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Association between Placental Malaria and Severe Pre-Eclampsia in two University Hospitals of Yaounde City

Open Journal of Obstetrics and Gynecology 2024年第9期14卷 1488-1511页

作者： Ayissi Gregory Astrid Ruth Ndolo Kondo Ndoumba Afouba Alice Noa Ndoua Claude Cyrille Essiben Félix Meka Esther Belinga Etienne Metogo Junie Engo Engo Samuel Désiré Bodo Edmond lemaire tchente Nguefack Charlotte Foumane Pascal mboudou emile télésphore Department of Obstetrics and Gynecology Faculty of Medicine and Biomedicals Sciences University of Yaound I Yaounde Cameroon Department of Obstetrics and Gynecology Faculty of Medicine and Pharmaceuticals Sciences University of Douala Douala Cameroon Department of Morphological and Anatomo-Pathological Sciences Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon. Department of Morphological and Anatomo-Pathological Sciences Faculty of Medicine and Biomedicals Sciences University of Yaound I Yaounde Cameroon

Context: Pre-eclampsia and placental malaria, are two diseases that share pathophysiological similarities, such as placental ischemia, endothelial dysfunction and production of pro-inflammatory cytokines. Objective: the objective of our study was to investigate the association between placental malaria lesions and severe pre-eclampsia. Methodology: We conducted a prospective analytical cross-sectional study in two University Hospitals in the city of Yaounde (Yaounde Central Hospital and the Gynaecological Obstetrics and Paediatrics Hospital), and in the laboratory of the Centre Pasteur in Yaounde over an eight-month period (1st January 2021 – 1st September 2021). All patients with pre-eclampsia diagnosed according to the criteria of the International Society for the Study of Hypertension (ISSHP) and free of chronic metabolic or infectious pathology were included in this study. the patients were divided into two groups: group 1 (mild pre-eclampsia) and group 2: severe pre-eclampsia. Socio-demographic, clinical and histopathological characteristics specific to pre-eclampsia and placental malaria were investigated. Statistical analysis was performed with SPSS 23.0 software, Chi 2 was used to compare categorical variables, Student t-test was used to compare means, and logistic regression was used to assess the association between placental malaria lesions and PES. Results: the mean age of our study population was 29.93 ± 7.36 years versus 28.28 ± 7.18 years in patients with mild and severe pre-eclampsia respectively. Pre-eclampsia placental lesions (accelerated villous maturation, infarction) were significantly greater in patients with severe pre-eclampsia (p Conclusion: Placental malaria lesions were significantly associated with severe pre-eclampsia and increased the risk of developing severe pre-eclampsia placental lesions by a factor of 10.

关键词： Mild Pre-Eclampsia Severe Pre-Eclampsia Malaria Placental lesions Association

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Successful laparoscopic Management of a Migrated Intrauterine Contraceptive Device in the Pelvic Cavity: A Case Report

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Open Journal of Obstetrics and Gynecology 2024年第1期14卷 36-43页

作者： tompeen Isidore Inna Rakya tchounzou Robert Neng Humphry Mangala Georges tchenté Charlotte mboudou emile Department of Gynecology and Obstetrics Faculty of Medicine and Biomedical Sciences The University of Yaoundé I Yaoundé Cameroon Department of Gynecology and Obstetrics Faculty of Medicine and Biomedical Sciences The University of Garoua Garoua Cameroon Department of Gynecology and Obstetrics Faculty of Health Sciences The University of Buea Buea Cameroon Department of Gynecology and Obstetrics Faculty of Medicine and Pharmaceutical Sciences The University of Douala Douala Cameroon

Background: An Intrauterine device (IUD) is a long-acting reversible contraceptive commonly used in clinical practice. Its insertion in the uterus is simple and safe. But sometimes, complications can occur. Case Report: Herein, we report a case of successful laparoscopic removal of a missing IUD Copper-t, mis-inserted in a 32-year-old woman, 4 months after she delivered by caesarian section, and presented persistent lower abdominal pain lasting 6 months. Uterine ultrasound was unremarkable, but a plain abdominopelvic X-ray confirmed the presence of the Copper-t inside the abdominal cavity. Conclusion: Insertion of IUD is simple and safe. When the diagnosis of uterine perforation following its insertion is clinically suspected and radiologically confirmed, laparoscopy, when available, remains one of the best options for removal.

关键词： IUD Ectopic Migration Contraception laparoscopy

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Successful laparoscopic Management of a Migrated Intrauterine Contraceptive Device in the Pelvic Cavity: A Case Report

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Open Journal of Obstetrics and Gynecology（妇产科期刊） 2024年第1期

作者： tompeen Isidore Inna Rakya tchounzou Robert Neng Humphry Mangala Georges tchenté Charlotte mboudou emile

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Radical Hysterectomy in Cervical Cancer: Patients’ Epidemiological and Clinical Profiles and Perioperative Outcome in two Referral Hospitals in Cameroon

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Open Journal of Obstetrics and Gynecology 2024年第3期14卷 466-479页

作者： théophile Njamen Nana Robert tchounzou Fulbert Nkwele Mangala Alphonse Ngalame Henri Essome Sedrick tiokeng Sidonie Noa Ananga Andrew tassang Humphry tatah Neng Isaac Mboh Eyong Gaetan Andre Wambo Simo Felix Adolphe Elong Fidelia Kobenge Mbi Junior Cédric Nana Njamen Charlotte tchente Nguefack thomas Obinchemti Egbe Gregory Ekane Halle emile telesphore mboudou Marcellin Ngowe Ngowe Department of Obstetrics and Gynaecology Douala General Hospital Douala Cameroon Department of Obstetrics and Gynaecology Faculty of Health Sciences University of Buea Buea Cameroon Department of Obstetrics and Gynaecology Douala Gynaeco-Obstetric and Pediatric Hospital Douala Cameroon Department of Surgery and Specialties Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Department of Pathology Douala General Hospital Douala Cameroon Faculté Des Sciences De la Santé Université Joseph Kizerbo Ouagadougou Burkina Faso

Background: Cervical cancer (CC) is one of the most frequent cancers and the leading cause of death from gynecological cancer in low and middle income countries, Cameroon inclusive. Surgery is the primary treatment modality when the disease is diagnosed at early stage. Radical hysterectomy in cervical cancer has not been evaluated in recent years in Cameroon. the purpose of this study is thus to evaluate the epidemiological and clinical features and short term outcomes of patients who underwent surgery. Patients and methods: this retrospective study was conducted at the Douala Gynaeco-obstetric and Pediatric Hospital and the Douala General Hospital. Cervical cancer patients who underwent Radical hysterectomy between January 2015 and December 2020 were included. A pre-established data collection tool was used to record socio-demographic, clinical and outcomes information from patients’ files;additional outcome information was obtained from phone calls. Descriptive analysis was done using the SPSS version 26. Bivariate analysis was used to determine associations between disease and patients characteristics and occurrence of adverse postoperative outcome. P value of 0.05 was considered. Results: Sixty one patients were enrolled. their ages ranged from 33 to 74 years with a mean age of 51.95 ± 10.29 years. Over 85% of women were married, 65.57% were unemployed and 86.88% were multiparous. Only 28% had never done cervical cancer screening. Most patients had stage IB1 to IB2 stage disease (57.1%). less than 9% underwent radical hysterectomy and 8 of those (13.11%) suffered intraoperative complications. twenty-five patients (40.98%) presented immediate and short term complications. there was no significant association between the disease or patients’ characteristics and adverse outcomes. Conclusion: Cervical cancer patients are relatively young in our settings and only 9% of them reach the hospital at early stage. Postoperative adverse outcomes rate is higher than that rep

关键词： Cervical Cancer Radical Hysterectomy Epidemiological and Clinical Profiles Outcomes Cameroon

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A comparative analysis of spontaneous fertility after myomectomy by laparotomy associated or not with a“second look”laparoscopy

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laparoscopic, Endoscopic and Robotic Surgery 2019年第2期2卷 27-30页

作者： Etienne Belinga Daniel Antony Bikak Djima Bruno Ela Ondo Esther Juliette Ngo Um Meka emile telesphore mboudou Pascal Foumane Department of Obstetrics and Gynecology Faculty of Medicine and Biomedical Sciencesthe University of Yaounde ICameroon Higher Institute of Health Sciences University of the MountainsCameroon Department of Epidemiology Higher Institute of Health SciencesUniversity of the MountainsCameroon

Objective:the importance of a“second look”laparoscopy for adhesion formation after myomectomy by laparotomy in improving fertility is not clearly defined in our *** aim of this study was to compare spontaneous fertility after myomectomy by laparotomy between women who underwent a“second look”laparoscopy and those who did ***:We conducted an analytical cross-sectional study with retrospective data collection from January 1,2008 to December 31,2015,comparing spontaneous fertility between patients who underwent“second-look”laparoscopy after myomectomy by laparotomy to those who did ***,data was collected from the records of patients included in the ***,through phone calls,informed consent for each participant was obtained after which inquiries were made regarding their fertility ***:After a period of 24 months,23 patients(47.9%)with“second look”laparoscopy conceived,compared to 37 patients(35.2%)without“second look”laparoscopy(p=0.136);and 24 patients(50.0%)with“second look”had term pregnancies compared to 39 patients(37.1%)without“second look”laparoscopy(p=0.134).Conclusion:Spontaneous fertility rates seemed to be improved after a“second look”laparoscopy,however,there was no statistically significant difference between spontaneous fertility rates obtained after myomectomy by laparotomy,irrespective of the fact that the patient had undergone a“second look”laparoscopy or not at Yaounde Gyneco-Obstetric and Pediatric Hospital.

关键词： Myomectomy laparotomy Infertility Adhesions “Second look”laparoscopy

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Risk factors of clinical birth asphyxia and subsequent newborn death following nuchal cord in a low-resource setting

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Open Journal of Obstetrics and Gynecology 2013年第9期3卷 642-647页

作者： Pascal Foumane Gustave Nkomom emile telesphore mboudou Julius Dohbit Sama Séraphin Nguefack Boniface Moifo Department of Obstetrics and Gynecology Faculty of Medicine and Biomedical Sciences (FMBS) The University of Yaoundé 1 Yaoundé Cameroon Department of Pediatrics Yaoundé Gyneco-Obstetric and Pediatric Hospital Yaoundé Cameroon Department of Radiology Yaoundé Gyneco-Obstetric and Pediatric Hospital Yaoundé Cameroon

Introduction: Our aim was to identify the risk factors of clinical birth asphyxia and subsequent newborn death in the presence of nuchal cord in a sub-Saharan Africa setting. Methodology: It was a six-months’ case-control study involving 117 parturients whose babies presented with a nuchal cord at delivery. the study was carried out at the Yaoundé Gyneco-Obstetric and Pediatric Hospital, Cameroon, from January 1st to June 30th 2013. Results: the risk factors of clinical birth asphyxia identified were: first delivery, absence of obstetrical ultrasound during pregnancy, nuchal cord with more than one loop, duration of second stage of labor more than 30 minutes during vaginal delivery. the risk factors for newborn death from clinical birth asphyxia in the presence of nuchal cord were: maternal age Conclusion: We recommend a systematic obstetrical ultrasound before labor, so as to detect the presence of a nuchal cord, its tightness and the number of loops. Also, cesarean section should be considered when a nuchal cord is associated with first delivery, tightness or multiple looping.

关键词： Risk Factors Nuchal Cord Adverse Outcome Birth Asphyxia Newborn Death Apgar Score Cameroon

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Risk Factors for Breast Cancer in the City of Douala: A Case Control Study

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Advances in Breast Cancer Research 2020年第3期9卷 66-77页

作者： Engbang Ndamba Jean Paul Essome Henri Mve Koh Valère Sukam Noutadjeu Diane Sara mboudou telesphore emile Faculty of Medicine and Pharmaceuticals Sciences of Douala University of Douala Douala Cameroon laquintinie Hospital of Douala Douala Cameroon Faculty of Medicine of Biomedical Sciences University of Yaounde I Yaounde Cameroon Gynaeco-Pediatric Hospital of Douala Douala Cameroon

Background: the breast cancer is an abnormal proliferation of mammary gland cells. this condition as well as other cancers is globally increasing in the world. It is the most frequent malignancy of women in the world ... 详细信息

trong>Background:trong> The breast cancer is an abnormal proliferation of mammary gland cells. This condition as well as other cancers is globally increasing in the world. It is the most frequent malignancy of women in the world and is a public health problem. Generally in Africa and central Africa in particular, few studies have been realized in search of risk factors of breast cancer. It’s all in this optical we began the study to determine the risk factors of this disease in the city of Douala. Patients and Methods: We conducted a case-control study, gave retrospectives collect on five years and prospectives collect on seven months. The studied population was all women aged 18 years and above with breast cancer diagnostic on histological plan for cases;and women from 18 years or more with normal physical examination and mammography. We have done our research in three reference hospitals of the city of Douala and two laboratories of pathological anatomy. The data were collected at the search files and the patients where interviewed. The parameters studied were: socio-demographic profile, clinic and Para clinic parameters, and the histological type. Results: tyle="font-family:Verdana;">At the end of this study, breast cancer is predominantly on young women in the city of Douala with a middle age of 44.08 ± 2.6 years. the most significant risk factors were age, age of the first birth ≥ 30 years, age of the first sexual act ≤ 18 y

关键词： Breast Cancer Factors of Risk City of Douala

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Insulin Sensitivity and Gynaecological Features of Infertile Cameroonian Females with Polycystic Ovary Syndrome: A Cross-Sectional Study

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Open Journal of Obstetrics and Gynecology 2017年第13期7卷 1247-1254页

作者： Julius Sama Dohbit Eugene Sobngwi Jean Dupont Kemfang Pascal Foumane Joel Noutakdie tochie Felix A. Elong Betsy Bate emile t. mboudou Department of Obstetrics and Gynaecology Faculty of Medicine and Biomedical Sciences University of Yaounde 1 Yaounde 1 Cameroon Department of Internal Medicine and Endocrinology Faculty of Medicine and Biomedical Sciences University of Yaounde 1 Yaounde 1 Cameroon Faculty of Medicine and Biomedical Sciences University of Yaounde 1 Yaounde 1 Cameroon Department of Obstetrics-Gynaecology and Surgery Faculty of Health Science University of Buea Buea Cameroon

Background: Polycystic ovary syndrome (PCOS), characterized by ovulatory dysfunction, polycystic ovary(PCO),hyperandrogenism and insulin resistance is the commonest endocrine disorder in women of reproductive age. It is an intriguing pathology that involves the perpetuation of a vicious circle with reproductive, endocrine and metabolic components. We aimed to assess the reproductive features and insulin sensitivity (IS) in infertile women with or without PCOS. Materials and Methods: We carried out a cross-sectional analytic study at the outpatient Obstetrics and Gynaecology Department of the Yaounde Gyneco-obstetric and Pediatrics Hospital, Cameroon from September 1st 2012 to March 31st 2013 giving total study duration of 07 months. laboratory analyses were carried out at the National Obesity Centre(NOC)of the Yaounde Central Hospital, Cameroon. Results: Overall, 36 infertile females were enrolled, which included 15 diagnosed cases of PCOS according to Rotterdam consensus meeting of 2003 and 21 non PCOS subjects as control. PCOS women were younger than non PCOS women (28.8 ± 5.5 vs. 35.0 ± 4.2 years;p = 0.0004). the majority of the women in the PCOS group were spaniomenorrheic (11/15), and ultrasonographic findings were typical of PCOS. Hirsutism score was higher in the PCOS group with a median of 9 (7 - 13). Insulin sensitivity was impaired in two-thirds of the study population, with 12 women found to be insulin resistant(6 PCOS, 6 non PCOS), 12 patients had intermediate insulin sensitivity(2 PCOS, 10 non PCOS)and 12 insulin sensitive(7 PCOS, 5 non PCOS). Apart from blood glucose levels (p = 0.007), all other anthropometric and biological parameters were not significant. Spearman’s correlation identified fasting plasma glucose and total cholesterol as factors associated with insulin sensitivity in females with PCOS. Impaired fasting glucose was observed in 13 patients with 08 from the PCOS group. Conclusion: We conclude that young age, spaniomenorrhea and hirsutism

关键词： Gynaecological Features Insulin Sensitivity Impaired Fasting Blood Sugar Infertility PCOS

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Risk Factors for Breast Cancer: A Case-Control Study of 315 Women Followed in the Gynecology and Oncology Departments of two University teaching Hospitals in Yaounde, Cameroon

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Open Journal of Obstetrics and Gynecology 2016年第12期6卷 676-688页

作者： Felix Essiben Pascal Foumane Esther Ngo Um Meka Patience Signing Soh Julius Dohbit Sama Eyongoben Osogo emile telesphore mboudou Department of Obstetrics and Gynecology Faculty of Medicine and Biomedical Sciences (FMBS) University of Yaoundé I YaoundéCameroon Department of Obstetrics and Gynecology Yaounde Central Hospital Yaoundé Cameroon Department of Obstetrics and Gynecology Yaounde Gyneco-Obstetric and Pediatric Hospital Yaoundé Cameroon Higher Institute of Health Université des Montagnes Bagangte Cameroon

Introduction: Breast cancer is the most common cancer and the first cause of cancer-related deaths among women in Cameroon. the aim of the study was to investigate its risk factors for breast cancer at two University teaching Hospitals in Yaoundé. Methodology: A case-control study was conducted for 5 months, from February 25th to July 25th 2015, at the Gynecology unit of the Yaoundé Gyneco-Obstetric and Pediatric Hospital (YGOPH) and the Medical Oncology unit of the Yaoundé General Hospital (YGH). One hundred and five patients with breast cancer (cases) were compared to 210 women who did not have breast cancer (controls). SPSS Version 18.0.0 software was used to analyze the data with a statistical significance considered at P-value 50 years (P three times per week (P = 0.002;OR = 2.14;CI = [1.33 - 3.45]), palm oil consumption > two times per week (P = 0.001;OR = 2.38;CI = [1.4 - 4.1]). After multivariate analysis, age > 50 years (aOR = 41.48;CI = [2.46 - 69.9]) and consumption of red meat > three times per week [aOR = 7.33;(1.49 - 36)] were the risk factors considered significant for breast cancer. Conclusion: Age > 50 years and red meat consumption are independent risk factors for breast cancer at the Yaoundé General Hospital and at the Yaoundé Gyneco-Obstetric and Pediatric Hospital.

关键词： Risk Factors Breast Cancer Red Meat Cameroon

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Clinical Study of Rape against Females at the YaoundéGyneco-Obstetric and Pediatric Hospital, Cameroun

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Advances in Sexual Medicine 2014年第2期4卷 11-16页

作者： Pascal Foumane Julius Sama Dohbit Francisca Monebenimp Bruno Natolga Esther Ngo Um Meka emile telesphore mboudou Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Cameroon Yaoundé Cameroon High Institute of Health Sciences Université des Montagnes Bangangté Cameroon Yaoundé Gyneco-Obstetric and Pediatric Hospital Yaoundé Cameroon

Objective: to describe the clinical and therapeutic aspects of rape against females in a tertiary level hospital, Yaoundé, Cameroon. Methods: this was a cross-sectional study with a retrolective collection of data, concerning the female patients with a clinical diagnosis of rape received from January 1st 2008 to December 31st 2012. Results: Rape was confirmed at physical examination in 131 cases. the rape victim survivals were mostly aged less than 20 years (85/131;64.9%), unmarried (127/131;97.0%), with no income (95/131;72.5%) and had no university education level (110/131;83.9%). the aggression commonly took place during the night (68/131;51.9%), at the victim’s or aggressor’s home (70/131;53.4%), with physical constraint (73/131;55.8%), by an unknown aggressor (88/131;67.2%). A vaginal penetration was reported by 97.0% of the victims (127/131) while 12.2% of them (16/122) had an anal ingress. Condom usage was uncommon during rape (3/131;2.3%). Vulvar and vaginal lesions were encountered in 32.8% of the cases (43/131). Only 27.5% (36/131) of the victims were prescribed an emergency contraception, while antiretroviral prophylaxis was administered to 46.6% (61/131) of them. Conclusion: these data might be useful for prevention of rape. the clinical management of survival victims of rape needs to be improved.

关键词： Rape Victims Genital lesions Vaginal and Anal Penetration HIV Prophylaxis Cameroon

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