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Musical and Photographic Stimulations on the Symptomatology of Alzheimer’s Disease in Elderly

World Journal of Neuroscience 2020年第4期10卷 155-165页

作者： Jamylly Ferreira Targino silva Mayara leite alves da silva maykon wanderley leite alves-da-silva Douglas Nijenhuis de Castro Euclides Maurício Trindade Filho Janise dal Pai Lysien Ivania Zambrano Valtuir Barbosa Felix Elionai Dias Soares Camila Conceição Luz Soares Albérico José de Moura Saldanha Filho Magnúcia de Lima leite Emanuel Guilherme de Almeida Carvalho Matheus Santos Freitas José Claudio da silva State University of Health Sciences of Alagoas (UNCISAL) Maceió Brazil CESMAC University Center Maceió Brazil Federal University of São Paulo (UNIFESP) S&#227o Paulo Brazil Facultad de Ciencias Medicas Universidad Nacional Autónoma de Honduras Tegucigalpa Honduras Division of Therapeutic Support and Diagnosis of HUPAA/UFAL/EBSERH Maceió Brazil Tiradentes University Center (UNIT-AL) Maceió Brazil Faculdade Tiradentes (FITS) Recife Brazil

Background: Alzheimer’s disease is a progressive and neurodegenerative disorder characterized by deterioration of brain functions. Psychosocial interventions such as music and photographic stimuli may contribute to cognitive and sensory exercise or rehabilitation. Objective: Evaluate musical and photographic stimuli in elderly people with Alzheimer’s disease. Methods: It is an uncontrolled clinical trial, before-after type, eleven subjects composing the sample. Participants were submitted to Katz Index, Autobiographical Memory Test, GDS-15, Mini-Mental State Examination. The collection instruments were used on the first and last day of intervention, individually. There were 2 sessions in the week with duration of 50 minutes totaling 20 sessions. data were analyzed by descriptive and inferential statistics and as variables expressed as mean standard deviation. Results: There was a significant effect of cognitive activity (P , it was observed that a small advance (P = 0.05) of the daily life activities. With the analysis of GDS-15, it is verified that they are more effective for the increase of the previous self-estimation of the therapy (P = 0.94). In the application of the AMT, it is observed that there was a better recruitment of the memory for the neutral words. Conclusion: Musical and photographic stimuli had a positive effect on the cognitive level, daily life activities and autobiographical memory in seniors with Alzheimer’s disease.

关键词： Alzheimer’s Disease Health of the Elderly Depression Memory

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The Quality of Life for People with Parkinson’s Disease in Relation to Their Oral Health

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Open Journal of Stomatology 2018年第11期8卷 312-318页

作者： Phablo Glewber Torres Bezerra Samuel Rodrigo de Andrade Veras Camila Caroline da silva Renato Mariano da silva Deivison Edson Pereira da silva Eduardo Borges da Costa leite Maria das Gracas wanderley de Sales Coriolano Carla Cabral dos Santos Accioly Lins Federal University of Pernambuco RecifeBrazil Department of Prosthodontics and Oral and Maxillofacial Surgery Federal University of PernambucoRecifeBrazil Department of Anatomy Federal University of PernambucoRecifeBrazil

The present study aimed to evaluate the correlation between the oral health status and the quality of life for people with Parkinson’s disease. The Decayed, Missing, Filled (DMFT) index and the quality of life questionnaire for people with Parkinson’s disease (Parkinson’s Disease Questionnaire-39) were used as evaluation instruments. Sixty-two people with a clinical diagnosis of Parkinson’s disease between stages 1 and 3, age between 46 and 86 years, of both sexes, with an average time of disease evolution of 7 years, participated in the study. data were evaluated using the Pearson’s correlation test, and one-way ANOVA (p daily living.

关键词： Parkinson’s Disease Quality of Life DMFT Index

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Inhibitory Effect of the Essential Oil from Hyptis suaveolens （L.） Poit on the Growth and Aflatoxins Synthesis of Aspergillus flavus

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Journal of Life Sciences 2013年第3期7卷 276-281页

作者： Ana Carolina Pessoa Moreira Egberto Santos Carmo Paulo alves wanderley Evandro leite de Souza Edeltrudes de Oliveira Lima Department of Pharmaceutical Sciences Federal University of Paraiba Joao Pessoa 58051-900 Brazil Academic Unit of Health Federal University of Campina Grande Cuitd 58175-000 Brazil Department of Agriculture Federal University of Paraiba Bananeiras 58220-000 Brazil Laboratory of Food Microbiology Department of Nutrition Federal University of Paraiba Joao Pessoa 58051-900 Brazil

H. suaveolens （L.） Poit has been used in folk medicine revealing a wide pharmacological potential. This study aimed to evaluate the efficacy of the essential oil from 11. suaveolens leaves in inhibiting the growth of A. flavus LM257 and synthesis of aflatoxins Bl and B2. The essential oil at 20, 40 and 80 laL/mL strongly reduced the biomass and spore germination ofA. flavus. A 100% inhibition was found at 40 μL/mL and 80μL/mL, while at 20 μL/mL the growth depressed over 50% for both tested parameters. The essential oil at all assayed concentrations totally inhibited the production of aflatoxin B1 and B2. From these results, the essential oil from 11. suaveolens leaves may be considered as an alternative and effective inhibitor ofA. flavus, in addition to offer some protective effect to the production of aflatoxins.

关键词： Hyptis suaveolens essential oil Aspergillusflavus mycotoxins inhibitory effect.

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Green tea polyphenols inhibit testosterone production in rat Leydig cells

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Asian Journal of Andrology 2009年第3期11卷 362-370页

作者： Marina S. Figueiroa Juliany S. B. Cesar Vieira Disleide S. leite Ruben C. O. Andrade Filho Fabiano Ferreira Patricia S. Gouveia daniel P. Udrisar Maria I. wanderley Department of Physiology and Pharmacology Federal University of Pernambuco 50607-901 Recife PE Brazil

This study investigated the acute effects of green tea extract （GTE） and its polyphenol constituents, （-）-epigallocatechin-3-gallate （EGCG） and （-）-epicatechin （EC）, on basal and stimulated testosterone production by rat Leydig cells in vitro. Leydig cells purified in a Percoll gradient were incubated for 3 h with GTE, EGCG or EC and the testosterone precursor androstenedione, in the presence or absence of either protein kinase A （PKA） or protein kinase C （PKC） activators. The reversibility of the effect was studied by pretreating cells for 15 min with GTE or EGCG, allowing them to recover for 1 h and challenging them for 2 h with human chorionic gonadotropin （hCG）, luteinizing hormone releasing hormone （LHRH）, 22（R）-hydroxycholesterol or androstenedione. GTE and EGCG, but not EC, inhibited both basal and kinase-stimulated testosterone production. Under the pretreatment conditions, the inhibitory effect of the higher concentration of GTE/EGCG on hCG/LHRH-stimulated or 22（R）- hydroxycholesterol-induced testosterone production was maintained, whereas androstenedione-supported testosterone production returned to control levels. At the lower concentration of GTE/EGCG, the inhibitory effect of these polyphenols on 22（R）-hydroxycholesterol-supported testosterone production was reversed. The inhibitory effects of GTE may be explained by the action of its principal component, EGCG, and the presence of a gallate group in its structure seems important for its high efficacy in inhibiting testosterone production. The mechanisms underlying the effects of GTE and EGCG involve the inhibition of the PKA/PKC signalling pathways, as well as the inhibition of P450 side-chain cleavage enzyme and 17β-hydroxysteroid dehydrogenase function.

关键词： green tea polyphenols Leydig cells protein kinase A protein kinase C testosterone

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Preparation of Reference Material for Proficiency Test for Enumeration of Coliforms in Cheese Matrix

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Detection 2013年第1期1卷 7-12页

作者： Marcelo Luiz Lima Brandao Carla de Oliveira Rosas Silvia Maria Lopes Bricio Valeria de Mello Medeiros Juliana de Castro Beltrao da Costa Rodrigo Rollin Pinheiro Paola Cardarelli-leite Marcus Henrique Campino de La Cruz Armi wanderley da Nobrega Laboratory of Products Department of MicrobiologyNational Institute of Quality Control in HealthOswaldo Cruz FoundationRio de JaneiroBrazil Proficiency Testing Program of Products Subject to Health Surveillance National Institute of Quality Control in HealthOswaldo Cruz FoundationRio de JaneiroBrazil

It is widely accepted that quantitative reference materials (RM), are indispensable tools for verification of the precision and accuracy of analytical measurements. The RM can be used by food microbiology laboratories, as part of their quality assurance programmes, to achieve their quality control. In Brazil, Anvisa RDC No. 12/01 specifies the enumeration of coliforms as one of the parameters for evaluating cheese quality. The aim of this study was to produce a quantitative RM for proficiency testing (PT) for use in the testing of enumeration of coliforms in cheese matrixes. A sample of an ultra-filtered cheese with a coliforms count of days). The material was also considered sufficiently stable at 4?C for six days, but instable at 30?C and 35?C for the same period. At ?20?C the RM was sufficiently stable for 161 days. It was concluded that the material showed all the necessary requirements for a quality RM to be used as PT items and could be transported to the laboratories taking part in a PT at up to 4?C for up to 6 days, since the results indicated maintenance of the cell concentrations during this period. This is the first study to describe a methodology for producing RM containing coliforms in a cheese matrix.

关键词： Coliforms Cheese Reference Material Proficiency Test

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