检索结果-南通市图书馆

Journal of Pharmaceutical Analysis 2015年第2期5卷 137-141页

作者： maximiliano s.sangoi Vítor Todeschini Martin steppe Faculty of Pharmacy Federal University of Rio de Janeiro Faculty of Pharmacy Federal University of Rio Grande do Sul

A dissolution test for fesoterodine low dose extended-release tablets using liquid chromatographic（LC） method equipped with a C18 monolithic column was developed and validated. LC system was operated isocratically at controlled temperature（40 1C） using a mobile phase of acetonitrile：methanol：0.03 M ammonium acetate（p H 3.8）（30：15：55, v/v/v）, run at a flow rate of 1.5 m L/min and detected at 208 nm. The best dissolution conditions for this formulation were achieved using a UsP apparatus 2（paddle） at 100 rpm and 900 m L of phosphate buffer at p H 6.8 as the dissolution *** parameters such as the specificity, linearity, accuracy, precision, and robustness were evaluated according to international guidelines, giving results within the acceptable range. The kinetic parameters of drug release were also investigated using model-dependent methods and the dissolution profiles were best described by the Higuchi model. The validated dissolution test can be applied for quality control of this formulation.

关键词： Fesoterodine Dissolution test Low dose extendedrelease tablets Monolithic LC Release kinetics

Dissolution method for delapril and manidipine combination tablets based on an absorption profile of manidipine

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2016年第1期6卷 49-55页

作者： Vitor Todeschini maximiliano s.sangoi Gustavo K.Goelzer Jaison C.Machado Clesio s.Paim Bibiana V.Araujo Nadia M.Volpato Federal University of Rio de Janeiro Faculty of Pharmacy27930-560 MacaeR JBrazil Federal University of Rio Grande do sul Faculty of Pharmacy90610-000 Porto AlegreRSBrazil Federal University of Pampa Faculty of Pharmacy97500-009 UruguaianaRSBrazil

The present study describes the development and validation of a dissolution method for delapril （DEL） and manidipine （MAN） combination tablets, using a simulated absorption profile based on in vivo data for MAN. The suitable in vitro dissolution profile for this formulation was obtained using 900 mL of citrate buffer pH 3.2 at 37 ℃ ± 0.5 ℃ as dissolution medium and UsP apparatus 2 （paddle） at 75 rpm. All samples were analyzed by a liquid chromatography （LC） method. Under these conditions, a significant linear relationship between the absorbed （calculated by deconvolution approach） and dissolved fractions of MAN was obtained （R=0.997） and an in vivo-in vitro （IVIV） correlation for this particular formulation containing MAN can be established. Validation parameters for dissolution methodology such as the specificity, linearity, accuracy and precision were also evaluated according to the international guidelines, giving results within the acceptable range. Therefore, the proposed dissolution conditions can be applied for the simultaneous release analysis of DEL and MAN from the solid dosage form, contributing to the improvement of the quality control of pharmaceutics and minimizing the number of bioavailability studies.

关键词： Delapril Dissolution Manidipine Validation in vivo-in vitro correlation

Revisiting cerebral endothelial cells in Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Preparation and characterization of phosphate-modified mesoporous TiO2 incorporated in a silica matrix and their photocatalytic properties in the photodegradation of Congo red

在线全文

学校读者我要写书评

暂无评论

Frontiers of Materials science 2017年第3期11卷 250-261页

作者： Alberto EsTRELLA GONZALEZ maximiliano AsOMOZA Ulises ARELLANO sandra CIPAGAUTA DiAZ silvia sOLís Department of Chemistry Metropolitan Autonomous University-lztapalapa P.O. Box 55-532 C.P. 09340 México City México

This study describes the development of mesostructured TiO2 photo- catalysts modified with PO4^3- to improve its specific surface area and reduce the recombination rate of the electron-hole pairs. The mesoporous photocatalyst was successfully incorporated into a high specific surface area silica matrix by the hydrolysis reaction of tetraethyl orthosilicate （TEOs）. Pluronic 123 and phosphoric acid were used as the directing agent for the structure of the mesoporous TiO2 and as a source of phosphorus, respectively, TiO2, P/TiO2, TiO2-siO2 and P/TiO2-siO2 materials were characterized by BET, XRD, TEM-EDs, FTIR and UV-vis DRs measurements. The photoactivity of TiO2-siO2 nanocomposites containing 15 wt.% photocatalystJsilica was evaluated in the degradation reaction of anionic dyes with UV radiation. The proposed nanomaterials showed high potential for applications in the remediation of wastewater, being able to reuse in several cycles of reaction, maintaining its photoactivity and stability. The separation and recovery time of the material is reduced between cycles since no centrifugation or filtration processes are required after the photooxidation reaction.

关键词： photocatalysis phosphated TiO2 TiO2-siO2 Congo red dye

Carbon stock estimation in halophytic wooded savannas of Uruguay:An ecosystem approach

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forest Ecosystems 2024年第4期11卷 580-589页

作者： Andres Baietto Andres Hirigoyen Carolina Toranza Franco schinato maximiliano Gonzalez Rafael Navarro Cerrillo Forest Department Faculty of AgronomyUniversity of the RepublicMontevideoPO 12900Uruguay National Research Program of Forest Production National Agriculture Research InstituteTacuaremboPO 97000Uruguay soil and Water Department Faculty of AgronomyUniversity of the RepublicMontevideoPO 12900Uruguay Department of Forestry Engineering University of CordobaCordobaPO 14014Spain

savannas constitute a mixture of trees and shrub patches with a more continuous herbaceous *** contribution of this biome to the soil organic carbon(sOC)and above-ground biomass(AGB)carbon(C)stock globally is ***,they are frequently subjected to land use changes,promoting increases in CO_(2) *** Uruguay,subtropical wooded savannas cover around 100,000 ha,of which approximately 28%is circumscribed to sodic soils(i.e.,subtropical halophytic wooded savannas).Nevertheless,there is little background about the contribution of each ecosystem component to the C stock as well as site-specific allometric *** study was conducted in 5 ha of subtropical halophytic wooded savannas of the national protected area Esteros y Algarrobales del Rio *** work aimed to estimate the contribution of the main ecosystem components(e.g.,soil,trees,shrubs,and herbaceous plants)to the C ***-specific allometric equations for the most frequent tree species and shrub genus were fitted based on basal diameter(BD)and total height(H).The fitted equations accounted for between 77%and 98%of the aerial biomass variance of Netuma affinis and Vachellia *** shrubs(Baccharis sp.),the adjusted equation accounted for 86%of total aerial biomass.C stock for the entire system was 116.71±11.07 Mg·ha^(-1),of which 90.7%was allocated in the soil,8.3%in the trees,0.8%in the herbaceous plants,and 0.2%in the *** results highlight the importance of subtropical halophytic wooded savannas as C sinks and their relevance in the mitigation of global warming under a climate change scenario.

关键词： Carbon stock Climate change Biomass modeling sodic soils

A systematic review of progenitor survival and maturation in Parkinsonian models

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

New Precipitation and Temperature Grids for Northern Patagonia： Advances in Relation to Global Climate Grids

在线全文

学校读者我要写书评

暂无评论

Journal of Meteorological Research 2016年第1期30卷 38-52页

作者： Emilio Bianchi Ricardo Villalba maximiliano Viale Fleur Couvreux Rocio Marticorena instituto nacional de tecnología agropecuaria estación experimental agropecuaria barilocheModesta Victoria 4450BarilocheArgentina consejo nacional de investigaciones científicas y tcnicas Argentina instituto argentino de nivología glaciología y ciencias ambientales-consejo nacional de investigaciones científicas y tcnicasMendozaRuiz LealMendozaArgentina centre national de recherches mtorologiques(cnrm-game) Mdtdo-FranceToulouseFrance autoridad interjurisdiccional de cuencas Argentina

Climate data of mean monthly temperature and total monthly precipitation compiled from different sources in northern Patagonia were interpolated to 20-km resolution grids over the period 1997-2010. This northern Patagonian climate grid （NPCG） improves upon previous gridded products in terms of its spatial resolution and number of contributing stations, since it incorporates 218 and 114 precipitation and temper- ature records, respectively. A geostatistical method using surface elevation from a Digital Elevation Model （DEM） as the ancillary variable was used to interpolate station data into even spaced points. The maps provided by NPCG are consistent with the broad spatial and temporal patterns of the northern Patagonian climate, showing a comprehensive representation of the latitudinal and altitudinal gradients in temperature and precipitation, as well as their related patterns of seasonality and continentality. We compared the per- formance of NPCG and various other datasets available to the climate community for northern Patagonia. The grids used for the comparison included those of the Global Precipitation Climatology Project, ERA- Interim, Climate Research Unit （University of East Anglia）, and University of Delaware. Based on three statistics that quantitatively assess the spatial coherence of gridded data against available observations （bias, MAE, and RMsE）, NPCG outperforms other global grids. NPCG represents a useful tool for understand- ing climate variability in northern Patagonia and a valuable input for regional models of hydrological and ecological processes. Its resolution is optimal for validating data from the general circulation models and working with raster data derived from remote sensing, such as vegetation indices.

关键词： northern Patagonia precipitation temperature co-kriging climate grids Cordillera de los Andes