期6卷 27-34页

作者： md kamrul hasan Moores Cancer Center University of California San Diego Health Sciences Dr La Jolla CA USA

Neuroblastoma (NBL) is one of the most common solid tumors and around 15% of cancer mortality in children. Amplification of the N-Myc proto-oncogene is strongly correlated with advanced disease and poor clinical outcome in NBL. Recent studies described that ubiquitin-specific protease 7 (USP7;also known as HAUSP) interacts with N-Myc, induces deubiquitination and subsequent stabilization of N-Myc that in-turn potentiates N-Myc function, and treatment with the HAUSP inhibitor (P22077) blocked such effects.

关键词： Neuroblastoma N-Myc PI3K/mTOR PARP1 PD-L1 HAUSP

Dynamic Hand Gesture-Based Person Identification Using Leap Motion and Machine Learning Approaches

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Computers, Materials & Continua 2024年第4期79卷 1205-1222页

作者： Jungpil Shin md.AlMehedi hasan md.Maniruzzaman Taiki Watanabe Issei Jozume School of Computer Science and Engineering The University of AizuAizuwakamatsuFukushima965-8580Japan Department of Computer Science&Engineering Rajshahi University of Engineering&TechnologyRajshahi6204Bangladesh

Person identification is one of the most vital tasks for network security. People are more concerned about theirsecurity due to traditional passwords becoming weaker or leaking in various attacks. In recent decades, fingerprintsand faces have been widely used for person identification, which has the risk of information leakage as a resultof reproducing fingers or faces by taking a snapshot. Recently, people have focused on creating an identifiablepattern, which will not be reproducible falsely by capturing psychological and behavioral information of a personusing vision and sensor-based techniques. In existing studies, most of the researchers used very complex patternsin this direction, which need special training and attention to remember the patterns and failed to capturethe psychological and behavioral information of a person properly. To overcome these problems, this researchdevised a novel dynamic hand gesture-based person identification system using a Leap Motion sensor. Thisstudy developed two hand gesture-based pattern datasets for performing the experiments, which contained morethan 500 samples, collected from 25 subjects. Various static and dynamic features were extracted from the handgeometry. Randomforest was used to measure feature importance using the Gini Index. Finally, the support vectormachinewas implemented for person identification and evaluate its performance using identification accuracy. Theexperimental results showed that the proposed system produced an identification accuracy of 99.8% for arbitraryhand gesture-based patterns and 99.6% for the same dynamic hand gesture-based patterns. This result indicatedthat the proposed system can be used for person identification in the field of security.

关键词： Person identification leap motion hand gesture random forest support vector machine

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Journal of Biosciences and Medicines 2022年第3期10卷 13-20页

作者： Sabrina Afrin Mushtaque Ahmed Nabeela Mahboob Hasina Iqbal md. kamrul hasan md. A. K. Shameem Kamrun Nahar Islam Sifat Uz Zaman Department of Microbiology Popular Medical College Dhaka Bangladesh Department of Management School of Business North South University Dhaka Bangladesh Department of Laboratory Medicine Biomed Laboratory Dhaka Bangladesh Department of Microbiology University of Chittagong Chittagong Bangladesh Infection Prevention and Control Division Medlife Healthcare Limited Dhaka Bangladesh

Allergy is an adverse immunologic response of increasing prevalence and severity in which immunoglobulin E plays a pivotal role. Total IgE (tIgE) levels show wide variations depending on various factors, such as age, sex, ethnicity, and geographic area. This study set out to quantitatively determine the serum tIgE levels in Bangladeshi population who were clinically suspected cases of allergic diseases and to find out the association of tIgE level with their age and gender. This cross-sectional descriptive exploratory study was conducted at Biomed Diagnostics Laboratory, Panthapath, Dhaka, from March 2021-September 2021. A total of 402 blood samples were collected from clinically suspected cases of allergic diseases. Quantitative detection of tIgE in serum was done by Immunoblot assay manufactured by Proteome Tech Inc. (PROTIATM Allergy-Q64S panel). Among 402 subjects, a wide variation of tIgE levels ranging from 5 to 2000 IU/ml was found but majority of the study population (30.35%) showed tIgE levels within the range of 201 - 350 IU/ml. The study population aging 1 - 10 years showed highest frequency (23.63%) in tIgE concentrations and the mean tIgE level exhibited a declining tendency with an increase in age. Depending on gender there was no difference in tIgE levels. Determination of tIgE level is imperative for screening allergic diseases. The present study enlightened the distribution of tIgE levels and suggested that among Bangladeshi subjects irrespective of gender there is an inverse relationship between tIgE level and age.

关键词： Allergy Serum Total IgE Bangladesh Age Gender

Genome-wide identification,characterization and functional prediction of the SRS gene family in sesame(Sesamum indicum L.)

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Oil Crop Science 2024年第2期9卷 69-80页

作者： Farjana Afroz Susmi Tasmina Islam Simi md Nahid hasan md Abdur Rahim Department of Genetics and Plant Breeding Sher-e-Bangla Agricultural UniversityDhaka1207Bangladesh

Sesame(Sesamum indicum L.)is an ancient oilseed crop of the Pedaliaceae family with high oil content and potential health *** RELATED SEQUENCE(SRS)proteins are the transcription factors(TFs)specific to plants that contain RING-like zinc finger domain and are associated with the regulation of several physiological and biochemical *** also play vital roles in plant growth and development such as root formation,leaf development,floral development,hormone biosynthesis,signal transduction,and biotic and abiotic stress ***,the SRS gene family was not reported in sesame *** this study,identification,molecular characterization,phylogenetic relationship,cis-acting regulatory elements,protein-protein interaction,syntenic relationship,duplication events and expression pattern of SRS genes were analyzed in *** identified total six SiSRS genes on seven different linkage groups in the *** genome by comparing with the other species,including the model plant Arabidopsis *** SiSRS genes showed variation in their structure like2–5 exons and 1–4 *** other species,SiSRS proteins also contained‘RING-like zinc finger'and‘LRP1'***,the SiSRS genes were clustered into subclasses via phylogenetic analysis with proteins of ***,***,and some other plant *** cis-acting regulatory elements analysis revealed that the promoter region of SiSRS4(SIN_1011561)showed the highest 13 and 16 elements for light-and phytohormone-responses whereas,SiSRS1(SIN_1015187)showed the highest 15 elements for *** ABREs,or ABA-responsive elements,were found in a maximum of 8 copies in the SiSRS3(SIN 1009100).Moreover,the available RNA-seq based expression of SiSRS genes revealed variation in expression patterns between stress-treated and non-treated samples,especially in drought and salinity conditions *** SiSRS genes like SiSRS1(SIN_1015187)and SiSRS5(SIN_1021065),also exhibited variabl

关键词： SiSRS gene family SHI Transcription factor Characterization Sesamum indicum

Diagnostic Dilemma with a Case of Primary Bronchopulmonary Actinomycosis Causing Unilateral Destroyed Lung: A Case Report and Literature Review

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Open Journal of Thoracic Surgery 2022年第1期12卷 1-10页

作者： md. Abir Tazim Chowdhury Sohail Ahmed md. Zulfiqur Haider S. M. A. Zulker Nine md. kamrul hasan md. Estiak Ullah Sahid Musfaqus Shalehin md. Abdullah Al-Mahammud Kabir Niaz Ahmed Munama Magdum Department of Cardiothoracic and Vascular Surgery Evercare Hospital Dhaka Bangladesh Department of Cardiothoracic Anesthesia Evercare Hospital Dhaka Bangladesh Department of Community Medicine Shaheed Monsur Ali Medical College Dhaka Bangladesh

Among chronic pulmonary infections, pulmonary actinomycosis is a rare one, caused by a gram-positive microaerophilic bacterium called Actinomyces. Aside from cervicofacial or abdominopelvic actinomycosis, pulmonary involvement is rare, and sometimes this type of infection results in a misdiagnosis of pulmonary tuberculosis or carcinoma. Clinical presentation of pulmonary actinomycosis could be acute or subacute, with lobar involvement. However, the disease is most commonly diagnosed at the chronic phase, with patients presenting mild fever, weight loss, and occasional hemoptysis. Here, we described the case of a 30-year-old male patient, presented with a history of respiratory complaints for more than three years and was diagnosed clinically and radiologically as a case of a destroyed left lung. Later on, post-operative tissue diagnosis was confirmed—pulmonary actinomycosis.

关键词： Pulmonary Actinomycosis Destroyed Lung Diagnostic Dilemma

Japanese Sign Language Recognition by Combining Joint Skeleton-Based Handcrafted and Pixel-Based Deep Learning Features with Machine Learning Classification

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2605-2625页

作者： Jungpil Shin md.Al Mehedi hasan Abu Saleh Musa Miah Kota Suzuki Koki Hirooka School of Computer Science and Engineering The University of AizuAizuwakamatsu965-8580Japan Department of Computer Science&Engineering Rajshahi University of Engineering&TechnologyRajshahi6204Bangladesh

Sign language recognition is vital for enhancing communication accessibility among the Deaf and hard-of-hearing *** Japan,approximately 360,000 individualswith hearing and speech disabilities rely on Japanese Sign Language(JSL)for ***,existing JSL recognition systems have faced significant performance limitations due to inherent *** response to these challenges,we present a novel JSL recognition system that employs a strategic fusion approach,combining joint skeleton-based handcrafted features and pixel-based deep learning *** system incorporates two distinct streams:the first stream extracts crucial handcrafted features,emphasizing the capture of hand and body movements within JSL ***,a deep learning-based transfer learning stream captures hierarchical representations of JSL gestures in the second ***,we concatenated the critical information of the first stream and the hierarchy of the second stream features to produce the multiple levels of the fusion features,aiming to create a comprehensive representation of the JSL *** reducing the dimensionality of the feature,a feature selection approach and a kernel-based support vector machine(SVM)were used for the *** assess the effectiveness of our approach,we conducted extensive experiments on our Lab JSL dataset and a publicly available Arabic sign language(ArSL)*** results unequivocally demonstrate that our fusion approach significantly enhances JSL recognition accuracy and robustness compared to individual feature sets or traditional recognition methods.

关键词： Japanese Sign Language(JSL) hand gesture recognition geometric feature distance feature angle feature GoogleNet