检索结果-南通市图书馆

Enhancement of mechanical properties of GTAW joints for ZC63 magnesium alloy by post-weld heat treatment

Journal of Materials Science & Technology 2024年第2期169卷 251-263页

作者： Weiyang Zhou Qichi Le Ye Shi Qiyu Liao Tong Wang Qi Zou Clodualdo Aranas jr Key Lab of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang 110819China Key Laboratory of Lightweight Structural Materials Liaoning ProvinceNortheastern UniversityShenyang 110819China School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Department of Mechanical Engineering University of New BrunswickFrederictonE3B 5A3New BrunswickCanada

To further improve the microstructure and mechanical properties of gas tungsten arc welded(GTAW)welded joints for ZC63 magnesium alloy,post-weld heat treatment is carried out.It is found that the majority of the MgZnCu phase in the fusion zone(FZ)is dissolved in theα-Mg matrix under suitable heat treatment conditions.The remainder is diffusely distributed as rods or granules at the grain bound-aries.The excessive heat treatment temperature(460℃)leads to abnormal grain growth(AGG)in the FZ.The substructure gradient between the abnormally grown grains and the surrounding small grains pro-vides the driving force for AGG.Meanwhile,the dissolution of the MgZnCu phase weakens the hindering effect of the second phase on grain boundary migration,setting the stage for AGG.In addition,the detri-mental impact of the continuous MgZnCu phase on the mechanical properties of the welded joint is also lessened by its dissolution.The ultimate tensile strength(UTS),yield strength(YS)and elongation(EL)of the welded joints are 255 MPa,119 MPa and 27.0%,respectively,under the post-weld heat treatment process of 440℃×12 h.The welding coefficient of the welded joint reaches 97.0%,satisfying the service criteria set forth by the mechanical properties of the welded joints.

关键词： GTAW FZ heat treatment AGG Mechanical properties

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Astrocytic calcium waves:unveiling their roles in sleep and arousal modulation

引用

Neural Regeneration Research 2024年第5期19卷 984-987页

作者： Erxi Wu Dan Qi Damir Nizamutdinov Jason h.huang Department of Neurosurgery and Neuroscience Institute Baylor Scott&White HealthTempleTXUSA Texas A&M University School of Medicine TempleTXUSA Texas A&M University School of Pharmacy College StationTXUSA LIVESTRONG Cancer Institutes and Department of Oncology Dell Medical Schoolthe University of Texas at AustinAustinTXUSA Department of Neurosurgery Baylor College of MedicineTempleTXUSA

Neuron-astrocyte interactions are vital for the brain’s connectome.Understanding astrocyte activities is crucial for comprehending the complex neural network,particularly the population-level functions of neurons in different cortical states and associated behaviors in mammals.Studies on animal sleep and wakefulness have revealed distinct cortical synchrony patterns between neurons.Astrocytes,outnumbering neurons by nearly fivefold,support and regulate neuronal and synaptic function.Recent research on astrocyte activation during cortical state transitions has emphasized the influence of norepinephrine as a neurotransmitter and calcium waves as key components of ion channel signaling.This summary focuses on a few recent studies investigating astrocyte-neuron interactions in mouse models during sleep,wakefulness,and arousal levels,exploring the involvement of noradrenaline signaling,ion channels,and glutamatergic signaling in different cortical states.These findings highlight the significant impact of astrocytes on large-scale neuronal networks,influencing brain activity and responsiveness.Targeting astrocytic signaling pathways shows promise for treating sleep disorders and arousal dysregulation.More research is needed to understand astrocytic calcium signaling in different brain regions and its implications for dysregulated brain states,requiring future human studies to comprehensively investigate neuron-astrocyte interactions and pave the way for therapeutic interventions in sleep-and arousal-related disorders.

关键词： arousal astrocyte calcium waves locus coeruleus neuron-astrocyte interaction norepinephrine sleep wakefulness

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Oral anti-coagulants use in Chinese hospitalized patients with atrial fibrillation

引用

Chinese Medical Journal 2024年第2期137卷 172-180页

作者： Jing Lin Deyong Long Chenxi Jiang Caihua Sang Ribo Tang Songnan Li Wei Wang Xueyuan Guo Man Ning Zhaoqing Sun Na Yang Yongchen hao Jun Liu Jing Liu Xin Du Louise Morgan Gregg C.Fonarow Sidney C.Smith jr Gregory Y.h.Lip Dong Zhao Jianzeng Dong Changsheng Ma On behalf of CCC-AF investigators Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China National Clinical Research Center for Cardiovascular Diseases Beijing 100029 China Department of Epidemiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing 100029China International Quality Improvement Department American Heart AssociationDallasTX 07076USA Division of Cardiology Geffen School of Medicine at University of CaliforniaLos Angeles CA 90024USA Division of Cardiology University of North CarolinaChapel HillNC 27599USA Department of Cardiology Liverpool Centre for Cardiovascular ScienceUniversity of Liverpool and Liverpool Heart&Chest HospitalLiverpool L143PEUK Department of Clinical Medicine Aalborg UniversityAalborg 9000Denmark 不详

Background:Oral anti-coagulants(OAC)are the intervention for the prevention of stroke,which consistently improve clinical outcomes and survival among patients with atrial fibrillation(AF).The main purpose of this study is to identify problems in OAC utilization among hospitalized patients with AF in China.Methods:Using data from the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation(CCC-AF)registry,guideline-recommended OAC use in eligible patients was assessed.Results:A total of 52,530 patients with non-valvular AF were enrolled from February 2015 to December 2019,of whom 38,203 were at a high risk of stroke,9717 were at a moderate risk,and 4610 were at a low risk.On admission,only 20.0%(6075/30,420)of patients with a diagnosed AF and a high risk of stroke were taking OAC.The use of pre-hospital OAC on admission was associated with a lower risk of new-onset ischemic stroke/transient ischemic attack among the diagnosed AF population(adjusted odds ratio:0.54,95%confidence interval:0.43-0.68;Pharge,the prescription rate of OAC was 45.2%(16,757/37,087)in eligible patients with high stroke risk and 60.7%(2778/4578)in eligible patients with low stroke risk.OAC utilization in patients with high stroke risk on admission or at discharge both increased largely over time(all Phowed that OAC utilization at discharge was positively associated with in-hospital rhythm control strategies,including catheter ablation(adjusted odds ratio[OR]11.63,95%confidence interval[CI]10.04-13.47;Phythmic drug use(adjusted OR 1.45,95%CI 1.38-1.53;Phospitals participated in the CCC-AF project,>70%of AF patients were at a high risk of stroke.Although poor performance on guideline-recommended OAC use was found in this study,over time the CCC-AF project has made progress in stroke prevention in the Chinese AF population.Registration:ClinicalTrials.gov,NCT02309398.

关键词： Atrial fibrillation Oral anti-coagulants OAC Stroke prevention Contraindication

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

high-entropy oxide,(FeCoNiMnV)_(x)O,boost the oxygen evolution

ChemPhysMater

引用

ChemPhysMater 2024年第1期3卷 111-117页

作者： Chendong Kou Meiling Qin Wei Song Weijun Zhu Jieshu Zhou Christopher Dorma Momo jr hongyan Liang School of Materials Science and Engineering Tianjin UniversityTianjin 300350China CETC Deqing huaying Electronics Co. Ltd.China

The sluggish kinetics of the oxygen evolution reaction(OER),an essential half-reaction of water splitting,lead to high OER overpotential and low energy-conversion efficiency,hampering its industrial application.Therefore,considerable attention has been paid to the development of efficient catalysts to accelerate the OER.In this study,we synthesized the high-entropy oxides[(FeCoNiMnV)_(x)O]and used them as efficient OER catalysts.A simple oil-phase method was used to synthesize(FeCoNiMnV)_(x)O.The catalytic performances of the(FeCoNiMnV)_(x)O catalysts were modified by tuning the reaction temperature.The optimized(FeCoNiMnV)_(x)O catalyst exhibited multiple elemental interactions and abundant exposed active sites,leading to an overpotential of approximately 264 mV to reach a current density of 10 mA cm^(-2) in 1 M KOh and stability of 50 h at 1000 mA cm^(-2).Thus,a highly active OER catalyst was synthesized.This study provides an efficient approach for the synthesis of high-entropy oxides.

关键词： high-entropy oxides Solvothermal method Oxygen evolution reaction Water splitting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

长波紫外线使(新西兰黑·新西兰白)第一代杂交鼠的生存期延长及免疫功能增强

引用

国外医学（物理医学与康复学分册） 1989年第2期9卷 78-79页

作者： mcgrath h jr 葛洪友

紫外线是诱发或加重全身性红斑狼疮的因素之一。然而,紫外线的有害作用大部分由UV-B 所致。尽管UV-A 对免疫功能的影响尚未被阐明,但在动物实验中已发现UV-A 可能有免疫刺激作用,而UV-B 却引起免疫抑制。作者用(新西兰黑·新西兰白)第... 详细信息

紫外线是诱发或加重全身性红斑狼疮的因素之一。然而,紫外线的有害作用大部分由UV-B 所致。尽管UV-A 对免疫功能的影响尚未被阐明,但在动物实验中已发现UV-A 可能有免疫刺激作用,而UV-B 却引起免疫抑制。作者用(新西兰黑·新西兰白)第一代杂交鼠(下称NZB/NZW)的全身性红斑狼疮模型研究了UV-A 辐射对其生存期、免疫力及自身免疫功能的影响。

关键词：紫外线生存期延长免疫功能增加

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Functionally graded structure of a nitride-strengthened Mg_(2)Si-based hybrid composite

引用

Journal of Magnesium and Alloys 2024年第3期12卷 1239-1256页

作者： Jeongho Yang Woongbeom heogh hogi Ju Sukhyun Kang Tae-Sik Jang hyun-Do Jung Mohammad Jahazi Seung Chul han Seong Je Park hyoung Seop Kim Susmita Bose Amit Bandyopadhyay Martin Byung-Guk Jun Young Won Kim Dae-kyeom Kim Rigoberto CAdvincula Clodualdo Aranas jr Sang hoon Kim School of Mechanical Engineering Pusan National UniversityBusan 46241Republic of Korea Department of Mechanical Design Engineering Hanyang UniversitySeoul 04763Republic of Korea Process Research 3 Team LG Display Co.Ltd.PajuGyeonggi-do 10845Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju 61452Republic of Korea Institute of Well-Aging Medicare&Chosun University LAMP Center Chosun UniversityGwangju 61452Republic of Korea Division of Materials Science and Engineering Hanyang UniversitySeoul 04763Republic of Korea Department of Mechanical Engineering École de Technologie SupérieureMontrealQuebec H3C 1K3Canada Material&Component Convergence R&D Center Korea Construction Equipment Technology InstituteGunsanJeollabuk-do 54002Republic of Korea School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Graduate Institute of Ferrous&Eco Materials Technology Pohang University of Science and TechnologyPohangGyeongsangbuk-do 37673Republic of Korea Advanced Institute for Materials Research Tohoku UniversitySendai 980-8577Japan Institute for Convergence Research and Education in Advanced Technology Yonsei UniversitySeoul 03722Republic of Korea School of Mechanical and Materials Engineering Washington State UniversityPullmanWashington 99164USA School of Mechanical Engineering Purdue UniversityWest LafayetteIndiana 47907USA Research Institute of Advanced Manufacturing Technology Korea Institute of Industrial TechnologyIncheon 21999Republic of Korea Department of Macromolecular Science and Engineering Case Western Reserve UniversityClevelandOhio 44106USA Department of Chemical and Biomolecular Engineering and Joint Institute for Advanced Materials University of TennesseeKnoxvilleTennessee 37996USA Center for Nanophase Materials and Sciences Oak Ridge National LaboratoryOak RidgeTennessee 37830USA Department of Mechanical Engineering University of New BrunswickFrederictonNew Brunswick E3B 5A3Cana

The ex-situ incorporation of the secondary SiC reinforcement,along with the in-situ incorporation of the tertiary and quaternary Mg_(3)N_(2) and Si_(3)N_(4) phases,in the primary matrix of Mg_(2)Si is employed in order to provide ultimate wear resistance based on the laser-irradiation-induced inclusion of N_(2) gas during laser powder bed fusion.This is substantialized based on both the thermal diffusion-and chemical reactionbased metallurgy of the Mg_(2)Si–SiC/nitride hybrid composite.This study also proposes a functional platform for systematically modulating a functionally graded structure and modeling build-direction-dependent architectonics during additive manufacturing.This strategy enables the development of a compositional gradient from the center to the edge of each melt pool of the Mg_(2)Si–SiC/nitride hybrid composite.Consequently,the coefficient of friction of the hybrid composite exhibits a 309.3%decrease to–1.67 compared to–0.54 for the conventional nonreinforced Mg_(2)Si structure,while the tensile strength exhibits a 171.3%increase to 831.5 MPa compared to 485.3 MPa for the conventional structure.This outstanding mechanical behavior is due to the(1)the complementary and synergistic reinforcement effects of the SiC and nitride compounds,each of which possesses an intrinsically high hardness,and(2)the strong adhesion of these compounds to the Mg_(2)Si matrix despite their small sizes and low concentrations.

关键词： Laser powder bed fusion Mg_(2)Si-SiC/nitride hybrid composite Both the thermal diffusion-and chemical reaction-based metallurgy Functionally graded structure Compositional gradient Wear resistance.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecular Docking Studies on Streptomycin Antileishmanial Activity

引用

Open Journal of Physical Chemistry 2024年第2期14卷 36-48页

作者： Todd A. Young Matthew George jr. Ayele Gugssa William M. Southerland Yayin Fang Clarence M. Lee Department of Biology Howard University Washington DC United States Department of Biochemistry and Molecular Biology Howard University Washington DC United States

Resistance to pentavalent antimonial drugs and the lack of vaccines make it urgent to find novel therapeutic options to treat Leishmaniasis, a tropical disease caused by the Leishmania protozoan parasite. The study reported here is to investigate if Streptomycin, an aminoglycoside, and Amphotericin B, the second-line treatment drug, exhibit antileishmanial activity through a similar mechanism. By using MOE (Molecular Operating Environment), we performed molecular docking studies on these drugs binding to a range of targets including ribosome targets in Leishmania and h. sapiens. Our study shows that the two drugs do not bind to the same pockets in Leishmania targets but to the same pockets in the human ribosome, with some differences in interactions. Moreover, our 2D maps indicated that Amphotericin B binds to the A-site in the human cytoplasmic ribosome, whereas streptomycin does not.

关键词： Leishmaniasis Streptomycin Amphotericin B Molecular Docking Aminoglycosides Antileishmanial

来源：

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

解读《史记·晋世家》和司马迁的“春秋”

引用

渭南师范学院学报 2024年第6期39卷 25-35页

作者：倪豪士刘城(译) 刘桂兰(译) 威斯康星大学麦迪逊分校亚洲语言文化系美国麦迪逊53711 广西民族大学文学院南宁530023 湖北大学外国语学院武汉430062

在《史记·晋世家》的编撰中,司马迁自由支配和运用着《春秋》三传。司马迁主要依靠《左传》,但在试图重述某些事件时,常常会综合参考《春秋》三传,其中一些文本重述融合了两种或两种以上的《春秋》经传。这种文本重述通常涉及缩写原文... 详细信息

在《史记·晋世家》的编撰中,司马迁自由支配和运用着《春秋》三传。司马迁主要依靠《左传》,但在试图重述某些事件时,常常会综合参考《春秋》三传,其中一些文本重述融合了两种或两种以上的《春秋》经传。这种文本重述通常涉及缩写原文,但有时似乎不够细致,以致于《史记》相关记载的语意表达会模糊不清。由此推测,在《史记》的编撰过程中,有助理或抄写员参与其中。另外,司马迁的时代并没有现代意义上的所谓“文本”,而只有口述传统和各种不便携带的书写载录(在丝绸或竹简上),司马迁所理解的“春秋”就是他所研习、记诵并阅读的与经典文本《春秋》相关的所有书面和口述文献。

关键词：《史记》《晋世家》司马迁《春秋》

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ground-state mass of ^(22)Al and test of state-of-the-art ab initio calculations

引用

Chinese Physics C 2024年第3期48卷 72-78页

作者：孙铭泽于越王新鹏王猛李健国张玉虎 K.Blaum 陈祖毅陈瑞九邓涵宇付超义葛文文黄文嘉焦红扬李红蕙李宏福罗胤芳廖挺 YuALitvinov 司敏帅鹏史金阳王茜邢元明徐星徐瑚珊许甫荣袁琪 T.Yamaguchi 颜鑫亮杨建成原有进周小红周旭张敏曾奇 CAS Key Laboratory of high Precision Nuclear Spectroscopy Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Max-Planck-Institut für Kernphysik Saupfercheckweg 169117 HeidelbergGermany GSI helmholtzzentrum für Schwerionenforschung Planckstraße 164291 DarmstadtGermany Advanced Energy Science and Technology Guangdong Laboratory Huizhou516007China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Department of Physics Saitama UniversitySaitama 338-8570Japan School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

The ground-state mass excess of the T_(z)=−2 drip-line nucleus ^(22)Al is measured for the first time as 18103(10)keV using the newly-developed Bρ-defined isochronous mass spectrometry method at the cooler storage ring in Lanzhou.The new mass excess value allowed us to determine the excitation energies of the two low-lying 1+states in ^(22)Al with significantly reduced uncertainties of 51 keV.When compared to the analogue states in its mirror nucleus ^(22)F,the mirror energy differences of the two 1^(+)states in the ^(22)Al-^(22)F mirror pair are determined to be−625(51)keV and−330(51)keV.The excitation energies and mirror energy differences are used to test the state-of-the-art ab initio valence-space in-medium similarity renormalization group calculations with four sets of interactions derived from the chiral effective field theory.The mechanism leading to the large mirror energy differences is investigated and attributed to the occupation of theπs_(1/2) orbital.

关键词： nuclear mass Bρ-defined IMS mirror energy difference ab initio VS-IMSRG calculations chiral interactions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CD40 interacts directly with RAG1 and RAG2 in autoaggressive T cells and Fas prevents CD40-induced RAG expression

引用

Cellular & Molecular Immunology 2013年第6期10卷 483-489页

作者： Gisela M Vaitaitis David h Wagner jr Department of Medicine and Webb-Waring Center University of Colorado Denver Aurora CO USA

CD4＋ T cells expressing CD40 （Th40 cells） constitute a pathogenic T-cell subset that is necessary and sufficient to transfer autoimmune disease. We have previously demonstrated that CD40 signals peripheral Th40 cells to induce RAG1 and RAG2 expression, proteins necessary for the expression of T-cell receptor （TCR）, leading to TCR revision. The dependency of TCR expression in the thymus on RAG proteins has long been known. however, despite numerous publications, there is controversy as to whether TCR expression can be altered in the periphery, post-thymic selective pressures. Therefore, a better understanding of TCR expression in primary peripheral cells is needed. We now show that the CD40 protein itself interacts with RAG1 and RAG2 as well as with Ku70 and translocates to the nucleus in Th40 cells. This indicates that the CD40 molecule is closely involved in the mechanism of TCR expression in the periphery. In addition, Fas signals act as a silencing mechanism for CD40-induced RAGs and prevent CD40 translocation to the nucleus. It will be important to further understand the involvement of CD40 in peripheral TCR expression and how TCR revision impacts auto-antigen recognition in order to effectively target and tolerize autoaggressive T cells in autoimmune disease.

关键词： autoimmunity CD40 Fas RAG T-cell receptor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：