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IPv6 Cryptographically Generated Address:Analysis,Optimization and Protection

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Computers, Materials & Continua 2021年第7期68卷 247-265页

作者： Amjed Sid Ahmed Rosilah Hassan Faizan Qamar mazhar malik Department of Computing and Information Technology Global College of Engineering and TechnologyRuwi112Sultanate of Oman Faculty of Information Science and Technology Center for Cyber SecurityUniversiti Kebangsaan MalaysiaBangi43600Malaysia Faculty of Information Science and Technology Universiti Kebangsaan Malaysia43600BangiMalaysia

In networking,one major difficulty that nodes suffer from is the need for their addresses to be generated and verified without relying on a third party or public authorized *** resolve this issue,the use of selfcertifying addresses have become a highly popular and standardized method,of which Cryptographically Generated Addresses(CGA)is a prime *** was primarily designed to deter the theft of IPv6 addresses by binding the generated address to a public key to prove address *** though the CGA technique is highly effective,this method is still subject to several vulnerabilities with respect to security,in addition to certain limitations in its *** this study,the authors present an intensive systematic review of the literature to explore the technical specifications of CGA,its challenges,and existing proposals to enhance the *** that CGA generation is a time-consuming process,this limitation has hampered the application of CGA in mobile environments where nodes have limited energy and *** Hash2 conditions in CGA is the heaviest and most timeconsuming part of *** improve the performance of CGA,we replaced the Secure Hash Algorithm(SHA1)with the Message Digest(MD5)hash ***,this study also analyzes the possible methods through which a CGA could be *** conducting this analysis,Denial-of-Service(DoS)attacks were identified as the main method of attack toward the CGA verification process,which compromise and threaten the privacy of ***,we propose some modifications to the CGA standard verification algorithm to mitigate DoS attacks and to make CGA more security conscious.

关键词： IPv6 GCA SEND DoS attacks RSA SHA-1

Impaired cell properties and down regulation of FAK-Src complex signaling in autistic B lymphoblasts

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Impaired cell properties and down regulation of FAK-Src comp...

Modeling and Comprehensive Review of Signaling Storms in 3GPP-Based Mobile Broadband Networks:Causes,Solutions,and Countermeasures

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： mazhar malik Ashfaq M.Sheikh George Merz W.Ted Brown Department of Neurochemistry NY State Institute for Basic Research in Developmental DisabilitiesNew YorkNY 10314USA

＜正＞Objective Recent studies suggest that one of the major pathways to the pathogenesis of autism is reduced cell migration,since the linkage between RELN and autism is a replicated genetic *** Reelin protein,encoded by the RELN gene,plays a pivotal role in neuronal *** adhesion kinase（FAK） has an important functional role in neural migration,dendritic morphology,axonal branching and synapse *** FAK/Src complex activated by up-stream reelin and integrinβ1 can initiate a cascade of phosphorylation events to trigger multiple intracellular pathways including MEK/ERK and PI3K/Akt *** aims of this study is to 1) determine whether integrinβ1 and FAK-Src signaling are abnormally regulated in autism by using B lymphoblasts as a study model, and 2) whether abnormal FAK-Src signaling leads to defects in B lymphoblast adhesion,migration,proliferation, and IgG *** Both autistic lymphoblasts and control lymphoblasts from the normal siblings were obtained from Autism Genetic Resource Exchange（AGRE,USA）.In this study,Western blot analyses were used to detect the expression and activity levels of Integrin,FAK,Src and *** adhesion assay,modified Boyden chamber migration assay and cell proliferation assay were used to examine the lymphoblasts’ adhesion,migration and proliferation.A human IgG ELISA kit was used to measure the immunoglobulin *** staining and computer-assisted morphometry were performed to determine the morphology of *** We show that（1） the protein expression of both integrinβ1 and FAK are significantly decreased in autistic lymphoblasts and（2） Src protein expression and the phosphorylation of active site（Y416） are also significantly *** findings suggest a reduced FAK-Src signaling activity in autistic *** also found that lymphoblasts from autistic subjects exhibit significantly decreased migration and increased adhesion properties,as well as an i

关键词： autism focal adhesion kinase Src lymphoblasts

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 123-153页

作者： Muhammad Qasim Khan Fazal malik Fahad Alturise Noor Rahman Department of Computer Science Iqra National UniversityPeshawar25000Pakistan Department of Cybersecurity College of ComputerQassim UniversityBuraydah52555Saudi Arabia Department of Computer Science and Engineering Al-Fayha CollegeAl Jubayl31961Saudi Arabia

Control signaling is mandatory for the operation and management of all types of communication networks,including the Third Generation Partnership Project(3GPP)mobile broadband ***,they consume important and scarce network resources such as bandwidth and processing *** have been several reports of these control signaling turning into signaling storms halting network operations and causing the respective Telecom companies big financial *** paper draws its motivation from such real network disaster incidents attributed to signaling *** this paper,we present a thorough survey of the causes,of the signaling storm problems in 3GPP-based mobile broadband networks and discuss in detail their possible solutions and *** provide relevant analytical models to help quantify the effect of the potential causes and benefits of their corresponding *** important contribution of this paper is the comparison of the possible causes and solutions/countermeasures,concerning their effect on several important network aspects such as architecture,additional signaling,fidelity,etc.,in the form of a *** paper presents an update and an extension of our earlier conference *** our knowledge,no similar survey study exists on the subject.

关键词： Signaling storm problems control signaling load analytical modeling 3GPP networks smart devices diameter signaling mobile broadband data access data traffic mobility management signaling network architecture 5G mobile communication

More than Half of Patients with Schizophrenia Are Receiving Polypharmacy and Co-Prescription of Anxiolytics in Pakistan —Findings from Research on Asian Prescription Pattern in 2016

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Open Journal of Psychiatry 2018年第3期8卷 199-211页

作者： mazhar malik Usman Ghani Nariman Awais Nargis Munir Afzal Javed Munir Hamirani Nasar Sayeed Kahn Shu-Yu Yang Liang-Yu Chen Shih-Ku Lin Norman Sartorius Chay-Hoon Tan Mian-Yoon Chong Masaki Shinfuku Sandeep Grover Winston W. Shen Naotaka Shinfuku Department of Psychiatry and Behavioral Sciences Rawal Institute of Health Sciences Islamabad Pakistan Pakistan Psychiatric Research Center Fountain House Lahore Pakistan Department of Psychiatry Abbasi Shaheed Hospital Karachi Pakistan Department of Psychiatry Services Hospital Lahore Pakistan Taipei City Hospital and Psychiatric Center Taiwan Institute of Epidemiology and Preventive Medicine National Taiwan University Taiwan Department of Psychiatry School of Medicine Taipei Medical University Taiwan Association for the Improvement of Mental Health Programs Geneva Switzerland National University of Singapore Singapore Chiayi Chang Gung Memorial Hospital and School of Medicine Chang Gung University Taiwan Department of Psychiatry Tokyo Medical Center Tokyo Japan Department of Psychiatry Post Graduate Institute of Medical Education and Research (PIGMER) Chandigah India Departments of Psychiatry Medical Center and College of Medicine Taipei Medical University Taiwan Kobe University School of Medicine Kobe Japan

Objective: Little is known about the prescription pattern of psychotropic drugs for patients with schizophrenia in Pakistan. The purpose of this study was to evaluate the characteristic features of psychotropic drug prescriptions for patients with schizophrenia in Pakistan. Methods: Three centers in Pakistan participated in a large scale collaborative study known as Research on Asian Prescription Pattern (REAP). The 2016 REAP survey included centers from 15 countries in Asia and used a unified research protocol. The design of the study was quantitative and of descriptive epidemiology. Analysis was made on the data collected from three centers i.e., Lahore, Karachi and Islamabad. The data collected in Pakistan were compared with those from other Asian countries. The details of REAP were presented on the homepage of REAP (http://***). Results: From Pakistan, 298 patients were included. Patients with schizophrenia in Pakistan received higher rate of antipsychotic polypharmacy and a higher rate of co-prescription of mood stabilizers and anxiolytics when compared with participants from other South Asian countries (India and Bangladesh). Conclusion: The main findings of the study were that a majority of the patients were prescribed antipsychotic polypharmacy drugs in Pakistan. Insufficient training on the use of psychotropic drugs and a lack of treatment guideline are considered to be the major contributing factors. Further education and training on the proper use of psychotropic drugs are recommended to psychiatrists in Pakistan. The guidelines on pharmacotherapy for patients with schizophrenia should also be developed and promoted in Pakistan.

关键词： Pakistan Psychotropic Drugs Polypharmacy REAP Schizophrenia

Sliding Mode Control-Based Autonomous Control of a Tri-rotor Unmanned Aerial Vehicle

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Guidance, Navigation and Control 2021年第3期1卷 52-75页

作者： Abid Raza Fahad Mumtaz malik Rameez Khan Naveed mazhar Hameed Ullah Nigar Ahmed Department of Electrical Engineering College of Electrical and Mechanical EngineeringNational University of Sciences and Technology46000IslamabadPakistan College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjingJiangsu 210016P.R.China

A nonlinear control technique for autonomous control of a tri-rotor unmanned aerial vehicle is presented in this ***,a comprehensive mathematical model is developed using the Newton–Euler approach for a tri-rotor,which is found to be highly nonlinear and ***,the equivalent input a±ne model is extracted by applying a suitable ***,the sliding mode control for trajectory tracking is chosen which is immune to matched external disturbances,parametric uncertainties,and modeling *** proposed controller performance has been veri¯ed for appropriate inputs under wind disturbances using MATLAB,and the simulation results are presented.

关键词： Autonomous control nonlinear control sliding mode control unmanned aerial vehicle tri-rotor

Papaya Ring Spot Virus:An Understanding of a Severe Positive-Sense Single Stranded RNA Viral Disease and Its Management

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Phyton-International Journal of Experimental Botany 2022年第10期91卷 2099-2110页

作者： Muhammad Umer Mustansar Mubeen Yasir Iftikhar Haider Ali Muhammad Zafar-ul-Hye Rafia Asghar mazhar Abbas malik Abdul Rehman Ernesto A.Moya-Elizondo Yuejun He Institute for Forest Resources and Environment of Guizhou and Forestry College Research Centre of Forest EcologyGuizhou UniversityGuiyang550025China Department of Plant Pathology College of AgricultureUniversity of SargodhaSargodha40100Pakistan College of Bioscience University of BirminghamBirminghamB152TTUK Department of Soil Science Faculty of Agricultural Sciences and TechnologyBahauddin Zakariya UniversityMultan60800Pakistan Department of Plant Pathology PMAS University of Arid AgricultureRawalpindi43490Pakistan Department of Agriculture and Agribusiness Management University of Karachi Karachi75270Pakistan Citrus Research Institute Sargodha40100Pakistan Department of Plant Production Faculty of AgronomyUniversidad de ConcepciónChillán3780000Chile

Viral diseases have been studied in-depth for reducing quality,yield,health and longevity of the fruit,to highlight the economic ***-sense single-stranded RNA viruses are more devastating among all viruses that infect fruit *** of the best examples is papaya ringspot virus(PRSV).It belongs to the genus Potyvirus and it is limited to cause diseases on the family Chenopodiaceae,Cucurbitaceae and *** virus has a serious threat to the production of papaya,which is famous for its high nutritional and pharmaceutical *** plant parts such as leaves,latex,seeds,fruits,bark,peel and roots may contain the biological compound that can be isolated and used in pharmaceutical industries as a disease *** disease symptoms consist of vein clearing and yellowing of young *** ring spot patterns with concentric rings and spots on fruit reduce its quality and *** virus has two major strains P and *** former cause disease in papaya and cucurbits while the later one in *** comprises 94.4%protein,including a 36 kDa coat protein which is a component responsible for a non-persistent transmission through aphids,and 5.5%nucleic *** protection,development of transgenic crops,exploring the resistant sources and induction of pathogen derived resistance have been recorded as effective management of *** with these practices reduced aphid population through insecticides and plant extracts have been found ecofriendly approaches to minimize the disease *** of transgenic crops is a big challenge for the success of disease resistant papaya *** aim of this review is to understand the genomic nature of PRSV,detection methods and the different advanced control meth*** review article will be helpful in developing the best management strategies for controlling PRSV.

关键词： Papaya obligate parasite +ssRNA PRSV aphid genomic characterization and functions

Active Queue Management Exploiting the Rate Information in TCP-IP Networks

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IEEE/CAA Journal of Automatica Sinica 2018年第1期5卷 223-231页

作者： Abderrahmane Boudi malik Loudini Laboratoire de la Communication dans les Systemes Informatiques Ecole nationale Superieure d'Informatique ESI Algiers 16309 Algeria IEEE

In this paper, we propose a new mechanism called explicit rate notification(ERN) to be used in end-to-end communications. The ERN scheme encodes in the header of transmission control protocol(TCP) packets information about the sending rate and the round trip time(RTT) of the flows. This new available information to the intermediate nodes(routers) is used to improve fairness, increase utilization, decrease the number of drops, and minimize queueing delays. Thus, it induces a better management of the queue. A comparison of our scheme with preexistent schemes, like the explicit congestion notification scheme, shows the effectiveness of the proposed mechanism.

关键词： Active queue management congestion control fairness transmission control protocol(TCP)

Pulsed Corona Discharges and Their Applications in Toxic VOCs Abatement

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Chinese Journal of Chemical Engineering 1999年第4期7卷 351-362页

作者： Muhammad Arif malik Salman Akbar malik Applied Chemistry Division PINSTECHPO NiloreIslamabadPakistanDepartment of Biological SciencesQuaid-i-Azam UniversityIslamabadPakistan

Plasma processes are among the emerging technologies for volatile organic compounds (VOCs) abatement[1]. Both thermal plasmas and non-equilibrium plasmas (cold plasmas) are being developed for VOCs cleanup[2,3]. Particularly, pulsed corona discharges offer several advantages over conventional VOCs abatement techniques[4-7]. To optimize the existing technology and to develop it further, there is need to understand the mechanisms involved in plasma chemical reactions. Furthermore, it is strongly desirable to be able to predict the behavior of new VOCs in non-equilibrium plasma environment from the data known for a few representative compounds. Pulsed corona discharge technique is introduced here with citation of relevant literature. Fundamental principles, useful for predicting the VOCs' decomposition behavior, have been worked out from the published literature. Latest developments in the area, targeted to minimize the energy losses, improve the VOCs destruction efficiency and reduce the generation of unwanted organic and inorganic by-products, are presented.

关键词： corona discharges volatile organic compounds air purification water purification nonequilibrium plasma

Hemogram-derived ratios as prognostic markers for major adverse cardiovascular events in patients with non-ST-segment elevation myocardial infarction

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World Journal of Methodology 2025年第2期15卷 125-136页

作者： Emir Bećirović Minela Bećirović SabinaŠegalo Amir Bećirović Semir Hadžić Kenana Ljuca Emsel Papić Lamija Ferhatbegović malik Ejubović Amira JagodićEjubović Amila Kovčić ArminŠljivo Emir Begagić Department of Intensive Care University Clinical Center TuzlaTuzla 75000Bosnia and Herzegovina Department of Nephrology University Clinical Center TuzlaTuzla 75000Bosnia and Herzegovina Department of Laboratory Technologies Faculty of Health SciencesUniversity of SarajevoSarajevo 71000Bosnia and Herzegovina Department of Endocrinology University Clinical Center TuzlaTuzla 75000Bosnia and Herzegovina School of Medicine University of TuzlaTuzla 75000Bosnia and Herzegovina Department for Internal Diseases and Hemodialysis Canton Hospital ZenicaZenica 72000Bosnia and Herzegovina Department of Internal Medicine Canton Hospital ZenicaZenica 72000Bosnia and Herzegovina Department of Radiotherapy University Clinical Center TuzlaTuzla 75000Bosnia and Herzegovina Department of Cardiology University Clinical Center SarajevoSarajevo 72000Bosnia and Herzegovina Department of General Medicine University of ZenicaSchool of MedicineZenica 72000Bosnia and Herzegovina

BACKGROUND Non-ST segment elevation myocardial infarction(NSTEMI)poses significant challenges in clinical management due to its diverse *** the prognostic role of hematological parameters and derived ratios in NSTEMI patients could aid in risk stratification and improve patient *** To evaluate the predictive value of hemogram-derived ratios for major adverse cardiovascular events(MACE)in NSTEMI patients,potentially improving clinical *** A prospective,observational cohort study was conducted in 2021 at the Internal Medicine Clinic of the University Hospital in Tuzla,Bosnia and *** study included 170 patients with NSTEMI,who were divided into a group with MACE and a control group without ***,the MACE group was subdivided into lethal and non-lethal groups for prognostic *** hematological parameters,an additional 13 hematological-derived ratios(HDRs)were monitored,and their prognostic role was *** Hematological parameters did not significantly differ between non-ST segment elevation myocardial infarction(NSTEMI)patients with MACE and a control group at T1 and ***,significant disparities emerged in HDRs among NSTEMI patients with lethal and non-lethal outcomes ***,neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)were elevated in lethal ***,C-reactive protein-to-lymphocyte ratio(CRP/Ly)at T1(>4.737)demonstrated predictive value[odds ratio(OR):3.690,P=0.024].Both NLR at T1(>4.076)and T2(>4.667)emerged as significant predictors,with NLR at T2 exhibiting the highest diagnostic performance,as indicated by an area under the curve of 0.811(95%CI:0.727-0.859)and OR of 4.915(95%CI:1.917-12.602,P=0.001),emphasizing its important role as a prognostic *** This study highlights the significant prognostic value of hemogram-derived indexes in predicting MACE among NSTEMI *** follow-up,NLR,PLR,and CRP/Ly off

关键词： Hemogram-derived ratios Prognostic markers Neutrophil-to-lymphocyte ratio Myocardial infarction