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自我血压监测对药物依从性和生活方式因素的影响:系统回顾和荟萃分析

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中华高血压杂志 2016年第4期24卷 398-398页

作者： Fletcher BR Hartmann-Boyce J Hinton L mcmanus rj 陈云叶鹏

自我血压监测（self-monitoringofbloodpressure，SMBP）有助于降低高血压患者的血压，但是具体机制并不是十分明了。可能的解释包括药物治疗改善（遵医嘱延长药物治疗时间，改善依从性）和生活方式改善（改变膳食习惯，增加体力活动）。

关键词：自我血压监测生活方式改善药物依从性荟萃分析系统回顾高血压患者治疗时间药物治疗

家庭与门诊血压差异的预测因子:一项系统回顾和荟萃分析

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中华高血压杂志 2016年第9期24卷 898-898页

作者： Sheppard JP Fletcher B Gill P Martin U Roberts N mcmanus rj 陈云

与诊室血压相比，高血压患者在家中的血压可能较低（白大衣性高血压）或较高（隐蔽性高血压），其结果可能导致误诊和高血压控制不理想。该研究旨在系统地回顾文献，并探讨造成家庭与诊室血压差异的最重要预测因子。

关键词：血压差异系统回顾预测因子荟萃分析家庭白大衣性高血压门诊高血压患者

Health behavior outcomes in stroke survivors prescribed wearables for atrial fibrillation detection stratified by age

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Journal of Geriatric Cardiology 2024年第3期21卷 323-330页

作者： Joanne Mathew Jordy Mehawej Ziyue Wang Taylor Orwig Eric Ding Andreas Filippaios Syed Naeem Edith Mensah Otabil Alex Hamel Kamran Noorishirazi IrinaRadu Jane Saczynski David D.mcmanus Khanh-Van Tran Division of Cardiovascular Medicine Department of MedicineUniversity of Massachusetts Chan Medical SchoolLake Avenue NorthWorcesterUSA Department of Internal Medicine Central Michigan UniversityMount PleasantUSA Department of Pharmacy and Health Systems Sciences School of PharmacyNortheastern UniversityBostonUSA Department of Population and Quantitative Health Sciences University of Massachusetts Chan Medical SchoolLake Avenue NorthWorcesterUSA

BACKGROUND Smartwatches have become readily accessible tools for detecting atrial fibrillation(AF).There remains limited data on how they affect psychosocial outcomes and engagement in older *** examine the health behavior outcomes of stroke survivors prescribed smartwatches for AF detection stratified by *** We analyzed data from the Pulsewatch study,a randomized controlled trial that enrolled patients(≥50 years)with a history of stroke or transient ischemic attack and CHA2DS2-VASc≥*** participants were equipped with a cardiac patch monitor and a smartwatch-app dyad,while control participants wore the cardiac patch monitor for up to 44 *** evaluated health behavior parameters using standardized tools,including the Consumer Health Activation Index,the Generalized Anxiety Disorder questionnaire,the 12-Item Short Form Health Survey,and wear time of participants categorized into three age groups:Group 1(ages 50-60),Group 2(ages 61-69),and Group 3(ages 70-87).We performed statistical analysis using a mixedeffects repeated measures linear regression model to examine differences amongst age *** Comparative analysis between Groups 1,2 and 3 revealed no significant differences in anxiety,patient activation,perception of physical health and wear *** use of smartwatch technology was associated with a decrease in perception of mental health for Group 2 compared to Group 1(β=-3.29,P=0.046).CONCLUSION Stroke survivors demonstrated a willingness to use smartwatches for AF ***,among these study participants,the majority did not experience negative health behavior outcomes or decreased engagement as age increased.

关键词： prescribed stratified wear

自我监测血压和自我调整药物对合并高危心血管疾病的高血压患者收缩压的影响--脑卒中和高危人群血压控制目标和自我管理随机临床试验

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中华高血压杂志 2014年第11期22卷 1087-1088页

作者： mcmanus rj Mant J Haque MS Bray EP Bryan S Greenfield SM Jones MI Jowett S Little P Penaloza C Schwartz C Shackleford H Shovelton C Varghese J Williams B Hobbs FD 练桂丽叶鹏 unknown

血压升高是全球疾病负担的主要危险因素。虽然在过去10年中得到了改善,但是血压控制率仍然很低。修订后的美国高血压预防、检测、评估与治疗联合委员会（the joint national committee on prevention,detection,evaluation,and treatmen... 详细信息

血压升高是全球疾病负担的主要危险因素。虽然在过去10年中得到了改善,但是血压控制率仍然很低。修订后的美国高血压预防、检测、评估与治疗联合委员会（the joint national committee on prevention,detection,evaluation,and treatment of high blood pressure,JNC）专家组成员第8次报告（JNC8）2014年高血压循证管理指南提出≥60岁的老年人,糖尿病和慢性肾脏病患者血压的控制目标可以放宽。目前接受高血压治疗的美国人达到血压控制目标的比例,

关键词：血压控制目标高血压患者高危心血管疾病随机临床试验自我管理高危人群自我调整 prevention

临床实践中血压晨峰的预后重要性:系统性综述

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中华高血压杂志 2015年第8期23卷 798-798页

作者： Sheppard JP Hodgkinson J Riley R Martin U Bayliss S mcmanus rj 练桂丽叶鹏

过高的血压晨峰可能与脑卒中和其他心血管事件相关，但血压晨峰的阈值为多少时具有病理性作用还不清楚。该研究系统性复习现有的文献，旨在确定病理性血压晨峰的合适定义。方法：用MEDLINE检索各个数据库中高血压晨峰与心血管终点相关... 详细信息

过高的血压晨峰可能与脑卒中和其他心血管事件相关，但血压晨峰的阈值为多少时具有病理性作用还不清楚。该研究系统性复习现有的文献，旨在确定病理性血压晨峰的合适定义。方法：用MEDLINE检索各个数据库中高血压晨峰与心血管终点相关性的前瞻性研究文献。用随机效应模型荟萃分析计算HR。结果：共检索文献2964篇，17篇符合人选标准。检索出几种不同的血压晨峰定义，最常见的为觉醒前血压晨峰（起床后2h内的平均血压一起床前2h内的平均血压；n=6项研究）。

关键词：血压晨峰系统性综述临床实践 MEDLINE检索心血管事件预后随机效应模型检索文献

Liver alveolar echinococcosis in China: Clinical aspect with relative basic research

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World Journal of Gastroenterology 2005年第30期11卷 4611-4617页

作者： Ci-Peng Jiang mcmanus Don Malcolm Jones Hydatidosis Research Laboratory of Basic Medical School Lanzhou University Lanzhou 730000 Gansu Province China Post Office Royal Brisbane Hospital Q 4029 Australia

This paper deals with all aspects of liver alveolar echinococcosis (AE) including epidemiology, pathology, clinical manifestations, imaging examinations, diagnosis and differential diagnosis, surgical treatment and *** review is not only based on personal clinical experiences but also in combination with relative basic research such as proliferation and growth of alveococcus, preclinical studies of a novel compound extracted from TCM for treatment of liver AE, and molecular immunology used for specific AE diagnosis, etc.

关键词： Echinococcosis Alveolar echinococcosis Liver Clinical aspect Basic research China

Corrosive injury to upper gastrointestinal tract: Still a major surgical dilemma

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World Journal of Gastroenterology 2006年第32期12卷 5223-5228页

作者： Siew Min Keh Nzewi Onyekwelu Kieran mcmanus Jim McGuigan The Royal National Nose Throat & Ear Hospital LondonUnited Kingdom Thoracic Surgical Unit Royal Victoria Hospital BelfastUnited Kingdom

In the developed and developing countries, corrosive injury to the gastrointestinal system as a consequence of either accidental ingestion or as a result of self-harm has become a less common phenomenon compared to decades ago. This could partly be attributed to the tighter legislation imposed by the government in these countries on detergents and other corrosive products and general public awareness. Most busy upper gastrointestinal surgical units in these countries, especially in the developed countries will only encounter a small number of cases per year. Up to date knowledge on the best management approach is lacking. In this article, we present our experience of two contrasting cases of corrosive injury to the upper gastrointestinal tract in our thoracic unit in the last 2 years and an up-to-date Medline literature search has been carried out to highlight the areas of controversies in the management of corrosive injuries of the upper gastrointestinal tract. We concluded that the main principle in managing such patients requires a good understanding of the pathophysiology of corrosive injury in order to plan both acute and future management. Each patient must be evaluated individually as the clinical picture varies widely. Signs and symptoms alone are an unreliable guide to injury.

关键词： K Acid Alkali Oesophageal stricture Endoscopy Steroids Oesophageal and gastric carcinoma

在血压控制不良的高血压患者中使用数字化干预的家庭和在线血压管理:随机对照试验

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中华高血压杂志 2021年第5期29卷 427-427页

作者： McMa-nus rj Little P Stuart B Morton K Raftery J Kelly J Bradbury K Zhang J Zhu S Murray E May CR Mair FS Michie S Smith P Band R Ogburn E AllenJ Rice C Nut-tall J Williams B Yardley L 陈嘉睿(译) 叶鹏(审校) 不详

HOME BP试验(The home and online management and evaluation of blood pressure)的目的是评估在初级预防中结合自我监测和自我管理的数字化干预在高血压管理中的作用。研究者纳入英国76个治疗中心经过治疗但血压控制不好(>140/90 mm H... 详细信息

HOME BP试验(The home and online management and evaluation of blood pressure)的目的是评估在初级预防中结合自我监测和自我管理的数字化干预在高血压管理中的作用。研究者纳入英国76个治疗中心经过治疗但血压控制不好(>140/90 mm Hg, 1 mm Hg=0.133 kPa)并能上网的患者622例,进行自动确定主要终点的公开随机对照试验。

关键词：初级预防血压管理随机对照试验自我监测血压控制高血压患者自我管理

How location and cellular signaling combine to activate the NLRP3 inflammasome

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Cellular & Molecular Immunology 2022年第11期19卷 1201-1214页

作者： Anil Akbal Alesja Dernst Marta Lovotti Matthew S.J.Mangan Róisín M.mcmanus Eicke Latz Institute of Innate Immunity University Hospital BonnUniversity of Bonn53127 BonnGermany German Center for Neurodegenerative Diseases 53127 BonnGermany Department of Infectious Diseases&Immunology UMass Medical SchoolWorcesterMA 01605USA Centre of Molecular Inflammation Research Norwegian University of Science and Technology7491 TrondheimNorway

NOD-,LRR-,and pyrin domain-containing 3(NLRP3)is a cytosolic innate immune sensor of cellular stress signals,triggered by infection and sterile *** detection of an activating stimulus,NLRP3 transitions from an inactive homo-oligomeric multimer into an active multimeric inflammasome,which promotes the helical oligomeric assembly of the adaptor molecule *** oligomers provide a platform for caspase-1 activation,leading to the proteolytic cleavage and activation of proinflammatory cytokines in the IL-1 family and gasdermin D,which can induce a lytic form of cell *** studies investigating both the cellular requirement for NLRP3 activation and the structure of NLRP3 have revealed the complex regulation of NLRP3 and the multiple steps involved in its *** review presents a perspective on the biochemical and cellular processes controlling the assembly of the NLRP3 inflammasome with particular emphasis on structural regulation and the role of *** also highlight the latest research on metabolic control of this inflammatory pathway and discuss promising clinical targets for intervention.

关键词： NLRP3 Inflammasome Mechanism Localization Structure Regulation