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Gene-activated matrix harboring a miR20a-expressing plasmid promotes rat cranial bone augmentation

Regenerative Biomaterials 2021年第2期8卷 34-42页

作者： Rena Shido Yoshinori Sumita Masahito Hara mayumi Iwatake Shun Narahara mayumi umebayashi Kei-ichiro Miura Yukinobu Kodama Izumi Asahina Department of Regenerative Oral Surgery Unit of Translational MedicineNagasaki University Graduate School of Biomedical Sciences1-7-1 SakamotoNagasaki 852-8588Japan Basic&Translational Research Center for Hard Tissue Disease Unit of Translational MedicineNagasaki University Graduate School of Biomedical Sciences1-7-1 SakamotoNagasaki 852-8588Japan Laboratory of Craniofacial Tissue Engineering and Stem Cells Faculty of DentistryMcGill University3640 University StreetM43MontrealQuebec H3A 2B2Canada Department of Hospital Pharmacy Nagasaki University Hospital1-7-1 SakamotoNagasaki 852-8501Japan

Gene-activated matrix(GAM)has a potential usefulness in bone engineering as an alternate strategy for the lasting release of osteogenic proteins but efficient methods to generate non-viral GAM remain to be *** this study,we investigated whether an atelocollagen-based GAM containing naked-plasmid(p)DNAs encoding microRNA(miR)20a,which may promote osteogenesis in vivo via multiple pathways associated with the osteogenic differentiation of mesenchymal stem/progenitor cells(MSCs),facilitates rat cranial bone ***,we confirmed the osteoblastic differentiation functions of generated pDNA encoding miR20a(pmiR20a)in vitro,and its transfection regulated the expression of several of target genes,such as Bambi1 and PPARc,in rat bone marrow MSCs and induced the increased expression of ***,when GAMs fabricated by mixing 100 ll of 2%bovine atelocollagen,20mg b-TCP granules and 0.5mg(3.3 lg/ll)AcGFP plasmid-vectors encoding miR20a were transplanted to rat cranial bone surface,the promoted vertical bone augmentation was clearly recognized up to 8 weeks after transplantation,as were upregulation of VEGFs and BMP4 expressions at the early stages of ***,GAM-based miR delivery may provide an alternative non-viral approach by improving transgene efficacy via a small sequence that can regulate the multiple pathways.

关键词： gene-activated matrix in vivo gene transfer bone augmentation atelocollagen mir20a

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Correlation between dose-volume parameters and rectal bleeding after 12 fractions of carbon ion radiotherapy for prostate cancer

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World Journal of Radiology 2024年第7期16卷 256-264页

作者： Takashi Ono Hiraku Sato Yuya Miyasaka Yasuhito Hagiwara Natsuko Yano Hiroko Akamatsu mayumi Harada mayumi Ichikawa Department of Radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan Department of Heavy Particle Medical Science Yamagata University Graduate School of Medical ScienceYamagata 990-9585Japan

BACKGROUND Carbon ion radiotherapy(CIRT)is currently used to treat prostate *** bleeding is a major cause of toxicity even with ***,to date,a correlation between the dose and volume parameters of the 12 fractions of CIRT for prostate cancer and rectal bleeding has not been ***,the clinical risk factors for rectal bleeding were absent after 12 fractions of *** To identify the risk factors for rectal bleeding in 12 fractions of CIRT for prostate *** Among 259 patients who received 51.6 Gy[relative biological effectiveness(RBE)],in 12 fractions of CIRT,15 had grade 1(5.8%)and nine had grade 2 rectal bleeding(3.5%).The dose-volume parameters included the volume(cc)of the rectum irradiated with at least x Gy(RBE)(Vx)and the minimum dose in the most irradiated x cc normal rectal volume(Dx).RESULTS The mean values of D6cc,D2cc,V10 Gy(RBE),V20 Gy(RBE),V30 Gy(RBE),and V40 Gy(RBE)were significantly higher in the patients with rectal bleeding than in those *** cutoff values were D6cc=34.34 Gy(RBE),D2cc=46.46 Gy(RBE),V10 Gy(RBE)=9.85 cc,V20 Gy(RBE)=7.00 cc,V30 Gy(RBE)=6.91 cc,and V40 Gy(RBE)=4.26 *** D2cc,V10 Gy(RBE),and V20 Gy(RBE)cutoff values were significant predictors of grade 2 rectal *** The above dose-volume parameters may serve as guidelines for preventing rectal bleeding after 12 fractions of CIRT for prostate cancer.

关键词： Carbon ion radiotherapy Prostate cancer Rectal bleeding Dose volume parameters Prevention

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Prioritizing Strategies for Building the Resilience of Public Health Systems to Disasters Across Multiple Communities and Countries

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International Journal of Disaster Risk Science 2024年第1期15卷 1-17页

作者： Benjamin J.Ryan mayumi Kako Shelby Garner Rok Fink Ismail Tayfur Jonathan Abrahams Sanjaya Bhatia Adriana Campelo Matthew Fendt Alicia Fontenot Nahuel Arenas Garcia Tim Hatch Ryoma Kayano LaShonda Malrey‑Horne Makiko MacDermot Md Moshiur Rahman Chaverle Noel Shuhei Nomura Jeremy P.Novak Maria Opazo Kendell Oliver Luciana Peters Sohel Rahman PerihanŞimşek Andrew Stricklin Raymond Swienton Bryan W.Brooks Frist College of Medicine Belmont UniversityNashvilleTN 37212USA Department of Environmental Science Environmental Health Science ProgramCollege of Arts and SciencesBaylor UniversityWacoTX 76798USA Division of Nursing Science School of Biomedical and Health SciencesHiroshima UniversityHiroshima 734-8553Japan Gordon E.Inman College of Health Sciences and Nursing Belmont UniversityNashvilleTN 37212USA Faculty of Health Sciences University of Ljubljana1000 LjubljanaSlovenia Department of Emergency Medicine University of Health Sciences34668 IstanbulTurkey Monash University Accident Research Center MelbourneVIC 3800Australia Global Education and Training Institute United Nations Ofce for Disaster Risk ReductionIncheon 22004Republic of Korea Regional Ofce for the Americas and Caribbean United Nations Ofce for Disaster Risk ReductionPanama City 0843-03441Panama Engineering and Computer Science Baylor UniversityWacoTX 76798USA Department of Public Health Robbins College of Health and Human SciencesBaylor UniversityWacoTX 76798USA Alabama Department of Public Health MontgomeryAL 36092USA World Health Organization Centre for Health Development(WHO Kobe Centre) Kobe 651-0073Japan Waco-McLennan County Public Health District WacoTX 76707USA Department of Health Policy and Management School of MedicineKeio UniversityTokyo 160-8582Japan Department of Global Health Policy Graduate School of MedicineThe University of TokyoTokyo 113-0033Japan Tokyo Foundation for Policy Research Tokyo 106-6234Japan Global Development College BrisbaneQLD 4000Australia Municipality of Pudahuel 13124 PudahuelChile City Hall of Porto Alegre Porto Alegre 90010-170Brazil Ministry of Health and Family Welfare Government of the People’s Republic of BangladeshDhaka 1000Bangladesh Department of Emergency Aid and Disaster Management Trabzon University61335 TrabzonTurkey Department of Emergency Medicine UT SouthwesternDallasTX 75390USA

The COVID-19 pandemic highlighted the urgent need to strengthen public health *** response,the United Nations Disaster Risk Reduction(UNDRR) Public Health System Resilience Scorecard(Scorecard) was applied in workshops across multiple *** aim of our research was to explore the workshop findings to develop priority strategies for strengthening public health system *** conducted a workshop from 14 to 16 March 2023,at the UNDRR Global Education and Training Institute in Incheon,Republic of Korea.A sequential modified Delphi method was utilized to develop a set of prioritized resilience *** were drawn from 70 strategies identified from 13 distinct workshops in eight *** two surveys,23 strategies were *** received ratings of "High" or Very High" from89% of *** related to the inclusion of public health risks in emergency plans,integrating multidisciplinary teams into public health,enabling local transport mechanisms,and improving the ability to manage an influx of *** Scorecard provides an adaptable framework to identify and prioritize strategies for strengthening public health system *** leveraging this methodology,our study demonstrated how resilience strategies could inform disaster risk reduction funding,policies,and actions.

关键词： Health system resilience Public policy Resilience scorecard Workshops

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Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease

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World Journal of Gastroenterology 2007年第42期13卷 5581-5593页

作者： mayumi Kawada Atsuko Arihiro Emiko Mizoguchi Gastrointestinal Unit Department of Medicine Massachusetts General Hospital Harvard Medical School Boston MA 02114 United States

Inflammatory bowel disease(IBD),the most important being Crohn's disease and ulcerative colitis,results from chronic dysregulation of the mucosal immune system in the gastrointestinal *** the pathogenesis of IBD remains unclear,it is widely accepted that genetic,environmental,and immunological factors are *** studies suggest that intestinal epithelial defenses are important to prevent inflammation by protecting against microbial pathogens and oxidative *** investigate the etiology of IBD,animal models of experimental colitis have been developed and are frequently used to evaluate new anti-inflammatory treatments for *** models of experimental colitis that demonstrate various pathophysiological aspects of the human disease have been *** this manuscript,we review the characteristic features of IBD through a discussion of the various chemically induced experimental models of colitis(*** sodium sulfate-,2,4,6-trinitrobenzene sulfonic acid-,oxazolone-,acetic acid-,and indomethacin-induced models).We also summarize some regulatory and pathogenic factors demonstrated by these models that can,hopefully,be exploited to develop future therapeutic strategies against IBD.

关键词： Inflammatory bowel disease Experimental colitis Dextran sodium sulfate Trinitrobenzene sulfonicacid Oxazolone Pathogenesis

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Sequence-Independent Identification of Active LTR Retrotransposons in Arabidopsis

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Molecular Plant 2018年第3期11卷 508-511页

作者： Jayne,Griffiths Marco,Catoni mayumi,Iwasaki Jerzy,Paszkowski The Sainsbury Laboratory University of Cambridge Cambridge UK [∗]Corresponding author Present Address: University of Geneva Geneva Switzerland

Dear Editor,LTR retrotransposons （LTR-TEs） are mobile genetic elements that often comprise a large portion of the host genome and are particularly abundant in genomes of plants （Lisch, 2013）. They transpose through an RNA transcript that is reverse transcribed to an extrachromosomal DNA （ecDNA） of the original element that can insert at a new genomic location （Wicker et al., 2007）.

关键词： Arabidopsis LTR 鉴定人染色体 DNA RNA 元素植物

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Improving conditional random field model for prediction of protein-RNA residue-base contacts

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Frontiers of Electrical and Electronic Engineering in China 2018年第2期6卷 155-162页

作者： Morihiro Hayashida Noriyuki Okada mayumi Kamada Hitoshi Koyano Department of Electrical Engineering and Computer Science National Institute of Technology Matsue College Shimane 690- 8518 Japan Graduate School of Medicine Kyoto University Kyoto 606-8507 Japan Riken Quantitative Biology Center Hyogo 650-0047 Japan

Background： For understanding biological cellular systems, it is important to analyze interactions between protein residues and RNA bases. A method based on conditional random fields （CRFs） was developed for predicting contacts between residues and bases, which receives multiple sequence alignments for given protein and RNA sequences, respectively, and learns the model with many parameters involved in relationships between neighboring residue-base pairs by maximizing the pseudo likelihood function. Methods： In this paper, we proposed a novel CRF-based model with more complicated dependency relationships between random variables than the previous model, but which takes less parameters for the sake of avoidance of overfitting to training data. Results： We performed cross-validation experiments for evaluating the proposed model, and took the average of AUC （area under receiver operating characteristic curve） scores. The result suggests that the proposed CRF-based model without using Ll-norm regularization （lasso） outperforms the existing model with and without the lasso under several input observations to CRFs. Conclusions： We proposed a novel stochastic model for predicting protein-RNA residue-base contacts, and improved the prediction accuracy in terms of the AUC score. It implies that more dependency relationships in a CRF could be controlled by less parameters.

关键词： protein-RNA interaction residue-base contact conditional random field

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Modified simultaneous integrated boost radiotherapy for an unresectable huge refractory pelvic tumor diagnosed as a rectal adenocarcinoma

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World Journal of Gastroenterology 2014年第48期20卷 18480-18486页

作者： Takuma Nomiya Hiroko Akamatsu mayumi Harada Ibuki Ota Yasuhito Hagiwara mayumi Ichikawa Misako Miwa Shouhei Kawashiro Motohisa Hagiwara Masahiro Chin Eiji Hashizume Kenji Nemoto Department of Radiation Oncology National Institute of Radiological Sciences Chiba 263-8555 Japan Department of Radiation Oncology Yamagata University Hospital Yamagata 990-8560 Japan Department of Surgery Nihonkai General Hospital Yamagata 990-8560 Japan

A clinical trial of radiotherapy with modified simultaneous integrated boost(SIB)technique against huge tumors was conducted.A 58-year-old male patient who had a huge pelvic tumor diagnosed as a rectal adenocarcinoma due to familial adenomatous polyposis was enrolled in this *** total dose of 77 Gy(equivalent dose in 2Gy/fraction)and 64.5 Gy was delivered to the center of the tumor and the surrounding area respectively,andapproximately 20%dose escalation was achieved with the modified SIB *** tumor with an initial maximum size of 15 cm disappeared 120 d after the start of the *** status of the patient improved from 4 to *** with modified SIB may be effective for patients with a huge tumor in terms of tumor shrinkage/disappearance,improvement of QOL,and prolongation of survival.

关键词： Clinical trial Image-guided radiotherapy Rectal neoplasms Quality of life Neoplasm recurrence

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Focus on using nanopore technology for societal health,environmental,and energy challenges

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Nano Research 2022年第11期15卷 9906-9920页

作者： Izadora mayumi Fujinami Tanimoto Benjamin Cressiot Sandra J.Greive Bruno Le Pioufle Laurent Bacri Juan Pelta LAMBE CNRSUniv EvryUniversitéParis-Saclay91025Evry-CourcouronnesFrance LuMIn CNRSInstitut d'AlembertENS Paris-SaclayUniversitéParis-Saclay91190Gif-sur-YvetteFrance LAMBE CNRSCY Cergy Paris Université95000CergyFrance DreamPore S.A.S. 33 Boulevard du Port 95000CergyFrance

With an increasing global population that is rapidly ageing,our society faces challenges that impact health,environment,and energy *** this ageing comes an accumulation of cellular changes that lead to the development of diseases and susceptibility to *** impacts not only the health system,but also the global *** the population increases,so does the demand for energy and the emission of pollutants,leading to a progressive degradation of our *** in turn impacts health through reduced access to arable land,clean water,and breathable *** monitoring approaches to assist in environmental control and minimize the impact on health are urgently needed,leading to the development of new sensor technologies that are highly sensitive,rapid,and *** sensing is a new technology that helps to meet this purpose,with the potential to provide rapid point-of-care medical diagnosis,real-time on-site pollutant monitoring systems to manage environmental health,as well as integrated sensors to increase the efficiency and storage capacity of renewable energy *** this review we discuss how the powerful approach of nanopore based single-molecule,or particle,electrical promises to overcome existing and emerging societal challenges,providing new opportunities and tools for personalized medicine,localized environmental monitoring,and improved energy production and storage systems.

关键词： electric sensor nanoparticles environment biomarkers energy storage

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An Integrated Workflow for DNA Methylation Analysis

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Journal of Genetics and Genomics 2013年第5期40卷 249-260页

作者： Pingchuan Li Feray Demirci Gayathri Mahalingam Caghan Demirci mayumi Nakano Blake C.Meyers Department of Plant & Soil Sciences Delaware Biotechnology InstituteUniversity of DelawareNewarkDE 19711USA

The analysis of cytosine methylation provides a new way to assess and describe epigenetic regulation at a whole-genome level in many *** methylation has a demonstrated role in the genome stability and protection,regulation of gene expression and many other aspects of genome function and ***-seq is a relatively unbiased method for profiling the DNA methylation,with a resolution capable of measuring methylation at individual *** we describe,as an example,a workflow to handle DNA methylation analysis,from BS-seq library preparation to the data *** describe some applications for the analysis and interpretation of these *** laboratory provides public access to plant DNA methylation data via visualization tools available at our ＂Next-Gen Sequence＂ websites（http：//***）,along with small RNA,RNA-seq and other data types.

关键词： DNA methylation BS-seq Epigenetics

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Impairment of IFN-a production capacity in patients with hepatitis C virus and the risk of the development of hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第46期11卷 7330-7334页

作者： Kazuko Uno Yoshiki Suginoshita Kazuhiro Kakimi Fuminori Moriyasu mayumi Hirosaki Taro Shirakawa Tsunataro Kishida Louis Pasteur Center for Medical ResearchKyoto Japan Department of Gastroenterology and HepatologyFaculty of Medicine Kyoto UniversityKyotoJapan Department of Health Promotion and Human BehaviorKyoto University Graduate School of Public Health KyotoJapan

AIM: To determine the utility of interferon (IFN) -αproduction capacity in patients with hepatitis C virus (HCV) infection for the measurement of immunosurveillance potential and for the early detection of hepatocellular carcinoma (HCC) by investigating the Sendai virus (HVJ) stimulated IFN-α production capacity of patients with HCV ***: HVJ stimulated IFN-α production was determined in a large number of patients with HCV infection and the development of HCC was monitored for 3 years in patients with liver cirrhosis (LC).RESULTS: IFN-α production capacity decreases gradually with the progression of liver disease from chronic hepatitis (CH) to HCC. A significant correlation between the duration of HCV infection and impaired IFN-α production capacity was observed. IFN-α production in patients who developed HCC within 3 years was significantly lower than that of patients who remained in LC without developing ***: Measurement of IFN-α production in LC patients may be useful for the early detection of HCC.

关键词： IFN-α production capacity Hepatitis C virus Hepatocellular carcinoma

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