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Multilocular thymic cysts-a diagnostic challenge on computed tomography

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World Journal of Clinical Cases 2025年第3期13卷 61-65页

作者： Nirmal kumar Reddy Onteddu Naga Sai Rasagna Mareddy Sai Swarupa R Vulasala Jayabharath Onteddu mayur Virarkar Department of Internal Medicine University of Florida College of MedicineJacksonvilleFL 32209United States Department of Diagnostic Radiology University of AlabamaBirminghamAL 35294United States Department of Diagnostic Radiology University of Florida College of MedicineJacksonvilleFL 32209United States Department of Public Health Sciences University of FloridaGainesvilleFL 32611United States

A recent case report provided a patient scenario,wherein,a 39-year-old male patient presented with occasional palpitations,headache,and *** of tumor markers did not show any abnormal ***,a computed tomography(CT)scan was undertaken,and its findings were affirmative of thymic ***,the postoperative histopathological assessment of the mass,after its resection,confirmed it as an anterior mediastinal multilocular thymic cyst(MTC),with concurrent acute upper respiratory tract infection and acute ***,this case report advocates the need for a preoperative histopathological examination with CT imaging to minimize the risk of confusing an MTC with a malignant thymic tumor.

关键词： Imaging findings Multilocular thymic cyst Histopathology Thymic cancer Mediastinal mass

Intrahepatic and intra-abdominal splenosis:A case report and review of literature

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World Journal of Hepatology 2019年第12期11卷 773-779页

作者： Kiruthika Ananthan Gibran Timothy Yusuf mayur kumar GKT School of Medical Education King’s College LondonLondon WC2R 2LSUnited Kingdom Department of Radiology Princess Royal University HospitalKing’s College Hospital NHS Foundation TrustKent BR68NDUnited Kingdom Department of Gastroenterology Princess Royal University HospitalKing’s College Hospital NHS Foundation TrustKent BR68NDUnited Kingdom

BACKGROUND Splenosis is defined as the process by which tissue from the spleen disseminates through the body and grows in an ectopic location following trauma or a *** sites of splenosis are *** SUMMARY We report a case of intrahepatic splenosis in a 57-year-old man with a history of trauma over 40 years ago who initially presented with chest *** initially mimicked malignancy but a diagnosis of intrahepatic splenosis was confirmed using computed tomography and scintigraphy with technetium-99m heat-denatured red blood cells(Tc-99 DRBC).CONCLUSION Scintigraphy with Tc-99 DRBC is a reliable technique to diagnose splenosis and should be performed before using more invasive procedures are carried *** should be considered as a possible differential diagnosis for a hepatic nodule in any patient with a history of abdominal trauma,previous splenectomy or atypical radiological features on imaging.

关键词： Intrahepatic splenosis Abdominal splenosis Computed tomography Scintigraphy Hepatocellular carcinoma Case report

Revolutionizing palliative care:Electrocautery-enhanced lumenapposing metal stents in endoscopic-ultrasound-guided biliary drainage for malignant obstructions

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2358-2361页

Patients with malignant biliary obstruction,following endoscopic retrograde cholangiopancreatography(ERCP)failure could be referred for endoscopicultrasound-guided biliary drainage through electrocautery-enhanced(ECE)lumen-apposing metal stent(LAMS)***,the efficacy and safety of ECE-LAMS in this scenario have remained debatable due to minimal scientific *** current confirmed 91.0%clinical success,96.7%technical success,7.3%reintervention rate,and 17.5%adverse events,following the treatment of malignant biliary obstruction with ECE-LAMS ***,ECE-LAMS proved to be a generalizable strategy for managing biliary obstruction for patients who were excluded from ERCP.

关键词： Endoscopic retrograde cholangiopancreatography Electrocautery-enhancedlumen-apposing metal stent Biliary drainage Biliary stent Endoscopic ultrasound

Advances and effectiveness of the immunotherapy after liver transplantation

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World Journal of Gastrointestinal Surgery 2022年第6期14卷 629-631页

作者： Sai Swarupa R Vulasala Nirmal K Onteddu Sindhu P kumar Chandana Lall Priya Bhosale mayur K Virarkar Department of Radiology University of Florida College of MedicineJacksonvilleFL 32209United States Department of Internal Medicine Flowers HospitalDothanAL 36305United States Division of Diagnostic Imaging Department of Diagnostic RadiologyThe University of Texas MD Anderson Cancer CenterHoustonTX 77030United States

Transplant recipients usually have increased chances of graft rejection and graft vs host disease,requiring chronic immunosuppressive ***,longterm immunosuppression risks malignancies such as skin cancer,lymphoma,and Kaposi ***,there are very few studies that included solid organ transplant recipients while studying the efficacy of immunotherapy.“Immunotherapy after liver transplantation:Where are we now?”is a study,where the authors described the mechanism of action and outcomes of immune checkpoint inhibitors specific to liver transplant *** authors reported the graft rejection rates and the factors contributing to the rejection in the liver transplant recipients.

关键词： Immunotherapy Hepatocellular carcinoma Immune checkpoint inhibitors Liver transplantation Solid organ transplant Graft rejection

Measurement of neutron capture cross section on^(71)Ga at 2.15 and 3.19 MeV and uncertainty propagation and covariance analysis

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Chinese Physics C 2023年第7期47卷 72-80页

作者： Rebecca Pachuau A.Gandhi Namrata Singh A.kumar mayur Mehta S.V.Suryanarayana L.S.Danu B.K.Nayak B.Lalremruata Department of Physics Banaras Hindu UniversityVaranasi-221005India Institute for Plasma Research Gandhinagar-382428India Nuclear Physics Division Bhabha Atomic Research CentreMumbai-400085India Homi Bhabha National Institute AnushaktinagarMumbai-400094India Department of Physics Mizoram UniversityTanhrilAizawl-796004India Horia Hulubei National Institute of Physics and Nuclear Engineering-IFIN-HH Bucharest077125Romania MCNS Manipal Academy of Higher EducationManipal 576104India

The cross section values of the^(71)Ga(n,γ)^(72)Ga reaction are measured,which are 9.14±0.81 mb and 5.74±0.50 mb at 2.15 and 3.19 MeV,*** detailed uncertainty propagation and covariance analysis are also ***^(7)Li(p,n)^(7)Be reaction was used to generate the neutrons,and the neutron flux was normalized using the^(115)In(n,n′)^(115)In^(m)monitor *** measured cross section data are compared with the data available in the EXFOR database,the data obtained using nuclear reaction model codes EMPIRE-3.2 and TALYS-1.95,and also the evaluated nuclear data from ENDF/B-VIII.0 and JEFF-3.1/*** comparison shows that our result at 3.19 MeV is in good agreement with those of EMPIRE-3.2 and JEFF-3.1/*** there are no other measurements available at3.19 MeV,our data could not be compared with literature data at 3.19 MeV,but they are consistent with the cross section values available at 2.98±0.26 and 3.0±0.1 *** result at 2.15 MeV is slightly higher than the literature value available in EXFOR,evaluated value,and theoretically predicted result.

关键词： neutron capture cross section gallium uncertainty propagation and covariance analysis

A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases

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Oncology Research 2024年第5期32卷 849-875页

作者： NILAM BHUSARE MAUSHMI kumar Somaiya Institute for Research&Consultancy Somaiya Vidyavihar UniversityVidyavihar(East)Mumbai400077India

Glioblastoma,the most aggressive form of brain tumor,poses significant challenges in terms of treatment success and patient *** treatment modalities for glioblastoma include radiation therapy,surgical intervention,and ***,the median survival rate remains dishearteningly low at 12–15 *** of the major obstacles in treating glioblastoma is the recurrence of tumors,making chemotherapy the primary approach for secondary glioma ***,the efficacy of drugs is hampered by the presence of the blood-brain barrier and multidrug resistance ***,considerable research efforts have been directed toward understanding the underlying signaling pathways involved in glioma and developing targeted *** tackle glioma,numerous studies have examined kinase-downstream signaling pathways such as *** targeting specific signaling pathways,heterocyclic compounds have demonstrated efficacy in glioma ***,key kinases including phosphatidylinositol 3-kinase(PI3K),serine/threonine kinase,cytoplasmic tyrosine kinase(CTK),receptor tyrosine kinase(RTK)and lipid kinase(LK)have been considered for *** pathways play crucial roles in drug effectiveness in glioma *** compounds,encompassing pyrimidine,thiazole,quinazoline,imidazole,indole,acridone,triazine,and other derivatives,have shown promising results in targeting these *** part of this review,we propose exploring novel structures with low toxicity and high potency for glioma *** development of these compounds should strive to overcome multidrug resistance mechanisms and efficiently penetrate the blood-brain *** optimizing the chemical properties and designing compounds with enhanced drug-like characteristics,we can maximize their therapeutic value and minimize adverse *** the complex nature of glioblastoma,these novel structures should be rigorously tested and e

关键词： Glioblastoma Kinase pathway Pyrimidine Quinazoline Heterocycles

New Method of Palladium Metal Trapping through Resins in Antiviral Drug: Valacyclovir HCl

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International Journal of Organic Chemistry 2013年第4期3卷 251-255页

作者： Keshava Navin kumar Reddy Murugulla Adharvana Chari mayur D. Khunt V. V. N. K. V. Prasada Raju Bojja Ramachandra Reddy Vurimidi Himabindu Ghanta Mahesh Reddy Department of Chemistry Institute of Science and Technology J. N. T. University Kukatpally Hyderabad India Dr. MACS Bio-Pharma Pvt. Ltd. Western Hills Kukatpally Hyderabad India Research and Development Integrated Product Development Innovation Plaza Dr. Reddy’s Laboratories Ltd. Bachupally Quthubullapur India

This process describes a novel technique for effective trapping of “Pd” metal through resins during the process development of L-valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl) methoxy] ethyl ester, and mono hydrochloride known as a Valacyclovir hydrochloride (1). This technique is suitable for large-scale production of 1 and it is described here Pd metal trapping by using different resins.

关键词： Valacyclovir Hydrochloride Antiviral Drug N-Phthalimide-L-Valine Ester Monomethylamine Commercially Scalable Process Less Cycle Time

儿童先天性上睑下垂患者行额肌悬吊术后屈光改变的临床观察

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世界核心医学期刊文摘（眼科学分册） 2005年第9期1卷 44-45页

作者： kumar S. Chaudhuri Z. Chauhan D. 杨建刚 Anand Lok Society Mayur Vihar phase-I Delhi-110091 India

BACKGROUND AND OBJECTIVE: To evaluate the postoperative visual acuity and refractive changes occurring after bilateral frontalis brow suspension surgery in pediatric patients with congenital blepharoptosis. PATIENTS ANDMETHODS: Twenty-three patients between 4 and 12 years old with severe congenital blepharoptosis (unilateral in 21 cases and bilateral in 2 cases; total of 25 eyes) and poor levator function underwent bilateral frontalis brow suspension surgery by Crawford’s double triangle method with 4:0 expanded polytetrafluoroethylene sutures. The non-ptotic eyes (21 eyes) undergoing frontalis brow suspension surgery served as the control group. All patients had best-corrected spectacle visual acuity (BCSVA) of more than 6/9 preoperatively in both eyes. Changes in the postoperative BCSVA, binocularity, relevant refractive parameters, lid position, lagophthalmos, lid lag, and tear break-up timewere evaluated in both groups for 12 weeks and appropriate statistical tests were applied. RESULTS: Significant differences were found in the baseline characteristics and the postoperative changes in the eyes with and without ptosis. However, these were found to be transient and did not result in any new cases of amblyopia postoperatively. No complications requiring revision of surgerywere seen. CONCLUSIONS: The changes in the BCSVA after frontalis brow suspension surgery are transient. Retinoscopy, manual keratometry, and corneal videokeratoscopy are simple and effective methods to evaluate the sequential refractive changes occurring in these eyes.

关键词：额肌悬吊术先天性上睑下垂临床观察上睑手术矫正兔眼聚四氟乙烯缝线泪膜破裂时间角膜镜检查术后视力