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Evaluation of the Estrogenic Activity of Pueraria (Kudzu) Flower Extract and Its Major Isoflavones Using ER-Binding and Uterotrophic Bioassays

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Pharmacology & Pharmacy 2013年第2期4卷 255-260页

作者： Tomoyasu kamiya Akira Takano Yayoi Kido Yuki Matsuzuka mayu sameshima-kamiya Masahito Tsubata Motoya Ikeguchi Kinya Takagaki Junei Kinjo Faculty of Pharmaceutical Sciences Fukuoka University Fukuoka Japan Research and Development Division Toyoshinyaku Co. Ltd. Tosu-shi Japan

Pueraria flower extract (PFE) is a hot water extract of the Kudzu flower (Pueraria thomsonii). Tea made from dried Kudzu flower is widely used inChina, and PFE is utilized as a nutritional supplement inJapan. PFE contains unique isoflavones such as 6-hydroxygenistein 6,7-di-O-glucoside (6HGDG), tectorigenin 7-O-xylosylglucoside (TGXG), and tectoridin. 6HGDG is known to be metabolized into 6-hydroxygenistein, and TGXG and tectoridin are known to be metabolized into tectorigenin in the digestive tract. Isoflavones typically mimic the effects β-estradiol has on estrogen receptors (ERs) and may influence the female genital system in the case of excessive intake. As a result, the upper limit of safe daily consumption of soy isoflavones has been enforced inJapan. In the present study, ER-binding assays were performed using the EnBio estrogen receptor/cofactor assay system to compare the estrogenic activity of 6-hydroxygenistein and tectorigenin to that of the soy isoflavone genistein. In addition, uterotrophic bioassays were performed to investigate the estrogenic effects of PFE in vivo. The ER-binding assays revealed that the ER-binding affinities of 6-hydroxygenistein and tectorigenin were approximately 0.01 - 0.04 that of genistein. Soy isoflavone products also induced an increase in uterine wet and blotted weight at doses of 500 mg/kg and 1000 mg/kg, whereas PFE did not cause adverse estrogenic effects, even at a dose of 1000 mg/kg. Based on these results, PFE does not appear to contain compounds with strong estrogenic activity or cause adverse estrogenic effects in vivo. Importantly, the results of this study confirm the safety of PFE as a food supplement.

关键词： Estrogenic Activity 6-Hydroxygenistein Kudzu Flower Extract Safety Evaluation Tectorigenin

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Epidemiological impact of revoking mask-wearing recommendation on COVID-19 transmission in Tokyo,Japan

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Infectious Disease Modelling 2024年第4期9卷 1289-1300页

作者： mayu Nagata Yuta Okada Hiroshi Nishiura Kyoto University School of Public Health Yoshida-KonoeSakyoKyoto606-8601Japan

Despite the global implementation of COVID-19 mitigation measures,the disease continues to maintain *** mask wearing became one of the key measures for preventing the transmission of COVID-19 early in the pandemic period,many countries have relaxed the mandatory or recommended wearing of *** objective of the present study was to estimate the epidemiological impact of removing the mask-wearing recommendation in *** developed a model to assess the consequences of declining mask-wearing coverage after the government revoked its recommendation in February *** declining mask-wearing coverage was estimated using serial cross-sectional data,and a mathematical model was devised to determine the age-specific incidence of COVID-19 using the observed case count in Tokyo from week of October 3,2022 to October 30,*** explored model-based counterfactual scenarios to measure hypothetical situations in which the mask-wearing coverage decreases or increases relative to the observed *** results show that mask-wearing coverage declined from 97%to 69%by the week of October 30,2023,and that if the mask-wearing recommendation had continued,427 lives could have been saved in *** the mask-wearing coverage had declined to 25%of the observed level,the model suggests there might have been 1587 additional ***,revoking the mask-wearing recommendation had a substantial epidemiological *** future pandemics,our proposed approach could provide a realtime quantification of the effects of relaxing countermeasures.

关键词： COVID-19 Mask wearing recommendation Health policy Counterfactual Mathematical model

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Ordered Structures of a Binary Mixture with Mobile Particles System

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Chinese Physics Letters 2003年第5期20卷 703-705页

作者： ZHUYue-Jin mayu-Qiang DepartmentofPhysics NingboUniversityNingbo315211 NationalLaboratoryofSolidStateMicrostructures NanjingUniversityNanjing210093

We study the ordered structures of a binary mixture through the introduction of mobile particles under periodically oscillating driving fields, and find that the particle motion can break up the isotropy of the system, so that the continuous structure along the oscillation forcing direction is observed for properly chosen oscillating field. Furthermore, the dependences of the morphology and domain size on the mixture-particle coupling interaction, the diffusion coefficient, and the quench depth are examined in details.

关键词：粒子运动各向异性二元混合物规则结构周期振荡

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Recent progress of nuclear liquid gas phase transition

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Nuclear Science and Techniques 2004年第1期15卷 4-29页

作者： mayu-Gang SHENWen-Qing ShanghaiInstituteofAppliedPhysics theChineseAcademyofSciencesShanghai201800

Recent progress on nuclear liquid gas phase transition (LGPT) has been reviewed, especially for the signals of LGPT in heavy ion collisions. These signals include the power-law charge distribution, cluster emission rate, nuclear Zipf law, bimodality, the largest fluctuation of the fragments, Δ-scaling, caloric curve, phase coexis- tence diagram, critical temperature, critical exponent analysis, negative specific heat capacity and spinodal instability etc. The systematic works of the authors on experimental and theoretical LGPT are also introduced.

关键词：核液化气相变 LGPT 重离子碰撞临界温度热量曲线

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Magnetization Configuration in Magnetic Trilayer System with Out-of-Plane Component Defect

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Communications in Theoretical Physics 2003年第4X期40卷 507-512页

作者： HUJing-Guo JINGuo-Jun mayu-Qiang DepartmentofPhysics YangzhouUniversityYangzhou225002China NationalLaboratoryofSolidStateMicrost-ructuresandDepartmentofPhysics NanjingUniversityNanjing210093China

The equilibrium magnetization configuration, the inducing field and the coercive field in trilayer magnetic materials having an out-of-plane anisotropy defect interlayer between two in-plane anisotropy layers are discussed by both analytical and numerical calculations based on a micromagnet approach. It is shown that the above physical parameters strongly depend on the defect layer such as its thickness and exchange stiffness etc., as well as on the applied fields. It is found that there is a special thickness of defect layer, in which the inducing effect begin to occur, and the critical behavior of inducing field in the vicinity of the special thickness is linearly characterized. Particularly, the magnetic hysteresis shows typical soft hysteresis shape, even though the host material is composed of hard magnets, and the coercivity increases with increasing the thickness of the interlayer.

关键词：微磁学矫顽磁性场磁化构造三层磁系统非零磁化场零场状况

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Thermal Charmed Quark Contribution to Dileptons in Chemically Equilibrating Quark—Gluon Matter

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Chinese Physics Letters 2003年第6期20卷 836-838页

作者：贺泽君龙家丽 LUZhao-Hui mayu-Gang LIUBo ShanghaiInstituteofNuclearResearch ChineseAcademyofSciencesPOBox800-204Shanghai201800 InstituteofHighEnergyPhysics ChineseAcademyofSciencesBeijing100039

We find that in a chemically equilibrating baryon-rich quark-gluon matter, due to the slow cooling rate, high initial temperature, large gluon density as well as large fusion cross section of gg→c in the intermediate mass region, the gluon fusion gg→c provides a dominant contribution to dileptons with intermediate masses, resulting in the significant enhancement of intermediate mass dileptons.

关键词： Physical properties

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Volatilization behaviors of diesel oil from the soils

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Journal of Environmental Sciences 2004年第6期16卷 1033-1036页

作者： LIYu-ying ZHENGXi-lai LIBing mayu-xin CAOJing-hua InstituteofEnvironmentalScienceandEngineering OceanUniversityofChinaQingdao266003China.

The volatilization of diesel oil, Shengli crude oil and 90# gasoline on glass surface of petri dishes were conducted at the ambient temperature of 25℃. Diesel oil evaporates in a power manner, where the loss of mass is approximately power with time. 90# gasoline evaporates in a logarithmic with time. Where as the volatilization of Shengli crude oil fit either the logarithmic or power equation after different time, and has similar R2. And the effects of soil type and diesel oil and water content on volatilization behavior in unsaturated soil were studied in this paper. Diesel oil and water content in the soils play a large role in volatilization from soils. Appropriate water helps the wicking action but too much water stops it. The wicking action behaves differently in four different types of soils in the same volatilization experiment of 18% diesel oil content and air-dry condition.

关键词： volatilization diesel oil power curve

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Syntheses of Nucleoside Derivatives Containing Fmocor Trityl-protected Amino Acids

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Chemical Research in Chinese Universities 2005年第4期21卷 447-451页

作者： GUOHui ZOUWu-xin JIQi mayu-xin MENGJi-ben DepartmentofChemistry NankaiUniversityTianjin300071P.R.China

Facile direct esterification reactions between 2′,3′-O-isopropylidene-nucleosides and Fmoc- or trityl-protected amino acids %via% N,N-dicyclohexyl-carbodiimide(DCC) mediated condensation are described. These reactio... 详细信息

关键词： Nucleoside Amino acid Esterification 2′,3′-O-Isopropylidene-nucleoside

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Photoluminescence and Electroluminescence Properties of 2,5-Bis[2,2′-bis(5-phenyl)-1,3,4-oxadiazole] Thiophene(T-OXD) and T-OXD/Poly(9-vinylcarbazole) Blends

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Chemical Research in Chinese Universities 2004年第1期20卷 114-117页

作者： ZHANGZhi-ming mayu-guang LIGuo-wen SHENjia-cong Key Laboratory for supram olecular Structure and Materials of M inistry of Education Jilin Universitychangchun130023P．R．China College of Chemistry and Chemical Engineering Ocean University of Qingdao，Qingdao 266003，P.R.China

The photoluminescence(PL) and the electroluminescence(EL) properties of a novel organic compound, 2,5-bis(2,2′-bis(5-phenyl)-1,3,4-oxadiazole(T-OXD), were studied in chloroform and in a solid thin film. The PL and the EL properties of T-OXD/poly(9-vinylcarbazole)(PVK) blends were also studied, which contained various contents of T-OXD. The PL maximum emission peaks of T-OXD/PVK blends show gradual bathochromtic-shift with the increase of the T-OXD content. The EL spectra of T-OXD/PVK devices are similar to their PL spectra, and all the EL maximum emission peaks show bathochromtic-shift compared with the corresponding PL spectra, which is ascribed to the formation of electroplex. The turn-on voltages for ITO/T-OXD:PVK/Al devices decreased from 13.5 V of the device cotaining 0.1% T-OXD(mass fraction) to 5 V of the device containing 5% T-OXD, which suggests that T-OXD improves the energy level match between T-OXD and PVK and enhances the emission efficiency. The experimental results indicate that T-OXD can be used as a good electron transporting material.

关键词： 2,2'(2,5-Thiophenediyl) bis(5-phenyl)-1,3,4-oxadiazole(T-OXD) Photoluminescence Electroluminescence Electroplex LEDs

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Sono-chemical Synthesis and Mechanism of Dibenz[a,c]anthracene

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Chemical Research in Chinese Universities 2012年第2期28卷 220-224页

作者： MUDDASIR Hanif WANG Zhi-ming LU Ping mayu-guang State Key Laboratory for Supramolecular Structure and Materials Jilin UniversityChangchun 130012P.R.China School of Petrochemical Engineering Shenyang University of TechnologyLiaoyang 111003P.R.China

Planar polycyclic aromatic hydrocarbons have important applications in optoelectronics,environmental chemistry and cancer *** improved sono-chemical synthetic procedure of dibenz[a,c]anthracene（D[a,c]A） was reported in this *** yield was increased to 56% and the resultant was carefully characterized via gas chromatography-electron impact mass spectrometry（GC-EIMS）,matrix assisted laser desorption ionization-time of flight（MALDI-TOF）,1 H NMR,13 C NMR,correlation spectrometry（1 H1 H COSY）,heteronuclear multiple bond correlation（HMBC） and heteronuclear multiple quantum coherence（HMQC）.Based on the characterization data,we proposed a 4-step mechanistic explanation for the formation of D[a,c]A under sono-chemical bis-ortho-Wittig reaction conditions.

关键词： Phenanthrene-9 10-dione Sono-chemistry Bis-ortho-Wittig reaction mechanism NMR

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