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SARS-CoV-2 spike RBD-specific IgA and IgG antibodies in breast milk after vaccination with the protein subunit vaccine Abdala

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Infectious Medicine 2022年第4期1卷 253-261页

作者： Maylin Pérez-Bernal Carlos Hernández Rafael Ibargollín Midalis Martínez Migdiala Soria Magali Delgado Onel Valdivia DayamíDorta Andy Domínguez Enrique pérez Yeosvany Cabreraa Research&Development Department Center for Genetic Engineering and BiotechnologyCircunvalante NorteOlivos IIISancti SpiritusCuba Neonatology Service General Hospital“Camilo Cienfuegos”128 Bartolome MasoSancti SpiritusCuba production Department Center for Genetic Engineering and BiotechnologyCircunvalante NorteOlivos IIISancti SpiritusCuba

Background:COVID-19 vaccines that trigger a strong secretory antibody response in breast milk may achieve effective passive protection of vulnerable newborns and breastfed infants of immunized mothers.The aim of this work was to investigate the presence of SARS-CoV-2 spike RBD-specific IgA and IgG antibodies in breast milk,5 and 9 weeks after vaccination with 3 doses of the protein subunit vaccine Abdala,compared to those found in breast milk from COVID-19-recovered women,collected at least 40 days after the infection.Methods:SARS-CoV-2 spike RBD-specific IgA and IgG antibodies were semi-quantified by indirect ELISA,using a homemade standard generated by pooling twenty breast milk samples with high absorbance values according to preliminary data.The validity of the standard curves was proved following the European Medicines Agency Guideline.Two breast milk samples from 2 unvaccinated women who had not been infected with COVID-19 were included as negative controls.potentially neutralizing antibodies was assessed by a SARS-CoV-2 surrogate virus neutralization test.Results:High levels of anti-RBD IgA antibodies were detected in breast milk samples 9 weeks after vaccination and anti-RBD IgG antibodies rise from the fifth to the ninth week.In the post-COVID-19 time that was evaluated,the IgG-type response was notably higher compared to both post-vaccination periods.Neutralizing antibody titers were similar in breast milk from vaccinated and COVID-19 recovered women.Conclusions:This is the first report about the immune response in breast milk after the administration of a COVID-19 protein subunit vaccine,which could provide analogous protection to that conferred by SARS-CoV-2 infection.This implies a potential passive immunity that breastfed infants receive from their mothers vaccinated with Abdala.

关键词： Abdala vaccine IgA IgG Neutralizing antibody titers SARS-CoV-2

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马体内的硒和维生素E

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国外畜牧科技 1982年第1期 13-16页

作者：祁周约 George A.maylin

在纽约州的四个种马场进行了马体内硒和维生素E浓度的测定.在三次采样中,马平均血硒浓度没有明显改变,而维生素E的浓度呈季节性波动.本次测定饲喂当地饲料的马平均血硒浓度为7.7微克/分升,饲喂商品饲料的马平均血硒浓度15.6微克/分升.... 详细信息

在纽约州的四个种马场进行了马体内硒和维生素E浓度的测定.在三次采样中,马平均血硒浓度没有明显改变,而维生素E的浓度呈季节性波动.本次测定饲喂当地饲料的马平均血硒浓度为7.7微克/分升,饲喂商品饲料的马平均血硒浓度15.6微克/分升.确定了马血液谷胱甘肽过氧化物酶(GSH-px)活性和血硒浓度之间的相关系数为0.94. 还研究了口服和注射硒对血液硒浓度和血液GSH-px的作用.每日口服补充1.0毫克硒,血硒浓度高于患肌变性成年马及马驹的水平.妊娠后期母马注射补充硒的试验表明,只有有限的硒通过胎盘屏障.母马在妊娠和泌乳期注射补充硒,或马驹在出生后开始补充硒,马驹血硒水平高于患硒-维生素E缺乏症的马驹.

关键词：血硒浓度马驹 GSH 硒水平母马维生素

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一种检查尿中乙二醇的简易方法——薄层色谱法

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动物医学进展 1982年第3期 50-50页

作者： George A. maylin 丁伯良

本文介绍了一种用薄层色谱法检查尿中乙二醇的方法。用5％硫酸香草醛用作显色剂,方法简便、灵敏,对临床上诊断乙二醇中毒具有实践意义。

关键词：薄层色谱法乙二醇二元醇展开剂香草醛

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Neuroinmunological response in HIV-associated Guillain-Barre syndrome: A case report

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World Journal of Neuroscience 2012年第1期2卷 32-35页

作者： Ivonne M. Iglesias-González Alberto J. Dorta-Contreras Bárbara padilla-Docal maylin Victoria-Garcia Ricardo Junco-Calzadilla Faculty of Medical Sciences “Dr Miguel Enríquez” Central Laboratory of Cerebrospinal Fluid (LABCEL) Havana Medical Sciences University Havana City Cuba Raúl Gómez García Hospital Havana City Cuba

Introduction: Human immunodeficiency virus infec- tion is associated with several different types of peripheral neuropathy: distal predominantly sensory axonal polyneuropathy, like Guillain Barre syndrome. Case presentation: A 55-year-old Caucasian woman with Human immunodeficiency virus infection, diag- nosed with Guillain Barre syndrome was studied. Serum and CSF immunoglobulin G and Albumin levels were quantified by using an immunodiffusion technique. She had preceding viral symptoms. The clinical diagnosis of the illness in this patient was pa-resthesias or sensory loss, tendon reflexes. It was also observed cranial nerves abnormalities, acute mo- tor and sensory axonal neuropathy and ophthalmoplegia. The mean CD4 count was 367/mm3, CSF white blood cell 25 wbc/mm3. The serum sodium concentration was significantly low (133 mmol/L). She had a respiratory compromise as a result of their neuropa- thy and developed congestive heart failure and hy- potension and died of a cardiac arrest. The neuro-immunological response described by our patient was a blood/CSF barrier dysfunction without IgG intra-thecal synthesis. Conclusion: There is no doubt that this study is of great importance because will help clinicians increase their knowledge of the immune response in patients with this autoimmune disorder on the basis of this case report, in which, for first time, could be seen the neuroimmunological response through the reibergram in a patient with HIV- asso-ciated Guillain-Barre syndrome.

关键词： Guillain Barre Human Immunodeficiency Virus Neuroimmunological Response Blood/CSF

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