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Where does selective laser trabeculoplasty stand now? A review

Eye and Vision 2016年第1期3卷 75-83页

作者： Myrjam de Keyser maya de belder Simon de belder Veva de Groot department of Medicine University of AntwerpUniversiteitsplein 1B-2610 AntwerpBelgium Medipolis Boomsesteenweg 223B-2610 AntwerpBelgium Faculty of Psychology and Education Department of Experimental PsychologyGhent UniversityHenri Dunantlaan 2B-9000 GhentBelgium department of Ophthalmology University Hospital AntwerpWilrijkstraat 10B-2650 EdegemBelgium

Background:Chronic treatment of glaucoma can present a challenge in patients who lack the means and/or the discipline to use daily glaucoma *** wondered if selective laser trabeculoplasty(SLT)could be a useful ***:Inclusion criteria:controlled trials comparing efficacy of SLT in adult patients with any form of open angle glaucoma or ocular hypertension and case reports on side effects of *** recent meta-analyses identified eight randomized clinical trials(RCTs)comparing the effect of SLT with medication(prostaglandin analogs)and with argon laser trabeculoplasty(ALT).We took these eight RCTs as reference base and calculated their success rates where they were not *** articles were added to elaborate on technique and side ***:Mean intraocular pressure(IOP)reduction after SLT was 3.8–8.0 mmHg after 6 months to 1 *** success rate of SLT at 6 months to 1 year is 55–82%.Higher IOP before laser predicts a higher IOP-lowering *** terms of mean IOP reduction,reduction in number of medications and treatment success,the effect of SLT was found to show no clinically relevant difference from that of contemporary medication(prostaglandin analogs)and from ***:The evidence indicates that SLT is an efficacious primary or adjunctive therapy for treating glaucoma.

关键词： Glaucoma Selective laser trabeculoplasty Review Open angle glaucoma Glaucoma treatment Ocular hypertension

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Selective laser trabeculoplasty in pseudophakic and phakic eyes:a prospective study

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 593-598页

作者： Myrjam de Keyser maya de belder Veva de Groot department of Medicine University of Antwerp Universiteitsplein Antwerp B-2610 Belgium department of Experimental Psychology Faculty of Psychology and Education Ghent University Henri DunantlaanGhent B-9000 Belgium department of Ophthalmology Antwerp University HospitalWilrijkstraat Edegem B-2650 Belgium

AIM：To compare the efficacy of selective laser trabeculoplasty（SLT） in replacing medical therapy in pseudophakic and phakic ***：Subgroup of a prospective randomized clinical trial including patients with primary open angle glaucoma or ocular hypertension controlled with *** 38 pseudophakic eyes were matched with 38 phakic *** was offered as a way to decrease medication while maintaining the same low eye *** was performed over 360°,at 3ns,spotsize 400 μm,100 *** [intraocular pressure（IOP）,number of medications needed] were measured at 1h,1wk,1,3,6 and 12 *** independent-samples t-test was performed to compare baseline characteristics of the phakic and the pseudophakic group and differences in evolution of mean IOP and number of used ***-squared analysis was performed to investigate proportions of fast,slow and ***：The mean IOP measurement was 13.00± 2.88 mm Hg in the phakic group（38 eyes） and 13.51±3.06 mm Hg in the pseudophakic group（38 eyes）（P〉0.05）.This changed little after SLT and IOP lowering effect was comparable between the two *** aim however was to lower the amount of medication *** the phakic group medication lowered from 1.29±0.62 at baseline,to 0.15±0.46 after 12mo;a reduction of 88.37%.In the pseudophakic group,used medication changed from 1.71±1.04,to 0.41±0.61;a 76.02% *** differences were not statistically significant at any time point（P〉0.05）.IOP lowering occurred slightly faster in thepseudophakic group（50% of patients after one week） than in the phakic group（68% of patients after more than 4wk）.The difference was not significant（P〉0.05）.CONCLUSION：IOP lowering effect of SLT is comparable between phakic and pseudophakic eyes.

关键词： mechanism of trabeculoplasty selective laser trabeculoplasty pseudophakes versus phakic eyes open angle glaucoma pressure lowering after lens extraction

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Quality of life in glaucoma patients after selective laser trabeculoplasty

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International Journal of Ophthalmology(English edition) 2017年第5期10卷 742-748页

作者： Myrjam de Keyser maya de belder Veva de Groot department of Medicine University of Antwerp Universiteitsplein 1 Antwerp B-2610 Belgium department of Experimental Psychology Ghent UniversityHenri Dunantlaan 2 Ghent B-9000 Belgium department of Ophthalmology University Hospital AntwerpWilrijkstraat 10 Edegem B-2650 Belgium

AIM：To compare quality of life and treatment satisfaction between patients who had selective laser trabeculoplasty（SLT） and those on ***：A prospective clinical trial on 143 glaucoma patients that received SLT and a control group that continued using anti glaucoma medication was conducted. Tear break-up time（BUT）, punctuate keratitis, need for help, use of artificial tears and the treatment satisfaction survey of intraocular pressure（IOP） were measured at baseline, 6 and 12 mo. RESULTS：SLT was able to reduce the mean number of medications needed from 1.56±0.81 to 0.42±0.66 at six months and to 0.33±0.69 at one year. Punctuate keratitis was observed significantly less often（12.24%） after SLT than before（35.94%; P=0.03）. Use of artificial tears and BUT did not change significantly after SLT（P〉0.05）. At baseline, patients in the SLT group were significantly less convinced of medication effectiveness（P=0.006） and complained more about side effects（P=0.003）. After SLT, these patients had significantly more confidence in their therapy（P〈0.001）, showed less side effects（P=0.006）, complained less about changes in appearance of the eyes（P=0.003） and were less inconvenienced by the use of eye drops（P〈0.001）.CONCLUSION：SLT is able to improve treatment-related quality of life in glaucoma patients.

关键词： glaucoma laser treatment medical treatment quality of life

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