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An integrated system for planning, navigation and robotic assistance for skull base surgery

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中国神经肿瘤杂志 2008年第3期6卷 161-161页

作者： Baird C Jallo G Hayes K Nakajima N Hata N Kazanzides P Department of Computer Science Johns Hopkins University

BACKGROUND: We developed an image-guided robot system to provide mechanical assistance for skull base drilling,which is performed to gain access for some neurosurgical interventions, such as tumour resection. The motivation for introduc-ing this robot was to improve safety by preventing the surgeon from accidentally damaging critical neurovascular structures dur-

关键词：颅底手术肿瘤临床分析治疗方法手术治疗

撒哈拉以南非洲的社会经济状况与高血压控制的关系

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中华高血压杂志 2018年第3期26卷 224-224页

作者：刘青叶鹏 Antignac M Diop IB Macquart de Terline D Kramoh KE Balde DM Dzudie A Ferreira B Houenassi md Hounsou D Ikama MS Kane A Kimbally-Kaki SG Kingue S Kouam Kouam C Limbole E Mfeukeu Kuate L Mipinda JB N'Guetta R Nhavoto C Sesso Z Sidy Ali A Ali Toure I Plouin PF Perier MC Narayanan K Empana JP Jouven X

高血压在非洲是一种迅速增长的流行病。在这一地区,社会经济状况对血压控制的作用还没有得到很好的研究。因此,Antignac等对非洲撒哈拉以南地区的12个低收入和中等收入国家的城市诊疗中心进行了横断面研究,旨在量化个人和国家水平的社... 详细信息

高血压在非洲是一种迅速增长的流行病。在这一地区,社会经济状况对血压控制的作用还没有得到很好的研究。因此,Antignac等对非洲撒哈拉以南地区的12个低收入和中等收入国家的城市诊疗中心进行了横断面研究,旨在量化个人和国家水平的社会经济状况与撒哈拉以南非洲的血压控制之间的关系。

关键词：撒哈拉以南非洲社会经济状况高血压控制中等收入国家撒哈拉以南地区流行病横断面

Association between Sputum Atypia and Lung Cancer Risk Occupational-based Cohort in Yunnan, China

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Association between Sputum Atypia and Lung Cancer Risk Occup...

Plant Biosystems Design Research Roadmap 1.0

全国个人剂量监测研讨会

作者： Ya-Guang Fan~1 Ping Hu~(2*) Yong Jiang~3 Run-Sheng Chang~4 Shu-Xiang Yao~5 Wendy Wang~2 Philip Taylor~2 Jie He~3 Yong-Chen Zhao~1 Philip Prorok~2 You-Lin Qiao~(3*) 1 Department of Biology, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin,People’s Republic of China 2 Divisions of Cancer Prevention and Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, md, United States of America 3 Departments of Cancer Epidemiology & Thorax, Cancer Institute, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China 4 Third People’s Hospital of Honghe Autonomous District, Yunnan province, P.R. China 5 Kunming Medical College, Yunnan province, P.R. China

OBJECTIVE To investigate the association between sputum cytologic atypia and lung cancer risk. METHODS A prospective cohort study was conducted among occupational tin miners in Yunnan China based on annual lung cancer screening *** samples were collected prospectively at basdine and the following seven annual *** association between risk factors and sputum cytology results was analyzed by univariate and multivariate logistic *** hazard model was used to analyze the association between the baseline sputum results and lung cancer *** effect of consecutive sputum cytology on the increase of lung cancer risk was analyzed by logistic regression. RESULTS Sputum cytologic atypia was associated with age, smoking, occupational radon and arsenic exposure and asthma. Sputum cytologic atypia was an independent risk factor of lung cancer with an adjusted hazard ratio (HR) of 3.82 (95%CI: 2.82-5.18) in comparing normal to moderate or worse atypia. Age, smoking, occupational radon and arsenic exposure might be main confounding factors. CONCLUSIONS Sputum cytologic examination might play an important role in the early detection of lung cancer or in the selection of the optimal target population for more intensive lung cancer screening with high risk of lung cancer among this occupational cohort.

关键词： sputum atypia lung cancer Yunnan China

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BioDesign Research 2020年第1期2020卷 53-90页

作者： Xiaohan Yang June I.Medford Kasey Markel Patrick M.Shih Henrique C.De Paoli Cong T.Trinh Alistair J.McCormick Raphael Ployet Steven G.Hussey Alexander A.Myburg Poul Erik Jensen md Mahmudul Hassan Jin Zhang Wellington Muchero Udaya C.Kalluri Hengfu Yin Renying Zhuo Paul E.Abraham Jin-Gui Chen David J.Weston Yinong Yang Degao Liu Yi Li Jessy Labbe Bing Yang Jun Hyung Lee Robert W.Cottingham Stanton Martin Mengzhu Lu Timothy J.Tschaplinski Guoliang Yuan Haiwei Lu Priya Ranjan Julie C.Mitchell Stan D.Wullschleger Gerald A.Tuskan Biosciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA The Center for Bioenergy Innovation Oak Ridge National LaboratoryOak RidgeTN 37831USA Department of Biology Colorado State UniversityFort CollinsCO 80523USA Department of Plant Biology University of CaliforniaDavisDavisCAUSA Feedstocks Division Joint BioEnergy InstituteEmeryvilleCAUSA Department of Biodesign Biological Systems and Engineering DivisionLawrence Berkeley National LaboratoryBerkeleyCAUSA Department of Chemical and Biomolecular Engineering University of TennesseeKnoxvilleTN 37996USA SynthSys and Institute of Molecular Plant Sciences School of Biological SciencesUniversity of EdinburghEdinburgh EH93BFUK Department of Biochemistry Genetics and MicrobiologyForestry and Agricultural Biotechnology Institute(FABI)University of PretoriaPretoria 0002South Africa Department of Food Science University of CopenhagenRolighedsvej 26DK-1858FrederiksbergCopenhagenDenmark State Key Laboratory of Subtropical Silviculture School of Forestry and BiotechnologyZhejiang A&F UniversityHangzhouZhejiang 311300China State Key Laboratory of Tree Genetics and Breeding Research Institute of Subtropical ForestryChinese Academy of ForestryHangzhouZhejiang 311400China Department of Plant Pathology and Environmental Microbiology and the Huck Institute of the Life Sciences The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Genetics Cell Biology and DevelopmentCenter for Precision Plant Genomics and Center for Genome EngineeringUniversity of MinnesotaSaint PaulMN 55108USA Department of Plant Science and Landscape Architecture University of ConnecticutStorrsCT 06269USA Division of Plant Sciences Bond Life Sciences CenterUniversity of MissouriColumbiaMOUSA Donald Danforth Plant Science Center St.LouisMOUSA Environmental Sciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA

Human life intimately depends on plants for food,biomaterials,health,energy,and a sustainable *** plants have been genetically improved mostly through breeding,along with limited modification via genetic engineering,yet they are still not able to meet the ever-increasing needs,in terms of both quantity and quality,resulting from the rapid increase in world population and expected standards of living.A step change that may address these challenges would be to expand the potential of plants using biosystems design *** represents a shift in plant science research from relatively simple trial-and-error approaches to innovative strategies based on predictive models of biological *** biosystems design seeks to accelerate plant genetic improvement using genome editing and genetic circuit engineering or create novel plant systems through de novo synthesis of plant *** this perspective,we present a comprehensive roadmap of plant biosystems design covering theories,principles,and technical methods,along with potential applications in basic and applied plant biology *** highlight current challenges,future opportunities,and research priorities,along with a framework for international collaboration,towards rapid advancement of this emerging interdisciplinary area of ***,we discuss the importance of social responsibility in utilizing plant biosystems design and suggest strategies for improving public perception,trust,and acceptance.

关键词： Plant utilizing breeding

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多层军事网络路由体系规划与设计

通信对抗 2015年第1期34卷 56-62页

作者： J.Lee L.Kant A.McAuley K.Sinkar C.Graff M.Patel 杨红娃蒋盘林 Applied Communication Sciences (A CS).One Telcordia Drive Piscataway NJ 08854USA U. S. Army CERDEC Aberdeen MD US 不详

军事网络设计与规划需在多个功能域完成复杂的性能与价格折中,包括子网创建、拓扑生成、路由层次设计与协议选择、波形及频率规划与MAC选择。文章集中讨论与单元任务组(UTO)需求相关的由子网形成路由体系的问题,这是军事网络设计的关键... 详细信息

军事网络设计与规划需在多个功能域完成复杂的性能与价格折中,包括子网创建、拓扑生成、路由层次设计与协议选择、波形及频率规划与MAC选择。文章集中讨论与单元任务组(UTO)需求相关的由子网形成路由体系的问题,这是军事网络设计的关键问题。路由体系选择包含子网、路由区和网关选择中的复杂的性能与价格折中。为此,使用了MANET网络设计工具——认知网络工程设计分析工具箱(CNEDAT)[1]。它是ACS和美国陆军CERDEC项目的联合研究成果,包含了可用于异构、多层军事网络的一系列分析模型、算法与协议分析工具。CNEDAT可同时用于:a)在给定的一组网络资源、目标与约束条件下,通过组合各种波形、MAC和网络算法与协议,生成或合成备用网络设计或规划;b)分析优化特定网络性能,提供可满足任务目标的多个备选网络和结构方案。

关键词：路由区平面网络层次网络边界网关网络扩展性性能价格折中

科研与临床并重——纪念斯隆-凯特琳癌症中心脑肿瘤中心简介

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中国神经肿瘤杂志 2008年第3期6卷 218-220页

作者：赛克中山大学肿瘤医院神经外科广东广州510060 美国德州大学md安德森癌症中心神经肿瘤科

纪念斯隆-凯特琳癌症中心始建于1884年,是世界上历史最悠久、规模最大的私立癌症中心。2007年,为了加强临床与基础研究的合作,纪念斯隆-凯特琳癌症中心成立了脑肿瘤中心。神经外科、神经肿瘤科、放疗科、影像科医生与基础研究学者密切合... 详细信息

纪念斯隆-凯特琳癌症中心始建于1884年,是世界上历史最悠久、规模最大的私立癌症中心。2007年,为了加强临床与基础研究的合作,纪念斯隆-凯特琳癌症中心成立了脑肿瘤中心。神经外科、神经肿瘤科、放疗科、影像科医生与基础研究学者密切合作,旨在为脑肿瘤患者提供高质量的多学科综合治疗,同时探索治疗治疗脑肿瘤的新方法。本文将对纪念斯隆-凯特琳癌症中心脑肿瘤中心进行简要介绍。

关键词：纪念斯隆-凯特琳癌症中心脑肿瘤中心介绍

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杜克大学脑肿瘤中心简介

中国神经肿瘤杂志 2008年第4期6卷 290-292页

作者：赛克中山大学肿瘤防治中心神经外科广东广州510060 美国德州大学md安德森癌症中心神经肿瘤科

杜克大学脑肿瘤中心始建于1937年,是全美乃至全球最先开展神经肿瘤诊疗与科研的单位之一。在70多年的历史当中,杜克大学脑肿瘤中心取得令人瞩目的成绩。目前,中心在Darell ***教授的领导下,杜克脑肿瘤中心正在向着旨在通过多学科合作,... 详细信息

杜克大学脑肿瘤中心始建于1937年,是全美乃至全球最先开展神经肿瘤诊疗与科研的单位之一。在70多年的历史当中,杜克大学脑肿瘤中心取得令人瞩目的成绩。目前,中心在Darell ***教授的领导下,杜克脑肿瘤中心正在向着旨在通过多学科合作,改善神经肿瘤患者的预后及生存质量的目标前进。

关键词：杜克大学脑肿瘤中心

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麻萨诸塞州总医院脑肿瘤中心简介

中国神经肿瘤杂志 2008年第2期6卷 146-148页

作者：赛克中山大学肿瘤医院神经外科

麻萨诸塞州总医院是哈佛大学医学院的附属教学医院,是全美历史最悠久的医院之一。其下属的脑肿瘤中心核心团队由神经肿瘤科、神经科、神经外科及放射肿瘤科医生构成,并与神经病理科及神经影像科密切合作。脑肿瘤中心旨在通过多学科协作... 详细信息

麻萨诸塞州总医院是哈佛大学医学院的附属教学医院,是全美历史最悠久的医院之一。其下属的脑肿瘤中心核心团队由神经肿瘤科、神经科、神经外科及放射肿瘤科医生构成,并与神经病理科及神经影像科密切合作。脑肿瘤中心旨在通过多学科协作为脑肿瘤患者提供高质量的医疗服务。同时,通过基础及临床科学研究探索脑肿瘤发生及进展的机制,开发新型治疗手段,改善脑肿瘤患者预后。本文将对麻萨诸塞州总医院脑肿瘤中心进行简要介绍。

关键词：麻萨诸塞州总医院脑肿瘤中心

Low Frequencies of CCR5-Δ32 and CCR5-m303,but High Frequencies of CCR2-641 and SDF1-3’A Alleles in Indigenous Ethnic Groups in Mainland China

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Chinese Journal of Sexually Transmitted Infections 2002年第1期2卷 7-12页

作者：王福生金磊洪卫国刘明旭周越塑张冰施明王吉明雷周云王哲冯铁建侯静李光汉曹韵贞 Division of Biological Engineering and Department of Out-Patients Beijing Institute of Infectious Disease Beijing Hospital of Infectious Disease Division of Biological Engineering and Department of Out-Patients Beijing Institute of Infectious Disease Laboratory of Molecular Immunoregulation Division of Basic Sciences National Cancer Institute The Health and Anti-Epidemic Center of Henan Province The Shenzhen Health and Anti-Epidemic Station Shenzhen Guangdong Province National Center for AIDS Prevention and Control of China Beijing 100039 P.R.China.Dr FCRDC md 21702-1201 USA Zhengzhou 450003 P. R. China 518020 P. R. China Beijing 100050 P. R. China

Objective: The aim in this study was to identify the allelicfrequencies of the chemokine (SDF1-3’A) and chemokinereceptor (CCR5△32, CCR5m303 and CCR2-64I) genesresistant to HIV-1 infection and/or disease progression inindigenous Chinese populations. Methods: By using QIAamp DNA Blood Mini Kit, thegenomic DNA samples were purified from whole peripheralblood of healthy individuals (n=2067) from Han, Uygur,Mongolian and Tibetan ethnic groups, as well as Han patientsincluding HIV-1 carriers (n=330), patients with other sexuallytransmitted diseases (STDs, n=259) and intravenous drugusers (IVDUs, n=125). The allelic polymorphisms wereidentified by means of PCR or PCR-RFLP analyses. Thesequences of randomly selected amplified PCR products werefurther confirmed by direct DNA sequencing. Results: The mutant frequencies were identified to be0%～3.48% for CCR5△32, 0% for CCR5m303,19.15%～28.79% for CCR2-64 and 19.10%～28.73% for SDF1-3’A alleles, respectively, in Chinese healthy individuals fromfour ethnic groups. Our findings indicated the allelicfrequencies vary among the different ethnic ***, the HIV-1 carriers, STD cases and IVDUs (all ofHan ethnicity) were found to have the allelic frequencies of0%～0.19% (CCR5△32), 0% (CCR5m303), 19.31%～20.45%(CCR2-64) and 25.61%～26.83% (SDF1-3’A) with minorvariations in their frequencies between the patients andhealthy Han groups. There was no CCR5-m303 mutationfound in any subject in this study. Conclusion: The examined subjects of four Chinese ethnicorigins showed lower frequencies of CCR5△32 andCCR5m303 alleles, but higher frequencies of mutant CCR2-64I and SDF1-3’A alleles compared to those identified innorthern-European and American Caucasians. Thesignificance of the different frequencies and polymorphisms ofthe above alleles in Chinese populations needs to be furtherexamined in HIV-1/AIDS diseases.

关键词： HIV-1 coreceptors polymorphism Allelic frequency mutation