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设计 2013年第1期26卷 142-147页

作者： msright mcbride charles ryan John Gollings Trevor Mein

一个数学名词会和一座建筑产生怎样的关系？当你看到KLEIN BOTTLE HOUSE后，便会恍然大悟，KLEIN BOTTLE HOUSE不仅仅是利用了KLEIN BOTTL这个数学名词，

关键词：建筑变形 KLEIN HOUSE 数学名词

符号的魅力墨尔本Penleigh and Essendon文法学校高中校区

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室内设计与装修 2013年第7期 40-45页

作者： mcbride charles ryan 和维

澳大利亚的设计师mcbridecharlesryan曾以克莱因瓶这个数学概念设计了以此为名的别墅，得到业界的一致好评，也让人们对数学与建筑的结合有了新的认识。而此次，他又带领自己的设计团队以数学领域中的另一个概念——“无穷大”为主题设... 详细信息

澳大利亚的设计师mcbridecharlesryan曾以克莱因瓶这个数学概念设计了以此为名的别墅，得到业界的一致好评，也让人们对数学与建筑的结合有了新的认识。而此次，他又带领自己的设计团队以数学领域中的另一个概念——“无穷大”为主题设计了PenleighandEssendon文法学校（以下简称PEGS）的高中新校区。

关键词：新校区高中学校墨尔本概念设计克莱因瓶澳大利亚主题设计

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云中曲墨尔本云屋

室内设计与装修 2013年第10期 80-83页

作者： mcbride charles ryan 时颜

本案位于澳大利亚的菲茨罗伊，是一座建成于爱德华七世时期的房子，在过去的一个世纪内，这座老建筑已经过多次维修和改建。而最近的这次改建，让这里焕然一新。

关键词：墨尔本澳大利亚老建筑改建房子

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“克莱因”住宅

建筑技艺 2010年第6期16卷 92-95页

作者： mcbride charles ryan(Rob mcbride & Debbie-Lyn ryan) John Gollings 李昭君

克莱因瓶（Klein Bottle）是数学名词，意思是把圆柱体两端黏合在一起，读者不妨想像一下扭曲的麦芽糖吧，这种立体环面空间是一种没有内外之分、没有定向性的平面，建筑师的意图就是要模糊建筑体“内部表面”和“外部表面”的概念，给... 详细信息

克莱因瓶（Klein Bottle）是数学名词，意思是把圆柱体两端黏合在一起，读者不妨想像一下扭曲的麦芽糖吧，这种立体环面空间是一种没有内外之分、没有定向性的平面，建筑师的意图就是要模糊建筑体“内部表面”和“外部表面”的概念，给人一种置身异次元世界的感觉。

关键词：克莱因瓶住宅数学名词建筑师圆柱体麦芽糖定向性表面

Aging impairs the osteocytic regulation of collagen integrity and bone quality

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Bone Research 2024年第1期12卷 78-94页

作者： charles A.Schurman Serra Kaya Neha Dole Nadja M.Maldonado Luna Natalia Castillo ryan Potter Jacob P.Rose Joanna Bons Christina D.King Jordan B.Burton Birgit Schilling Simon Melov Simon Tang Eric Schaible Tamara Alliston Department of Orthopaedic Surgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley/UCSF Graduate Program in Bioengineering San FranciscoCA 94143USA Buck Institute for Research on Aging NovatoCA 94945USA Washington University in St Louis Department of OrthopedicsSt.LouisMO 63130USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor bone quality is a major factor in skeletal fragility in elderly *** molecular mechanisms that establish and maintain bone quality,independent of bone mass,are unknown but are thought to be primarily determined by *** hypothesize that the age-related decline in bone quality results from the suppression of osteocyte perilacunar/canalicular remodeling(PLR),which maintains bone material *** examined bones from young and aged mice with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses *** control aged bone displayed decreased TGFβsignaling and PLR,but aging did not worsen the existing PLR suppression in male TβRII^(ocy−/−)*** relationship impacted the behavior of collagen material at the nanoscale and tissue scale in macromechanical *** effects of age on bone mass,density,and mineral material behavior were independent of osteocytic TGFβ.We determined that the decline in bone quality with age arises from the loss of osteocyte function and the loss of TGFβ-dependent maintenance of collagen integrity.

关键词： maintain primarily integrity

The secondary injury cascade after spinal cord injury:an analysis of local cytokine/chemokine regulation

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Neural Regeneration Research 2024年第6期19卷 1308-1317页

作者： Daniel J.Hellenbrand charles M.Quinn Zachariah J.Piper ryan T.Elder Raveena R.Mishra Taylor L.Marti Phoebe M.Omuro Rylie M.Roddick Jae Sung Lee William L.Murphy Amgad S.Hanna Department of Neurosurgery University of Wisconsin-Madison School of Medicine and Public HealthMadisonWIUSA Department of Biomedical Engineering University of Wisconsin-MadisonMadisonWIUSA Department of Orthopedics and Rehabilitation University of Wisconsin-MadisonMadisonWIUSA Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWIUSA Forward BIO Institute University of Wisconsin-MadisonMadisonWIUSA

After spinal cord injury,there is an extensive infiltration of immune cells,which exacerbates the injury and leads to further neural ***,a major aim of current research involves targeting the immune response as a treatment for spinal cord *** much research has been performed analyzing the complex inflammatory process following spinal cord injury,there remain major discrepancies within previous literature regarding the timeline of local cytokine *** objectives of this study were to establish an overview of the timeline of cytokine regulation for 2 weeks after spinal cord injury,identify sexual dimorphisms in terms of cytokine levels,and determine local cytokines that significantly change based on the severity of spinal cord *** were inflicted with either a mild contusion,moderate contusion,severe contusion,or complete transection,7 mm of spinal cord centered on the injury was harvested at varying times post-injury,and tissue homogenates were analyzed with a Cytokine/Chemokine 27-Plex *** demonstrated pro-inflammatory cytokines including tumor necrosis factorα,interleukin-1β,and interleukin-6 were all upregulated after spinal cord injury,but returned to uninjured levels within approximately 24 hours post-injury,while chemokines including monocyte chemoattractant protein-1 remained upregulated for days *** contrast,several anti-inflammatory cytokines and growth factors including interleukin-10 and vascular endothelial growth factor were downregulated by 7 days *** spinal cord injury,tissue inhibitor of metalloproteinase-1,which specifically affects astrocytes involved in glial scar development,increased more than all other cytokines tested,reaching 26.9-fold higher than uninjured *** a mild injury,11 cytokines demonstrated sexual dimorphisms;however,after a severe contusion only leptin levels were different between female and male *** conclusion,pro-inflammatory cytokines in

关键词： astrocytes chemokines cytokines inflammation macrophages microglia secondary damage spinal cord injury

Machine learning-guided accelerated discovery of structure-property correlations in lean magnesium alloys for biomedical applications

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Journal of Magnesium and Alloys 2024年第6期12卷 2267-2283页

作者： Sreenivas Raguraman Maitreyee Sharma Priyadarshini Tram Nguyen ryan McGovern Andrew Kim Adam J.Griebel Paulette Clancy Timothy P.Weihs Department of Materials Science and Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Hopkins Extreme Materials Institute Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Department of Chemical and Biomolecular Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Translational Tissue Engineering Center Johns Hopkins School of Medicine400 N BroadwayBaltimore21231MDU.S.A Department of Biomedical Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Research and Development Fort Wayne Metals Research ProductsLLC9609 Ardmore AveFort Wayne46809INU.S.A Department of Mechanical Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A

Magnesium alloys are emerging as promising alternatives to traditional orthopedic implant materials thanks to their biodegradability,biocompatibility,and impressive mechanical ***,their rapid in-vivo degradation presents challenges,notably in upholding mechanical integrity over *** study investigates the impact of high-temperature thermal processing on the mechanical and degradation attributes of a lean Mg-Zn-Ca-Mn alloy,*** rapid,cost-efficient characterization methods like X-ray diffraction and optical microscopy,we swiftly examine microstructural changes post-thermal *** Pearson correlation coefficient analysis,we unveil the relationship between microstructural properties and critical targets(properties):hardness and corrosion ***,leveraging the least absolute shrinkage and selection operator(LASSO),we pinpoint the dominant microstructural factors among closely correlated *** findings underscore the significant role of grain size refinement in strengthening and the predominance of the ternary Ca_(2)Mg_(6)Zn_(3)phase in corrosion *** suggests that achieving an optimal blend of strength and corrosion resistance is attainable through fine grains and reduced concentration of ternary *** thorough investigation furnishes valuable insights into the intricate interplay of processing,structure,and properties in magnesium alloys,thereby advancing the development of superior biodegradable implant materials.

关键词： Magnesium alloys Machine learning Corrosion Mechanical properties Rapid characterization

Characterizing objective and self-report habitual physical activity and sedentary time in outpatients with an acquired brain injury

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Sports Medicine and Health Science 2024年第4期6卷 338-343页

作者： Liam P.Pellerine Katerina Miller ryan J.Frayne Myles W.O'Brien Division of Kinesiology School of Health and Human PerformanceFaculty of HealthDalhousie UniversityHalifaxNova ScotiaCanada Acquired Brain Injury NeuroCommons Nova Scotia Health AuthorityHalifaxNova ScotiaCanada School of Physiotherapy(Faculty of Health)&Department of Medicine(Faculty of Medicine) Dalhousie UniversityHalifaxNova ScotiaCanada Geriatric Medicine Research Dalhousie University&Nova Scotia HealthHalifaxNova ScotiaCanada Centre de Formation Medicale Du Nouveau-Brunswick New Brunswick&Department of MedicineUniversite de SherbrookeSherbrookeQuebecCanada

Outpatients with an acquired brain injury(ABI)experience physical,mental,and social *** can be classified into two subgroups based on mechanism of injury:mild traumatic brain injury(mTBI;e.g.,concussion)and other ABI(e.g.,stroke,brain aneurysm,encephalitis).Our understanding of habitual activity levels within ABI populations is limited because they are often collected using self-report *** purpose of this study was to,1)describe the habitual activity levels of outpatients with ABI using objective and self-report monitoring,and 2)compare the activity levels of outpatients with mTBI *** *** outpatients with other ABI(mean±standard deviation:[58±13]years,9 females)and 12 outpatients with mTBI([48±11]years,9 females)wore a thigh-worn activPAL 24 h/day(h/day)for *** with ABI averaged(6.0±2.3)h/day of upright time,(10.6±2.2)h/day of sedentary time,(5.6±2.7)h/day in prolonged sedentary bouts>1 h,(5960±3037)steps/day,and(11±13)minutes/day(min/day)of moderate-vigorous physical activity(MVPA).There were no differences between activPAL-derived upright,sedentary,prolonged sedentary time,and physical activity between the mTBI and other ABI groups(all,p>0.31).Outpatients with ABI overestimated their MVPA levels(t138 min/week)and underestimated sedentary time(-4.3 h/day)compared to self-report(all,p<0.001).Despite self-reporting high activity levels,outpatients with ABI objectively exhibit highly inactive and sedentary *** habitual movement behaviours of our sample did not differ by mechanism of injury(i.e.,mTBI versus other ABI).Targeting reductions in objectively measured sedentary time are needed to progressively improve the habitual movement behaviours of outpatients with ABI.

关键词： Accelerometry Stroke Brain aneurysm Encephalitis Mild traumatic brain injury Rehabilitation

Review of Mercury's dynamic magnetosphere:Post-MESSENGER era and comparative magnetospheres

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Science China Earth Sciences 2022年第1期65卷 25-74页

作者： Weijie SUN ryan MDEWEY Sae AIZAWA Jia HUANG James A.SLAVIN Suiyan FU Yong WEI charles F.BOWERS Department of Climate and Space Sciences and Engineering University of MichiganAnn ArborMl 48109USA Institut de Recherche en Astrophysique et Planetologie CNRS-UPS-CNESToulouse 31400France Department of Geophysics Graduate School of ScienceTohoku UniversitySendai 980-8578Japan School of Earth and Space Sciences Peking UniversityBeijing 100871China Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China School of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100864China

This review paper summarizes the research of Mercury’s magnetosphere in the Post-MESSENGER era and compares its dynamics to those in other planetary magnetospheres,especially to those in Earth’s *** review starts by introducing the planet Mercury,including its interplanetary environment,magnetosphere,exosphere,and conducting *** frequent and intense magnetic reconnection on the dayside magnetopause,which is represented by the flux transfer event"shower",is reviewed on how they depend on magnetosheath plasma β and magnetic shear angle across the magnetopause,followed by how it contributes to the flux circulation and magnetosphere-surface-exosphere *** the next,Mercury’s magnetosphere under extreme solar events,including the core induction and the reconnection erosion on the dayside magnetosphere,as well as the responses of the nightside magnetosphere,are ***,the dawn-dusk properties of the plasma sheet,including the features of the ions,the structure of the current sheet,and the dynamics of magnetic reconnection,are *** last topic is devoted to the particle energization in Mercury’s magnetosphere,which includes the energization of the Kelvin-Helmholtz waves on the magnetopause boundaries,reconnection-generated magnetic structures,and the cross-tail electric *** each chapter,the last section discusses the open questions related to each topic,which can be considered by the simulations and the future spacecraft *** end this paper by summarizing the future Bepi Colombo opportunities,which is a joint mission of ESA and JAXA and is en route to Mercury.

关键词： Mercury’s magnetosphere Flux transfer event shower Extreme solar events Core induction Reconnection erosion Dawn-dusk asymmetry Substorm current wedge Particle energization Kelvin-Helmholtz wave

Plants as Objects： Challenges for anAesthetics of Flora

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Journal of Philosophy Study 2011年第3期1卷 222-236页

作者： John charles ryan Edith Cowan University

This paper presents the conceptual challenges to an aesthetic model of living plants based in embodied interaction with flora through smell, taste, touch, sound and sight. I argue that the science of aesthetics is deterministically visual. Drawing from theories of landscape aesthetics put forth by Carlson and Berleant, I outline four primary obstacles to an embodied aesthetics： plants as objects of sight, plants as objects of art, plants as objects of disinterestedness and plants as objects of scientific discourse. A multi-sensorial aesthetics of flora requires auto-centric proximity and degrees of intersubjectivity between the appreciator and the appreciated plant that raise important philosophical questions about aesthetic experience of the natural world.

关键词： aesthetics philosophy environment plants Berleant Carlson embodiment