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Evaluation of Kidney Function in Patients with COVID-19 at the Epidemiological Treatment Centre in CHNU Fann

Advances in Biological Chemistry 2023年第1期13卷 17-24页

作者： Thioune Ndeye Mareme Kandji Pape Matar Djite Moustapha Barry Nene Oumou Kesso Zaamoumi Bassma Kane mame Coumba Diagne Bineta mbacke mame ndoumbé Sagne René Ngor Ndour El Hadji Malick Gueye-Tall Fatou Lopez-Sall Philomene Cisse Aynina Diop Pape Amadou Gueye Papa Madieye Laboratory of Biochemistry-Hematology National University Hospital of Fann Dakar Senegal Laboratory of Pharmaceutical Biochemistry Faculty of Medicine Pharmacy Cheikh Anta Diop University Dakar Senegal

Alteration of renal function during SARS-CoV-2 infection is frequent and is associated with excess mortality. It is multifactorial, involving mechanisms more specific to COVID-19: viral invasion, endothelitis and thrombosis, activation of the renin-angiotensin-aldosterone system, and elevation of pro-inflammatory cytokines. Thus, the objective of this work was to assess renal function in patients with moderate and severe forms of COVID-19. This was a prospective cross-sectional study of patients with COVID-19. The parameters studied were age, sex, uremia, creatinine and glomerular filtration rate (GFR). All biological parameters were measured with the A15 Biosystems automated system (Barcelona, Spain) and the GFR was calculated according to the MDRD formula. Data processing was carried out with the SPSS (Statistical Package for Social Sciences) software version 23. Our study population consisted of 192 subjects with COVID-19, of which 111 were moderate and 81 were severe. The mean age of our subjects was 60 years and a sex ratio of 1.02. GFR assessment showed that 28% of the population had a lowered GFR (2). Analysis of the results according to the clinical forms showed frequencies of 19% of disturbance of renal function for the moderate forms against 40% for the severe forms. Impaired renal function appears to be frequent in patients with severe SARS-CoV-2 infection and is associated with a bad prognosis. Any patient hospitalized with SARS-CoV-2 should benefit from an initial nephrological assessment which could be used as a marker to dictate the prognosis of the severity of COVID-19.

关键词： COVID-19 CTE GFR Renal Function SARS-CoV-2

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Association between Uric Acid and Metabolic Syndrome in Homozygous Sickle Cell Patients

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Advances in Biological Chemistry 2021年第3期11卷 142-148页

作者： Kandji Pape Matar Djite Moustapha Barry Nene Oumou Kesso Sagne Rene Ngor Thioune Ndeye Mareme mbacke ndoumbé mame Ndour El Hadji Malick Gueye-Tall Fatou Lopez-Sall Philomene Cisse Aynina Diop Pape Amadou Gueye Papa Madieye Laboratory of Biochemistry-Hematology National University Hospital of Fann Dakar Senegal Laboratory of Pharmaceutical Biochemistry Faculty of Medicine Pharmacy Cheikh Anta Diop University Dakar Senegal

The objective of this study was to assess the association between uric acid and the metabolic syndrome and its components in homozygous sickle cell patients. This is a prospective case/control study of sickle cell SS patients. Each patient was matched to a control of the same sex and age ± 2 years. In our framework, we used the criteria for defining metabolic syndrome according to International Diabetes Federation (IDF) 2009. Assay of all biological parameters was performed with the ARCHITECT ci4100, Abbot (Chicago, Illinois, USA). Data were collected with Excel 2016 software and statistical analysis was done using XLSTAT 2019 software. Student’s T test was used to compare means and a p-

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Evaluation of Kidney Function in Patients with COVID-19 at the Epidemiological Treatment Centre in CHNU Fann

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Advances in Biological Chemistry（生物化学进展） 2023年第1期

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Button Cell Ingestion in Infants: A Report of Five Cases

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Journal of Biosciences and Medicines 2024年第8期12卷 199-209页

作者： Mbène Fall Aminata Diop Nakoulima Khadija Fall Alice Ingabiré Goumba mame Aïta Seck Tagouthie Niang Madawase Mboup mame Diarra Mbacké Ibrahima Diallo Meissa Ndew Seye Department of Pediatrics Dakar Principal Hospital Dakar Senegal Department of Surgery Dakar Principal Hospital Dakar Senegal Department of Medecine Dakar Principal Hospital Dakar Senegal

Button cell ingestion is a common household accident among infants, often leading to serious complications that require immediate diagnosis and urgent removal. We report five cases of button cell ingestion involving infants aged between 9 and 32 months, including four boys and one girl. The ingestion was accidentally discovered in two infants, while in the other three, it was suspected during play. In three cases, mothers attempted to induce vomiting by giving fluids, but the batteries remained in the digestive tract for 38 hours to 5 days. After confirming the diagnosis, the batteries were removed within 4 to 36 hours. The locations of the cells were the esophagus in two cases, the cardia in one, the stomach in one, and the bowel in one. One case involved a large cell in the esophagus, while the others involved smaller cells. Complications occurred in four cases, including esotracheal fistula, esophageal ulceration, and perforation of the jejunum and caecum. In one case, the digestive mucosa appeared normal upon endoscopy. One patient died.

关键词： Button Cell Domestic Accident Infant

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Accidental Ingestion of Nitric Acid in an Agricultural Company: A Case Study and Literature Review

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Occupational Diseases and Environmental Medicine 2024年第1期12卷 21-27页

作者： Asséga Sylvain Sagna mame Thioro Aïssatou Fall Mossane Dominique Ndour Sidy Diallo Société de Cultures Légumières (SCL) Saint-Louis Sénégal West Africa Farms (WAF) Yamane Louga Sénégal International Committee of The Red Cross Dakar Sénégal Saint-Louis Regional Hospital Center Saint-Louis Sénégal

Introduction: Though common in society, caustic accidental ingestion is rare in the agricultural industry. This study describes a case of ingestion of nitric acid used as an agricultural fertilizer by an ordinary worker at the Société de Cultures Légumières. Clinical Case: This is a 33-year-old unschooled woman who ingested a sip of nitric acid from an abandoned labelled acid canister near a farming plot of land. She showed a burn of the oral cavity with a bleeding tablecloth and an intense retrosternal pain. The duodenal oesophagus fibroscopy screening that was carried out 18 hours after the accident, revealed an esophagitis class 2b. The tests revealed no anomalies. Fifteen (15) days after the accident, the FOGD was normal. Following an 8-month-follow up, no signs of stenosis or degeneration were noted. Conclusion: The accidental ingestion of nitric acid is rare in adult. Its treatment is mainly symptomatic and aims at preserving vital functions without directly fighting the ingested substance off. The right actions must be integrated into the 15-minute Health and Safety awarenesssessions for optimum pre-hospital management. The hospital evaluation is mandatory and is carried out thanks to the digestive endoscopy, which is still relevant in this indication, but is completed by the thoraco-abdominal CT. The latter is very sensitive the transmural necrosis diagnosis.

关键词： Accident Agriculture Caustic Fibroscopy Senegal

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Obstructive Tumor of the Palate in the Old Person: A Case Report

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Open Journal of Stomatology 2024年第5期14卷 199-205页

作者： Silly Toure Mouhamadou Makhtar Ndiaye Abibou Ndiaye Mamadou Coume mame Sanou Diouf Baye Karim Diallo Maxillofacial Surgery and Stomatology Department Aristide Le Dantec University Hospital of Dakar Dakar Senegal Geriatrics Department Aristide Le Dantec University Hospital of Dakar Dakar Senegal ENT and Head and Neck Surgery Department FANN University Hospital of Dakar Dakar Senegal

Introduction: Pleomorphic adenoma or mixed salivary gland tumor is a heterogeneous benign tumor of the salivary glands. The most common site is the parotid gland. Its extra-parotid locations, particularly in the accessory salivary glands, are rarer. We report a case of a pleomorphic adenoma of the posterior palate which posed management problems. Observation: This is an 85-year-old patient who consulted for a tumor of the posterior palate that had been evolving for 3 years. The examination revealed a globular tumor of the posterior palate extending beyond the midline by approximately 7 cm in long axis, shooting towards the oropharynx and hindering breathing, speech and eating, indicating a life-saving tracheotomy. A CT scan of the facial area revealed a well-circumscribed tumor at the expense of the soft palate, with multiple sites of bone lysis. The biopsy performed was in favor of a pleomorphic adenoma. The patient underwent total surgical excision of a huge tumor on the palate. The aftermath of the operation was marked by a loosening of the sutures with an oronasal fistula requiring the creation of an obturator plate due to the patient’s refusal to have another operation. Conclusion: Large pleomorphic adenoma of the posterior palate is a rare entity that can cause respiratory problems and surgical difficulties. His prognosis is generally good.

关键词： Pleomorphic Adenoma Posterior Palate Respiratory Disorders Prognosis Obturator Plaque

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Management of Square Carcinoma of the Lower Lip Using Camille-Bernard Flap under Local Anesthesia: When Constraints Dictate Our Attitude

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Open Journal of Stomatology 2024年第4期14卷 191-197页

作者： Silly Toure Mouhamadou Makhtar Ndiaye Abibou Ndiaye mame Sanou Diouf Birame Loum Baye Karim Diallo Department of Maxillofacial Surgery and Stomatology CHU Aristide Le Dantec of Dakar Dakar Senegal ENT Department Fann University Hospital Dakar Senegal

Introduction: Squamous cell carcinomas of the lip essentially pose a therapeutic management problem. In the West, their treatment is done under general anesthesia and follows the classic rules of oncology. In our context of exercise, we sometimes have a different attitude dictated by various constraints. Observation: 55-year-old patient with no notable history, seen in consultation for a very large ulcerative-budding lesion on the right 2/3 of the lower lip with mucocutaneous involvement without lymph node findings found on examination. Faced with this suspicious lesion and the patient’s financial difficulties, we decided to operate under local anesthesia to remove this tumor. The oncological excision was followed by immediate plasty using a Camille-Bernard flap with a good immediate aesthetic and functional result and postoperative day 7. The patient was unable to take his surgical specimen to anatomy-pathology and was lost to follow-up due to lack of financial resources. On anatomo-pathological analysis of the surgical specimen, the margins were healthy with confirmation of squamous cell carcinoma (anapathological reading made for scientific interest). Discussion: The particular mentality of certain patients and their difficult financial conditions push us to have an unconventional therapeutic attitude in oncology, but which nevertheless makes it possible to resolve certain problems that we often face. Local anesthesia is possible and realistic in cases like ours and the results can be acceptable and life-saving.

关键词： Squamous Cell Carcinoma Lower Lip Camille Bernard Flap Local Anesthesia

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When the Combination of a Chinese Flap and Dufourmentel Makes It Possible to Treat a Hopeless Case of Squamous Cell Carcinoma of the Upper Lip

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Open Journal of Stomatology 2024年第7期14卷 327-335页

作者： Silly Toure Abibou Ndiaye Mouhamadou Makhtar Ndiaye Mamadou Coume mame Sanou Diouf Baye Karim Diallo Department of Maxillofacial Surgery and Stomatology CHU Aristide Le DANTEC Dakar Senegal Geriatrics Department CHU AT LE DANTEC Dakar Senegal Otorhinolaryngology and Head and Neck Surgery Department FANN University Hospital Dakar Senegal

Cancers of the lip are the leading cause of labial defects, and treatment is essentially surgical. The success of a repair is assessed by two essential criteria: The functional character of the lip (restoration of continence allowing feeding) and the aesthetic quality of the repair. However, for many patients from countries whose medical infrastructure does not allow them to undertake complex reconstructions locally, medical transfers represent their only chance of treatment. The aim of this article is to share with you an extreme clinical case of labial reconstruction, the management of which was a real challenge, using two major flaps: the free ante-brachial flap and the DUFOURMENTEL-type bi-pediculated scalp flap.

关键词： Surgical Flap Reconstruction Aesthetic Lip Cancer-Plastic Surgery

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Detailed Analyses of Nymphea Seeds Consumed in the Senegal River Valley

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Food and Nutrition Sciences 2024年第8期15卷 695-700页

作者： Nicolas Cyrille Ayessou Michel Bakar Diop Fatou Kiné Gueye César Bassène mame Samba Mbaye Centre dEtudes sur la Scurit Alimentaire et les Molcules Fonctionnelles (CESAM-RESCIF) Universit Cheikh Anta DIOP Dakar Sngal Unit de formation et de Recherche des Sciences Agronomiques de lAquaculture et des Technologies Alimentaires Universit Gaston Berger Saint-Louis Sngal Laboratoire de Botanique-Biodiversit Biologie Vgtale Universit Cheikh Anta Diop Dakar Senegal

Physicochemical investigations were performed on seeds of Nymphea lotus and N. micrantha consumed in the Senegal River valley. They revealed a composition similar to that of cereals. In order to estimate their intrinsic quality, the determination of their amino acid, fatty acid and monosaccharids profiles was done. The results indicate that monosaccharides are represented specifically by saccharose (7%) and glucose (0.67%);a predominance of stearic acid and linoleic acid as unsaturated acids (24.86%);arachidic and palmitic acids as the only saturated acid found (11.12%);a good ratio of unsaturated/saturated acid (2.23);a lack of oleic acid, linoleic, palmitoleic, myristic, caprylic acids;a poor-quality index protein due to low quantity amino acids. Nevertheless, all essential amino acids are present in the seeds. The Nymphea sp grains consumed by the populations around the Senegal River valley offer an interesting nutritional quality linked to fatty acids and carbohydrates.

关键词： Nymphea Seeds Composition

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Assessment of Some Secondary Metabolites, Minerals and Alcohol Content of Noni Juice Obtained by Fermentation of Morinda citrifolia L. Fruit from Senegal

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American Journal of Plant Sciences 2024年第7期15卷 577-588页

作者： Ndèye Adiara Ndiaye mame Ndew Mbaye Lahat Niang Modou Dieng Nicolas Cyrille Ayessou Ndeye Coumba Kane Touré Laboratory of Microbiology Graduate School Polytechnique (ESP)-UCAD Dakar Senegal Department of Chemical Engineering and Applied Biology Graduate School Polytechnique (ESP)-UCAD Dakar Senegal Water Energy Environment and Industrial Processes Laboratory (LE3PI) Graduate School Polytechnique (ESP)-UCAD Dakar Senegal University Sine Saloum El Hadj Ibrahima Niass (USSEIN) Kaolack Senegal

The fruit of Morinda citrifolia L., commonly known as noni, has an extensive history of use as a food and traditional medicine around the world. Adding value to Morinda citrifolia L. products, particularly the fruit, could be one way of building resilience in vulnerable farming households. The aim of this study was to determine the secondary metabolite and mineral composition of noni juice obtained by fermenting the fruit of Morinda citrifolia L. Fruits were collected in August 2022 from the local field in Thiès region, West of Senegal. Extraction yields were determined and the secondary metabolites were determined using conventional analytical methods. Calcium, magnesium, iron, sodium and potassium were determined by atomic absorption spectrophotometer coupled with a CCD detector. The results show that an average fruit mass (503.2 ± 110.96 g) consists of 171.44 ± 50.01 g pulp and 34.06 ± 10.35 g seeds. The traditional extraction yield of noni juice is 16.46% after three weeks of fermentation. The contents of total polyphenols, flavonoids and tannins obtained in noni are 608.97 ± 4.53 mg EAG/100mL, 7.78 ± 0.01 mg EQ/100mL and 0.191 ± 0.01 mg EC/100mL respectively. The ethanol content of noni varies from 3.57 to 5.23 mL/100mL during extraction. Noni has a high calcium content with a concentration of 383.79 ± 33.23 mg/L. This is followed by a good concentration of magnesium, potassium and sodium, at 278.47 ± 26.30, 187.43 ± 10.7 and 155.95 ± 28.66 mg/L respectively. Noni also has an iron content of 202.15 ± 0.05 mg/L.

关键词： Morinda citrifolia L. Juice Alcohol Total Phenols Flavonoids Tannins Minerals

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