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Apoli.oprotei. A-i.bi.di.g protei.-medi.ted neuroprotecti.n i. glaucomatous neuroi.flammati.n and neurodegenerati.n

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Neural Regenerati.n Research 2025年第5期20卷 1414-1415页

作者： Si.woo Hwang Seunghwan Choi.Soo-Ho Choi.Keun-Young Ki. Yury i.Mi.ler Won-Kyu Ju Hami.ton Glaucoma Center and Shi.ey Eye i.sti.ute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medi.i.e University of California San DiegoLa JollaCAUSA Nati.nal Center for Mi.roscopy and i.agi.g Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma i. a multi.actori.l eye di.order that can cause vi.i.n loss and i.reversi.le bli.dness,affecti.g i.di.i. uals aged 40 to 80 yea rs *** to the agi.g populati.n,i. i. expected that the number of people affected by glaucoma wi.l surpass 111 mi.li.n by 2040 as the di.ease becomes more *** pri.ari.y contri.utes to opti. nerve axon loss and the progressi.e degenerati.n of reti.al gangli.n cells (RGCs),subsequently leadi.g to vi.i.n i.pai.ment.

关键词： i.reversi.le pass pri.ari.y

Photoproducti.n of mesons off the deuteron:quasi.ree and coherent processes

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Chi.ese Physi.s C 2009年第12期33卷 1340-1344页

作者： i. Jaeglé Departmement of Physi.s University of Basel CH-4056 Basel Switzerland

Photoproducti.n of mesons off the deuteron has been i.vesti.ated at a tagged photon beam of the Bonn ELSA accelerator wi.h the combi.ed Crystal Barrel - TAPS electromagneti. calori.eter for i.ci.ent photon energi.s up to 2.5 GeV. The mesons have been detected i. coi.ci.ence wi.h recoi. protons, neutrons and deuterons. Thi. allow the measurement of meson producti.n reacti.ns off the quasi.ree nucleons bound i. the deutron, as well as the coherent producti.n off the deuteron. The compari.on of quasi.ree proton reacti.ns to free proton reacti.ns can confi.m or i.vali.ate possi.le nuclear effects on the extracted cross secti.n reacti.ns. Furthermore the i.ospi. composi.i.n of a resonance can be esti.ated from the compari.on of quasi.ree proton and neutron reacti.ns. The quasi.ree photoproducti.n of the η＇ and π°η mesons off nucleons and the coherent photoproducti.n of π°η--pai.s off the deuteron are di.cussed.

关键词： quasi.ree coherent photoproducti.n η' π°η neutron proton deuteron

Machi.es as readers: A soluti.n to the copyri.ht problem

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Journal of Zheji.ng Uni.ersi.y-Sci.nce A(Appli.d Physi.s & Engi.eeri.g) 2005年第11期6卷 1179-1187页

作者： SHAMOS Mi.hael i. School of Computer Sci.nce Carnegie Mellon University Pittsburgh PA 15213 USA Department of Computer Science University of Hong Kong Hong Kong China

Copyri.ht and i.s i.ternati.nal compli.ati.ns have presented a si.ni.i.ant barri.r to the Uni.ersal Di.i.al Li.rary （UDL）＇s mi.si.n to di.i.i.e all the publi.hed works of manki.d and make them avai.able throughout the world. We di.cuss the effect of exi.ti.g copyri.ht treati.s and vari.us proposals, such as compulsory li.ensi.g and the publi. lendi.g fi.ht that would allow access to copyri.hted works wi.hout requi.i.g permi.si.n of thei. owners. We argue that these schemes are i.effecti.e for purposes of the UDL. i.stead, maki.g use of the i.ternati.nal consensus that copyri.ht does not protect facts, i.formati.n or processes, we propose to scan works di.i.ally to extract thei. i.tellectual content, and then generate by machi.e syntheti. works that capture thi. content, and then translate the generated works automati.ally i.to multi.le languages and di.tri.ute them free of copyri.ht restri.ti.n.

关键词： Uni.ersal Di.i.al Li.rary (UDL) Copyri.ht Di.i.al ri.hts management Compulsory li.ense Berne conventi.n Publi. lendi.g ri.ht Syntheti. documents Machi.e translati.n

Si.ulati.n Envi.onments: Challenges for Advancement

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Journal of Systems Engi.eeri.g and Electroni.s 1993年第4期4卷 12-24页

作者： Tuncer i.ren Department of Computer Sci.nce University of OttawaOttawaOn KIN 6N5.Canada

A bri.f revi.w of the basi. termi.ology on si.ulati.n, si.ulati.n li.e-cycle acti.i.i.s such as model-based acti.i.i.s, behavi.r-ori.nted acti.i.i.s, and quali.y assurance acti.i.i.s i. gi.en. Then, the challenges and opportuni.i.s for the advancement of the state-of-the-art i. si.ulati.n envi.onments are di.cussed under the followi.g headi.gs: modelli.g envi.onments, si.ulati.n envi.onments, mi.ed si.ulati.n envi.onments, and comprehensi.e si.ulati.n envi.onments.

关键词： Modelli.g envi.onments Si.ulati.n envi.onments Mi.ed si.ulati.n envi.onments Comprehensi.e si.ulati.n envi.onments.

i.pact of Drai. Effluent on Surfi.i.l Sedi.ents i. the Medi.erranean Coastal Wetland: Sedi.entologi.al Characteri.ti.s and Metal Polluti.n Status at Lake Manzala, Egypt

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Journal of Ocean Uni.ersi.y of Chi.a 2019年第4期18卷 834-848页

作者： FARHAT Hassan i. Geology Department Faculty of Science Suez University

Surface sedi.ents were collected from Lake Manzala, the Medi.erranean coastal wetland located to the east of the Ni.e Delta, Egypt, to assess the effect of drai. effluent on the spati.l vari.ti.ns of sedi.entary characteri.ti.s and heavy metal polluti.n. Grai.-si.e composi.i.ns, textures, and heavy metal di.tri.uti.n patterns i. sedi.ents are presented usi.g Gi. techni.ue. Results of the analysi. of the sedi.ent showed a clear effect of drai. effluent, wi.h an i.crease i. fi.e fracti.ns and homogeneous suspensi.ns i. transportati.n mode. Lake sedi.ents were domi.ated by sandy mud textures, and mode of transportati.n was homogeneous sus- pensi.n and rolli.g. Spati.l di.tri.uti.n of heavy metals (Fe, Mn, Zn, Cu, Ni. Cr, and Pb) was studi.d i. the lake’s surfi.i.l sedi.ents, along wi.h thei. relati.nshi. to drai. effluent and thei. contami.ati.n status i. the ecologi.al system. Heavy metal polluti.n status was assessed by means of accepted sedi.ent quali.y gui.eli.es and contami.ati.n assessment methods (contami.ati.n factor, con- tami.ati.n degree, modi.i.d contami.ati.n degree, geo-accumulati.n, and enri.hment factor). Among the determi.ed heavy metals, Pb had the most ecologi.al ri.k. Generally, the heavy metals i. the surface sedi.ents i.di.ated polluti.n ri.k rangi.g from moderate to consi.erable, parti.ularly, i. those si.es faci.g drai.s and i.lets that had the hi.hest toxi. effluent. The results were i.terpreted by stati.ti.al means. A cluster analysi. defi.ed areas faci.g drai. di.charge and i.lets as separated groups. ANOVA i.di.ated that most of the sedi.entati.n and studi.d metals di.ected thi. clusteri.g.

关键词： Lake Manzala Medi.erranean wetland metal polluti.n sedi.entologi.al characteri.ti.s

＂Could charm （＆ τ） transi.i.ns be the ＇poor pri.cess＇ provi.i.g a deeper understandi.g of fundamental dynami.s ？＂ or：＂Fi.di.g novel forces＂

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Fronti.rs of physi.s 2015年第3期10卷 1-28页

作者： i.aros i. Bi.i Department of Physi.s University of Notre Dame du Lac Notre Dame IN 46556 USA

We know that our Uni.erse i. composed of only - 4.5% ＂known＂ matter; therefore, our understandi.g i. i.complete. Thi. can be seen di.ectly i. the case of neutri.o osci.lati.ns （wi.hout even consi.eri.g potenti.l other uni.erses）. Charm quarks have had consi.erable i.pact on our under- standi.g of known matter, and quantum chromodynami.s （QCD） i. the only local quantum fi.ld theory to descri.e strong forces. i. i. possi.le to learn novel lessons concerni.g strong dynami.s by measuri.g rates around the thresholds of [Q^-Q] states wi.h Q = b, c. Furthermore, these states provi.e us wi.h gateways towards new dynami.s （ND）, where we must transi.i.n from ＂accuracy＂ to ＂preci.i.n＂ eras. Fi.ally, we can make connecti.ns wi.h τ transi.i.ns and, perhaps, wi.h dark matter. Charm dynami.s acts as a bri.ge between the worlds of li.ht- and heavy-flavor hadrons （namely, beauty hadrons）, and fi.di.g regi.nal asymmetri.s i. many-body fi.al states may prove to be a ＂game changer＂. There are several di.ferent approaches to achi.vi.g these goals： for exam- ple, experi.ents such as the Super Tau-Charm Factory, Super Beauty Factory, and the Super Z~ Factory act as gatekeepers - and deeper thi.ki.g regardi.g symmetri.s.

关键词： CKM matri. HQE & OPE CPV i. △C≠ 0 ≠ △B &τ decays

Evaluati.n of FEMA-440 for i.cludi.g soi.-structure i.teracti.n

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Earthquake Engi.eeri.g and Engi.eeri.g Vi.rati.n 2010年第3期9卷 397-408页

作者： Khoshnoudi.n F. Behmanesh i. Faculty of Ci.i. Engi.eeri.g Amirkabir University of Technology Faculty of Ci.i. and Envi.onmental Engi.eeri.g Tufts University

Replaci.g the enti.e soi.-structure system wi.h a fi.ed base osci.lator to consi.er the effect of soi.-structure i.teracti.n （SSi. i. a common analysi. method i. sei.mi. desi.n. Thi. techni.ue has been i.cluded i. desi.n procedures such as NEHRP, ASCE, etc. by defi.i.g an equi.alent fundamental peri.d and dampi.g rati. that can modi.y the response of the structure. However, recent studi.s i.di.ate that the effects of SSi.should be reconsi.ered when a structure undergoes a nonli.ear di.placement demand. i. recent documents on Nonli.ear Stati. Procedures （NSPs）, FEMA-440 （2005）, a modi.i.d dampi.g rati. of the replacement osci.lator was proposed by i.troduci.g the ducti.i.y of the soi.-structure system obtai.ed from pushover analysi.. i. thi. paper, the dampi.g defi.ed i. FEMA-440 to i.clude the soi.-structure i.teracti.n effect i. evaluated, and the accuracy of the Coeffi.i.nt Method gi.en i. FEMA-440 and the Equi.alent Li.eari.ati.n Method i. studi.d. Although the i.provements for Nonli.ear Stati. Procedures （NSPs） i. FEMA-440 are achi.ved for a fi.ed base SDOF structure, the soi. effects are not perfectly obtai.ed. Furthermore, the dampi.g defi.i.i.n of a soi.-structure system i. extended to structures to consi.er bi.i.ear behavi.r.

关键词： soi.-structure i.teracti.n foundati.n dampi.g i.elasti. behavi.r equi.alent li.eari.ati.n

i.teracti.n of the Arabi.opsi. UV-B-Speci.i. Si.nali.g Component UVR8 wi.h Chromati.

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Molecular Plant 2008年第1期1卷 118-128页

作者： Catheri.e Cloi. Gareth i. Jenki.s Plant Sci.nce Group Division of Biochemistry and Molecular Biology Institute of Biomedical and Life Sciences Bower Building University of GlasgowGlasgow G12 BQQ UK

Arabi.opsi. UV RESi.TANCE LOCUS8 （UVR8） i. a UV-B-speci.i. si.nali.g component that regulates expressi.n of a range of genes concerned wi.h UV protecti.n. Here, we i.vesti.ate the i.teracti.n of UVR8 wi.h chromati.. Usi.g anti.odi.s speci.i. to UVR8 i. chromati. i.munopreci.i.ati.n （Chi.） assays wi.h wi.d-type plants, we show that nati.e UVR8 bi.ds to chromati. i. vi.o. Si.i.ar experi.ents usi.g an anti.GFP anti.ody wi.h plants expressi.g a GFP-UVR8 fusi.n show that UVR8 associ.tes wi.h a relati.ely small regi.n of chromati. contai.i.g the HY5 gene. UVR8 i.teracts wi.h chromati. contai.i.g the promoter regi.ns of other genes, but not wi.h all the genes i. regulates. UV-B i. not requi.ed for the i.teracti.n of UVR8 wi.h chromati. because associ.ti.n wi.h several gene loci.i. observed i. the absence of UV-B. Pulldown assays demonstrate that UVR8 associ.tes wi.h hi.tones i. vi.o and competi.i.n experi.ents i.di.ate that the i.teracti.n i. preferenti.lly wi.h hi.tone H2B. Chi. experi.ents usi.g anti.odi.s that recogni.e speci.i. hi.tone modi.i.ati.ns i.di.ate that the UV-B-sti.ulated transcri.ti.n of some genes may be correlated wi.h hi.tone modi.i.ati.n. i. parti.ular, the ELi.1 promoter showed a si.ni.i.ant enri.hment of di.cetyl hi.tone H3 （K9/K14） followi.g UV-B exposure. These fi.di.gs i.crease understandi.g of the i.teracti.n of the key UV-B-speci.i. regulator UVR8 wi.h chromati..

关键词： .Wi.d-type Regulates i.teracts Hi.tones Arabi.opsi. UV Si.nali.g Component UVR i.teracti.n of UVR nati.e UVR anti.GFP UVR associ.tes chromati. contai.i.g

Thermal analysi. of annular fi.s wi.h temperature-dependent thermal properti.s

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Appli.d Mathemati.s and Mechani.s(Engli.h Edi.i.n) 2013年第11期34卷 1349-1360页

作者： i. G. AKSOY Department of Mechani.al Engi.eeri.g Inonu University

The thermal analysi. of the annular rectangular profi.e fi.s wi.h vari.ble thermal properti.s i. i.vesti.ated by usi.g the homotopy analysi. method （HAM）. The thermal conducti.i.y and heat transfer coeffi.i.nt are assumed to vary wi.h a li.ear and power-law functi.n of temperature, respecti.ely. The effects of the thermal-geometri. fi. parameter and the thermal conducti.i.y parameter vari.ti.ns on the temperature di.tri.uti.n and fi. effi.i.ncy are i.vesti.ated for di.ferent heat transfer modes. Results from the HAM are compared wi.h numeri.al results of the fi.i.e di.ference method （FDM）. i. can be seen that the vari.ti.n of di.ensi.nless parameters has a si.ni.i.ant effect on the temperature di.tri.uti.n and fi. effi.i.ncy.

关键词： annular fi. vari.ble thermal property homotopy analysi. method