检索结果-南通市图书馆

Ethnic differences in inflammatory bowel disease: Results from the United Kingdom inception cohort epidemiology study

引用

World Journal of Gastroenterology 2019年第40期25卷 6145-6157页

作者： Ravi Misra Jimmy Limdi Rachel Cooney Samia sakuma Matthew Brookes Edward Fogden Sanjeev Pattni Naveen Sharma Tariq Iqbal Pia Munkholm Johan Burisch Naila Arebi Gastroenterology St.Mark’s Hospital and Academic InstituteLondon HA13UJUnited Kingdom The Pennine Acute Hospitals NHS Trust Institute of Inflammation and RepairUniversity of ManchesterManchester BL97TDUnited Kingdom Gastroenterology University Hospitals BirminghamBirmingham B122THUnited Kingdom Gastroenterology Royal Wolverhampton NHS TrustLondon WV100QPUnited Kingdom Gastroenterology Sandwell and West Birmingham HospitalsBirmingham B714HJUnited Kingdom Gastroenterology University Leicester HospitalsLeicester LE15WWUnited Kingdom Gastroenterology Heartlands HospitalBirmingham B95SSUnited Kingdom Department of Gastroenterology North Zealand University HospitalFrederikssund 3600Denmark

BACKGROUND The current epidemiology of inflammatory bowel disease(IBD)in the multiethnic United Kingdom is *** last incidence study in the United Kingdom was carried out over 20 years *** To describe the incidence and phenotype of IBD and distribution within ethnic *** Adult patients(>16 years)with newly diagnosed IBD(fulfilling Copenhagen diagnostic criteria)were prospectively recruited over one year in 5 urban catchment areas with high South Asian *** demographics,ethnic codes,disease phenotype(Montreal classification),disease activity and treatment within 3 months of diagnosis were recorded onto the Epicom *** Across a population of 2271406 adults,339 adult patients were diagnosed with IBD over one year:218 with ulcerative colitis(UC,64.3%),115 with Crohn's disease(CD,33.9%)and 6 with IBD unclassified(1.8%).The crude incidence of IBD,UC and CD was 17.0/100000,11.3/100000 and 5.3/100000 *** age adjusted incidence of IBD and UC were significantly higher in the Indian group(25.2/100000 and 20.5/100000)compared to White European(14.9/100000,P=0.009 and 8.2/100000,P<0.001)and Pakistani groups(14.9/100000,P=0.001 and 11.2/100000,P=0.007).The Indian group were significantly more likely to have extensive disease than White Europeans(52.7%vs 41.7%,P=0.031).There was no significant difference in time to diagnosis,disease activity and *** This is the only prospective study to report the incidence of IBD in an ethnically diverse United Kingdom *** Indian ethnic group showed the highest age-adjusted incidence of UC(20.5/100000).Further studies on dietary,microbial and metabolic factors that might explain these findings in UC are underway.

关键词： Inflammatory bowel disease Ethnicity Epidemiology Incidence Phenotype

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Suppressive Effect of Brassica juncea on the Root-Lesion Nematode （ Pratylenchus penetrans）

引用

Journal of Agricultural Science and Technology(A) 2011年第5期1卷 621-628页

作者： F. sakuma K. Hashizume N. Kondo Grass and Forage Crop Research Group Snow Brand Seed Co. Ltd Naganuma 069-1464 Japan Grass and Forage Crop Research Group Snow Brand Seed Co. Ltd Chiba 263-0001 Japan Research Faculty of Agriculture Hokkaido University Sapporo 060-8589 Japan

Incorporation of sulfur-rich crucifer tissues into soil is known to suppress a variety of soil-bome plant pathogens and pests. The potentials of using Brassica juncea as green manure to kill the root lesion nematode Pratylenchus penetrans m soil and to decrease damages to subsequent crops were assessed in field and pot experiments. In the first trial, green manures containing B. juncea were grown and incorporated during spring to summer 2009. Japanese radish was then cultivated in each plot. In the second trial in spring 2010, green manure was grown and incorporated during summer to autumn 2009, and greater burdock was cultivated in pots containing soil sampled from each plot. Neither trial showed clear effects on nematode populations in the soil. However, in the first trial, Japanese radish grown following a B. juncea breeding line with a high content of sinigrin had a lower root lesion index and a higher number of marketable taproots than grown in the fallow soil. In the second trail, greater burdock cultivated in pots following incorporation ofB. juncea had a lower root lesion index with the incorporation of white mustard, which is widely used as a landscape plant. These findings suggest that B. juncea used as green manure can potentially decrease damage to subsequent crops caused by the root-lesion nematode, although it had no positive effect on decreasing populations of the root-lesion nematode in the soil.

关键词： Biofumigation green manure Brassicajuncea Pratylenchuspenetrans root-lesion nematode, soil.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

光合作用系统II外周蛋白——P23k去折叠的热力学和动力学

引用

Acta Biochimica et Biophysica Sinica 2003年第7期35卷 677-681页

作者：谭翠燕,徐春和,沈均人,sakuma Shinsuke,YAMAMOTO Yasushi,BALNY Claude,阮康成中国科学院上海生命科学研究院生物化学与细胞生物学研究所蛋白质组学重点实验室中国科学院上海生命科学研究院植物生理生态研究所 Department of Biology Department of Biology Department of Biology Institut National de la Santé et de la Recherche Médicale 中国科学院上海生命科学研究院生物化学与细胞生物学研究所蛋白质组学重点实验室上海200031 上海200031 Faculty of Science Okayama University Faculty of Science Okayama University Faculty of Science Okayama University INSERM U 128 IFR 24 CNRS Montpellier 上海200031

利用荧光光谱学等方法结合高压力技术研究了光合作用系统II中的一个外周蛋白——— 2 3kD(以P2 3k表示 )蛋白的去折叠。热力学研究表明 ,在 2 0℃、180MPa(1MPa =10 .0大气压 )可使该蛋白质完全去折叠 ,而在3℃ ,16 0MPa即可使该蛋白质... 详细信息

利用荧光光谱学等方法结合高压力技术研究了光合作用系统II中的一个外周蛋白——— 2 3kD(以P2 3k表示 )蛋白的去折叠。热力学研究表明 ,在 2 0℃、180MPa(1MPa =10 .0大气压 )可使该蛋白质完全去折叠 ,而在3℃ ,16 0MPa即可使该蛋白质完全去折叠 ,这是迄今为止有关研究中最易被高压力去折叠的一个蛋白质。在2 0℃ ,该蛋白质在常压下去折叠反应的标准自由能与标准体积变化分别为 2 3.4 5kJ mol和 - 15 0 .3ml mol;动力学研究揭示该蛋白质的折叠反应的活化体积ΔV f 为正值 (84 .1ml mol) ,而去折叠反应的活化体积ΔV u 为负值(- 6 6 .2ml mol)。在常压下 ,折叠和去折叠反应的速度常数 (K0f,K0u)分别为 1.87s- 1 和 1.3× 10 - 4s- 1 ,这些结果为解释该蛋白质易被压力去折叠提供了线索

关键词：荧光光谱学高压力技术蛋白质去折叠

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Clearance of the liver remnant predicts short-term outcome in patients undergoing resection of hepatocellular carcinoma

引用

World Journal of Gastroenterology 2022年第38期28卷 5614-5625页

作者： Atsushi Miki Yasunaru sakuma Hideyuki Ohzawa Akira Saito Yoshiyuki Meguro Jun Watanabe Kazue Morishima Kazuhiro Endo Hideki Sasanuma Atsushi Shimizu Alan Kawarai Lefor Yoshikazu Yasuda Naohiro Sata Department of Surgery Jichi Medical UniversityShimotsuke 329-0498TochigiJapan

BACKGROUND Estimation of the functional reserve of the remnant liver is important to reduce morbidity and *** To estimate the functional reserve of the remnant liver in patients with hepatocellular carcinoma(HCC).METHODS We reviewed the medical records of 199 patients who underwent resection of *** clearance of the remnant liver was calculated using fusion images of 99mTc-labelled galactosyl-human serum albumin liver scintigraphy and computed *** liver failure(PHLF)was classified according to the International Study Group of Liver *** was classified according to Clavien–Dindo *** analyzed by the risk factors for PHLF,morbidity and mortality with multivariate *** Twenty-seven(30%)patients had major complications and 23(12%)developed *** incidence of major complications increased with increasing albumin–bilirubin(ALBI)*** area under the curve values for hepatic clearance of the remnant liver,liver to heart-plus-liver radioactivity at 15 min(LHL15),and ALBI score predicting PHLF were 0.868,0.629,and 0.655,*** area under the curve for hepatic clearance of the remnant liver,LHL15,and ALBI score predicting major complications were 0.758,0.594,and 0.647,*** risk factors for PHLF and major complications were hepatic clearance of the remnant liver and intraoperative *** The measurement of hepatic clearance may predict PHLF and major complications for patients undergoing resection of HCC.

关键词： Liver function Hepatectomy Cirrhosis Fusion image Complication Mortality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pressure Equilibrium and Jump Study on Unfolding of 23kDa Protein from Spinach Photosystem Ⅱ

Pressure Equilibrium and Jump Study on Unfolding of 23kDa Pr...

引用

第六届全国光生物学学术研讨会

作者： Shinsuke sakuma Yasusi Yamamoto Claude Balny Department of Biology Faculty of ScienceOkayama University Okayama 700-8530 Japan Department of Biology Faculty of ScienceOkayama University Okayama 700-8530 Japan Institute National de la Sante et de la Recherche Medicale INSERM U 128IFR 24CNRS 1919 route de Mende 34293 Montpellier Cedex 5 France

＜正＞ Pressure-induced unfolding of 23kDa protein （P23k）, one ofthree extrinsic proteins of spinach photosystem Ⅱ, has beensystematically investigated using intrinsic fluorescencespectroscopy and the 4th derivative UV absorbance spectra atvarious experimental conditions. Thermodynamic equilibriumstudies indicate that the protein is very sensitive to *** 20℃and pH 5.5,P23k shows a reversible two-state unfoldingtransition under pressure with a midpoint near 160 MPa, apressure much lower than those observed for

关键词： 23kDa protein photosystem Ⅱ fluorescence spectroscopy unfolding pressure

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Generation of Arbitrary Pressure Pulsation of Wide Frequency Range for Flow Meter Testing in a Laminar Gas Pipeline

引用

Journal of Flow Control, Measurement & Visualization 2014年第4期2卷 125-137页

作者： Mitsuhiro Nakao Tomonori Kato Takashi Oowaku Hirohisa sakuma Toshiharu Kagawa Department of Mechanical Engineering Kagoshima University Kagoshima Japan Faculty of Engineering Fukuoka Institute of Technology Fukuoka Japan Tokyo Gas Co. Ltd. Yokohama Japan Precision and Intelligence Laboratory Tokyo Institute of Technology Yokohama Japan

The present paper presents a device to test flow meters under an arbitrary pressure pulsation in a gas pipeline with a laminar flow containing frequency components up to 50 Hz, with the amplitude reaching hundreds of pascals. In order to reduce flow noise, the device has a strainer-like element connected to a pipeline under test and uses an open-loop control law based on the frequency response test. The control signal is calculated by adding the inputs to obtain each of the sinusoidal waves included in the original wave, which was decomposed by Fourier analysis. The validity of the developed method is demonstrated through the generation tests of superimposed pressure waves containing frequency components up to 50 Hz. Analysis of the relative uncertainty demonstrated the relative uncertainty to be less than 10% when the generated pressure is larger than 360 Pa.

关键词： Unsteady Flow Flow Meter Linear Wave Superimposed Wave Pneumatics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Simplified Intraoperative Goal-Directed Therapy Using the FloTrac/Vigileo System: An Analysis of Its Usefulness and Safety

引用

Open Journal of Anesthesiology 2017年第1期7卷 1-14页

作者： Kenji Ito Miho Ito Aki Ando Yuki sakuma Toshiyasu Suzuki Department of Anesthesiology Tokai University School of Medicine Kanagawa Japan

Purpose: We investigated whether the simplified intraoperative Goal-Directed Therapy (GDT) could improve the factors affecting medical costs, and contribute in standardizing intraoperative fluid management. Methods: The enrolled patients underwent esophagectomy, pancreatoduodenectomy, or aortic stent grafting in 2012, and between March 2013 and October 2014. We conducted a comparison study on the effects of GDT, between the before-GDT historical control group (n = 100) and GDT group (n = 100). The hemodynamic indices used for control group patients were conventional: Blood pressure, heart rate, and urine output. For GDT group, additionally, we used stroke volume variation (SVV) and stroke volume index (SVI). The primary outcomes were the length of intensive care unit (ICU) stay and hospital stay (LOS). Regression analysis was used to identify factors affecting LOS. The secondary outcomes were the albumin use, the fluid amount administered, and the variation in the fluid administration rate. Results: The control and GDT groups comprised 96 and 99 patients, respectively. The patient characteristics were similar. The length of ICU stay was significantly shorter (2.1 ± 2.1 days vs. 2.8 ± 1.9 days, P = 0.0009) and LOS was shorter but without statistical significance (24.5 ± 17.7 days vs. 27.7 ± 20.1 days, P = 0.21) in the GDT group than in the control group. The fluid amount administered and the presence/ absence of albumin use were factors affecting LOS. The variation of the fluid administration rate was significantly lower in the GDT group. Conclusion: The simplified GDT may contribute to the improvement of medical economics and standardize the fluid management.

关键词： FloTrac/Vigileo Fluid Management Goal-Directed Therapy Patient Outcome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

固体气泡损伤探测器阈起源的实验判别

引用

核技术 2002年第7期25卷 506-510页

作者：郭士伦李丽 Doke T Kikuchi J Terasawa K Hara K sakuma N Yasuda N Murakami T 中国原子能科学研究院核物理研究所北京102413 Advanced Research Institute for Science and Engineering Waseda University National Institute of Radiological Science

用 5 0 0MeV/u56Fe,6 5 0MeV/u40Ar ,6 0 0MeV/u2 8Si和 180MeV/u4He对固体气泡损伤探测器 (T- 12型 )进行了实验研究 ,实验结果表明 ,固体气泡损伤探测器的阈特性可用临界能量损失率表征。在一般条件下 ,限定能量损失率在不同重离子产... 详细信息

用 5 0 0MeV/u56Fe,6 5 0MeV/u40Ar ,6 0 0MeV/u2 8Si和 180MeV/u4He对固体气泡损伤探测器 (T- 12型 )进行了实验研究 ,实验结果表明 ,固体气泡损伤探测器的阈特性可用临界能量损失率表征。在一般条件下 ,限定能量损失率在不同重离子产生径迹时不具有相同临界值 ,因此。

关键词：固体气泡损伤探测器阈起源临界能量损失率限定能量损失率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhancement in Thermal Stability of Polyoxymethylene (POM)-Based Biopolymer Blend Materials

引用

Journal of Materials Science and Chemical Engineering 2019年第7期7卷 67-78页

作者： Jitlada Boonlertsamut Supaphorn Thumsorn Toshikazu Umemura Hiroyuki Hamada Atsushi sakuma Department of Advanced Fibro-Science Kyoto Institute of Technology Kyoto Japan Department of Industrial Engineering Pathumwan Institute of Technology Bangkok Thailand Plaisir Co. LTD. Osaka Japan

In this study, we demonstrate the enhancement in thermal stability of polyoxymethylene (POM)-based biopolymer blend materials. Polyoxymethylene (POM)/Polylactic acid (PLA) blends have been used as alternative biopolymer materials for supporting environmental problems with thermal stability feature. The effects on POM biopolymer blend materials with a controlled PLA amount in their compositions under various injection conditions, were investigated by thermogravimetric analysis, dynamic mechanical analysis, and differential scanning calorimetry. The POM/PLA biopolymer blend materials showed POM phase acted as a homogeneous nucleating site for increasing PLA crystallization, which improves storage modulus of the blend materials. The decomposition temperatures of POM/PLA biopolymer blends tend to shift around 30˚C - 50˚C lower compared to the decomposition temperatures of PLA. Thus, the decomposition temperature behavior of POM/PLA blends seems to be closer to POM. The suitable ratio in POM70/PLA30 resulted in the high strength of the blend materials. The POM/PLA biopolymer blend material was tested at various injection speeds and good miscibility was obtained at an injection speed of 100 mm/s. This enhancement of thermal stability in POM/PLA blend materials should be useful in the development of high-performance bio-based thermoplastic materials.

关键词： Polyoxymethylene Poly (Lactic Acid) Biopolymer Injection Speeds

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improvement in social skills in patients with schizophrenia following 6 months of day-care treatment

引用

Open Journal of Psychiatry 2012年第4期2卷 347-354页

作者： Hiroshi sakuma Yasuhisa Miyamoto Yoshiko Yamamoto Sachie Miura Shin-Ichi Niwa Department of Neuropsychiatry School of Medicine Fukushima Medical University Fukushima Japan

Using role-playing tests simulating real-life situations, we investigated improvement in the social skills, especially information processing, of patients with schizophrenia in response to day-care in psychiatry and social skills training. From 20 pair-matched schizophrenia patients, 10 were assigned to a day-care/SST group and 10 to a control group undergoing usual treatment. After 6 months, sending and receiving skills were assessed by means of role-playing tests, psychiatric symptoms, social function, and cognitive function. The day-care/SST group showed a significant improvement and a large effect size in sending skills. Receiving skills also improved, showing a medium effect size, but the difference from the control group was not statistically significant. No statistically significant changes were observed in the other measures. That no changes occurred in social function, psychiatric symptoms, or cognitive function leads to two conclusions: 1) cognition targeted, specialized training and comprehension of cognitive remediation, psychiatric rehabilitation, and social skill development are necessary for improvement in other domains, especially symptoms and social functions;and 2) improvement resulting from day-care in psychiatry and SST alone is limited. In addition, further investigations over a longer observation period and a greater sample size are needed.

关键词： Role-Playing Schizophrenia Rehabilitation Social Skills Training Day-Care in Psychiatry Cognitive Dysfunction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：