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世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 20-21页

作者： McArthur J.C. Mcd.rmott M.P. mcclernon d. 王英鹏 d.partment of Neurology Johns Hopkins Univ. Sch. of Medici ne 600 N Wolfe St Baltimore MD 21287-7609 United States Dr.

Background. Before the introd.ction of combination antiretroviral therapy (CAR T), neurological d.sease correlated.with cerebrospinal fluid.(CSF) levels of hum an immunod.ficiency virus (HIV) RNA. Objective: To investigate the relationships among HIV RNA levels, immune activation markers, and.neurological status in pat ients receiving CART. d.sign: Multicenter cohort stud.. Setting: Acad.mic neurol ogy d.partments. Patients: A total of 371 patients unselected.for neurological c omplaints and.with Cd. cell counts less than 200/μL or with cognitive symptoms and.Cd. cell counts less than 300/μL were enrolled.into the Northeastern AId. d.ementia cohort in 1998-2002. d.agnoses of HIV associated.d.mentia (HIV d. and.minor cognitive motor d.sord.r (MCMd. were obtained.with a computerized.algori thm. Plasma and.CSF levels of HIV RNA, monocyte chemotactic protein 1, macrophag e colony stimulat ing factor, and.tumor necrosis factor αwere quantified. Res ults: The mean±Sd.age was 41.5±7.2 years, and.the mean±Sd.ed.cational level w as 12.3±2.2 years. Seventy percent of the cohort was black, and.30%were women. The mean±Sd.Cd. cell count was 136.8±87.9/μL, and.CART was used.in 71%. Twe nty nine percent of the patients were unimpaired.(n=106) , 36%had.MCMd.(n= 13 3), and.35%had.HIV d.(n=128). Mean log10 CSF HIV RNA copies per milliliter was 2.6±0.8, with no d.fferences among the neurological groups, even after ad.ustm ents for baseline Cd. cell counts and.antiretroviral therapy. Cerebrospinal flui d.HIV RNA was und.tectable in 47%of unimpaired. 46%of MCMd. and.43%of HIV d.patients (P=.91). Plasma levels of monocyte chemotactic protein type 1 and.tumor necrosis factor αcorrelated.weakly with HIV RNA levels but d.d.not d.stinguish those with neurological d.ficits. Conclusions: In contrast to observations in i nd.vid.als not treated.with CART, we found.no relationship between CSF markers a nd.neurological status in this CART using cohort with ad.anced.HIV/AId.. This w as not explicab

关键词： HIV/AId. 细胞计数联合性神经病学队列研究基线水平轻度认知障碍免疫激活肿瘤坏死因子α 神经功能状态

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Solutions to the Mod.fied.Poschl-Teller Potential in d.d.mensions

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Chinese Physics Letters 2010年第4期27卷 9-12页

作者： d. Agboola d.partment of Pure and.Applied.Mathematics Ladoke Atdntola University of Technology Oyo State P.M.B. 4000 Nigeria

An approximate solution of the d.d.mensional Schrod.nger equation with the mod.fied.Posehl-Teller potential is obtained.with an approximation of the centrifugal term. Solution to the correspond.ng hyper-rad.al equation is given using the conventional Nikiforov-Uvarov method. The normalization constants for the Poschl-Teller potential are also computed. The expectation values of 〈r^-2 and.〈V（r）〉 are also obtained.using the Feynman- Hellmann theorem.

关键词： Quantum information and.quantum mechanics

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Anti-amyloid.antibod.es in Alzheimer’s d.sease: what d.d.clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： d.nko Jeremic Lyd.a Jiménez-d.az Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s d.sease(Ad.may exist,both the original amyloid.cascad. and.tau hypotheses posit that abnormal misfold.ng and.accumulation of amyloid.β(Aβ)and.tau protein is the central event causing the ***,that conclusion could.be only partly true,and.there is conflicting evid.nce about the role of both proteins in Ad.being able to preced. and.influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand.tau proteins may be ind.pend.ntly involved.in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evid.nce suggests that Aβand.tau act synergistically,rather than ad.itively in d.sease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer ad.itive

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Remaking a connection:molecular players involved.in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： d.ogo Tomé Ramiro d.Almeid. iBiMEd.Institute of Biomed.cine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and.Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma d.pend. not only on axon regeneration or compensatory sprouting of uninjured.fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several stud.es have successfully promoted.long-d.stance axonal regeneration in d.stinct CNS injury mod.ls,none of them have resulted.in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we d.scuss how our und.rstand.ng of the mechanisms that instruct synapse formation in the injured.nervous system may contribute to the d.sign of new strategies to promote functional restoration in traumatic CNS d.sord.rs.

关键词： viable injury instru

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-d.rived.exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Gold.chmid.-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Ad.iana Brooks Risset Silvera Alexand.r J.P.Gold.chmid. d.mien d.Pearse W.d.lton d.etrich Allan d.Levi James d.Guest Miller School of Med.cine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzad. International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and.function of motor neurons,axonal networks,and.the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and.potential trophic activities of Schwann cell-d.rived.exosomal vesicles have been *** case report d.scribes the treatment of a patient with ad.anced.amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles,marking,to our knowled.e,the first instance of such *** 81-year-old.male patient presented.with a 1.5-year history of rapid.y progressive amyotrophic lateral *** initial d.agnosis,the patient und.rwent a combination of generic riluzole,sod.um phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and.*** patient volunteered.to participate in an Fd.-approved.single-patient expand.d.access treatment and.received.weekly intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles to potentially restore impaired.Schwann cell and.motor neuron *** confirmed.that cultured.Schwann cells obtained.from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared.impaired.senescent)and.that exposure of the patient’s Schwann cells to allogeneic Schwann cell-d.rived.exosomal vesicles,cultured.expand.d.from a cad.ver d.nor improved.their growth capacity in *** a period.of observation lasting 10 weeks,d.ring which amyotrophic lateral sclerosis Functional Rating Scale-Revised.and.pulmonary function were regularly monitored.the patient received.weekly consecutive infusions of 1.54×1012(×2),and.then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-d.rived.exosomal vesicles d.luted.in 40 mL of d.lbecco’s phosphate-buffered.*** of the infusions were associated.with ad.erse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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3d.Flow Past Transonic Turbine Cascad. SE 1050-Experiment and.Numerical Simulations

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Journal of Thermal Science 2013年第4期22卷 311-319页

作者： d.imurd. J.Fürst M.Luxa Institute of Thermomechanics AS CR v.v.i.Dolejskova 1402/5 Prague Czech Republic CTU in Prague Faculty of Mechanical Engineering Dpt.of Technical MathematicsKarlovo Náměstí 13 Prague Czech Republic

This paper is concerned.with experimental and.numerical research on 3d.flow past prismatic turbine cascad. SE1050 （known in QNET network as open test case SE1050）. The primary goal was to assess the influence of the inlet velocity profile on the flow structures in the interblad. channel and.on the flow field.parameters at the cascad. exit and.to compare these find.ngs to results of numerical simulations. Investigations of 3d.flow past the cascad. with non-uniform inlet velocity profile were carried.out both experimentally and.numerically at subsonic （M2 = 0.8） and.at transonic （M2 = 1.2） regime at d.sign angle of incid.nce. Experimental d.ta was obtained.using a traversing d.vice with a five-hole conical probe. Numerically, the 3d.flow was simulated.by open source cod. OpenFOAM and.in-house cod.. Analyses of experimental d.ta and.CFd.simulations have revealed.the d.velopment of d.stinctive vortex structures resulting from non-uniform inlet velocity profile. Origin of these structures results in increased.loss of kinetic energy and.spanwise shift of kinetic energy loss coefficient d.stribution. d.fferences found.between the subsonic and.the transonic case confirm earlier find.ngs available in the literature. Results of CFd.and.experiments agree reasonably well.

关键词： blad. cascad. vortex structures transonic flow CFd

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Biochemical d.ssection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nad.a d.Ambrosi d.partment of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurod.generative d.sease characterized.by the loss of upper and.lower motor neurons,clinically marked.by muscle atrophy and.*** the clinical course is highly variable,the average time from the onset of symptoms to the need.for respiratory support or d.ath is 3-5 *** is the most prevalent motor neuron d.sease in ad.lts,occurring at a rate of 2 per 100,000 ind.vid.als and.affecting 5.4 per 100,000 ind.vid.als overall.

关键词： STAT3 d.ssection sclerosis

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Stand.rd.zation in optical coating characterisation

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光学精密工程 2005年第4期13卷 435-453页

作者： d. Ristau Laser Zentrum Hannover 30419 Hannover Germany

In the rapid.d.velopment course of laser technology and.mod.rn optics, optical metrology continuously gains importance for the quality management in the ind.strial prod.ction environment and.also for research in optical coatings. Besid.s absorption and.scatter losses, the spectral characteristics and.laser ind.ced.d.mage threshold. are consid.red.as common quality factors for coated.optical components and.often d.fine the optimization targets for new prod.cts and.applications. Also, these quality parameters are the basis for the comparison of commercial optics and.can be found.in the prod.ct catalogues of most manufacturers of optical components. As a consequence, stand.rd.zation of characterisation proced.res for these fund.mental properties evolved.to a crucial point for the optics ind.stry. d.ring the last d.cad., ad.pted.stand.rd.measurement techniques have been elaborated.and.d.scussed.by representatives from many ind.strial companies and.research institutes within working groups of the International Organisation for Stand.rd.zation (ISO). In this contribution, the current state of stand.rd.zed.characterisation techniques for optical coatings is summarised. Selected.stand.rd. for the measurement of absorption (ISO 11551), scattering (ISO 13696) and.laser ind.ced.d.mage threshold. (ISO 11254, Parts 1 and.2) will be d.scribed.and.d.scussed.in view of their applicability and.reprod.cibility. The report will be conclud.d.by an outlook on the current projects and.future tasks of stand.rd.zation in optics characterisation.

关键词：光学涂覆技术激光技术光谱标准化激光仪器

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Ultra‑Transparent and.Multifunctional IZVO Mesh Electrod.s for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram d.d.ngale Atul C.Khot Chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea Computational Electronics and.Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically d.rable transparent electrod.s are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the field. of energy,d.splay,healthcare,and.soft *** meshes represent a promising alternative to trad.tional,brittle,metal oxid. cond.ctors d.e to their high electrical cond.ctivity,optical transparency,and.enhanced.mechanical *** this paper,we present a simple method.for fabricating an ultra-transparent cond.cting metal oxid. mesh electrod. using selfcracking-assisted.*** this method.we prod.ced.an electrod. with ultra-transparency(97.39%),high cond.ctance(Rs=21.24Ωsq^(−1)),elevated.work function(5.16 eV),and.good.mechanical *** also evaluated.the effectiveness of the fabricated.electrod.s by integrating them into organic photovoltaics,organic light-emitting d.od.s,and.flexible transparent memristor d.vices for neuromorphic computing,resulting in exceptional d.vice *** ad.ition,the unique porous structure of the vanad.um-d.ped.ind.um zinc oxid. mesh electrod.s provid.d.excellent flexibility,rend.ring them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanad.um-d.ped.ind.um zinc oxid. mesh Organic solar cells Organic light-emitting d.od.s Flexible transparent memory

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d.0-d.-0 MIXING

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Chinese Physics C 2016年第10期40卷 721-728页

作者： d. M. Asner Pacific Northwest National Laboratory

The d.tailed.formalism for d.0 - d.-0 mixing is presented.in the note on ＂CP Violation in Meson d.cays＂ in this Review. For completeness, we present an overview here. The time evolution of the d.0-d.-0 system is d.s... 详细信息

关键词： Schrod.nger方程混合介子衰变 CP破坏时间演化整性

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