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Microalbuminuria and Kidney Disease Risk in HIV Patients Taking Combined Antiretroviral Therapy

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World Journal of AIDS 2014年第2期4卷 242-248页

作者： Huylmer Lucena Chaves mayanna pinho batista Adriana de Menezes Gomes Amanda Antunes Costa André Tigre Lima Vinícius Diniz Arcelino do Ceará Pedro Rubens Araújo Carvalho Linna Albuquerque Sampaio Fabrício de Maicy Bezerra Melissa Soares Medeiros Medicine School Unichristus Fortaleza Brazil

Objectives: This study proposes to evaluate risk factors for kidney disease in HIV patients treated chronically and correlate with microalbuminuria measurements. Methods: Review charts and analyses of microalbuminuria in subgroup of HIV patients treated at Ceara/Brazil. Results: 149 patients, 69.1% male, mean 38.5 years old, infection mean 86.8 months. Mean Creatinine Clearance 110.2%, Creatinine 0.97, Urea 27.76 mg/dl, CD4+ 600.37 cels/mm3 and detectable viral load 530.59 copies with 61.7% undetectable. Mean Dosages of microalbuminuria/24h 147, 46 ± 820, 45 (N = 48) and microalbuminuria (mg/dl) 32.05 ± 85.25 (N = 43). Kidney Diseases Classification analyses evidenced 6.4% patients in stages ≥3 and 6.2% presented altered Microalbuminuria/24h. Patients using Tenofovir (TDF) 27.27% had Stage 2 and protease inhibitors (PI) had 4.1% in Stage 3. Proteinuria was observed in 5% stage ≥3. Association PI/TDF had 4.1% in Stage 3. No statistical difference between CD4 > or 3 and microalbuminuria/24h > 300 mg (p = 0.69);detectable/undetectable viral load and microalbuminuria/24h (p = 0.63) or stage ≥3 (p = 0.17);relation to Diabetes or arterial hypertension and microalbuminuria 24 h (p = 0.5 and p = 0.21);relation stage ≥3 and microalbuminuria/24h (p = 0.33);relation HIV diagnoses >/ or or < 50 years and microalbuminuria/24h (p = 0.55) or microalbuminuria mg/d (p = 0.32). Relating comorbidities risk (Diabetes Mellitus plus Systemic Arterial Hypertension) to Kidney Diseases, it was found that 55.5% patients in Stage 3 or above with comorbidities compared with 15% with comorbidities in lower stages (P = 0.005). Nevertheless, comorbidities presence was not associated with microalbuminuria (p = 0.08). Conclusion: Kidney disease is a real risk for HIV patients and stages ≥

关键词： HIV AIDS Antiretroviral Kidney Disease Microalbuminuria

Machine learning algorithm partially reconfigured on FPGA for an image edge detection system

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Journal of Electronic Science and Technology 2024年第2期22卷 48-68页

作者： Gracieth Cavalcanti batista Johnny Oberg Osamu Saotome Haroldo F.de Campos Velho Elcio Hideiti Shiguemori Ingemar Soderquist Division of Electronic and Embedded Systems KTH Royal Institute of TechnologyStockholm 16440Sweden Electronic Engineering Division Aeronautics Institute of TechnologySao Josédos Campos SP 12228-900Brazil Laboratory of Applied Computing and Mathematics National Institute for Space ResearchSao Josédos Campos SP 12227-900Brazil Department of C4ISR Institute of Advanced StudiesSao Josédos Campos SP 12228-001Brazil Saab AB Linkoping 58188Sweden

Unmanned aerial vehicles(UAVs)have been widely used in military,medical,wireless communications,aerial surveillance,*** key topic involving UAVs is pose estimation in autonomous navigation.A standard procedure for this process is to combine inertial navigation system sensor information with the global navigation satellite system(GNSS)***,some factors can interfere with the GNSS signal,such as ionospheric scintillation,jamming,or *** alternative method to avoid using the GNSS signal is to apply an image processing approach by matching UAV images with georeferenced *** a high effort is required for image edge *** a support vector regression(SVR)model is proposed to reduce this computational load and processing *** dynamic partial reconfiguration(DPR)of part of the SVR datapath is implemented to accelerate the process,reduce the area,and analyze its granularity by increasing the grain size of the reconfigurable *** show that the implementation in hardware is 68 times faster than that in *** architecture with DPR also facilitates the low power consumption of 4 mW,leading to a reduction of 57%than that without *** is also the lowest power consumption in current machine learning hardware ***,the circuitry area is 41 times *** with Gaussian kernel shows a success rate of 99.18%and minimum square error of 0.0146 for testing with the planning *** system is useful for adaptive applications where the user/designer can modify/reconfigure the hardware layout during its application,thus contributing to lower power consumption,smaller hardware area,and shorter execution time.

关键词： Dynamic partial reconfiguration(DPR) Field programmable gate array(FPGA)implementation Image edge detection Support vector regression(SVR) Unmanned aerial vehicle(UAV) pose estimation

Phylogeny,identification and pathogenicity of the Botryosphaeriaceae associated with collar and root rot of the biofuel plant Jatropha curcas in Brazil,with a description of new species of Lasiodiplodia

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Fungal Diversity 2014年第4期67卷 231-247页

作者： Alexandre Reis Machado Danilo batista pinho Olinto Liparini Pereira Departamento de Fitopatologia Universidade Federal de VicosaVicosa 36570-000Brazil

The global expansion of cultivation areas of Jatropha has contributed to the emergence of various *** in Brazil,the occurrence of a new disease has been reported that not only reduces the productivity but also causes the death of *** disease is associated with collar and root rot of *** morphological and phylogenetic studies(based on Internal Transcribed Spacers,β-tubulin and Translation Elongation Factor 1-αsequences),nine species of Botryosphaeriaceae were *** species include Lasiodiplodia egyptiacae,***,***,Macrophomina phaseolina,Neoscytalidium hyalinum and four Lasiodiplodia *** are proposed as new species(***,***,*** and ***).All the species in this study,except ***,are *** results show that root rot of physic nut plants is caused by complex *** study provides new information for future studies of disease management,quarantine programs and,especially,the development of resistant varieties for collar and root rot disease in ***.

关键词： Aetiology Botryosphaeriales Dothideomycetes Phylogeny Taxonomy Tropical fungi

Iron-Deficiency Anemia Management in Gynecological Surgery: A Review of Current Evidence and Best Practices

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Open Journal of Obstetrics and Gynecology 2024年第8期14卷 1223-1241页

作者： Aline Evangelista Santiago Artur Lima Sendin Víctor Nilo Nogueira Rogério Adão Braga Admilson Lemos Costa Filho Eduardo batista Cândido Agnaldo Lopes Silva Filho Department of Gynecology and Obstetrics Faculty of Medicine Santo Amaro University (UNISA) So Paulo Brazil Department of Gynecology and Obstetrics Federal University of Minas Gerais (UFMG) Belo Horizonte Brazil Department of Gynecology and Obstetrics Faculty of Medicine So Paulo State University (UNESP) So Paulo Brazil

Purpose: Due to the high prevalence of iron deficiency anemia in women undergoing gynecological surgeries and its association with worse postoperative results, it is necessary to identify and treat anemia preoperatively. However, although anemia and iron deficiency are significant global health problems, there are still disparities in the recognition and implementation of “Patient Blood Management” (PBM) as a comprehensive approach to mitigating the risks associated with these diseases. The purpose of the study is to review best practices for the treatment of anemia based on the Enhanced Recovery After Surgery (ERAS) protocol and PBM recommendations. Methods: This study reviewed the literature on preoperative iron deficiency anemia in patients undergoing gynecological surgery. We identified references through searches in PubMed using relevant search terms. Results: Among the various strategies used in PBM, perhaps the most important is the early detection and management of anemia. In gynecological surgery, there are several approaches to reducing perioperative blood loss, highlighting the use of gonadotropin-releasing hormone (GnRH) agonists (aGnRh) and antifibrinolytics. Oral and intravenous iron supplementation can be performed in addition to blood transfusion to treat anemia. Conclusion: Addressing preoperative and postoperative anemia through systematic correction, following the guidelines of the ERAS protocol and PBM guidelines, is essential to improving perioperative outcomes in women undergoing gynecological surgery.

关键词： Anemia Gynecological Surgery Iron Supplementation Iron Deficiency

Optimal velocity functions for car-following models

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第7期11卷 520-529页

作者： Milan batista Elen TWRDY Faculty of Maritime Studies and Transport University of Ljubljana

The integral part of the optimal velocity car-following models is the optimal velocity function (OVF), which can be derived from measured velocity-spacing data. This paper discusses several characteristics of the OVF and presents regression analysis on two classical datasets, the Lincoln and Holland tunnels, with different possible OVFs. The numerical simulation of the formation of traffic congestion is conducted with three different heuristic OVFs, demonstrating that these functions give results similar to those of the famous Bando OVF (Bando et al., 1995). Also an alternative method is present for determining the sensitivity and model parameters based on a single car driving to a fixed barrier.

关键词： Traffic flow Car following Optimal velocity function

The RNA Modification N^6-methyladenosine and Its Implications in Human Disease

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Genomics, Proteomics & Bioinformatics 2017年第3期15卷 154-163页

作者： Pedro J.batista Laboratory of Cell Biology Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesda MD 20892USA

Impaired gene regulation lies at the heart of many disorders, including developmental diseases and cancer. Furthermore, the molecular pathways that control gene expression are often the target of cellular parasites, such as viruses. Gene expression is controlled through multiple mechanisms that are coordinated to ensure the proper and timely expression of each gene. Many of these mechanisms target the life cycle of the RNA molecule, from transcription to translation. Recently, another layer of regulation at the RNA level involving RNA modifications has gained renewed interest of the scientific community. The discovery that N6-methyladenosine （m6A）, a mod- ification present in mRNAs and long noncoding RNAs, can be removed by the activity of RNA demethylases, launched the field of epitranscriptomics; the study of how RNA function is regulated through the addition or removal of post-transcriptional modifications, similar to strategies used to regulate gene expression at the DNA and protein level. The abundance of RNA post-transcriptional modifications is determined by the activity of writer complexes （methylase） and eraser （RNA demethylase） proteins. Subsequently, the effects of RNA modifications materialize as changes in RNA structure and/or modulation of interactions between the modified RNA and RNA binding proteins or regulatory RNAs. Disruption of these pathways impairs gene expression and cellular function. This review focuses on the links between the RNA modification m6A and its implications in human diseases.

关键词： N6-methyladenosine Epitranscriptomics Cancer Viral replication Metabolic disease

A new species of Atelopus(Amphibia:Bufonidae)from eastern Panama

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Zoological Research 2021年第3期42卷 272-279页

作者： Milan Vesely Abel batista Department of Zoology Faculty of Natural SciencesPalacky UniversityOlomouc 77146Czech Republic Universidad Autónoma de Chiriquí Ciudad Universitaria El Cabrero DavidChiriquí427Panama Asociacion ADOPTA el Bosque Panamá Gamboa 119xPanama Fundacion Los Naturalistas DavidChiriquí426-01459Panama

A new species of the genus Atelopus,Atelopus fronterizo ***.,from eastern Panama is described herein based on molecular,morphological,and bioacoustic *** new species can be distinguished from its congeners occurring in the region by a combination of the following characters:(1)phalangeal reduction in thumb;(2)SVL(females only)(35.1-50.1;n=13),HW/SVL(0.23-0.34;n=59),EYND/HW(0.27-0.39;n=60),TIBL/SVL(0.41-0.56;n=58),and HAL/SVL(0.22-0.28;n=49);(3)dorsal color pattern with green or yellow background and extensive dark olive blotches forming transversal bands or mottling;(4)advertisement call duration 176-235 ms with 19-34 pulses,average pulse rate 131.69 pulses/s,and dominant frequency 2422.50-2606.50 *** new species is nested within the Central American clade of *** minimum Kimura‐2‐parameter(K2P)genetic divergence between Atelopus fronterizo *** its most phylogenetically similar congeners(*** and ***)is>2.6%for 16S and>4.9%for COI(Table 1).The phylogenetic relationship is strongly supported by ultrafast bootstrap values for the maximum-likelihood trees of both genetic markers(16S,96;COI,100,Figure 1A).Bayesian analysis of the concatenated sequences resulted in a tree with similar topology and high posterior probability support(0.99;Supplementary Figure S1).In addition,haplotype networks inferred from COI and 16S(Supplementary Figure S2)showed a well-separated clade containing the new species(two for COI,four for 16S).

关键词： 16S Figure eastern

Analysis of the Most Likely Regions of Stability of an NCS and Design of the Corresponding Event-driven Controller

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International Journal of Automation and computing 2018年第1期15卷 39-51页

作者： Ana Paula batista Fabio Goncalves Jota Centre for Intelligent Energy Research Federal Centre of Technological Education of Minas Gerais Belo Horizonte Brazil Graduate Program in Electrical Engineering Federal University of Minas Gerais Belo Horizonte Brazil

In this paper, some issues related to design and analysis of real networked control systems （NCS） under the focus of the most likely region of stability are addressed. Such a system is cumbersome due to its inherent variable time delays, ranging from microseconds to hours. To show the influence of such huge variations in the control performance, a laboratory-scale luminosity system has been setup using the Internet as part of the control loop with dominant time constant in the order of milliseconds. Proportional and integral （PI） control strategies with and without explicit compensation for the time-delay variations were implemented using an event-driven controller. Using the well-known Monte Carlo method and subsequent analyses of time responses, it has been possible to identify the most likely region of stability. Some experimental results show the influence of the statistical parameters of the delays on the determination of the most likely regions of stability of the NCS and how these can be used in assessment and redesign of the control system. The experiments show that much larger delays than one sample period can be supported by real NCSs without becoming unstable.

关键词： Networked control systems real NCS delay compensation most likely regions of stability delay statistics.

Machine learning assisted derivation of minimal low-energy models for metallic magnets

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npj Computational Materials 2023年第1期9卷 353-364页

作者： Vikram Sharma Zhentao Wang Cristian D.batista Department of Physics and Astronomy The University of TennesseeKnoxvilleTN 37996USA School of Physics and Astronomy University of MinnesotaMinneapolisMN 55455USA Quantum Condensed Matter Division and Shull-Wollan Center Oak Ridge National LaboratoryOak RidgeTN 37831USA Present address:Center for Correlated Matter and School of Physics Zhejiang UniversityHangzhou 310058China

We consider the problem of extracting a low-energy spin Hamiltonian from a triangular Kondo Lattice Model(KLM).The non-analytic dependence of the effective spin-spin interactions on the Kondo exchange excludes the use of perturbation theory beyond the second *** then introduce a Machine Learning(ML)assisted protocol to extract effective two-and four-spin *** resulting spin model reproduces the phase diagram of the original KLM as a function of magnetic field and single-ion anisotropy and reveals the effective four-spin interactions that stabilize the field-induced skyrmion crystal ***,this model enables the computation of static and dynamical properties with a much lower numerical cost relative to the original KLM.A comparison of the dynamical spin structure factor in the fully polarized phase computed with both models reveals a good agreement for the magnon dispersion even though this information was not included in the training data set.

关键词： Kondo dynamical derivation