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美国国立老化研究所与阿尔茨海默病协会诊断指南写作组：阿尔茨海默病源性轻度认知障碍诊断标准推荐

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中华神经科杂志 2012年第5期45卷 345-351页

作者： mckhann gm Knopman DS Chertkow H Hyman BT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly JJ Mayeux R Mohs RC Morris JC Rossor MN Schehens P Carrillo MC Thies B Weintraub S Phelps CH 贾建平（译）陆璐（译）张逸驰（译）黄丽黄（译）礼媛（译）不详首都医科大学宣武医院神经内科北京100053

美国国立老化研究所（NIA）和阿尔茨海默病协会（ADA）组织了一个工作组，负责阿尔茨海默病（AD）痴呆前症状阶段——即本文所称的AD源性轻度认知障碍（MCI）的诊断标准的制订及完善。该工作组制订了以下两套标准：（1）在缺乏相应条件... 详细信息

美国国立老化研究所（NIA）和阿尔茨海默病协会（ADA）组织了一个工作组，负责阿尔茨海默病（AD）痴呆前症状阶段——即本文所称的AD源性轻度认知障碍（MCI）的诊断标准的制订及完善。该工作组制订了以下两套标准：（1）在缺乏相应条件进行先进影像技术及脑脊液检查时，医务人员适用的核心临床标准；（2）适用于包括临床试验在内的科学研究的研究标准。后者纳入了基于影像技术及脑脊液检查的生物标志物的应用。并根据所出现的生物标志物的性质，将最终MCI诊断的确定性程度分为4个级别。而要使生物标志物有效应用于诊断，并在社区医疗服务中规范使用，尚需做大量的工作。

关键词：阿尔茨海默病轻度认知障碍诊断标准研究所诊断指南源性协会老化

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美国国立老化研究所与阿尔茨海默病协会诊断指南写作组：阿尔茨海默病痴呆诊断标准的推荐

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中华神经科杂志 2012年第5期45卷 352-355页

作者： mckhann gm Knopman DS Chertkow H Hyman BT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly J J Mayeux R Mohs RC Morris JC Rossor MN Scheltens P Carrillo MC Thies B Weintraub S Phelps CH 贾建平（译）陆璐（译）张逸驰（译）黄丽（译）韩阅（译）不详首都医科大学宣武医院神经科北京100053

由美国国立老化研究所（NIA）和阿尔茨海默病（AD）协会组织了一个工作组，负责修订1984年版AD痴呆的诊断标准。旨在确保修订后的标准具有足够的灵活性，既可供缺乏神经心理学测验、先进的影像技术和脑脊液检查措施的普通医务人员使用... 详细信息

由美国国立老化研究所（NIA）和阿尔茨海默病（AD）协会组织了一个工作组，负责修订1984年版AD痴呆的诊断标准。旨在确保修订后的标准具有足够的灵活性，既可供缺乏神经心理学测验、先进的影像技术和脑脊液检查措施的普通医务人员使用，也可供具备上述措施的科研、临床试验的专业研究者使用。新的标准广泛适用于各种原因的痴呆以及专门针对AD痴呆的标准，保留了1984年版标准中的“很可能的AD痴呆”的总体框架。在过去27年的经验基础上，工作组对临床诊断标准做了一些修改，保留了“可能的AD痴呆”的术语，但对其进行了更有针对性的重新定义。在科研用的“很可能的和可能的AD痴呆”的诊断标准中纳入了生物标志物证据。AD痴呆的核心临床标准仍将是临床实践中诊断的基础，但用生物标志物证据来提高AD痴呆诊断的病理生理学特异性也被人们寄予厚望。要实现AD痴呆的生物标志物诊断，还有许多工作摆在面前。

关键词：临床诊断标准阿尔茨海默病研究所痴呆诊断指南协会老化美国

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术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除（英文）

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中华神经外科疾病研究杂志 2016年第5期15卷 465-465页

作者： Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA mckhann gm 2nd Sisti MB Canoll P D'Amico RS Bruce JN Department of Neurological Surgery Columbia University Medical Center Department of Neuroradiology Columbia University Medical Center Department of Pathology and Cell Biology Columbia University Medical Center Department of Radiology Columbia University Medical Center

Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 *** localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of *** Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the u

关键词：神经外科学疾病研究医学研究临床分析

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Early deficits in synaptic mitochondria in an Alzheimer s disease mouse model

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Early deficits in synaptic mitochondria in an Alzheimer s di...

2011全国老年痴呆与衰老相关疾病学术会议第三届山东省神经内科医师（学术）论坛

作者： Alexander A Sosunov Guy M mckhann Shirley ShiDu Yan Department of Neurosurgery Columbia University.630 W168th street New York NY 10032 Department of Surgery The Taub institute for Research on Alzheimer s Disease and the Aging Brain Department of Pathology＆Cell Biology.Columbia University.630 W168th street New York NY 10032

Synaptic dysfunction and the loss of synapses are early pathological features of Alzheimer s disease (AD).Synapses are sites of high energy demand and extensive calcium fluxes;accordingly,synaptic transmission requires high levels of ATP and constant calcium ***,synaptic mitochondria are vital for maintenance of synaptic function and transmission through normal mitochondrial energy metabolism,

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神经外科手术技巧 1

2003年

作者：（美）E.Sander Connolly Judy Huang Guy M.mckhann Tanvir Choudhri 周良辅主译

本书首先对进行手术的手术室用品、器械和设备进行介绍，提供了涉及术前准备、影像学资料、麻醉、手术步骤、术后处理等神经外科医生的必备知识。

ISBN: (纸本)7533134621

关键词：神经外科手术

来源：汇雅图书（南通市图书馆... 评论

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小儿患急性小球性肾炎所显脑并发症之治法

中华医学杂志 1932年第4期18卷 673-674页

作者： Blackfan and mckhann. J. A. M. A. Oct. 10, 1931. 陈淑娥

去年十月美国医学会杂志载Blackfan医士用硫酸镁溶液治此并合症状颇为新颖,亟节译如下: 所谓小儿在患急性小球性肾炎所显脑并合症状者,即呕吐,头痛。视力紊乱,血压加高,心动徐缓,呼吸慢,昏迷,搐搦终至於死。亦即所称为尿毒症(Uremia),...

去年十月美国医学会杂志载Blackfan医士用硫酸镁溶液治此并合症状颇为新颖,亟节译如下: 所谓小儿在患急性小球性肾炎所显脑并合症状者,即呕吐,头痛。视力紊乱,血压加高,心动徐缓,呼吸慢,昏迷,搐搦终至於死。亦即所称为尿毒症(Uremia),假尿毒症(Pseudo-

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冠状动脉搭桥术后1年的认知功能是否会下降手术和非手术对照的比较

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世界核心医学期刊文摘(神经病学分册) 2006年第2期 42-42页

作者： mckhann G.M. Grega M.A. Borowicz Jr. L.M. 赵天智 338 Krieger Hall Johns Hopkins University 3400 North Charles Street Baltimore MD 21218 United States.Dr

Background: It is widely assumed that decline in cognition after coronary artery bypass grafting (CABG) is related to use of the cardiopulmonary bypass pump. Because most studies have not included comparable control groups, it remains unclear whether postoperative cognitive changes are specific to cardiopulmonary byp ass, general aspects of surgery, or vascular pathologies of the aging brain. Met hods: This nonrandomized study included four groups: CABG patients (n = 140); of f-pump coronary surgery (n = 72); nonsurgical cardiac controls (NSCC) with diag nosed coronary artery disease but no surgery (n = 99); and heart healthy control s (HHC) with no cardiac risk factors (n = 69). Subjects were evaluated at baseli ne (preoperatively), 3 months, and 12 months. Eight cognitive domains and a glob al cognitive score, as well as depressive and subjective symptoms were analyzed. Results: At baseline, patients with coronary artery disease (CABG, off-pump, a nd NSCC) had lower performance than the HHC group in several cognitive domains. By 3 months, all groups had improved. From 3 to 12 months, there were minimal in trasubject changes for all groups. No consistent differences between the CABG an d off-pump patients were observed. Conclusions: Compared with heart healthy con trols (HHC), the groups with coronary artery disease had lower cognitive test sc ores at baseline. There was no evidence that the cognitive test performance of c oronary artery bypass grafting (CABG) patients differed from that of control gro ups with coronary artery disease over a 1-year period. This study emphasizes th e need for appropriate control groups for interpreting longitudinal changes in c ognitive performance after CABG.

关键词：认知功能 CABG 患者受试者得分非手术冠状动脉疾病