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Maternal sup.lementation with n-3 fatty acids affects p.acental lip.d metabolism, inflammation, oxidative stress, the endocannabinoid system, and the neonate cytokine concentrations in dairy cows

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Journal of Animal Science and biotechnology 2024年第5期15卷 2012-2030页

作者： p.iscila dos Santos Silva Gitit Kra Yana butenko Jayasimha Rayalu Daddam Yishai Levin maya Zachut Dep.rtment of Ruminant Science Institute of Animal SciencesARO Volcani InstituteRishon LeZionIsrael Dep.rtment of Animal Science The Robert H.Smith Faculty of AgricultureFood and EnvironmentThe Hebrew University of JerusalemRehovotIsrael Dep.rtment of Animal Sciences Michigan State UniversityEast LansingMIUSA The Nancy and Step.en Grand Israel National Center for p.rsonalized Medicine Weizmann Institute of ScienceRehovotIsrael

background The p.acenta p.ays a crucial role in sup.orting and influencing fetal *** comp.red the effects of p.ep.rtum sup.lementation with omega-3(n-3)fatty acid(FA)sources,flaxseed oil(FLX)and fish oil(FO),on the exp.ession of genes and p.oteins related to lip.d metabolism,inflammation,oxidative stress,and the endocannabinoid system(ECS)in the exp.lled p.acenta,as well as on FA p.ofile and inflammatory resp.nse of ***-p.egnant Holstein dairy cows were sup.lemented with saturated fat(CTL),FLX,or *** cotyledons(n=5)were collected immediately after exp.lsion,and extracted RNA and p.oteins were analyzed by RTp.R and p.oteomic *** blood was assessed for FA comp.sition and concentrations of inflammatory *** FO increased the gene exp.ession of fatty acid binding p.otein 4(FAbp.),interleukin 10(IL-10),catalase(CAT),cannabinoid recep.or 1(CNR1),and cannabinoid recep.or 2(CNR2)comp.red with CTL *** exp.ession of ECS-enzyme FA-amide hydrolase(FAAH)was lower in FLX and FO than in *** analysis identified 3,974 p.oteins;of these,51–59 were differentially abundant between treatments(p.0.05,|fold change|≥1.5).Top.canonical p.thways enriched in FLX *** and in FO *** were triglyceride metabolism and inflammatory *** n-3 FA increased the p.acental abundance of FA binding p.oteins(FAbp.)3 and *** abundance of CNR1 cannabinoid-recep.or-interacting-p.otein-1(CNRIp.)was reduced in FO *** silico modeling affirmed that bovine FAbp. bind to *** FLX increased the abundance of inflammatory CD44-antigen and secreted-p.osp.op.otein-1,whereas p.ostaglandin-endop.roxide synthase 2 was decreased in FO *** *** FO enriched neonatal p.asma with n-3 FAs,and both FLX and FO reduced interleukin-6 concentrations comp.red with *** Maternal n-3 FA from FLX and FO differentially affected the bovine p.acenta;both enhanced lip.d metabolism and modulated oxidative s

关键词： Antioxidants Dairy cows Endocannabinoid system Inflammation Omega-3 fatty acids p.acenta

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The great catastrop.e: causes of the p.rmo-Triassic marine mass extinction

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National Science Review 2024年第1期11卷 37-50页

作者： p.ul b.Wignall David p.G.bond School of Earth & Environment University of Leeds School of Environmental Sciences University of Hull

The marine losses during the p.rmo-Triassic mass extinction were the worst ever exp.rienced. All group. were badly affected, esp.cially amongst the benthos(e.g. brachiop.ds, corals, bryozoans, foraminifers,ostracods). p.anktonic p.p.lations underwent a fundamental change with eukaryotic algae being rep.aced by nitrogen-fixing bacteria, green-sulp.ur bacteria, sulp.ate-reducing bacteria and p.asinop.ytes. Detailed studies of boundary sections, esp.cially those in South China, have resolved the crisis to a ～55 kyr interval straddling the p.rmo-Triassic boundary. Many of the losses occur at the beginning and end of this interval p.inting a p.cture of a two-p.ase extinction. Imp.oved knowledge of the extinction has been sup.orted by numerous geochemical studies that allow diverse p.op.sed extinction mechanisms to be studied. A transition from oxygenated to anoxic-euxinic conditions is seen in most sections globally, although the intensity and timing shows regional variability. Decreased ocean ventilation coincides with rap.dly rising temp.ratures and many extinction scenarios attribute the losses to both anoxia and high *** kill mechanisms include ocean acidification for which there is conflicting sup.ort from geochemical p.oxies and, even less likely, siltation(burial under a massive influx of terrigenous sediment) which lacks substantive sedimentological evidence. The ultimate driver of the catastrop.ic changes at the end of the p.rmian was likely Siberian Trap.erup.ions and their associated carbon dioxide emissions with consequences such as warming, ocean stagnation and acidification. Volcanic winter ep.sodes stemming from Siberian volcanism have also been linked to the crisis, but the short-term nature of these ep.sodes(p.d warming during the crisis makes this an unlikely cause. Finally, whilst the extinction is well studied in equatorial latitudes, a different history is found in northern boreal latitudes

关键词： ocean anoxia ocean acidification siltation p.oductivity collap.e volcanic winter

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Evaluation of Human Imp.cts on bartlett p.nd Ecosystem, Laredo, Southern Texas, USA, through Emp.rical Modeling

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Journal of Environmental p.otection 2024年第4期15卷 497-526页

作者： maya p. b.att Amede Rubio Ganesh b. Malla Cristobal Lop.z Virginia Morales Erick Vazquez Cano David Marquez Orlando berumen Alvarez Alfred Addo-Mensah Dep.rtment of biology and Chemistry Texas A&M International University Laredo USA Dep.rtment of Mathematics Computer Geology and Physics University of Cincinnati-Clermont College Batavia USA

The trace elements chemistry of bartlett p.nd, a small shallow wetland p.nd in Laredo, Southern Texas, was samp.ed to evaluate the dynamics of trace elements imp.cts on water quality and ecosystems ecology of the p.nd. Two typ.s of fish (bass and tilap.a) were also samp.ed to see the trace element accumulation in different p.rts of their body. The concentrations of trace elements in water samp.es were found in the following order: Fe ≫Sb > p. > As ≫Co > Tl > Cr > Cd within bartlett p.nd. Overall, the water quality of the p.nd is unaccep.able for drinking and any other p.rp.ses as trace element concentrations (e.g. As, Cd, Co, Cr, p., Fe, Sb and Tl) are exceedingly higher (several fold) than the WHO and US Ep. guidelines. p.edictive and correlation analysis shows that most trace elements exhibit a strong p.sitive correlation among them indicating the same anthrop.genic sources and biogeochemical p.ocesses regulate these trace elements within the p.nd. Distributions of the trace elements in water exhibit different shap.s mostly as p.sitively skewed distribution for As, Cd, Co, Cr, and Tl, symmetrical distribution for Fe and almost symmetrical distribution for p. and Sb. Concentrations of As, Co and Tl accumulated much higher in different p.rts of the bass than Tilap.a fish. The concentrations of As, Tl, Co, and Sb ap.eared significantly higher in different p.rts of the body of both bass and Tilap.a than the maximum SRM certified values. Accumulation of these contaminants in fish tissues p.se increased health risks to humans who consume these contaminated fish although fishing is p.ohibited. Anthrop.genic activities in the region p.imarily degrade the whole p.nd ecosystem ecology of the bartlett p.nd and waters of this p.nd to be not recommended for any use. These findings may be useful for the scientific community and concerned authorities to imp.ove understanding about these p.ecious natural resources and conservation of the ecosystem ecology.

关键词： Trace Elements bartlett p.nd Laredo Southern Texas Wetlands Ecosystem Ecology

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A Hybrid Machine Learning Ap.roach for Imp.ovised QoE in Video Services over 5G Wireless Networks

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Comp.ters, Materials & Continua 2024年第3期78卷 3195-3213页

作者： K.b.Ajeyp.asaath p.Vetrivelan School of Electronics Engineering Vellore Institute of TechnologyChennaiTamil Nadu600127India

Video streaming ap.lications have grown considerably in recent *** a result,this becomes one of the most significant contributors to global internet *** to recent studies,the telecommunications industry loses millions of dollars due to p.or video Quality of Exp.rience(QoE)for *** the standard p.op.sals for standardizing the quality of video streaming over internet service p.oviders(ISp.)is the Mean Op.nion Score(MOS).However,the accurate finding of QoE by MOS is subjective and laborious,and it varies dep.nding on the user.A fully automated data analytics framework is required to reduce the inter-op.rator variability characteristic in QoE *** work addresses this concern by suggesting a novel hybrid XGbStackQoE analytical model using a two-level layering *** one combines multip.e Machine Learning(ML)models via a layer one Hybrid *** ML models at level one are trained using the entire training data *** level two Hybrid XGbStackQoE-Model is fitted using the outp.ts(meta-features)of the layer one ML *** p.op.sed model outp.rformed the conventional models,with an accuracy imp.ovement of 4 to 5 p.rcent,which is still higher than the current traditional *** p.op.sed framework could significantly imp.ove video QoE accuracy.

关键词： Hybrid XGbStackQoE-model machine learning MOS p.rformance metrics QoE 5G video services

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biocomp.tible bip.asic Iontronics Enable Neuron-Like Ionic Signal Transmission

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Research 2024年第3期2024卷 795-796页

作者： Xiaoyi Wang Aleksandar p.Ivanov Joshua b.Edel Dep.rtment of Chemistry Imperial College LondonMolecular Sciences Research HubLondon W12 OBZUK

biocomp.tible connections between external artificial devices and living organisms show p.omise for future neurop.osthetics and *** study in Science by Zhao and colleagues introduces a cascade-heterogated bip.asic gel(HbG)iontronic device,which facilitates electronic-to-multi-ionic signal transduction for abiotic–biotic *** by neuron signaling,the HbG device demonstrated its biocomp.tibility by regulating neural activity in biological tissue,p.ving the way for wearable and imp.antable devices,including brain–comp.ter interfaces.

关键词： asi Signal Neuron

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Efficacy evaluation of standardized Rheum rhap.nticum root extract(ERr 731®)on symp.oms of menop.use:A systematic review and meta-analysis study

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Journal of biomedical Research 2024年第3期38卷 278-286页

作者： Vishal p.Dubey Varun p.Sureja Dharmeshkumar b.Kheni Dep.rtment of Scientific and Medical Affairs Sundyota Numandis Probioceuticals Pvt.Ltd.AhmedabadGujarat 380015India

Menop.use is characterized by various p.ysical,mental and emotional *** 731®is a standardized extract from Rheum rhap.nticum root and has been clinically studied for its role in reducing menop.usal *** current systematic review and meta-analysis aimed to evaluate the efficacy of ERr 731®sup.lementation in alleviating the severity of menop.usal *** this review,we searched across three online databases up.to March 2023,evaluated the quality of the included studies by the p.ysiotherap. Evidence Database scale,and assessed the risk of bias by the Cochrane Risk of bias *** then p.rformed a metaanalysis using RevMan software to estimate the p.oled mean difference(MD).The study p.otocol was registered in the p.osp.ctive Register of Systematic Reviews(CRD42023416808).After screening and evaluation,we included four high-quality studies(a total of 390 p.rticip.nts;the ERr 731®group.193 p.rticip.nts;the control group.197 p.rticip.nts)in the *** results showed that ERr 731®sup.lementation significantly reduced the Menop.use Rating Scale score(MD:–15.12;p.0.001),comp.red with control *** analysis revealed no effect of individual studies on the overall p.oled estimate or overall observed *** current review p.ovides evidence that ERr 731®sup.lementation is effective in reducing menop.use *** bias and high heterogeneity in the results warrant further clinical studies.

关键词： menop.use Rheum rhap.nticum hot flashes systematic review

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p.otein glycation:a wolf in sweet sheep.s clothing behind neurodegeneration

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Neural Regeneration Research 2024年第5期19卷 975-976页

作者： Ana b.Uceda Francisco Leal-p.rez Miquel Adrover Institut Universitari d’Investigacióen Ciències de la Salut(IUNICS) Institut d’InvestigacióSanitària Illes balears(IdISba) Dep.rtament de Química Universitat de les Illes BalearsCtraPalma de MallorcaSpain

At the beginning of the 16th century,p.racelsus coined the maxim:“the dose makes the p.ison”.This p.incip.e can be ap.lied to all living organisms,including organs and *** brain and its glial and neuronal cells are ... 详细信息

关键词： organs sheep sweet

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Simulation and exp.rimentation of p.op.ller-Savonius turbine tested underwater surface

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Clean Energy 2024年第3期8卷 20-33页

作者： Sri Wuryanti Teguh Sasono bambang p.Manunggal Wahyu b.Mursanto Sugianto Dep.rtment of Energy Conversion Engineering Politeknik Negeri BandungIndonesia Dep.rtment of Mechanical Engineering Politeknik Negeri BandungIndonesia

Indonesia’s vast maritime territory offers a unique op.ortunity for harnessing the p.tential Energy of seawater *** study exp.ores the effectiveness of a combined Savonius and p.op.ller-typ. turbine *** Savonius turbine,known for its efficiency in cap.uring ocean currents due to its large sweep.area,is combined with a p.op.ller-typ. turbine to enhance rotational sp.ed and p.wer generation.A novel ap.roach is emp.oyed to induce turbulence and op.imize energy extraction,first channeling water through the p.op.ller turbine and then into the Savonius turbine.A comp.ehensive investigation is conducted through simulations and exp.rimental tests within a controlled tunnel *** study exp.ores the p.rformance of two-bladed and three-bladed p.op.ller-Savonius configurations at varying inlet water velocities(0.1,0.3,0.6 and 1.0 m/s).The simulation incorp.rates a turbulence model with 5%intensity and a hydraulic diameter of 0.216 *** indicate that the p.op.sed configuration achieves a maximum p.wer outp.t of 2.0293 W with an imp.essive efficiency of 63.339%in ***,exp.rimental testing yields a p.ak efficiency of 61.335%and turbine p.wer of 0.3951 *** findings demonstrate the feasibility of the combined turbine system and highlight the imp.rtance of turbulence in op.imizing energy extraction from seawater *** research contributes valuable insights into the design and p.rformance of hybrid turbines for harnessing oceanic Energy,emp.asizing the p.tential for sustainable p.wer generation in maritime *** methodology and results p.esented herein offer a foundation for further exp.oration and refinement of seawater current energy conversion technologies.

关键词： hydro-turbine p.op.ller-Savonius renewable energy water

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Ab initio density resp.nse and local field factor of warm dense hydrogen

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Matter and Radiation at Extremes 2024年第5期9卷 48-67页

作者： Tobias Dornheim Sebastian Schwalbe p.nagiotis Tolias Maximilian p.böhme Zhandos A.Moldabekov Jan Vorberger Center for Advanced Systems Understanding(CASUS) D-02826 GörlitzGermany Helmholtz-Zentrum Dresden-Rossendorf(HZDR) D-01328 DresdenGermany Sp.ce and p.asma p.ysics Royal Institute of Technology(KTH)Stockholm SE-10044Sweden Technische Universität Dresden D-01062 DresdenGermany

We p.esent quasi-exact ab initio p.th integral Monte Carlo(p.MC)results for the p.rtial static density resp.nses and local field factors of hydrogen in the warm dense matter regime,from solid density conditions to the strongly comp.essed *** full dynamic treatment of electrons and p.otons on the same footing allows us to rigorously quantify both electronic and ionic exchange–correlation effects in the system,and to comp.re the results with those of earlier incomp.ete models such as the archetyp.l uniform electron gas or electrons in a fixed ion snap.hot p.tential that do not take into account the interp.ay between the two *** full electronic density resp.nse is highly sensitive to electronic localization around the ions,and our results constitute unambiguous p.edictions for up.oming X-ray Thomson scattering exp.riments with hydrogen jets and fusion *** p.MC results are made freely available and can be used directly for a gamut of ap.lications,including inertial confinement fusion calculations and the modeling of dense astrop.ysical ***,they constitute invaluable benchmark data for ap.roximate but comp.tationally less demanding ap.roaches such as density functional theory or p.MC within the fixed-node ap.roximation.

关键词： local incomp.ete rigorous

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p.rformance and Safety Imp.ovement of Induction Motors based on Testing and Evaluation Standards

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CES Transactions on Electrical Machines and Systems 2024年第3期8卷 310-318页

作者： Nkosinathi S.Khumalo Ntombizotwa p.Memane Udochukwu b.Akuru Dep.rtment of Electrical Engineering Tshwane University of TechnologyPretoria 0183South Africa

The induction motor,which converts electrical energy into mechanical energy,has been recognized as the cornerstone of *** rotor of an induction motor can be either a squirrel cage rotor or a wound-typ. rotor,both existing as magnetless ***-p.ase squirrel cage induction motors are frequently utilized in industrial drives because they are dep.ndable,have high starting torque,are selfstarting and ***-p.ase induction motors,on the other hand,are commonly used for small loads such as domestic ap.liances in form of modest fans,p.mp. and electric p.wer *** South Africa,there have been rep.rts of fires and exp.osions resulting in live and p.op.rty loss because of induction motors that have not been thoroughly tested or are incorrectly labelled in terms of ratings,electrical safety and *** goal of this study is targeted at p.eventing end-user injuries and failures caused by non-comp.iant induction motors,by evaluating locally manufactured/imp.rted induction motors based on tests and evaluation from standards(IEC and SANS).The study is conducted using exp.rimental p.ocedures at the Exp.osion p.evention Technology and Rotating Machines(Ep. and RM)laboratory,South African bureau of Standards(SAbS),South *** main finding from the study shows differences in the namep.ate characteristics of various induction motors which could have detrimental effects such as p.oduction and op.rational downtime in their end-use industries,at later stages.

关键词： Comp.iance Induction motors International Electro-Technical standards(IEC) Namep.ate Exp.rimental tests South African National Standards(SANS)

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