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Assessment of in Situ Anthelminthic Activity of Ethanolic Extract of Bidens pilosa against Adult’s Gastro-Intestinal Strongyle of Small Ruminants

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American Journal of Plant Sciences 2022年第4期13卷 433-442页

作者： mbogning tayo gertrude Yondo Jeannette Tsila Henri Gabriel Mpoame Mbida Department of Animal Biology Faculty of Science University of Dschang Dschang Cameroon Department of Microbiology Haematology and Immunology Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon

Infections caused by gastrointestinal nematodes are major threats to livestock industry in the developing countries. They cause direct effects in form of loss in production and indirect economic losses due to high cost of anthelmintic drugs. Various alternative strategies are in practice to control parasitism which includes the usage of medicinal plants. This study evaluates the in situ anthelminthic activity of Bidens pilosa ethanolic extract on gastro-intestinal strongyles of small ruminants. Twenty (20) naturally infested goats of both sexes were distributed into 5 groups (n = 4) corresponding to groups receiving Tween 80 at 2.8%, Albendazole at 5 mg/kg and the three doses of extract (125, 250 and 500 mg/kg). The doses of extract and 2.8% Tween 80 were administered twice daily for 3 consecutive days while Albendazole was administered in a single dose. Faecal eggs count reduction, body weight, packed cell volume (PCV) and total worm count reduction were determined. Results showed that the ethanolic extract of B. pilosa was not effective against adult worms while Albendozole inflicted a 100% reduction of eggs count and total worm count of digestive strongyle. Body weight and PCV remain almost constant. This study indicates that ethanolic extract of B. pilosa at tested doses has no anthelminthic activity. However, further optimization and standardization of the ethanolic extract of B. pilosa could enhance its anthelminthic activity.

关键词： Gastro-Intestinal Strongyle Bidens pilosa Anthelminthic Activity in Situ

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In vitro anthelminthic efficacy of Dichrocephala integrifolia(Asteraceae)extracts on the gastro-intestinal nematode parasite of mice:Heligmosomoides bakeri(Nematoda,Heligmosomatidae)

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Asian Pacific Journal of Tropical Biomedicine 2013年第2期3卷 100-104页

作者： Wabo Poné J Payne V K mbogning tayo gertrude Komtangi Marie Claire Yondo Jeannette Ngangout Alidou M Mpoame Mbida Bilong Bilong CF Laboratory of Applied Biology and Ecology(LABEA) Department of Animal BiologyFaculty of ScienceUniversity of Dschang Laboratory of General Biology Department of Animal Biology and PhysiologyFaculty of ScienceUniversity of Yaoundé1

Objective:To evaluate the ovicidal and larvicidal activities of aqueous and ethanolic extracts of leaves of Dichrocephala integrifolia(***)against the eggs(fresh and embryonnated),the first and second larval stages of Heligmosomoides *** order to verify if this medicinal plant possesses active compounds capable of inhibiting the embryonation and hatching of eggs or to induce the mortality of larvae(L1 and L2).Methods:Dried extracts were diluted in distilled water to obtain five different concentrations:625,1 250,2500,3750 and 5000μg/*** eggs obtained from artificially infected mice feces were exposed to these different concentrations for 48 *** of contact for embryonated eggs was 6 h while L1 and L2 larvae were exposed for 24 *** water(placebo)and 1.5%DMSO were used as negative ***:Distilled water,and1.5%DMSO had no effect on embryonation,hatching and larval *** extracts of *** showed a weak activity against all stages of the parasite at all concentrations *** the contrary,the ethanolic extract of *** inhibited the embryonation of 87.5%of fresh eggs,the hatching of 81.1%of embryonated eggs and induced the mortality of 98.1%and 98%of L1 and L2 larvae respectively at 5000μg/***:The results of the present study indicate that the ethanolic extracts of *** contained compounds with ovicidal and larvicidal *** spite of these results,in vivo tests,studies on toxicity and mechanism of action of active compounds are also needed to validate the utilisation of this medicinal plant by population of Dschang-Cameroon to treat gastro-intestinal parasites.

关键词： Dichrocephala integrifolia Heligmosomoides bakeri In vitro Eggs Larvac

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In VitroOvicidal and Larvicidal Activities of Stem Bark of Terminalia glaucescens(Combretaceae) against Haemonchus contortus

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American Journal of Plant Sciences 2014年第19期5卷 2859-2868页

作者： Mbafor Fidelia Lem Khan Payne Vincent Wabo Pone Josue Yondo Jeannette mbogning tayo gertrude Tchoumboue Joseph Laboratory of Applied Biology and Ecology Department of Animal Biology Faculty of Science University of Dschang Dschang Cameroon Laboratory of Animal Health Department of Animal Production Faculty of Agronomy and Agricultural Sciences University of Dschang Dschang Cameroon

Objectives: To evaluate the in vitro activity of aqueous and methanolic extracts of stem bark of Terminalia glaucescens on the eggs and larval stages of Haemonchus contortus of sheep. Methods: The eggs were exposed for 24 hours in five different concentrations (625, 1250, 2500, 3750 and 5000 μg/ml) of methanol, hot water (decoction) and cold water extracts at room temperature (25°C). Distilled water, 1.25% DMSO and Albendazole were used as negatives and positive control respectively in the bioassay. Results: A significant effect was obtained with all of the three extracts and differences were observed depending on the parasitic stage. Hot water extract (HWE), Methanol (MET) and Cold water extract (CWE) inhibited embryonic development by 98.1%, 96% and 86.5% respectively at 5000 μg/ml, meanwhile Albendazole had a 77.9% inhibition. For the mean inhibition rate of egg hatching, there was a general increase in the inhibition rate with increase in concentration of the extract from 625 to 5000 μg/ml. Methanol extract had the highest inhibition rate in all concentration from 625 to 5000 μg/ml. Concerning larval mortality, HWE had the highest effect in L1 larval mortality in all concentration above 1250 μg/ml. Distilled water had very little larval mortality on L1 and L2 larvae by 3.3 and 3.3% respectively. Conclusion: This in vitro study brought out the ovicidal and larvicidal properties of stem bark of Terminalia glaucescens.

关键词： Anthelmintic Extract Haemonchus contortus Ovicidal and Larvicidal Activities Terminalia glaucescens

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Anthelminthic Activity of Moringa oleiferaLeaf Extracts Evaluated in Vitroon Four Developmental Stages of Haemonchus contortusfrom Goats

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American Journal of Plant Sciences 2014年第11期5卷 1702-1710页

作者： gertrude mbogning tayo Josué Wabo Poné Marie Claire Komtangi Jeannette Yondo Alidou Marc Ngangout Mpoame Mbida Department of Animal Biology Faculty of Science University of Dschang Dschang Cameroon

Haemonchus contortus is a blood-sucking abomasal helminth of small ruminants responsible for major economic losses to small farmers worldwide. Widespread resistance to synthetic anthelminthics has stimulated a need for alternative strategies of parasite control, among which is the use of medicinal plants with natural anthelminthic properties. This study assessed in vitro the efficacy of infused and macerated aqueous extract as well ethanolic extract of Moringa oleifera against fresh eggs, embryonated eggs, L1 and L2 larvae of H. contortus. For this purpose, five different concentrations (0.625, 1.25, 2.5, 3.75 and 5 mg/ml) were prepared from dry extracts via serial dilutions with distilled water. Fresh eggs obtained from artificially infected goat feces were exposed to these different concentrations for 48 hours, while embryonated eggs and larvae were exposed for 6 and 24 hours respectively. Distilled water and 1.5% DMSO were used as negative control. The results were expressed in terms of mean inhibition percentage of egg embryonation, mean inhibition percentage of egg hatch and mean percentage of larval mortality. An overview of results revealed that ethanolic leaf extract of M. oleifera was most efficient on eggs by inhibiting 60.3% ± 8.2% and 92.8% ± 6.2% eggs embryonation at 3.75 and 5 mg/ml respectively with a significant difference (P 0.05), which contributed to obtaining the lowest LC50 value of 0.985 mg/ml. This extract also inhibited 99% ± 2% egg hatching of H. contortus at 5 mg/ml with an LC50 value of 1.7 mg/ml. Concerning activity on larvae, the ethanolic extract was also most potent against them by inducing 98.8% ± 2.5% and 100% ± 0% mortality of L1 and L2 larvae at 5 mg/ml respectively. Infused aqueous extract was more efficient on eggs than on larvae with an IC50 value less than 2 mg/ml and an LC50 value more than 3.5 mg/ml. Macerated aqueous extract showed good activity against the four developmental stages with LC50 values ranging from 2.08 mg/ml f

关键词： Moringa oleifera Ovicidal Larvicidal Haemonchus contortus Goats Cameroon

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