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Biologics:how far can they go in Crohn’s disease?

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Gastroenterology Report 2022年第1期10卷 155-170页

作者： Katie A.Dunleavy Darrell s.Pardi Division of Gastroenterology and Hepatology Mayo ClinicRochesterMNUSA

Crohn’s disease is a chronic gastrointestinal inflammatory disorder,characterized by episodes of relapsing and remitting *** the disease mechanism becomes better elucidated,there is a significant increase in the number of available biologic *** article summarizes and synthesizes current Food and Drug Administration-approved biological therapy for Crohn’s disease and examines the positioning of medical therapy as emerging biologics break onto the market.

关键词： Crohn’s disease medical treatment biologics anti-TNFs anti-integrins anti-interleukins JAK inhibitors s1Pinhibitors

Prof. Robert s. Warren: come early, stay late and listen

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Hepatobiliary surgery and Nutrition 2020年第1期9卷 122-123页

作者：无 Robert s.Warre HBsN the University of California school of Medicine

Expert’s introduction Robert ***,MD(Figure 1)is a Professor of surgery in the University of California school of Medicine and a specialist in gastrointestinal and liver *** earned a medical degree at the University of Minnesota,where he completed a general surgery *** completing an oncology research fellowship at Memorial sloan-Kettering Cancer Center in New York,***,joined UCsF Medical Center in 1988.A board-certified surgeon,he later became the Chief of surgical Oncology at *** respected by his peers,*** was named to the list of ***"America’s Top Doctors",a distinction reserved for the top 1%of physicians in the nation for a given *** research focuses on the biology of colorectal cancer(CRC)and how it spreads.

关键词： surgery Figure Warren

Effect of temperature on the ML of Au doped(Zn,Cd)s mixed phosphors

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Chinese Chemical Letters 2011年第6期22卷 709-712页

作者： Jagjeet Kaur N.s.suryanarayana Vikas Dubey Department of Physics Govt.Vishwanath Yadav Tamaskar Post Graduate Autonomous College Durg(C.G.)India

In this paper the effect of temperature on the mechanoluminescence of Au doped phosphors of（Zn,Cd）s is *** is found that the ML disappears beyond a particular *** temperature dependence of ML intensity follows the relation I =I_T^O（1-TIT_C）~n,where I_T^O is a constant,n is the slop of log I_T versus log（1- TIT_C） plot which lies between 0.9 and 1.10,T_C is the temperature at which ML *** is found that the ML intensity in（Zn,Cd）s：Au disappear at 600 K.

关键词： Mechanoluminescence Temperature dependence in Ⅱ-Ⅵ semiconductors

Dynamics of Apparent Horizons in (N+2)-Dimensional space-Times

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Chinese Physics Letters 2012年第11期29卷 23-26页

作者： s.s.Zade Department of Mathematics J.B.College of ScienceWardhaIndia

We analyze the time of formation of central singularities in(N+2)-dimensional *** is shown that the time of formation of central singularity decreases with the increase in dimensions of the *** dynamics of trapped sur... 详细信息

关键词： singularity dimensions graphical

Thermodynamic Performance and Flammability studies of Hydrocarbon Based Low Global Warming Potential Refrigerant Mixtures

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Journal of Thermal science 2022年第5期31卷 1487-1502页

作者： Nagarjuna KUMMA s s Harish KRUTHIVENTI Department of Mechanical Engineering Low Temperature LaboratoryNational Institute of TechnologyTiruchirappalliTrichy620015India

This paper presents a theoretical method to calculate the minimum inerting concentration(MIC)of binary and ternary blends(refrigerants)that are used in small refrigeration *** is the concentration of the dilutant which makes the flammable mixture into just non-flammable(at non-zero quenching potential).In this study,the refrigerant safety parameters such as flammability,Global Warming Potential(GWP)and performance(COP)are analyzed for twelve binary and thirteen ternary blends containing one flammable and two nonflammable(dilutant)*** investigation was carried out with the hydrocarbon refrigerants R290,R600,R600a each mixed with dilutants R227ea,R125,R245fa,R13I1 and R134a at different concentrations *** methods,thermal balance method(TBM)and modified thermal balanced method(MTBM),are used to estimate the MIC(which decides the flammable zone).Thirteen ternary blends were identified based on the MIC values estimated using *** the case of ternary blends,it was observed that the non-flammable zone is high for the compositions of the Mixture G,Mixture H and Mixture *** was also estimated that the COPs of the proposed mixtures M22,M24,M25 and M27 are 4%greater than the COP of R134a(for the same operating conditions).Further,it was also understood that the corresponding GWP value is reduced by 90%to 97%for the mixtures(M21,M22,M24,M25 and M27)when compared to R134a(GWP=1300).Therefore,out of the thirteen proposed ternary mixtures(M15 to M27),the mixtures(M21,M22,M24,M25 and M27)are safe in terms of flammability,GWP and possess reasonable COP which can be a potential alternative refrigerant mixture to R134a in small refrigeration systems.

关键词： hydrocarbons minimum inerting concentration ternary Global Warming Potential

Unstable mode of ion-acoustic waves with two temperature q-nonextensive distributed electrons

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Chinese Physics B 2021年第9期30卷 313-319页

作者： s Bukhari Nadeem Hussain s Ali Department of Physics The University of Azad Jammu and KashmirMuzaffarabad 13100Azad KashmirPakistan National Center for Physics at QAU Campus Shahdra Valley RoadIslamabad 44000Pakistan

The linear characteristics of the unstable mode of ion-acoustic waves are examined in an electrostatic electron-ion plasma composed of streaming hot electrons,non-streaming cold electrons and dynamical positive *** plasma under consideration is modeled by using a non-gyrotropic nonextensive q-distribution function in which the free energy source for wave excitation is provided by the relative directed motion of streaming hot electrons with respect to the other plasma *** the frame work of kinetic model,a linearized set of Vlasov-Poisson's equations are solved to obtain the analytical expressions for dispersion relation and Landau damping *** threshold condition for the unstable ion-acoustic wave is derived to assess the stability of the wave in the presence of nonextensive *** in the wave spectrum and nontrivial effects of q-nonextensive parameter on the ion-acoustic waves can be of interest for the readers in the regions of saturns's magnetosphere.

关键词： non-gyrotropic nonextensivity saturns's magnetosphere

structural and magnetic properties of BiFe_(1-x)Cr_xO_3 synthesized samples

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Chinese Physics B 2014年第6期23卷 398-400页

作者： s.s.Arafat Department of Physics College of Science King Faisal University Department of Physics College of Science Fayoum University

Chromium doping effects on the structure and the magnetic properties of bismuth ferrite BiFe1-xCrxO3 （x = 0-0.3）（BFCxO） polycrystalline samples are examined. The Perovskite-type oxide samples are synthesized by the conventional solid state reaction at a high pressure of 7 GPa and a temperature of 1273 K. The X-ray powder diffraction patterns at room temperature show that all the samples with x = 0.0-0.3 are described by the rhombohedral structure. In the meantime, it is revealed that the doping of Cr can induce noticeable lattice distortions in the doping samples, and the largest distortion is observed in the case x = 0.1. The magnetic hysteresis loops measured at room temperature exhibit week ferromagnetic behaviors of the samples and the magnetization is found to increase with the increase in Cr concentration. The temperature- dependent magnetization curves indicate antiferromagnetic features in samples. Moreover, Cr-doping tends to reduce the ordering temperature.

关键词： X-ray diffraction magnetic properties

Predictors of bowel damage in the long-term progression of Crohn’s disease

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World Journal of Clinical Cases 2022年第33期10卷 12208-12220页

作者： Agnes Fernández-Clotet Julian Panés Elena Ricart Jesús Castro-Poceiro Maria Carme Masamunt sonia Rodríguez Berta Caballol Ingrid Ordás Jordi Rimola Department of Gastroenterology Hospital ClinicBarcelona 08036Spain Universitat de Barcelona Institut d'Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)Barcelona 08036Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHDMadrid 28029Spain Department of Radiology Hospital ClinicBarcelona 08036Spain

BACKGROUND Crohn’s disease(CD)is a chronic inflammatory bowel disorder that progresses to bowel damage(BD)over *** image-based index,the Lémann index(LI),has been developed to measure cumulative *** To characterize the long-term progression of BD in CD based on changes in the LI and to determine risk factors for long-term *** This was a single-center longitudinal cohort *** who had participated in prospective studies on the accuracy of magnetic resonance imaging using endoscopy as a gold standard and who had a follow-up of at least 5 years were reevaluated after 5-12 *** seventy-two patients were *** increased in 38 patients(52.8%),remained unchanged in 9 patients(12.5%),and decreased in 25 patients(34.7%).The small bowel score and surgery subscale significantly increased(P=0.002 and P=0.001,respectively),whereas the fistulizing subscale significantly decreased(P=0.001).Baseline parameters associated with BD progression were ileal location(P=0.026),CD phenotype[stricturing,fistulizing,or both(P=0.007,P=0.006,and P=0.035,respectively)],disease duration>10 years(P=0.019),and baseline LI stricturing score(P=0.049).No correlation was observed between BD progression and baseline clinical activity,biological markers,or severity of endoscopic *** BD,as assessed by the LI,progressed in half of the patients with CD over a period of 5-12 *** main determinants of BD progression were ileal location,stricturing/fistulizing phenotype,and disease duration.

关键词： Crohn’s disease Lémann index Bowel damage Inflammatory bowel disease Magnetic resonance imaging

Hot Forging of Nitrogen Alloyed Duplex stainless steels

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Journal of Materials science & Technology 2007年第1期23卷 111-117页

作者： P. Chandramohan s.s.Mohamed Nazirudeen s. s.Ramakrishnan Department of Mechatronics Eng Sri Krishna College of Eng and TechCoimbatore 641008India Dept. of Metallurgy PSG College of TechnologyCoimbatore 641004India Mechanical Eng VLB Janakiammal college of Eng and TechCoimbatore 641004India

Duplex stainless steels are gaining global importance because of the need for a high strength corrosion resistant material. Three compositions of this group were selected with three different nitrogen contents ciz, 0.15 wt pct （alloy 1）, 0.23 wt pct （alloy 2） and 0.32 wt pct （alloy 3）. The steels were melted in a high frequency induction furnace and hot forged to various reductions from 16% to 62%. In this work, the effect of hot forging on the ferrite ***, hardness, yield strength, impact strength and grain orientation （texture） were studied. Fracture analysis on all the forged specimens using sEM reveals that a size reduction of 48% results in maximum ductility and impact strength as well as minimal ferrite content and grain size. Thus the mechanical properties are found to have a direct correlation to ferrite content and grain size. The highest impact strength was observed in specimens with the smallest grain size, which was observed in specimens forged to 48% reduction in size.

关键词： Duplex Austenite Ferrite Forging solutionizing