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Th. common pentanucleotide polymorph.sm of th. 3’-untranslated region of th. leptin receptor gene is associated with.obesity in Saudi females

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h.alth 2013年第2期5卷 285-291页

作者： Mah. h. daghestani mazin h. daghestani Pinar T. Ozand Ah.ed R. Al-h.maidi Mamoon h. daghestani Nadia A. Aleisa h.na h. h.kami Abdelmoneim Eldali Ali N. Al-odaib Biostatistics Epidemiology & Scientific Computing (MBC-03) King Faisal Specialist Hospital and Research Center Riyadh KSA Department of Genetics King Faisal Specialist Hospital and Research Center Riyadh KSA Department of Obstetrics & Gynecology Umm-Al-Qura University Makkah KSA Department of Surgery King Abdulaziz Medical City National Guard Health Affairs Jeddah KSA Department of Zoology Center for Scientific and Medical Female Colleges King Saud University Riyadh KSA Department of Zoology Science College King Saud University Riyadh KSA Duzen Laboratories Istanbul Turkey

Obesity is due to th. combined effects of genes, environment, lifestyle, and th. interactions of th.se factors. Leptin receptor (LEPR) gene h.s been intensively evaluated in th. search.of variants th.t could be related to obesity. Th. results of most of th.se studies h.ve been controversial. We investigated th. effects of leptin receptor gene 3’-untranslated region (3’-UTR) polymorph.sm on ph.notype, metabolic parameters and anth.opometric measurements of obese Saudi females. 122 h.alth. women aged 19 to 36 years. Th. subjects were divided into 3 groups according to th.ir body mass index BMI;lean (BMI 18 - 24), overweigh. (BMI 25 - 29) and obese (BMI ≥ 30). Th.re were 13 h.mozygotes and 34 h.terozygotes for th. 3’-UTR insertion allele amongst all 122 women. Th. results of th.s study sh.w th.t th. allele frequency of th. insertion allele (I) of 3’UTR was significantly h.gh.r in overweigh. (35.3) and obese females (32.2) compared to th. frequency in lean females (15.6). Th. insertion allele was associated with.increased BMI in obese groups. Th. results obtained from th.s study indicated th.t in th. obese subjects most variable values increased in I/I h.mozygote but th. significant h.gh.value recorded among BMI (40.9 ± 7.11 kg/m2, P = 0.042). Our findings indicated th.t, th. obesity in Saudi females is influenced by alteration in th. leptin receptor gene 3’-UTR polymorph.sm.

关键词： Pentanucleotide Polymorph.sm Leptin Obesity Saudi Females

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Response Evaluation Using Contrast-Enh.nced Ultrasound for Unresectable Advanced h.patocellular Carcinoma Treated With.Tyrosine Kinase Inh.bitors Plus Anti-PD-1 Antibody Th.rapy

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Ultrasound in Medicine and Biology 2024年第1期50卷 142-149页

作者： Zh.o C.-K. Guan X. Pu Y.-Y. Zh.u B.-Y. Wang L.-F. Sun Y.-K. Yin h.-h. Xia h.-S. Wang X. h.n h. Xu h.-X. Department of Ultrasound Zhongshan Hospital Institute of Ultrasound in Medicine and Engineering Fudan University Shanghai China Sh.ngh.i Institute of Medical Imaging Shanghai China Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China

Objective: Th. aim of th. work described h.re was to evaluate th. role of contrast-enh.nced ultrasound (CEUS) in response evaluation for unresectable advanced h.patocellular carcinoma (h.C) treated with.tyrosine kinase inh.bitors (TKIs) plus anti-programmed cell death.protein-1 (PD-1) antibody th.rapy. Meth.ds: A prospective coh.rt of consecutive patients with.h.C wh. received combined TKI/anti-PD-1 antibody treatment for unresectable h.C between January 2022 and October 2022 was included in th.s study. Th. patients underwent unenh.nced ultrasound (US) and CEUS examinations before treatment and at follow-up. Ch.nges in th. largest diameters of th. target tumor on unenh.nced US and th. largest diameters of th. enh.ncing target tumors on CEUS were evaluated. Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 with.unenh.nced US and magnetic resonance imaging/computed tomograph. (MRI/CT) and modified RECIST (mRECIST) with.CEUS and CEMRI/CT were used to assess treatment response. Results: A total of 24 h.C patients (23 men and 1 woman; mean age: 56.5 ± 8.5 y; Barcelona Clinic Liver Cancer stage C, 62.5%; 29 intrah.patic target tumors) were studied. Calculations of degree of necrosis in th. target tumors revealed no significant differences between CEUS and CEMRI/CT (44.5 ± 36.2% vs. 45.3 ± 36.8%, p = 0.862). As for th. differentiation of responders from non-responders, th. agreement between RECIST version 1.1 of unenh.nced US and mRECIST-CEUS was poor (κ coefficient = 0.233). Meanwh.le, th.re was a h.gh.degree of concordance between mRECIST-CEUS and mRECIST-CEMRI/CT (κ coefficient = 0.812). Conclusion: CEUS proved to be superior to baseline US and is comparable to CEMRI/CT in defining treatment outcome for combined TKI/anti-PD-1 antibody th.rapy. © 2023 World Federation for Ultrasound in Medicine & Biology

关键词： Anti-angiogenic th.rapy Anti-PD-1 antibody Contrast-enh.nced ultrasound h.patocellular carcinoma

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Effect of cold-working on corrosion induced damage in lug joints

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Defence Tech.ology（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath.M.N Ch.kmath.L. Murth. h. Department of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India Department of Aeronautical Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

Lug joints are preferred joineries for transferring h.avy loads to parent components in aerospace *** experience corrosion due to environmental conditions,improper surface finish.s and rubbing displacement between th. pin and *** causes damage of different sizes and sh.pes near th. *** degradation due to corrosion-induced damage is modelled as a th.ough.pit at one of th. identified critical locations th.ough.stress *** effect of th.s pit on fatigue crack initiation life is ***-h.le is pre-stressed by cold-working and th. benefits of inducing plastic wake on th. intended performance of th. lug joint during th. damages due to corrosion are brough. out and compared with.non-cold-worked *** analysis is performed on th.s lug joint with.*** results obtained h.gh.igh. th. benefits of cold-working and th. meth.dology can be extended to damage growth.and analyse th. effect of surface treatments for better structural integrity of components of aerospace veh.cles.

关键词： Lug joint Corrosion Crack initiation Cold-working Structural integrity

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Editorial for th. Special Issue on Emerging Tech.ology and Advanced Application of Nondestructive Detection for Power Equipment

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Ch.nese Journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li J. Mei h. Li S. Tianjin University China Tsingh.a Sh.nzh.n International Graduate Sch.ol China Lanzh.u Jiaotong University China

Th. rapid development of clean and renewable energy tech.ologies represented by wind and solar energy,as well as th. continuous growth.of load demand,h.ve put forward h.gh.r requirements for th. safe operation of th. power *** performance of power equipment based on traditional dielectric materials is often limited by various defects generated during molding,transportation,assembly,and operation,wh.ch.cannot meet th. reliability requirements of power systems in th. new *** detection is an essential tech.ical meth.d in industrial development,wh.ch.can detect and evaluate th. defect and damage status of in-service equipment,key components,and materials with.ut damaging th. object.

关键词： service Application operation

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Cognitive navigation for intelligent mobile robots: A learning-based approach.with.topological memory configuration

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 1-11页

作者： Liu Q. Cui X. Liu Z. Wang h. Department of Automation Shanghai Jiao Tong University Shanghai 200240 China MoE Key Laboratory of Artificial Intelligence AI Institute Shanghai Jiao Tong University Shanghai 200240 China Department of Automation Key Laboratory of System Control and Information Processing of Ministry of Education Key Laboratory of Marine Intelligent Equipment and System of Ministry of Education Shanghai Engineering Research Center of Intelligent Control and Management Shanghai Jiao Tong University Shanghai 200240 China

Autonomous navigation for intelligent mobile robots h.s gained significant attention, with.a focus on enabling robots to generate reliable policies based on maintenance of spatial memory. In th.s paper, we propose a learning-based visual navigation pipeline th.t uses topological maps as memory configurations. We introduce a unique online topology construction approach.th.t fuses odometry pose estimation and perceptual similarity estimation. Th.s tackles th. issues of topological node redundancy and incorrect edge connections, wh.ch.stem from th. distribution gap between th. spatial and perceptual domains. Furth.rmore, we propose a differentiable graph.extraction structure, th. topology multi-factor transformer (TMFT). Th.s structure utilizes graph.neural networks to integrate global memory and incorporates a multi-factor attention mech.nism to underscore elements closely related to relevant target cues for policy generation. Results from ph.torealistic simulations on image-goal navigation tasks h.gh.igh. th. superior navigation performance of our proposed pipeline compared to existing memory structures. Compreh.nsive validation th.ough.beh.vior visualization, interpretability tests, and real-world deployment furth.r underscore th. adaptability and efficacy of our meth.d. IEEE

关键词： Data mining Graph.neural networks (GNNs) Navigation Odometry Reliability Robots spatial memory Task analysis topological map Topology visual navigation

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Th. Substructure of Elementary Particles Demonstrated by th. I-Th.ory

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Journal of h.gh.Energy Ph.sics, Gravitation and Cosmology 2024年第2期10卷 469-514页

作者： h. h. Swami Isa Ch.istoph. Dumas Global Energy Parliament Trivandrum Kerala India

Present studies in ph.sics assume th.t elementary particles are th. building blocks of all matter, and th.t th.y are zero-dimensional objects wh.ch.do not occupy space. Th. new I-Th.ory predicts th.t elementary particles do indeed h.ve a substructure, th.ee dimensions, and occupy space, being composed of fundamental particles called I-particles. In th.s article we identify th. substructural pattern of elementary particles and define th. quanta of energy th.t form each.elementary particle. We demonstrate th.t th. substructure comprises two classes of quanta wh.ch.we call “attraction quanta” and “repulsion quanta”. We create a model th.t defines th. rest-mass energy of each.elementary particle and can predict new particles. Lastly, in order to incorporate th.s knowledge into th. contemporary models of science, a revised periodic table is proposed.

关键词： I-Th.ory I-Particle Causal Subtle Gross Quanta Attraction Quanta Repulsion Quanta Elementary Particles Leptons Bosons h.dron Periodic Table Black Matter Wh.te Matter Red Matter Gravitation Strong Force Weak Force Quantum Th.ory h.at Quantum Ph.ton Neutrino

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Neuroprotective effects of resveratrol on retinal ganglion cells in glaucoma in rodents:A narrative review

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Animal Models and Experimental Medicine 2024年第3期7卷 195-207页

作者： Maryam Golmoh.mmadi Seyed Arash.Agh.ei Meibodi Sulieman Ibrah.em Sh.lash.Al-h.wary Jitendra Gupta Ibroh.m B.Sapaev mazin A.A.Najm Marim Alwave Mozh.an Nazifi Moh.mmadreza Rah.ani Moh.mmad Yasin Zamanian Gervason Moriasi Sch.ol of Medicine Shahid Beheshti University of Medical SciencesTehranIran Department of Business Administration Business SchoolAl al-Bayt UniversityMafraqJordan Institute of Ph.rmaceutical Research GLA UniversityMathuraIndia Tash.ent Institute of Irrigation and Agricultural Mech.nization Engineers TashkentUzbekistan New Uzbekistan University TashkentUzbekistan Ph.rmaceutical Ch.mistry Department College of PharmacyAl-Ayen UniversityThi-QarIraq Medical Tech.ical College Al-Farahidi UniversityBaghdadIraq Department of Neurology Hamadan University of Medical SciencesHamadanIran Ph.siology-Ph.rmacology Research.Center Research Institute of Basic Medical SciencesRafsanjan University of Medical SciencesRafsanjanIran Department of Ph.siology and Ph.rmacology School of MedicineRafsanjan University of Medical SciencesRafsanjanIran Neuroph.siology Research.Center Hamadan University of Medical SciencesHamadanIran Department of Ph.rmacology and Toxicology School of PharmacyHamadan University of Medical SciencesHamadanIran Department of Medical Bioch.mistry School of MedicineCollege of Health SciencesMount Kenya UniversityThikaKenya

Glaucoma,an irreversible optic neuropath.,primarily affects retinal ganglion cells(RGC)and causes vision loss and *** damage to RGCs in glaucoma occurs by various mech.nisms,including elevated intraocular pressure,oxidative stress,inflammation,and oth.r neurodegenerative *** th. disease progresses,th. loss of RGCs leads to vision ***,protecting RGCs from damage and promoting th.ir survival are important goals in managing *** th.s regard,resveratrol(RES),a polyph.nolic ph.toalexin,exerts antioxidant effects and slows down th. evolution and progression of *** present review sh.ws th.t RES plays a protective role in RGCs in cases of isch.mic injury and h.poxia as well as in ErbB2 protein expression in th. ***,RES plays protective roles in RGCs by promoting cell growth.reducing apoptosis,and decreasing oxidative stress in h.(2)O_(2)-exposed *** was also found to inh.bit oxidative stress damage in RGCs and suppress th. activation of mitogen-activated protein kinase signaling *** could alleviate retinal function impairment by suppressing th. h.poxia-i nducible factor-1 alph./vascular endoth.lial growth.factor and p38/p53 axes wh.le stimulating th. PI3K/Akt ***,RES migh. exert potential th.rapeutic effects for managing glaucoma by protecting RGCs from damage and promoting th.ir survival.

关键词： glaucoma isch.mic-reperfusion injury oxidative stress resveratrol retinal ganglion cells

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Th. Fundamental Th.ory of Artificial Intelligence—Logic Structure and Logic Engineering

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Intelligent Control and Automation 2024年第1期15卷 28-62页

作者： Dong h. Liu Sch.ol of Computer Science Guangdong Normal University of Technology Guangzhou China

Th. research.purpose of th.s dissertation is th.eefold: to innovate artificial intelligence meth.ds, to create th. intersection of artificial intelligence and biological research. and to innovate h.man meth.dology. Th. work I h.ve done in my research.includes: improving logical structure and logical engineering, using my th.ory to study th. innovation of th. development path.of artificial intelligence, using my th.ory to create biomimetic logic, a new intersection of artificial intelligence and biological research. and exploring th. innovation of h.man meth.dology th.ough.th. previous two works. Th. results of th. research.are as follows: 1) Introduction to bionic logic, incorporating simulations of people, society, and life as core principles. 2) Definition of th. logical structure as th. primary focus of research. with.logic mech.nics serving as foundational research.principles. 3) Examination of th. logical structure’s environment th.ough.logical fields and networks. 4) Study of logical structure communication via logical networks and main lines. 5) Proposal of data logic. 6) Investigation into th. logic of logical structures, employing structural diagrams of logical equations. 7) Development of a th.ory of life activity with.n logical structures, encompassing information reasoning, its corresponding control structure, and structural reasoning. 8) Introduction of th. lifecycle th.ory for logical structures and examination of th. clock equation. 9) Exploration of logical structure intelligence. 10) Study of logical structures in math.matical forms. 11) Introduction of logic engineering. 12) Examination of artificial intelligence’s significance. 13) Investigation into th. significance of h.man meth.dology.

关键词： Bionic Logic Structural Diagram of Logical Equation Data Logic Intelligence

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Th.rmal Decomposition of Olive-Solid Waste by TGA: Ch.racterization and Devolatilization Kinetics under Nitrogen and Oxygen Atmosph.res

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Journal of Power and Energy Engineering 2024年第3期12卷 31-47页

作者： Yah.a h. Kh.aish. Ch.mical Engineering Department University of Jordan Amman Jordan

Despite th. fact th.t a few countries in th. Mediterranean and th. Middle East h.ve limited crude oil reserves, th.y h.ve abundant biomass feedstocks. For instance, Jordan relies h.avily on th. importation of natural gas and crude oil for its energy needs;but, by applying th.rmoch.mical conversion tech.iques, leftover olive oil can be used to replace th.se energy sources. Understanding th. ch.mical, ph.sical, and th.rmal ch.racteristics of raw materials is essential to obtaining th. most out of th.se conversion processes. Th.rmogravimetric analysis was used in th.s study to examine th. th.rmal beh.vior of olive-solid residue (kernel) at th.ee different h.ating rates (5, 20 and 40 C/min) in nitrogen and oxygen atmosph.res. Th. initial degradation temperature, th. residual weigh. at 500 and 700˚C and th. th.rmal degradation rate during th. devolatilization stage (below 400˚C) were all determined. It was found th.t in N2 and O2 atmosph.res, both.th. initial degradation temperature and th. degradation rate increase with.increasing h.ating rates. As h.ating rates increase in th. N2 atmosph.re, th. residual weigh. at 500 or 700˚C decreases sligh.ly, but at low h.ating rates compared to h.gh.h.ating rates in th. O2 atmosph.re, it decreases significantly. Th.s suggests th.t a longer lignin oxidation process is better th.n a sh.rter one. Coats and Redfern approach.was used to identify th. mech.nism and activation energy for th. devolatilization stage of pyrolysis and oxidation reactions. Th. process mech.nism analysis revealed th.t th. model of first-order and second-order reactions may adequately describe th. mech.nism of h.at degradation of th. devolatilization step of olive-solid waste for pyrolysis and oxidation processes, respectively.

关键词： Biomass Olive-Solid Waste Th.rmogravimetry Pyrolysis Oxidation h.ating Rates Kinetics

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Analysis of Temperature Trends and Variations in th. Arabian Peninsula’s Upper Atmosph.re

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Atmosph.ric and Climate Sciences 2024年第1期14卷 85-100页

作者： Abdullrah.an h. Magh.abi National Institute for Climate Ch.nge King Abdulaziz City for Science and Technology Riyadh Saudi Arabia

In th.s study, th. trends of upper-air temperatures are analysed by utilising radiosonde observations for th. barometric levels at 700, 500, 300, 200, 150, 100 and 50 h.a from five meteorological stations with.n th. Arabian Peninsula from January 1986 to August 2015. Th. mean month.y variations of th. temperatures at th.se levels are ch.racterised and establish.d. Th. magnitudes of th. annual trends of th. mean temperatures for each.site for th. selected barometric levels are studied and statistically tested using Mann-Kendall rank statistics at different significance levels. Th. temperature trends at different pressure levels sh.w th.t th. upper troposph.re and lower stratosph.re are warming, wh.le th. middle troposph.re is cooling wh.ch.is consistent with.th. findings of oth.r studies. Th. variations in upper air temperature observed in th.s study can be attributed to a range of factors, including increasing greenh.use gas concentrations, ch.nges in atmosph.ric circulation patterns, variations in solar activity, aerosols and volcanic eruptions, and land use and land cover ch.nge.

关键词： Upper-Air Temperature Variability Long-Term Trend Arabian Peninsula Climate Ch.nge Mann-Kendell

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