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A drospirenone-containing oral contraceptive improved bleeding pattern and personal satisfaction in 914 women from Jordan, Lebanon and Syria

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Health 2013年第7期5卷 39-44页

作者： Ramzi Finan Abeer Wasfi Annab Salwa Abdalla Farid Bedran mazen el-zibdeh Lina Shahen Christoph Gerlinger Erich Solomayer Kubilay Ertan Jan Endrikat Universite St.Joseph Hotel Dieu de FranceBeirutLebanon 2.Al Amal Maternity HospitalAmmanJordan 3.Private Clinic—Al-ShahBandar SquareDamascusSyria 4.Serhal Hospital-RabiehBeirutLebanon 5.Islamic HospitalAmmanJordan 6.Private Clinic—Al-Enshaat-Ragheb Al-Jamali StreetHomsSyria 7.Bayer HealtcareBayer AGBerlinGermany Department of OB/GYN Universitatskliniken des SaarlandesHomburg/SaarGermany 9.Department of OB/GYNLeverkusen Municipal HospitalLeverkusenGermany

Aim: We assessed bleeding pattern, tolerance and patient satisfaction of an oral contraceptive containing 3 mg drospirenone and 30 mcg ethinyl estradiol (DRSP/EE) under real-life conditions. Study Design: We performed a multicenter, prospective, 6-cycle, observational study in Canada, Europe and the Middle East. Detailed analyses of the three Middle East countries, Jordan, Lebanon andSyriawere presented here. The efficacy variables included an assessment of bleeding patterns, premenstrual symptoms of water retention and patient satisfaction, as determined by a visual analogue scale. Results: A total of 914 women were enrolled. The percentage of women with intermenstrual bleeding decreased from 37.4%, 48.7% and 32.2% at baseline to 9.7%, 6.1% and 10.9% at the end of cycle6 inJordan, Lebanon and Syria, respectively (creased sharply in all three countries (p Amenorrhea decreased significantly in Lebanon and Syria (p elling of extremities decreased significantly over the course of 6 treatment cycles (p < 0.001). Patient satisfaction increased for all investigated items. Upon completion of the study, 82.7% of women answered “Yes” to continue treatment with this oral contraceptive. Conclusion: The oral contraceptive containing 3 mg drospirenone and 30 mcg ethinyl estradiol has beneficial effects on bleeding pattern, symptoms of water retention and patient satisfaction.

关键词： Bleeding Pattern Tolerance Drospirenone Oral Contraception

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