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A new algorithm for the diagnosis of celiac disease

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Cellular & Molecular Immunology 2011年第2期8卷 146-149页

作者： Orit Rozenberg Aaron Lerner Avi Pacht maya Grinberg Dina Reginashvili Clara Henig Mira Barak Central Laboratory of Haifa and Western Galilee Clalit Health Services and Pediatric GastroenterologyHaifaIsrael Nutrition Unit Carmel Medical CenterHaifaIsrael Technion-Israel Institute of Technology HaifaIsrael

Celiac disease(CD)affects at least 1%of the Western population but remains largely *** our laboratory,we utilize a novel algorithm to diagnose pediatric CD that offers both high sensitivity and high specificity for diagnosis in an outpatient *** aim of the present study was to challenge this algorithm and to test its performance in children and adults suspected of having *** a three-assay algorithm,screening with the most sensitive tissue transglutaminase(tTG)complexed with deamidated gliadin peptide neoepitope immunoglobulin A(IgA)1IgG assay and confirming with the two specific tTG IgA and tTG IgA1IgG assays,we examined the serological results from 112 children aged 0–17 years old and 60 adults in comparison to their respective biopsy *** algorithm performance was calculated by statistical *** use of the new algorithm enabled us to diagnose CD with 98%sensitivity,93%specificity and 95%accuracy in the pediatric group and 94%sensitivity,92%specificity and 93%accuracy in the total population *** false-negative cases in the adult group were attributed to previous adherence to a gluten-free diet,and the single false-negative result in a young child became a true positive after 6 *** have also monitored three celiac patients before and after diagnosis and found that the algorithm may be suitable for disease *** newly proposed three-assay algorithm for celiac detection is very reliable in both children and *** to the high performance of this assay,the further need for confirmatory intestinal biopsies will be reassessed.

关键词： celiac disease diagnosis intestinal histopathology sensitivity specificity tissue transglutaminase

A research progress review on regional extreme events

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Advances in Climate Change Research 2018年第3期9卷 161-169页

作者： REN Fu-Min Blair TREWIN Manola BRUNET Pattanaik DUSHMANTA Andreas WALTER Omar BADDOUR maya KORBER State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences Beijing 100081 China Bureau of Meteorology Melbourne VIC 3001 Australia Centre for Climate Change Department of Geography University Rovira i Virgili Tarragona 43007 Spain Climatic Research Unit School of Environmental Sciences University of East Anglia Norwich NR4 7TJ UK India Meteorological Department New Delhi 110003 India German Meteorological Service (DWD) Offenbach 63067 Germany World Meteorological Organization Geneva 1211 Switzerland

An extreme （weather and climate） event does not only mean that an extreme occurs at a location, but more generally it can impact a certainarea and last a certain period of time, which is defined as a regional extreme event （REE） with a certain impacted area and duration. The conceptof REE has been defined to allow mainly objective assessment of the events without a pre-determined boundary and duration. This paper reviewsthe studies on REEs published during the past 20 years, especially recent years. Mainly in view of methodology, these studies can be divided intothree types studies focusing on spatial simultaneity, studies focusing on temporal persistence, and studies identifying REEs. The methodsidentifying REEs include two kinds, e.g., type-I methods stressing REE＇s temporal persistence within a relatively certain area and type-IImethods focusing on catching a complete REE. Identification methods proposed in this paper could provide valuable information for variouspurposes, such as real-time monitoring, estimating long-term changes, mechanism diagnosis, forecasting study and even attribution *** on REEs is important for objectively defining extreme weather and climate events, which depends on the spatial and temporal scales ofinterest. Such an objective definition will support ongoing climate monitoring and improve the assessment of how regional extreme events havechanged over time.

关键词： Extreme (weather and climate) events Regional extreme events Research progress Review

Amputation in diabetic foot ulcer:A treatment dilemma

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World Journal of Orthopedics 2023年第5期14卷 312-318页

作者： Raden Andri Primadhi Rani Septrina Putie Hapsari maya Kusumawati Department of Orthopaedics and Traumatology Universitas Padjadjaran/Hasan Sadikin HospitalBandung 40161Indonesia Division of Plastic Reconstructive and Aesthetic Surgery Department of SurgeryUniversitas Padjadjaran/Hasan Sadikin HospitalBandung 40161Indonesia Division of Vascular and Endovascular Surgery Department of SurgeryUniversitas Padjadjaran/Hasan Sadikin HospitalBandung 40161Indonesia Internal Medicine Universitas Padjadjaran/Hasan Sadikin HospitalBandung 40161Indonesia

Diabetic foot is a clinical manifestation of diabetes with a wide range of symptoms,including ulceration,osteomyelitis,osteoarticular destruction,and gangrene,as a consequence of advanced *** diabetic foot cases present general indications for amputation,including dead limb,threat to the patient’s life,pain,loss of function,or *** tools have been introduced to help decision-making in amputation for diabetic ***,it remains a conundrum because diabetic foot involves multiple pathomechanisms and factors that hinder its *** issues often impede treatment from the patient’s *** reviewed different perspectives in diabetic foot management,particularly related to *** addition to deciding whether to amputate,physicians should address amputation level,timing,and ways to avoid patient *** should not be autocratic in these circumstances and should be aware of beneficence and maleficence when considering whether to *** main goal should be improving the patients’quality of life rather than preserving the limb as much as possible.

关键词： Diabetic foot Ulcer Amputation Decision-making Perspective

Effect of Short-Term Exposure to Mercuric Chloride on the Air-Breathing Catfish,Heteropneustes fossilis──Ⅰ.Light Microscopic Study of the Gill

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Biomedical and Environmental Sciences 1994年第4期7卷 327-336页

作者： maya S. PRASAD (Department of Zoology, Bihar University, Muzaffarpur 842001, India) Department of Zoology Bihar University Muzaffarpur India.

Histopathological effects of sublethal (0.1, 0.2, 0.3 ppm) and lethal (0.5, 1.0 ppm)solutions of mercuric chloride (HgCl2) have been studied on the gills of the air breathing catfish, Heteropneustes fossilis at the intervals ranging from 6h to 15 days. Thickening of the epithelium, swelling and hyperplasia of the mucous cells, fusion of secondary lamellae, formation of interlamellar bridge and deposition of mucous over the entire surface are some noteworthy features of mercury poisoning in sublethal concentrations. Acute pathological manifestations are formation of subepithelial space, sloughing of the epithelial layer, hemorrhage and hypertrophy of the mucous cells. Causes and impact of these cellular alterations affecting survival of the fish have been discussed

关键词： Light Microscopic Study of the Gill Effect of Short-Term Exposure to Mercuric Chloride on the Air-Breathing Catfish,Heteropneustes fossilis

The role of DJ-1 in the oxidative stress cell death cascade after stroke

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Neural Regeneration Research 2014年第15期9卷 1430-1433页

作者： Paolina Pantcheva maya Elias Kelsey Duncan Cesar V.Borlongan Naoki Tajiri Yuji Kaneko Department of Neurosurgery and Brain Repair University of South FloridaTampaFLUSA

Oxidative stress is closely associated with secondary cell death in many disorders of the central nervous system including stroke, Parkinson＇s disease, Alzheimer＇s disease. Among many aber-rant oxidative stress-associated proteins, DJ-1 has been associated with the oxidative stress cell death cascade primarily in Parkinson＇s disease. Although principally expressed in the cytoplasm and nucleus, DJ-1 can be secreted into the serum under pathological condition. Recently, a close pathological association between DJ-I and oxidative stress in stroke has been implicated. To this end, we and others have demonstrated the important role of mitochondria in neuroprotection for stroke by demonstrating that the translocation of DJ-1 in the mitochondria could potentially mitigate mitochondrial injury. Here, we discuss our recent findings testing the hypothesis that DJ- 1 not only functions as a form of intracellular protection from oxidative stress, but that it also utilizes paracrine and/or autocrine cues in order to accomplish extracellular signaling between neighboring neuronal cells, resulting in neuroprotection. This article highlights recent evidence supporting the status of DJ-1 as key anti-oxidative stress therapeutic target for stroke.

关键词： cerebral ischemia neuroprotection mitochondria translocation extracellular signaling

Function and regulation of self-reactive marginal zone B cells in autoimmune arthritis

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Cellular & Molecular Immunology 2015年第4期12卷 493-503页

作者： Anna-Karin E Palm Heike C Friedrich Anja Mezger maya Salomonsson Linda K Myers Sandra Kleinau Department of Cell and Molecular Biology Uppsala University Uppsala Sweden Department of Pediatrics University of Tennessee Health ScienceCenter Memphis TN USA

Polyreactive innate-type B cells account for many B cells expressing self-reactivity in the periphery. Improper regulation of these B cells may be an important factor that underlies autoimmune disease. Here we have explored the influence of self-reactive innate B cells in the development of collagen-induced arthritis （CIA）, a mouse model of rheumatoid arthritis. We show that splenic marginal zone （MZ）, but not B- 1 B cells exhibit spontaneous IgM reactivity to autologous collagen II in na＇=＇ve mice. Upon immunization with heterologous collagen II in complete Freund＇s adjuvant the collagen-reactive MZ B cells expanded rapidly, while the B-1 B cells showed a modest anti-collagen response. The MZ B cells were easily activated by toll-like receptor （TLR） 4 and 9-1igands in vitro, inducing proliferation and cytokine secretion, implying that dual engagement of the B-cell receptor and TLRs may promote the immune response to self-antigen. Furthermore, collagen-primed MZ B cells showed significant antigen-presenting capacity as reflected by cognate T-cell proliferation in vitroand induction of IgG anti-collagen antibodies in vivo. MZ B cells that were deficient in complement receptors I and 2 demonstrated increased proliferation and cytokine production, while Fcy receptor lib deficiency of the cells lead to increased cytokine production and antigen presentation. In conclusion, our data highlight self-reactive MZ B cells as initiators of the autoimmune response in CIA, where complement and Fc receptors are relevant in controlling the self-reactivity in the cells.

关键词： arthritis complement receptors Fc receptors marginal zone B cells, mice

Tannins from Acacia mangium Bark as Natural Dyes for Textiles:Characteristics and Applications

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Journal of Renewable Materials 2024年第9期12卷 1625-1637页

作者： maya Ismayati Nissa Nurfajrin Solihat Fifi Melinda Setiawati Wasrin Syafii Yuki Tobimatsu Deni Zulfiana Research Center for Biomass and Bioproducts Research Organization for Life Sciences and EnvironmentNational Research and Innovation Agency(BRIN)Jl.Raya Bogor KM 46CibinongBogor16911Indonesia Department of Forest Product Technology Faculty of ForestryIPB UniversityBogor16680Indonesia Research Institute for Sustainable Humanosphere Kyoto UniversityUjiKyoto611-0011Japan Research Center for Applied Microbiology Research Organization for Life Sciences and EnvironmentNational Research and Innovation Agency(BRIN)Jl.Raya Bogor KM 46CibinongBogor16911Indonesia

Tannins are capable of producing natural dyes with antioxidant and antibacterial propertis,while synthetic dyes are commonly used in the textile industry,causing environmental issues like water *** research aims to utilize waste tannins as natural dyes as an alternative to synthetic *** study examined the effect of the extraction method on tannin properties such as phenolic content,antioxidants,and antibacterial *** addition,Pyrolysis Gas Chromatography‒Mass Spectrometry(Py-GCMS)analysis was used to identify the effect of extraction temperature on the chemical elucidation of *** effect of tannin concentration was evaluated against four bacteria that are usually found on human skin:Staphylococcus epidermidis,Bacillus subtilis,Propionibacterium acnes,and Staphylococcus *** temperature significantly influences the chemical composition of tannin,which leads to different antioxidant *** maximum antibacterial properties of tannin were obtained at 90℃with the inhibition zone in the range of 0.9–1.0 mm against four bacteria,tannin yield of 26.59%,Gallic Acid Equivalents or total phenolic content(GAE)of 40.30 mg/g,and Radical Scavenging Activity or antioxidant activity(RSA)of 89.88%.Moreover,the concentration of tannin was significantly linear with its antibacterial *** was successfully applied to the textile by using alum as a mordanting agent to create an antibacterial *** textile’s bacterial structure damage was analyzed under Field Emission Scanning Electron Microscopy(FESEM).After 50 washings,tannin-textiles with alum-modified properties remained stable compared to those without alum,with *** and *** being the most vulnerable bacteria,as confirmed by FESEM ***,tannin is a feasible alternative to harmful and nondegradable synthetic dyes and antibacterial agents.

关键词： Acacia mangium tannin antibacterial antioxidant different temperature extraction dyes

Shedding light on electrodeposition dynamics tracked in situ via soft X-ray coherent diffraction imaging

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Nano Research 2016年第7期9卷 2046-2056页

作者： George Kourousias Benedetto Bozzini Alessandra Gianoncelli Michael W. M. Jones Mark Junker Grant van Riessen maya Kiskinova Elettra Sincrotrone Trieste ScpA SS 14-km 163.5 in Area Science Park 34149 Trieste ltaly Dipartimento di Ingegneria dell'lnnovazione Universita del Salento via Monteroni 73100 Lecce Italy Australian Synchrotron Clayton 3168 Australia ARC Centre of Excellence for Advanced Molecular Imaging La Trobe Institute of Molecular Science La Trobe University Bundoora 3089 Australia Department of Chemistry and Physics La Trobe Institute for Molecular Science La Trobe University Bundoora 3086 Australia

The in situ physicochemical analysis of nanostructured functional materials is crucial for advances in their design and production. X-ray coherent diffraction imaging （CDI） methods have recently demonstrated impressive potential for characterizing such materials with a high spatial resolution and elemental sensitivity; however, moving from the current ex situ static regime to the in situ dynamic one remains a challenge. By combining soft X-ray ptychography and single-shot keyhole CDI, we performed the first in situ spatiotemporal study on an electrodeposition process in a sealed wet environment, employed for the fabrication of oxygen-reduction catalysts, which are key components for alkaline fuel cells and metal-air batteries. The results provide the first experimental demonstration of theoretically predicted Turing-Hopf electrochemical pattern formation resulting from morphochemical coupling, adding a new dimension for the in-depth in situ characterization of electrodeposition processes in space and time.

关键词： in situ electrodeposition X-ray coherent diffractionimaging keyhole coherentdiffraction imaging (CDI) X-ray ptychography

Anti-Saccharomyces cerevisiae antibody titers are stable over time in Crohn's patients and are not inducible in murine models of colitis

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World Journal of Gastroenterology 2005年第44期11卷 6988-6994页

作者： Stefan Müller maya Styner Beatrice Seibold-Schmid Beatrice Flogerzi Michael M(a|¨)hler Astrid Konrad Frank Seibold Division of Gastroenterology Central Animal Facility and Institute for Laboratory Animal Science

AIM： To investigate ASCA production over time in CD and murine colitis in order to further our understanding of their etiology. MATERIALS AND METHODS： Sixty-six CD patients were compared to ulcerative colitis （UC） and irritable bowel syndrome patients with respect to ASCA production as measured by ELISA. ASCA IgG or IgA positivity as well as change in titers over a period of up to 3 years （△tgG/A） was correlated with clinical parameters such as CD activity index （CDM） and C-reactive protein levels （CRP）. Moreover, two murine models of colitis （DSS and IL-10 knock out） were compared to control animals with respect to ASCA titers after oral yeast exposure. RESULTS： ASCA IgG and IgA titers are stable over time in CD and non-CD patients. Fistular disease was associated with a higher rate of ASCA IgA positivity （P = 0.014）. Ileal disease was found to have a significant influence on the △tgG of ASCA （P = 0.032）. There was no correlation found between ASCA positivity or △tgG/A and clinical parameters of CD： CDAI and CRP. In mice, neither healthy animals nor animals with DSS-induced or spontaneous colitis exhibited a marked increase in ASCA titers after high-dose yeast exposure. On the other hand, mice immunized intraperitoneally with mannan plus adjuvant showed a marked and significant increase in ASCA titers compared to adjuvant-only immunized controls （P = 0.014）. CONCLUSION： The propensity to produce ASCA in a subgroup of CD patients is largely genetically predetermined as evidenced by their stability and lack of correlation with clinical disease activity parameters. Furthermore, in animal models of colitis, mere oral exposure of mice to yeast does not lead to the induction of marked ASCA titers irrespective of concomitant colonic inflammation. Hence, environment may play only a minor role in inducing ASCA.

关键词： Crohn's disease Anti-Saccharomyces cerevisiae antibodies Colitis