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Microalbuminuria and Kidney Disease Risk in HIV Patients Taking Combined Antiretroviral Therapy

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World Journal of AIDS 2014年第2期4卷 242-248页

作者： Huylmer Lucena Chaves mayanna pinho batista Adriana de Menezes Gomes Amanda Antunes Costa André Tigre Lima Vinícius Diniz Arcelino do Ceará Pedro Rubens Araújo Carvalho Linna Albuquerque Sampaio Fabrício de Maicy Bezerra Melissa Soares Medeiros Medicine School Unichristus Fortaleza Brazil

Objectives: This study proposes to evaluate risk factors for kidney disease in HIV patients treated chronically and correlate with microalbuminuria measurements. Methods: Review charts and analyses of microalbuminuria in subgroup of HIV patients treated at Ceara/Brazil. Results: 149 patients, 69.1% male, mean 38.5 years old, infection mean 86.8 months. Mean Creatinine Clearance 110.2%, Creatinine 0.97, Urea 27.76 mg/dl, CD4+ 600.37 cels/mm3 and detectable viral load 530.59 copies with 61.7% undetectable. Mean Dosages of microalbuminuria/24h 147, 46 ± 820, 45 (N = 48) and microalbuminuria (mg/dl) 32.05 ± 85.25 (N = 43). Kidney Diseases Classification analyses evidenced 6.4% patients in stages ≥3 and 6.2% presented altered Microalbuminuria/24h. Patients using Tenofovir (TDF) 27.27% had Stage 2 and protease inhibitors (PI) had 4.1% in Stage 3. Proteinuria was observed in 5% stage ≥3. Association PI/TDF had 4.1% in Stage 3. No statistical difference between CD4 > or 3 and microalbuminuria/24h > 300 mg (p = 0.69);detectable/undetectable viral load and microalbuminuria/24h (p = 0.63) or stage ≥3 (p = 0.17);relation to Diabetes or arterial hypertension and microalbuminuria 24 h (p = 0.5 and p = 0.21);relation stage ≥3 and microalbuminuria/24h (p = 0.33);relation HIV diagnoses >/ or or < 50 years and microalbuminuria/24h (p = 0.55) or microalbuminuria mg/d (p = 0.32). Relating comorbidities risk (Diabetes Mellitus plus Systemic Arterial Hypertension) to Kidney Diseases, it was found that 55.5% patients in Stage 3 or above with comorbidities compared with 15% with comorbidities in lower stages (P = 0.005). Nevertheless, comorbidities presence was not associated with microalbuminuria (p = 0.08). Conclusion: Kidney disease is a real risk for HIV patients and stages ≥

关键词： HIV AIDS Antiretroviral Kidney Disease Microalbuminuria

Phylogeny,identification and pathogenicity of the Botryosphaeriaceae associated with collar and root rot of the biofuel plant Jatropha curcas in Brazil,with a description of new species of Lasiodiplodia

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Fungal Diversity 2014年第4期67卷 231-247页

作者： Alexandre Reis Machado Danilo batista pinho Olinto Liparini Pereira Departamento de Fitopatologia Universidade Federal de VicosaVicosa 36570-000Brazil

The global expansion of cultivation areas of Jatropha has contributed to the emergence of various *** in Brazil,the occurrence of a new disease has been reported that not only reduces the productivity but also causes the death of *** disease is associated with collar and root rot of *** morphological and phylogenetic studies(based on Internal Transcribed Spacers,β-tubulin and Translation Elongation Factor 1-αsequences),nine species of Botryosphaeriaceae were *** species include Lasiodiplodia egyptiacae,***,***,Macrophomina phaseolina,Neoscytalidium hyalinum and four Lasiodiplodia *** are proposed as new species(***,***,*** and ***).All the species in this study,except ***,are *** results show that root rot of physic nut plants is caused by complex *** study provides new information for future studies of disease management,quarantine programs and,especially,the development of resistant varieties for collar and root rot disease in ***.

关键词： Aetiology Botryosphaeriales Dothideomycetes Phylogeny Taxonomy Tropical fungi

Optimal velocity functions for car-following models

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第7期11卷 520-529页

作者： Milan batista Elen TWRDY Faculty of Maritime Studies and Transport University of Ljubljana

The integral part of the optimal velocity car-following models is the optimal velocity function (OVF), which can be derived from measured velocity-spacing data. This paper discusses several characteristics of the OVF and presents regression analysis on two classical datasets, the Lincoln and Holland tunnels, with different possible OVFs. The numerical simulation of the formation of traffic congestion is conducted with three different heuristic OVFs, demonstrating that these functions give results similar to those of the famous Bando OVF (Bando et al., 1995). Also an alternative method is present for determining the sensitivity and model parameters based on a single car driving to a fixed barrier.

关键词： Traffic flow Car following Optimal velocity function

The RNA Modification N^6-methyladenosine and Its Implications in Human Disease

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Genomics, Proteomics & Bioinformatics 2017年第3期15卷 154-163页

作者： Pedro J.batista Laboratory of Cell Biology Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesda MD 20892USA

Impaired gene regulation lies at the heart of many disorders, including developmental diseases and cancer. Furthermore, the molecular pathways that control gene expression are often the target of cellular parasites, such as viruses. Gene expression is controlled through multiple mechanisms that are coordinated to ensure the proper and timely expression of each gene. Many of these mechanisms target the life cycle of the RNA molecule, from transcription to translation. Recently, another layer of regulation at the RNA level involving RNA modifications has gained renewed interest of the scientific community. The discovery that N6-methyladenosine （m6A）, a mod- ification present in mRNAs and long noncoding RNAs, can be removed by the activity of RNA demethylases, launched the field of epitranscriptomics; the study of how RNA function is regulated through the addition or removal of post-transcriptional modifications, similar to strategies used to regulate gene expression at the DNA and protein level. The abundance of RNA post-transcriptional modifications is determined by the activity of writer complexes （methylase） and eraser （RNA demethylase） proteins. Subsequently, the effects of RNA modifications materialize as changes in RNA structure and/or modulation of interactions between the modified RNA and RNA binding proteins or regulatory RNAs. Disruption of these pathways impairs gene expression and cellular function. This review focuses on the links between the RNA modification m6A and its implications in human diseases.

关键词： N6-methyladenosine Epitranscriptomics Cancer Viral replication Metabolic disease

A new species of Atelopus(Amphibia:Bufonidae)from eastern Panama

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Zoological Research 2021年第3期42卷 272-279页

作者： Milan Vesely Abel batista Department of Zoology Faculty of Natural SciencesPalacky UniversityOlomouc 77146Czech Republic Universidad Autónoma de Chiriquí Ciudad Universitaria El Cabrero DavidChiriquí427Panama Asociacion ADOPTA el Bosque Panamá Gamboa 119xPanama Fundacion Los Naturalistas DavidChiriquí426-01459Panama

A new species of the genus Atelopus,Atelopus fronterizo ***.,from eastern Panama is described herein based on molecular,morphological,and bioacoustic *** new species can be distinguished from its congeners occurring in the region by a combination of the following characters:(1)phalangeal reduction in thumb;(2)SVL(females only)(35.1-50.1;n=13),HW/SVL(0.23-0.34;n=59),EYND/HW(0.27-0.39;n=60),TIBL/SVL(0.41-0.56;n=58),and HAL/SVL(0.22-0.28;n=49);(3)dorsal color pattern with green or yellow background and extensive dark olive blotches forming transversal bands or mottling;(4)advertisement call duration 176-235 ms with 19-34 pulses,average pulse rate 131.69 pulses/s,and dominant frequency 2422.50-2606.50 *** new species is nested within the Central American clade of *** minimum Kimura‐2‐parameter(K2P)genetic divergence between Atelopus fronterizo *** its most phylogenetically similar congeners(*** and ***)is>2.6%for 16S and>4.9%for COI(Table 1).The phylogenetic relationship is strongly supported by ultrafast bootstrap values for the maximum-likelihood trees of both genetic markers(16S,96;COI,100,Figure 1A).Bayesian analysis of the concatenated sequences resulted in a tree with similar topology and high posterior probability support(0.99;Supplementary Figure S1).In addition,haplotype networks inferred from COI and 16S(Supplementary Figure S2)showed a well-separated clade containing the new species(two for COI,four for 16S).

关键词： 16S Figure eastern

Analysis of the Most Likely Regions of Stability of an NCS and Design of the Corresponding Event-driven Controller

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International Journal of Automation and computing 2018年第1期15卷 39-51页

作者： Ana Paula batista Fabio Goncalves Jota Centre for Intelligent Energy Research Federal Centre of Technological Education of Minas Gerais Belo Horizonte Brazil Graduate Program in Electrical Engineering Federal University of Minas Gerais Belo Horizonte Brazil

In this paper, some issues related to design and analysis of real networked control systems （NCS） under the focus of the most likely region of stability are addressed. Such a system is cumbersome due to its inherent variable time delays, ranging from microseconds to hours. To show the influence of such huge variations in the control performance, a laboratory-scale luminosity system has been setup using the Internet as part of the control loop with dominant time constant in the order of milliseconds. Proportional and integral （PI） control strategies with and without explicit compensation for the time-delay variations were implemented using an event-driven controller. Using the well-known Monte Carlo method and subsequent analyses of time responses, it has been possible to identify the most likely region of stability. Some experimental results show the influence of the statistical parameters of the delays on the determination of the most likely regions of stability of the NCS and how these can be used in assessment and redesign of the control system. The experiments show that much larger delays than one sample period can be supported by real NCSs without becoming unstable.

关键词： Networked control systems real NCS delay compensation most likely regions of stability delay statistics.

Machine learning assisted derivation of minimal low-energy models for metallic magnets

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npj Computational Materials 2023年第1期9卷 353-364页

作者： Vikram Sharma Zhentao Wang Cristian D.batista Department of Physics and Astronomy The University of TennesseeKnoxvilleTN 37996USA School of Physics and Astronomy University of MinnesotaMinneapolisMN 55455USA Quantum Condensed Matter Division and Shull-Wollan Center Oak Ridge National LaboratoryOak RidgeTN 37831USA Present address:Center for Correlated Matter and School of Physics Zhejiang UniversityHangzhou 310058China

We consider the problem of extracting a low-energy spin Hamiltonian from a triangular Kondo Lattice Model(KLM).The non-analytic dependence of the effective spin-spin interactions on the Kondo exchange excludes the use of perturbation theory beyond the second *** then introduce a Machine Learning(ML)assisted protocol to extract effective two-and four-spin *** resulting spin model reproduces the phase diagram of the original KLM as a function of magnetic field and single-ion anisotropy and reveals the effective four-spin interactions that stabilize the field-induced skyrmion crystal ***,this model enables the computation of static and dynamical properties with a much lower numerical cost relative to the original KLM.A comparison of the dynamical spin structure factor in the fully polarized phase computed with both models reveals a good agreement for the magnon dispersion even though this information was not included in the training data set.

关键词： Kondo dynamical derivation

The effect of salinity on Fucus ceranoides (Ochrophyta,Phaeophyceae) in the Mondego River(Portugal)

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Journal of Oceanology and Limnology 2019年第3期37卷 881-891页

作者： COTAS Joao FIGUEIRINHA Artur PEREIRA Leonel batista Teresa Department of Life Sciences University of CoimbraCoimbra 3001-456Portugal MARE-Marine and Environmental Sciences Centre Faculty of Science and TechnologyUniversity of CoimbraCoimbra 3000-548Portugal Laboratory of Pharmacognosy Faculty of PharmacyUniversity of CoimbraCoimbra 3000-548Portugal LAQV REQUIMTEFaculty of PharmacyUniversity of CoimbraCoimbra 3000-548Portugal CIEPQPF Department of Chemical EngineeringFaculty of Science and TechnologyUniversity of CoimbraCoimbra 3030-790Portugal

Algae(and their extracts)are increasingly important for pharmaceutical applications due to the diversity of useful compounds they *** genus Fucus contains one of the most studied species,Fucus *** species *** differs from the others of the genus by presenting longitudinal air-vesicles and a capacity to survive at low *** is an alga that inhabits the Mondego River estuary(Portugal),at the southern limit of its distribution,and can serve as a role model to understand the effect of a salt gradient on the production of bioactive *** assessed the phenolic content and antioxidant activity of different *** extracts(***,aqueous and polysaccharide)prepared from samples harvested from two different zones to evaluate if the adaptation of *** to different salinity levels influenced its chemical *** antioxidant activity of the extracts was determined using 1,2-diphenyl-picrylhydrazyl(DPPH)and 2.2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS)*** assays demonstrated that the methanolic extract of lyophilized *** that grew at low salinities was the most bioactive,***(IC 50=50.39μg/mL)and ABTS(TEAC=2.42).The total phenolic content(Folin-Ciocalteu method)and the methanolic extract of the lyophilized *** collected from a low salinity habitat exhibited the highest phenolic content(PGE=49.48μg/mg of lyophilized extract)amongst those *** layer chromatography(TLC)and Fourier transform infrared spectroscopy(FTIR)were used for the identification of compounds in the *** characterization allowed confirmation that the various extracts contained almost the same compounds but with notable quantitative *** on these results,we conclude that there were differences in the quantity of the compounds due to the effect of *** drying methods used were also found to have influenced the quality of the extracted compounds.

关键词： Fucus ceranoides salinity gradient sequential extractions phenolic content dependent bioactivities spectroscopic analysis

Proportionally Modular Diophantine Inequalities and Their Multiplicity

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Acta Mathematica Sinica,English Series 2010年第11期26卷 2059-2070页

作者： José Carlos ROSALES Manuel batista BRANCO Paulo VASCO Departamento de lgebra Universidad de Granada Departamento de Matemática Departamento de Matemática Universidade de Trás-os-Montes e Alto Douro

Let I be an interval of positive rational numbers. Then the set S （I） = T ∩ N, where T is the submonoid of （Q0＋, ＋） generated by T, is a numerical semigroup. These numerical semigroups are called proportionally modular and can be characterized as the set of integer solutions of a Diophantine inequality of the form ax rood b 〈 cx. In this paper we are interested in the study of the maximal intervals I subject to the condition that S （I） has a given multiplicity. We also characterize the numerical semigroups associated with these maximal intervals.

关键词： Numerical semigroup Diophantine inequality multiplicity Frobenius number