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Neurodegenerative diseases:a hotbed for splicing defects and the potential therapies

Translational Neurodegeneration 2021年第2期10卷 195-212页

作者： Dunhui Li Craig Stewart McIntosh Frank Louis Mastaglia Steve Donald Wilton may thandar aung-htut Centre for Molecular Medicine and Innovative Therapeutics Health Futures InstituteMurdoch UniversityPerthWestern AustraliaAustralia Perron Institute for Neurological and Translational Science Centre for Neuromuscular and Neurological DisordersThe University of Western AustraliaPerthWestern AustraliaAustralia

Precursor messenger RNA(pre-mRNA)splicing is a fundamental step in eukaryotic gene expression that systematically removes non-coding regions(introns)and ligates coding regions(exons)into a continuous message(mature mRNA).This process is highly regulated and can be highly flexible through a process known as alternative splicing,which allows for several transcripts to arise from a single gene,thereby greatly increasing genetic plasticity and the diversity of *** splicing is particularly prevalent in neuronal cells,where the splicing patterns are continuously changing to maintain cellular homeostasis and promote neurogenesis,migration and synaptic *** continuous changes in splicing patterns and a high demand on many cis-and trans-splicing factors contribute to the susceptibility of neuronal tissues to splicing *** resultant neurodegenerative diseases are a large group of disorders defined by a gradual loss of neurons and a progressive impairment in neuronal *** of the most common neurodegenerative diseases involve some form of splicing defect(s),such as Alzheimer’s disease,Parkinson’s disease and spinal muscular *** growing understanding of RNA splicing has led to the explosion of research in the field of splice-switching antisense oligonucleotide *** we review our current understanding of the effects alternative splicing has on neuronal differentiation,neuronal migration,synaptic maturation and regulation,as well as the impact on neurodegenerative *** will also review the current landscape of splice-switching antisense oligonucleotides as a therapeutic strategy for a number of common neurodegenerative disorders.

关键词： Neurodegenerative diseases Parkinson’s disease Alzheimer’s disease Alternative splicing Splicing defects Antisense oligonucleotides Splice-switching Disease-modifying treatment

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Opportunities, Challenges, and Countermeasures of China Myanmar Economic and Trade Cooperation under the Background of RCEP

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Open Journal of Applied Sciences 2024年第4期14卷 991-1007页

作者： Chit Min htut School of Economics Guangxi University Nanning China

China and Myanmar are geographically adjacent and have close economic and trade cooperation. China has been Myanmar’s largest trading partner and largest source of investment for many consecutive years. With the official entry into force of RCEP (Regional Comprehensive Economic Partnership) for Myanmar on may 1, 2022, the reduction of trade tariffs on goods and flexible rules of origin between China and Myanmar will undoubtedly bring more practical results to China Myanmar economic and trade cooperation. However, the implementation of RCEP in Myanmar may face a series of challenges such as poor business environment, weak human resource management, and outdated infrastructure construction. Finally, the article provides countermeasures for China Myanmar economic and trade cooperation from three aspects: optimizing the business environment to attract Chinese investment, increasing investment in education and training to improve labor quality, strengthening infrastructure construction to enhance economic support.

关键词： RCEP Myanmar Opportunities Challenges Countermeasures

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Knockdown of <i>GmSOG1</i>Compromises Drought Tolerance in Transgenic Soybean Lines

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American Journal of Plant Sciences 2021年第1期12卷 18-36页

作者： Samuel Aduse Poku Peter Nkachukwu Chukwurah htut Htet aung Ikuo Nakamura Laboratory of Plant Cell Technology Chiba University Chiba Japan

Plants are regularly exposed to myriads of stress factors that cause tremendous damage to their genetic make-up. To ensure genome stability and survival over several generations under harsher environmental conditions, plants have evolved a unique mechanism for dealing with DNA damage known as the DNA damage response pathway (DDR). It has been proposed that there may exist a relationship between the DNA damage response pathway and abiotic stress response in plants. To further investigate this relationship, we knocked down the soybean suppressor of gamma response 1 gene (GmSOG1), a master regulatory gene of the DDR, in soybean plants and subjected the generated transgenic plants to drought stress analysis. Gene expression analysis of the GmSOG1 gene in drought stressed soybean tissues revealed high levels of expression in buds and young leaves. The root lengths and root fresh weights of transgenic soybean plants grown on Murashige and Skoog media supplemented with Gamborg B5 vitamins (MSB5 media) containing 200 mM mannitol for 10 days were significantly lesser than those of drought stressed wild-type plants. Polyethylene glycol (PEG) induced drought stress assay in vivo resulted in significant damage in transgenic plants compared with wild-type plants. Also, the relative expressions of known drought responsive transcription factors such as GmDREB1 and GmLEA as well as antioxidation related genes like

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针刺百会穴前后血管性痴呆患者不同脑区的脑葡萄糖代谢

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中国临床康复 2005年第36期9卷 68-70页

作者：黄泳赖新生陈静李东江唐安戊 Win Moe htut Fenanda Hamanenga 南方医科大学中医系广州中医药大学中医学博士后流动站广东省广州市510515 广州中医药大学针灸推拿学院广东省广州市510407 南方医科大学中医系广东省广州市510515 广东省人民医院PET中心广东省广州市510080 南方医科大学留学生广东省广州市510515

目的:运用正电子发射型计算机断层显像技术,观察百会穴针刺前后血管性痴呆患者对不同脑区葡萄糖代谢的变化。方法:收治2004-05/10广州星光老人之家二院和广州千禧颐老院的血管性痴呆患者10例。男4例,女6例;病程1～9年;均为右利手。随机... 详细信息

目的:运用正电子发射型计算机断层显像技术,观察百会穴针刺前后血管性痴呆患者对不同脑区葡萄糖代谢的变化。方法:收治2004-05/10广州星光老人之家二院和广州千禧颐老院的血管性痴呆患者10例。男4例,女6例;病程1～9年;均为右利手。随机分为常规体针治疗组5例和百会治疗组5例。5次/周,共治疗4周。10例中缺血性脑血管病8例,出血性脑血管病2例;有1次脑卒中史9例,有2次脑卒中史1例;右侧偏瘫7例,左侧偏瘫3例。所有患者均接受正电子发射型计算机断层显像法观察脑区感兴趣区[分别设为双侧额叶(眶回)、双侧顶叶、双侧颞叶(海马及海马旁回)、双侧枕叶、双侧丘脑、双侧扣带回、双侧尾状核、双侧豆状核和双侧小脑]的葡萄糖代谢水平,并进行治疗前后的比较。结果:10例患者均进入结果分析。①常规针刺组治疗前后脑部感兴趣区葡萄糖代谢变化:患脑豆状核治疗后明显高于治疗前[(2.49±0.99,1.85±0.53),t=2.90,P<0.05]。健脑治疗后颞叶明显高于治疗前[(1.59±0.63,1.28±0.36),t=2.88,P<0.05]。②百会组治疗前后脑部感兴趣区葡萄糖代谢变化:患脑额叶、豆状核治疗后显著高于治疗前[(2.78±0.27,2.80±0.40;2.21±0.34,2.25±0.35),t=3.01,3.25,P<0.05]。健脑颞叶、豆状核治疗后显著高于治疗前[(1.69±0.43,2.79±0.38;1.32±0.36,2.22±0.47),t=2.93,3.16,P<0.05]。结论:①常规针刺组能显著提高患脑豆状核和健脑颞叶的葡萄糖代谢水平。②百会穴治疗组对血管性痴呆患者的患脑额叶、健脑颞叶及双侧豆状核区的葡萄糖代谢有显著增高。

关键词：针刺治疗百会穴血管性痴呆脑区代谢脑葡萄糖代谢中医治疗

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Diversity and Abundance of Copepods in Taninthayi Coastal Waters, Myanmar

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Journal of Marine Science 2020年第3期2卷 35-39页

作者： Khin may Chit Maung Thaung htut Ei Thal Phyu Zaw Myo Hein Nyo Nyo Tun Myeik University 1 Saparshwewar St.Kalwin WardMyeik CityTanintharyi RegionMyanmar Wildlife Conservation Society-Myanmar Program MyanmarNo.12(B21-22)Yadanamyine RoadKamayutYangon

Diversity and abundance of copepods occurring in Taninthayi coastal waters were studied and analyzed from the samples collected by R/V *** NANSEN during the Myanmar ecosystem survey ***-nine copepods species belonging to calanoids(51 species),cyclopoids(21 species),and harpacticoids(7 species)were identified in the copepods community of Taninthayi coastal *** species number and density were high at the nearshore stations(Sts 799,842,788)and low at the offshore stations(Sts 846,802,823).The resulted diversity index values of copepods were varied from 2.61 to 3.78 in species diversity index(H'),from 0.89 to 0.97 in the evenness index(E'),and from 2.51 to 7.50 in species richness index(D').According to the correlation matrix,the abundance of copepods was positively correlated with temperature,chlorophyll a and fluorescence,and negatively correlated with salinity and oxygen.

关键词： Abundance Copepods Calanoids Cyclopoids Harpacticoids

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踏车运动期间B型利钠肽的变化百分比作为运动诱发心肌缺血的筛查试验

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世界核心医学期刊文摘(心脏病学分册) 2006年第2期 28-29页

作者： htut K. W. Raizner M. Zoghbi W. A. 任付先 Echocardiography Laboratory Methodist DeBakey Heart Center SM-677 6550 Fannin Houston TX 77030 United States Dr.

Background: Myocardial ischemia leads to changes in regional wall stress. Induction of ischemia during a treadmill exercise, although brief, may lead to transient elevation in the plasma level of B-type natriuretic peptide(BNP) from baseline levels, which could serve as a biochemical marker of myocardial ischemia. Methods: Sixty subjects(mean age 57, 41 men) undergoing myocardial single-photon emission computed tomography(SPECT) in conjunction with Bruce protocol treadmill exercise for evaluation of chest pain or screening for ischemia had their BNPs measured(Triage Biosite Test) at baseline, immediately postexercise, and 10 to 15 minutes after exercise. Results: Of the 60 patients, 10 had ischemic perfusion defects by SPECT(mean 14% , range 5% -37% ). In patients with no evidence of ischemia, median BNP level at baseline was 15.05 pg/mL(interquartile range 7-37.7), increased significantly immediately postexercise median level(34.7 pg/mL 14.9-67.6 ), and decreased toward baseline levels within 10 to 15 minutes postexercise(20.3 pg/mL 8.6-48.5 , analysis of variance P10% change in BNP level from rest per minute of exercise had a sensitivity of 80% , a specificity of 71% , and a negative predictive value of 92% to detect reversible ischemia by SPECT. Conclusion: Transient elevation in BNP occurs during treadmill exercise and is more pronounced in patients with ischemia. B-type natriuretic peptides may therefore be used in combination with treadmill exercise for the evaluation of

关键词：利钠肽心肌缺血踏车运动

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