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Excess dietary Lys reduces feed intake, stimulates jejunal CCK secretion and alters essential and non‑essential blood AA profile in pigs

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1336-1346页

作者： maximiliano muller Elout Van Liefferinge Alan Tilbrook Robert van Barneveld Eugeni Roura Centre for Nutrition and Food Sciences Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandBrisbaneQueensland 4072Australia Laboratory of Animal Nutrition and Animal Product Quality(LANUPRO) Department of Animal Sciences and Aquatic EcologyGhent University339000 GhentFlandersBelgium Centre for Animal Science Queensland Alliance for Agriculture and Food Innovation and the School of Veterinary ScienceThe University of QueenslandBrisbaneQueensland 4072Australia SunPork Group BrisbaneQueensland 4009Australia

Background Commercial diets are frequently formulated to meet or exceed nutrient levels including those of lim-iting essential amino acids(AA)covering potential individual variations within the ***,the provision of dietary excess of AA,such as Lys,may lead to reduced appetite and growth in *** mechanisms modulat-ing these responses have not been extensively *** study evaluated the effect of Lys dietary excesses on performance and satiety biomarkers in post weaning *** Twenty-four pigs aged 21 d and weighing 6.81±0.12kg(mean±SEM)were individually housed and offered 1 of 4 dietary treatments for 3weeks:a diet containing a standardized ileal digestible Lys reaching 100%(T0),120%(T1),150%(T2)or 200%(T3)of the NRC(2012)*** the end of the experiment,blood samples from the cephalic vein of the T0 and T3 groups were obtained for AA *** addition,primary intestinal cultures from T0 pigs were used,following their humane killing,to evaluate the effect of Lys on gut hormone secretion and AA sensors gene expression under ex vivo *** Feed intake was linearly reduced(P<0.001)and the weight gain to feed ratio reduced(P<0.10)with increased dietary levels of Lys during the third-and first-week post weaning,*** con-centration(P<0.05)and the metabotropic glutamate receptor 1 and the solute carrier family 7 member 2(P<0.10)gene expression was enhanced in proximal jejunum tissues incubated with Lys at 20mmol/L when compared to the control(Lys 0mmol/L).Plasma Lys and Glu(P<0.05)concentration increased in the T3 compared to T0 *** contrast,plasma levels of His,Val,Thr,Leu(P<0.05)and Gln(P<0.10)were lower in T3 than T0 *** The present results confirm that excess dietary Lys inhibits hunger in ***,the results provide evidence of pre-and post-absorptive mechanisms modulating these *** dietary excesses should be nar-rowed,when possible,to avoid negative effects of

关键词： Amino acid Blood Cholecystokinin Feed intake Lysine Pig Satiety

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CAIRO5 study from a surgical perspective

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 105-108页

作者： Andrius Meskauskas maximiliano Gelli Gustave Roussy Département de AnesthésieChirurgie et InterventionnelVillejuifFrance UniversitéParis-Saclay Gustave RoussyINSERMDynamique des Cellules Tumorales(U-1279)VillejuifFrance

The assessment of resectability,as well as the optimal induction treatment to achieve secondary resectability in patients with colorectal cancer liver metastases(CRLM)remain *** et al.(1)recently presented the results... 详细信息

关键词： Metastatic colorectal cancer(metastatic CRC) liver metastasis immunotherapy

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Take-over:multiple mechanisms of inter-adipocyte communication

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Journal of Molecular Cell Biology 2011年第2期3卷 81-90页

作者： Gunter muller Department Biology I Genetics MartinsriedBiocenterLudwig-Maximilians-University MunichMunichGermany

Adipose tissue mass in mammals is thought to expand with an increase in both volume and total number of the *** findings suggest that in normal-weight as well as obese individuals,the adipocyte number is set during adolescence prior to adulthood,whereas the subsequent increase in size predominantly drives *** simultaneous existence of large and small adipocytes and their unsynchronized growth,even within the same adipose tissue depot,argues against simple filling-up of emerging adipocytes with lipids and lipid droplets(LDs).Consequently,it is tempting to speculate about signals sent by large adipocytes to order small adipocytes the take-over of the burden of lipid *** there is experimental evidence for three distinct types of inter-adipocyte signals,***-to-cell contacts,adipokines,and other soluble factors and *** recently,microvesicles have been shown(i)to harbour the glycosylphosphatidylinositol-anchored(c)AMP-degrading phosphodiesterase Gce1 and 5′-nucleotidase CD73,(ii)to be released from large adipocytes,(iii)to interact with small adipocytes,and(iv)to transfer Gce1 and CD73 to plasma membranes and LDs of small adipocytes where they degrade(c)*** sequence of events leads to the up-regulation of lipid storage in small adipocytes in response to the microvesicle-encoded‘take-over’signal from large adipocytes.A model is proposed for the maturation of small adipocytes driven by large ones along a gradient of those inter-adipocyte *** modulation of inter-adipocyte communication and thereby adipocyte maturation may be useful for the therapy of metabolic diseases.

关键词： adipokines fat cells glycosylphosphatidylinositol lipid droplets lipid metabolism microvesicles obesity type 2 diabetes

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New Precipitation and Temperature Grids for Northern Patagonia： Advances in Relation to Global Climate Grids

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Journal of Meteorological Research 2016年第1期30卷 38-52页

作者： Emilio Bianchi Ricardo Villalba maximiliano Viale Fleur Couvreux Rocio Marticorena instituto nacional de tecnología agropecuaria estación experimental agropecuaria barilocheModesta Victoria 4450BarilocheArgentina consejo nacional de investigaciones científicas y tcnicas Argentina instituto argentino de nivología glaciología y ciencias ambientales-consejo nacional de investigaciones científicas y tcnicasMendozaRuiz LealMendozaArgentina centre national de recherches mtorologiques(cnrm-game) Mdtdo-FranceToulouseFrance autoridad interjurisdiccional de cuencas Argentina

Climate data of mean monthly temperature and total monthly precipitation compiled from different sources in northern Patagonia were interpolated to 20-km resolution grids over the period 1997-2010. This northern Patagonian climate grid （NPCG） improves upon previous gridded products in terms of its spatial resolution and number of contributing stations, since it incorporates 218 and 114 precipitation and temper- ature records, respectively. A geostatistical method using surface elevation from a Digital Elevation Model （DEM） as the ancillary variable was used to interpolate station data into even spaced points. The maps provided by NPCG are consistent with the broad spatial and temporal patterns of the northern Patagonian climate, showing a comprehensive representation of the latitudinal and altitudinal gradients in temperature and precipitation, as well as their related patterns of seasonality and continentality. We compared the per- formance of NPCG and various other datasets available to the climate community for northern Patagonia. The grids used for the comparison included those of the Global Precipitation Climatology Project, ERA- Interim, Climate Research Unit （University of East Anglia）, and University of Delaware. Based on three statistics that quantitatively assess the spatial coherence of gridded data against available observations （bias, MAE, and RMSE）, NPCG outperforms other global grids. NPCG represents a useful tool for understand- ing climate variability in northern Patagonia and a valuable input for regional models of hydrological and ecological processes. Its resolution is optimal for validating data from the general circulation models and working with raster data derived from remote sensing, such as vegetation indices.

关键词： northern Patagonia precipitation temperature co-kriging climate grids Cordillera de los Andes

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AN OUTLINE OF THE VARIETIES OF THE SECOND-ORDER SYSTEMS SCIENCES

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Journal of Systems Science and Systems Engineering 2017年第3期26卷 383-412页

作者： Karl H. muller International Academy for Systems Science and Cybernetics Steinbeis Transfer Center New Cybernetics Vienna Austria

The systems sciences are based on a universal language of systems which can be used within most academic disciplines in their endeavors for exploring the world. Currently, systems sciences cover a wide variety of different approaches like complex adaptive systems, resilient systems or systems engineering. One of the future extensions of the systems sciences comes through the applications of second-order systems science as a new field of reflexive studies on first-order systems science. This article provides a general background on the relations of first-order science and second-order science in general and then goes on to sketch a basic outline for the second-order systems sciences and their potentials for quality control and for innovations for the first-order systems sciences.

关键词： Optimization

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Biodegradation of polycyclic aromatic hydrocarbons(PAHs)by fungal enzymes:A review

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Journal of Environmental Sciences 2017年第1期29卷 52-74页

作者： Tayssir Kadri Tarek Rouissi Satinder Kaur Brar maximiliano Cledon Saurabhjyoti Sarma Mausam Verma INRS-ETE Universite du Quebec490 Rue de la CouronneQuebecQC G1K 9A9Canada CO2 Solutions Inc. 2300rue Jean-PerrinQuebecQC G2C 1T9Canada

Polycyclic aromatic hydrocarbons（PAHs） are a large group of *** represent an important concern due to their widespread distribution in the environment,their resistance to biodegradation,their potential to bioaccumulate and their harmful *** pilot treatments have been implemented to prevent economic consequences and deterioration of soil and water *** a promising option,fungal enzymes are regarded as a powerful choice for degradation of *** chrysosporium,Pleurotus ostreatus and Bjerkandera adusta are most commonly used for the degradation of such compounds due to their production of ligninolytic enzymes such as lignin peroxidase,manganese peroxidase and *** rate of biodegradation depends on many culture conditions,such as temperature,oxygen,accessibility of nutrients and agitated or shallow ***,the addition of biosurfactants can strongly modify the enzyme *** removal of PAHs is dependent on the ionization *** study of the kinetics is not completely comprehended,and it becomes more challenging when fungi are applied for *** studies in soil are much more complicated than liquid cultures because of the heterogeneity of soil,thus,many factors should be considered when studying soil bioremediation,such as desorption and bioavailability of *** degradation pathways can be *** peroxidases are heme-containing enzymes having common catalytic *** molecule of hydrogen peroxide oxidizes the resting enzyme withdrawing two ***,the peroxidase is reduced back in two steps of one electron *** are copper-containing *** reduce molecular oxygen to water and oxidize phenolic compounds.

关键词： Polycyclic aromatic hydrocarbons (PAHs) Biodegradation Fungi Enzymes

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Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus

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BIOCELL 2017年第1期41卷 1-12页

作者： maximiliano GIRAUD-BILLOUD Fernando EZQUER Javiera BAHAMONDE Marcelo EZQUER IHEM Universidad Nacional de CuyoCONICETFacultad de Ciencias MédicasMendozaArgentina Centro de Medicina Regenerativa Facultad de Medicina Clínica AlemanaUniversidad del DesarrolloAvenida Las Condes 12438SantiagoChile

A decrease in the tubular expression of albumin endocytic transporters megalin and cubilin has been associated with diabetic nephropathy,but there are no comprehensive studies to date relating early tubulointerstitial injury and the effect of the disease on both transporters in type 1 diabetes mellitus(T1DM).We used eight-week-old male C57BL/6 mice divided into two groups;one of them received the vehicle(control group),while the other received the vehicle+200 mg/kg streptozotocin(T1DM).Ten weeks after the injection,we evaluated plasma insulin,enzymuria,urinary vitamin D-binding protein(VDBP),tubulointerstitial fibrosis and proximal tubule histology,markers of autophagy,and megalin and cubilin *** found a reduction in tubular protein reabsorption(albumin and VDBP as specific substances carried by both transporters)with increased tubulointerstitial injury,development of fibrosis,thickening of tubular basement membrane,and an increase in tubular cell *** was associated with a decrease in the renal expression of megalin and *** also observed an increase in the amount of cellular vesicles of the phagocytic system in the tubules,which could be linked to an alteration of normal intracellular trafficking of both receptors,thus affecting the normal function of transporters in early stages of diabetic *** diabetic animals,the added effects of tubulointerstitial injury,the decreases in megalin and cubilin expression,and an altered intracellular trafficking of these receptors,seriously affect protein reabsorption.

关键词： Albuminuria Megalin Cubilin Autophagy

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Preparation and characterization of phosphate-modified mesoporous TiO2 incorporated in a silica matrix and their photocatalytic properties in the photodegradation of Congo red

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Frontiers of Materials Science 2017年第3期11卷 250-261页

作者： Alberto ESTRELLA GONZALEZ maximiliano ASOMOZA Ulises ARELLANO Sandra CIPAGAUTA DiAZ Silvia SOLíS Department of Chemistry Metropolitan Autonomous University-lztapalapa P.O. Box 55-532 C.P. 09340 México City México

This study describes the development of mesostructured TiO2 photo- catalysts modified with PO4^3- to improve its specific surface area and reduce the recombination rate of the electron-hole pairs. The mesoporous photocatalyst was successfully incorporated into a high specific surface area silica matrix by the hydrolysis reaction of tetraethyl orthosilicate （TEOS）. Pluronic 123 and phosphoric acid were used as the directing agent for the structure of the mesoporous TiO2 and as a source of phosphorus, respectively, TiO2, P/TiO2, TiO2-SiO2 and P/TiO2-SiO2 materials were characterized by BET, XRD, TEM-EDS, FTIR and UV-vis DRS measurements. The photoactivity of TiO2-SiO2 nanocomposites containing 15 wt.% photocatalystJsilica was evaluated in the degradation reaction of anionic dyes with UV radiation. The proposed nanomaterials showed high potential for applications in the remediation of wastewater, being able to reuse in several cycles of reaction, maintaining its photoactivity and stability. The separation and recovery time of the material is reduced between cycles since no centrifugation or filtration processes are required after the photooxidation reaction.

关键词： photocatalysis phosphated TiO2 TiO2-SiO2 Congo red dye

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Carbon stock estimation in halophytic wooded savannas of Uruguay:An ecosystem approach

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Forest Ecosystems 2024年第4期11卷 580-589页

作者： Andres Baietto Andres Hirigoyen Carolina Toranza Franco Schinato maximiliano Gonzalez Rafael Navarro Cerrillo Forest Department Faculty of AgronomyUniversity of the RepublicMontevideoPO 12900Uruguay National Research Program of Forest Production National Agriculture Research InstituteTacuaremboPO 97000Uruguay Soil and Water Department Faculty of AgronomyUniversity of the RepublicMontevideoPO 12900Uruguay Department of Forestry Engineering University of CordobaCordobaPO 14014Spain

Savannas constitute a mixture of trees and shrub patches with a more continuous herbaceous *** contribution of this biome to the soil organic carbon(SOC)and above-ground biomass(AGB)carbon(C)stock globally is ***,they are frequently subjected to land use changes,promoting increases in CO_(2) *** Uruguay,subtropical wooded savannas cover around 100,000 ha,of which approximately 28%is circumscribed to sodic soils(i.e.,subtropical halophytic wooded savannas).Nevertheless,there is little background about the contribution of each ecosystem component to the C stock as well as site-specific allometric *** study was conducted in 5 ha of subtropical halophytic wooded savannas of the national protected area Esteros y Algarrobales del Rio *** work aimed to estimate the contribution of the main ecosystem components(e.g.,soil,trees,shrubs,and herbaceous plants)to the C ***-specific allometric equations for the most frequent tree species and shrub genus were fitted based on basal diameter(BD)and total height(H).The fitted equations accounted for between 77%and 98%of the aerial biomass variance of Netuma affinis and Vachellia *** shrubs(Baccharis sp.),the adjusted equation accounted for 86%of total aerial biomass.C stock for the entire system was 116.71±11.07 Mg·ha^(-1),of which 90.7%was allocated in the soil,8.3%in the trees,0.8%in the herbaceous plants,and 0.2%in the *** results highlight the importance of subtropical halophytic wooded savannas as C sinks and their relevance in the mitigation of global warming under a climate change scenario.

关键词： Carbon stock Climate change Biomass modeling Sodic soils

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Globe penetration during loco-regional anesthesia: prevalence and review of cases

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International Journal of Ophthalmology(English edition) 2022年第10期15卷 1683-1690页

作者： Alba Gómez-Benlloch maximiliano Olivera Jeroni Nadal Gemma Julio Javier Elizalde Centro de Oftalmología Barraquer Barcelona 08021Spain Institut Universitari Barraquer Universitat Autònoma de BarcelonaBarcelona 08021Spain School of Medicine Universitat Internacional de CatalunyaBarcelona 08017Spain

AIM: To describe prevalence and different clinical signs and management of cases with penetrating eye injuries during loco-regional anesthesia for ophthalmic surgery. METHODS: A retrospective review of clinical records was carried out, identifying cases of globe penetration secondary to peribulbar anesthesia injection during 5 y activity in Centro de Oftalmología Barraquer. RESULTS: A total of 17 460 needle-based ocular anesthesia procedures were performed in our centre and 4 cases of globe penetration were recorded with an estimated prevalence of 0.024%. Globe penetrations were always detected in the first 24 h after surgery. Vitreous haemorrhage was found in all the cases. Two eyes presented retinal detachment and two eyes choroidal detachment(CD). The initial surgical approach was performed within the first 48 h. Silicone oil was used as tamponade in three eyes and the fourth case remained only with air. Detachments were solved successfully in all the cases. Functional results varied among cases, depending on ocular remarkable antecedent and globe penetration with or without retinal or ***: Prevalence of globe penetration during loco-regional anesthesia is low in our centre. Physicians should consider the possibility of globe penetration in eyes with postoperative atypical appearance after locoregional anesthesia. Immediate B-scan ultrasonography is recommended in suspicious cases with a dense vitreous haemorrhage. An early vitrectomy surgery in conjunction with laser or cryotherapy at the penetration sites is essential for good anatomical and functional results.

关键词： loco-regional anesthesia peribulbar retrobulbar globe penetration retina

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