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Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents

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Neural Regeneration Research 2024年第4期19卷 846-854页

作者： Willian Orlando Castillo-Ordoñez Nohelia Cajas-Salazar mayra Alejandra Velasco-Reyes Facultad de Ciencias Naturales-Exactas y de la Educación Departamento de Biología.Universidad del Cauca Departamento de Estudios Psicológicos Universidad Icesi

Alzheimer’s disease is a progressive neurodegenerative disorder and the most common cause of dementia that principally affects older *** factors,such as oxidative stress,an increase in acetylcholinesterase activity,mitochondrial dysfunction,genotoxicity,and neuroinflammation are present in this syndrome,which leads to *** pathologies such as Alzheimer’s disease are considered late-onset diseases caused by the complex combination of genetic,epigenetic,and environmental *** are two main types of Alzheimer’s disease,known as familial Alzheimer’s disease(onset<65 years)and late-onset or sporadic Alzheimer’s disease(onset≥65 years).Patients with familial Alzheimer’s disease inherit the disease due to rare mutations on the amyloid precursor protein(APP),presenilin 1 and 2(PSEN1 and PSEN2)genes in an autosomaldominantly fashion with closely 100%*** contrast,a different picture seems to emerge for sporadic Alzheimer’s disease,which exhibits numerous non-Mendelian anomalies suggesting an epigenetic component in its ***,the fundamental pathophysiological mechanisms driving Alzheimer’s disease are interfaced with epigenetic ***,the dynamic nature of epigenetics seems to open up new avenues and hope in regenerative neurogenesis to improve brain repair in Alzheimer’s disease or following injury or stroke in *** recent years,there has been an increase in interest in using natural products for the treatment of neurodegenerative illnesses such as Alzheimer’s *** epigenetic mechanisms,such as DNA methylation,non-coding RNAs,histone modification,and chromatin conformation regulation,natural compounds appear to exert neuroprotective *** we do not purport to cover every in this work,we do attempt to illustrate how various phytochemical compounds regulate the epigenetic effects of a few Alzheimer’s disease-related genes.

关键词： Alzheimer’s disease epigenetics genes methylation natural products

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Carpal Tunnel Syndrome: A Marker for Amyloidosis

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World Journal of Neuroscience 2024年第3期14卷 92-101页

作者： Luciana León Cejas Miguel Saucedo mayra Aldecoa Gustavo Teruya Fabricio Silva Alvaro Muratore Gonzalo Viollaz Cintia Marchesoni Ana Pardal Pablo Dezanzo Alejandro Iotti Ricardo Reisin Neurology Department Hospital Britnico de Buenos Aires Buenos Aires Argentina Orthopedics Department Hospital Britnico de Buenos Aires Buenos Aires Argentina Pathology Department Hospital Britnico de Buenos Aires Buenos Aires Argentina

Introduction: Amyloidosis are systemic conditions and carpal tunnel syndrome (CTS) precedes the principal systemic complications and can be used as an early marker. Our objective was to determine the frequency of amyloid deposition in idiopathic CTS and its systemic impact. Methods: We retrospectively evaluated patients with CTS between September 2019 to January 2020. Samples from the anterior carpal ligament were pathologically evaluated and amyloid deposition was confirmed by apple-green birefringence on polarized light using Congo red stain. When amyloid was detected we performed genetic testing for transthyretin variants (ATTRv), immunofixation electrophoresis in serum and urine for light chains and multidisciplinary evaluation. Results: Thirty consecutive patients were included, 19 women, 11 men, mean age 70 years old (range 42 - 89 years). We identified 3 patients (10%) with amyloid deposits (mean age: 78.6 years, 2 men, 1 woman). Genetic testing for ATTRv and light chains studies were negative. During follow-up: The first patient required aortic valve replacement. The second patient developed progressive cardiac failure with syncopal episodes, atrioventricular block and atrial fibrillation and required a pacemaker and anticoagulation. The third patient had unexplained chronic edemas. The cardiac evaluation in all 3 patients revealed left ventricular hypertrophy and myocardial uptake (Perugini Score > 2) in their nuclear bone scintigraphies with technetium pyrophosphate. Two patients were treated with tafamidis and one patient died due to refractory cardiac insufficiency. Discussion: Our findings underline the importance of investigating amyloidosis in idiopathic CTS. The identification of deposits allows early diagnosis of cardiac amyloidosis leading to timely intervention and treatment.

关键词： Carpal Tunnel Amyloid Transthyretin Amyloid Cardiac Transthyretin Variants Light Chains

Application of single‑cell multi‑omics approaches in horticulture research

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Molecular Horticulture 2023年第1期3卷 141-156页

作者： Jun Zhang mayra Ahmad Hongbo Gao Joint Center for Single Cell Biology School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China

Cell heterogeneity shapes the morphology and function of various tissues and organs in multicellular *** of the differences among cells and the mechanism of intercellular regulation is essential for an in-depth understanding of the developmental *** recent years,the rapid development of high-throughput singlecell transcriptome sequencing technologies has influenced the study of plant developmental ***,the accuracy and sensitivity of tools used to study the epigenome and metabolome have significantly increased,thus enabling multi-omics analysis at single-cell ***,we summarize the currently available single-cell multiomics approaches and their recent applications in plant research,review the single-cell based studies in fruit,vegetable,and ornamental crops,and discuss the potential of such approaches in future horticulture research.

关键词： Single-cell Multi-omics High throughput sequencing Cell atlas Developmental trajectory

The ultra-sonication of minerals in swine feed

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Journal of Animal Science and Biotechnology 2015年第4期6卷 416-423页

作者： mayra A.D.Saleh Pedro M.Padilha Lucelia Hauptli Dirlei A.Berto Department of Animal Production Lageado FarmFaculty of Animal Science and Veterinary MedicineUNESP-Sao Paulo State UniversityBotucatu Campus Department of Chemistry and Biochemistry Institute of BiosciencesUNESP-Sao Paulo State UniversityBotucatu CampusRubiao Junior District UFSC-Federal University of Santa Catarina Center for Agricultural Sciences

A sample preparation method based on ultrasound assisted-extraction （UAE） of Ca, Mg and P from swine feed has been described. The experiment was performed to cover the variables influencing the sonication process and, the method validation using standard reference material. Final solutions obtained upon sonication were analyzed by flame atomic absorption spectrometry （for Ca and Mg） and by UV-vis spectrophotometry （for P）. The best conditions for metal extraction were as follows： sample mass： 100 mg in 20 mL 0.10 mol/L HCI, a particle size：〈60 lam, sonication time： 5 cycles of 10 s and ultrasound power： 102 W. The UAE method was applied in digestibility assays in different piglet feeds and their results showed that it is highly comparable （P 〉 0.05） to the other methods used for such purposes, as block digestion, and offered a Ca, Mg and P method of quantification limit of 10.6, 12.4 and 14 mg/kg, respectively. The major advantages of the UAE method compared to other methods are the high treatment rate, low reagent usage in the extracts and, it does not generate toxic residues that might negatively affect human health and the environment, accompanied by good precision and accuracy.

关键词： Digestibility assay Green analytical chemistry Macronutrients Piglet Ultrasound-assisted extraction

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Efficient middlebox scaling for virtualized intrusion prevention systems in software-defined networks

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Science China(Information Sciences) 2022年第8期65卷 279-281页

作者： Junchi XING Chunming WU Haifeng ZHOU Qiumei CHENG Danrui YU mayra MACAS College of Computer Science Zhejiang University Zhejiang Lab

Dear editor,An intrusion prevention system(IPS) [1] is an important security function that detects and filters out the detected anomaly data traffic in networks. Currently, network function virtualization(NFV) [2] is able to virtualize IPSes as virtualized IPS(VIPS) [3] by encapsulating security functions in software-based middleboxes that can be elastically scaled to deal with traffic volume variations [4, 5].

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Natural Mg silicates with different structures and morphologies: Reaction with K to produce K2MgSiO4 catalyst for biodiesel production

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International Journal of Minerals,Metallurgy and Materials 2020年第1期27卷 46-54页

作者： Fabiane Carvalho Ballotin mayra Nascimento Sara Silveira Vieira Alexandre Carvalho Bertoli Ottávio Carmignano Ana Paula de Carvalho Teixeira Rochel Montero Lago Departamento de Química Universidade Federal de Minas GeraisBelo HorizonteBrasil Doutorado Inovação/Mineradora Pedras Congonhas Universidade Federal de Minas Gerais31270-901 Belo Horizonte-MGBrazil

In this work, different magnesium silicate mineral samples based on antigorite, lizardite, chrysotile(which have the same general formula Mg3Si2O5(OH)4), and talc(Mg3Si4O10(OH)2) were reacted with KOH to prepare catalysts for biodiesel production. Simple impregnation with 20 wt% K and treatment at 700–900°C led to a solid-state reaction to mainly form the K2MgSiO4 phase in all samples. These results indicate that the K ion can diffuse into the different Mg silicate structures and textures, likely through intercalation in the interlayer space of the different mineral samples followed by dehydroxylation and K2MgSiO4 formation. All the materials showed catalytic activity for the transesterification of soybean oil(1:6 of oil : methanol molar ratio, 5 wt% of catalyst, 60°C). However, the best results were obtained for the antigorite and chrysotile precursors, which are discussed in terms of mineral structure and the more efficient formation of the active phase K2MgSiO4.

关键词： silicate serpentinite lizardite antigorite talc chrysotile biodiesel

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Non-invasive digestion monitoring with an FDA-cleared wearable biosensor:further validation for use in tracking food ingestion

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Gastroenterology Report 2021年第5期9卷 475-477,I0003页

作者： Erica R.Cohen mayra Lopez Brennan M.R.Spiegel Christopher V.Almario Karsh Division of Gastroenterology and Hepatology Cedars-Sinai Medical CenterLos AngelesCAUSA Cedars-Sinai Center for Outcomes Research and Education(CS-CORE) Los AngelesCAUSA Division of Health Services Research Cedars-Sinai Medical CenterLos AngelesCAUSA Department of Health Policy and Management UCLA Fielding School of Public HealthLos AngelesCAUSA Division of Informatics Cedars-Sinai Medical CenterLos AngelesCAUSA

Introduction Obesity affects one-third of the US population and accounts for$200 billion/year in expenditures[1].Diet and exercise form the cornerstone of management,yet are often ineffective[2].Mobile health applications(mHealth apps)can augment traditional strategies;Gill and Panda[3]demonstrated that obese patients can modify their eating behavior and lose weight using an mHealth app to track food *** promising,these apps typically require active data input and currently lack passively collected,physiologic input to support sustained behavior change.

关键词：生物传感器消化功能食物摄入

Brain infiltration by cancer cells:different roads to the same target?

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 90-100页

作者： mayra Paolillo Sergio Schinelli Department of Drug Sciences University of Pavia27100 PaviaItaly

Brain infiltration by cancer cells is a complex process in which metastatic cells detached from the primary tumor must firstly survive i n t he blood flow,cross t he blood brain barrier(BBB)a nd finally colonize a foreign *** cells t hat successfully bypass the cellular barriers surrounding capillaries,proliferate to form micrometastasis and trigger the angiogenetic *** molecular mechanisms have been proposed to explain the metastatic behaviour of solid tumors that infiltrate brain tissue;in this review the most recent findings concerning mechanisms and genes potentially involved in brain metastasis,that differ according to primary tumor types,will be *** three tumors that more frequently develop brain metastasis,lung cancer,breast cancer and melanoma,will be considered and,in addition,the role of BBB and the process of endothelial to mesenchymal transition in cancer metastasis will be briefly described.

关键词： Brain metastasis breast epithelial-mesenchymal transition lung melanoma micro-RNA

The Future of Transcatheter Therapy for Mitral Valve Disease

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Cardiovascular Innovations and Applications 2016年第B5期1卷 287-299页

作者： Ted Feldman mayra Guerrero NorthShore University HealthSystem EvanstonILUSA

The develop percutaneous treatments for mitral regurgitation(MR)have been based on established surgical *** are based in some way on mitral *** angioplasty utilizing coronary sinus and leafl et repair with the MitraClip device have the most development and clinical *** recently,after the success of transcatheter aortic valve replacement,transcatheter mitral valve replacement has emerged.A critical unanswered question is what the relative roles of valve repair and valve replacement will *** largest experience in practice is with MitraClip leaflet *** evidence base for the development of these novel therapies includes some data in surgical candidates,and registry studies that have been done predominantly in high risk populations.

关键词： mitral regurgitation percutaneous mitral repair annuloplasty