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Transient Squeal Analysis of a Non Steady State Manoeuvre

Journal of Mechanics Engineering and Automation 2017年第5期7卷 269-277页

作者： Oliver Stump maximilian Konning Wolfgang Seemann Daimler AG Group Research & MBC Development Sindelfingen 71059 Germany Institute of Engineering Mechanies-Karlsruhe Institute of Technology (KIT) Karlsruhe 76131 Germany

Brake squeal is one of the main NVH （vibration harshness） challenges in the brake development of passenger cars. The conflict of goals in the development process and the late testability leads to the need of a deeper basic understanding of the squeal phenomenon and definition of design rules. On the other hand, brake squeal is still a very interesting field of research also for the universities because of its combination of different fundamentals, such as friction and stability behaviour of systems with local nonlinearities. Major nonlinearities of the brake system are the joints, especially the contact areas formed by the oscillating brake pad and the caliper. The state-of-the-art calculation method, which still is the ＂complex eigenvalue analysis＂, linearizes these joints, hence, neglecting its nonlinear influence in the stability analysis. Vehicle and bench experiments show that special driving manoeuvres like parking, where the brake pad often leaves the steady state, are likely causing brake squeal. The system in these manoeuvres sometimes behaves opposed to the linearized stability analysis, indicating a limit cycle beyond the Hopf point. Therefore, these states must be investigated more closely. This paper investigates the nonlinear influence of the pad caliper joint in a fixed brake caliper, also called abutment. Bench tests with pressure foils at the abutment of the brake caliper and mode shape analysis were done and a simple FE （finite element） model for a transient simulation is proposed. It is shown that the joint activity varies with driving manoeuvres, leading to different stability behaviours and limiting cycle amplitudes.

关键词： Brake squeal transient analysis nonlinear joint stability analysis finite element method.

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Artificial Intelligence in Neuro-oncology:Friend or Foe of Neurosurgeons?

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Clinical Cancer Bulletin 2022年第1期1卷 39-46页

作者： Zhenyu GONG maximilian SCHWENDNER Tao XU Department of Neurosurgery Klinikum rechts der IsarTechnische Universität MünchenIsmaninger Str.2281675 MunichGermany Department of Neurosurgery Shanghai Changzheng HospitalNaval Medical UniversityShanghai 200003China

As one of the tumors with substantial treatment difficulties,brain tumors have a high mortality rate and high treatment ***,surgical rection of deep-seated tumors or tumors involving eloquent areas is still a challenge for ***,accurate and early tumor diagnosis,selection of treatment options,and prediction of prognosis are important to improve patients’***,with the rapid development of computational technology,the frequency of its application in clinical work has increased enormously and the acquisition of medical data has become more convenient and ***,with the advancement of artificial intelligence(AI)—particularly,machine and deep learning—the applications of AI in medicine and especially neuro-oncology have enhanced diagnosis,treatment,and prognosis prediction of brain tumors topreviously unachievable *** article presents an overview of the applications of AI in neuro-oncology for diagnosis,prognosis,surgical treatment,and ***,the advantages,perspectives,and challenges of AI for clinical applications in neuro-oncology are discussed.

关键词： artificial intelligence deep learning machine learning neuro-oncology

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Colon cancer and the immune system:The role of tumor invading T cells

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World Journal of Gastroenterology 2006年第45期12卷 7233-7238页

作者： maximilian Waldner Carl C Schimanski Markus F Neurath I. Department of Medicine University of Mainz Mainz Germany

Colon cancer is still one of the leading causes of cancer death worldwide. Although the host immune system has been shown to react against tumor cells, mainly through tumor infi ltrating lymphocytes and NK cells, tumor cells may utilize different ways to escape anti-tumor immune response. Tumor infi ltration of CD8+ and CD4+ (T-bet+) effector T cells has been attributed to a beneficial outcome, and the enhancement of T cell activation through T cell receptor stimulation and co-stimulatory signals provides promising strategies for immunotherapy of colon cancer. Growing evidence supports a role for the Fas/FasL system in tumor immunology, although the mechanisms and consequences of FasL activation in colon cancer are not completely understood. In animal models, depletion of regulatory T cells (CD4+ CD25+ T cells) can enhance the anti-tumor immune response under certain conditions. Taken together, recent insights in the immune reaction against colon carcinoma have provided new approaches to immunotherapy, although much remains to be learned about the exact mechanisms.

关键词： CD4-positive T-lymphocytes CD8-positive T-lymphocytes Immunology Colonic neoplasms therapy Colorectal neoplasms Humans Lymphocytes Tumor-infiltrating Tumor escape

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Beyond total mesorectal excision: The emerging role of minimally invasive surgery for locally advanced rectal cancer

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2382-2385页

作者： Davina Perini Francesca Cammelli maximilian Scheiterle Jacopo Martellucci Annamaria Di Bella Carlo Bergamini Paolo Prosperi Alessio Giordano Department of Emergency and Acceptance Emergency Surgery UnitCareggi University HospitalFirenze 50137Italy

Multivisceral resection and/or pelvic exenteration represents the only potential curative treatment for locally advanced rectal cancer(LARC);however,it poses significant technical challenges,which account for the high risk of morbidity and mortality associated with the *** complete histopathologic resection is the most important determinant of patient outcomes,LARC often requires an extended resection beyond the total mesorectal excision plane to obtain clear re-section *** an era when laparoscopic surgery and robot-assisted surgery are becoming commonplace,the optimal approach to extensive pelvic inter-ventions remains ***,acceptance of the suitability of mini-mally invasive surgery is slowly gaining ***,there is still a lack of evidence in the literature about minimally invasive approaches in multiple and extensive surgical resections,highlighting the need for research studies to explore,validate,and develop this *** editorial aims to provide a critical overview of the currently available applications and challenges of minimally invasive abdo-minopelvic surgery for ***,we discuss recent developments in the field of robotic surgery for LARC,with a specific focus on new innovations and emerging frontiers.

关键词： Robotic surgery Pelvic exenteration Multivisceral resection Rectal cancer Total mesorectal excision

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Statistical Models for Condition Monitoring and State of Health Estimation of Lithium-Ion Batteries for Ships

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Journal of Dynamics, Monitoring and Diagnostics 2024年第1期3卷 11-20页

作者： Erik Vanem Qin Liang maximilian Bruch Gjermund Bøthun Katrine Bruvik Kristian Thorbjørnsen Azzeddine Bakdi DNV GRD HøvikNorway Department of Mathematics University of OsloOsloNorway Fraunhofer ISE FreiburgGermany Corvus Energy BergenNorway Corvus Energy PorsgrunnNorway

Battery systems are increasingly being used for powering ocean going ships,and the number of fully electric or hybrid ships relying on battery power for propulsion is *** ensure the safety of such ships,it is important to monitor the available energy that can be stored in the batteries,and classification societies typically require the state of health(SOH)to be verified by independent *** paper addresses statistical modeling of SOH for maritime lithium-ion batteries based on operational sensor *** methods for sensor-based,data-driven degradation monitoring will be presented,and advantages and challenges with the different approaches will be *** different approaches include cumulative degradation models and snapshot models,models that need to be trained and models that need no prior training,and pure data-driven models and physics-informed *** of the methods only rely on measured data,such as current,voltage,and temperature,whereas others rely on derived quantities such as state of *** include simple statistical models and more complicated machine learning *** from this exploration will be important in establishing a framework for data-driven diagnostics and prognostics of maritime battery systems within the scope of classification societies.

关键词： battery condition monitoring data-driven analytics diagnostics state of health

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Spatially engineered nonlinearity in resonant metasurfaces

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Photonics Research 2023年第2期11卷 252-259页

作者： ANNA FEDOTOVA MOHAMMADREZA YOUNESI maximilian WEISSFLOG DENNIS ARSLAN THOMAS PERTSCH ISABELLE STAUDE FRANK SETZPFANDT Institute of Solid State Physics Friedrich Schiller University Jena07743 JenaGermany Institute of Applied Physics Abbe Center of PhotonicsFriedrich Schiller University Jena07745 JenaGermany Max Planck School of Photonics 07745 JenaGermany Fraunhofer Institute for Applied Optics and Precision Engineering 07745 JenaGermany

Spatial engineering of the nonlinear susceptibility χ^((2)) in resonant metasurfaces offers a new degree of freedom in the design of the far-field response of second-harmonic generation(SHG). We demonstrate this by applying electric field poling to lithium niobate(LN) thin films, which inverts the spontaneous polarization and thus the sign of χ^((2)). Metasurfaces fabricated in periodically poled LN films reveal the distinct influence of theχ^((2))-patterning on the spatial distribution of the second harmonic. This work is a first step toward far-field engineering of SHG in metasurfaces with electric field poling.

关键词： resonant surfaces harmonic

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Influence of Deposition Temperature on the Electrical and Electrochemical Properties of Carbon-Based Coatings for Metallic Bipolar Plates, Prepared by Cathodic Arc Evaporation

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Advances in Materials Physics and Chemistry 2022年第4期12卷 47-57页

作者： maximilian Steinhorst Maurizio Giorgio Teja Roch Christoph Leyens Fraunhofer Institute for Material and Beam Technology IWS Dresden Germany Institute of Material Science Technische Universit&auml t Dresden Dresden Germany

Cathodic arc evaporation is a well-established physical vapor deposition technique which is characterized by a high degree of ionization and high deposition rate. So far, this technique has been mainly used for the deposition of tribological coatings. In this study, anti-corrosive and electrical conductive carbon-based coatings with a metallic interlayer were prepared on stainless steel substrates as surface modification for metallic bipolar plates. Hereby, the influence of the deposition temperature during the deposition of the carbon top layer was investigated. Raman spectroscopy revealed differences in the microstructure at 200°C compared to 300°C and 100°C. Measurements of the interfacial contact resistance showed that the deposited coatings significantly improve the electrical conductivity. There are only minor differences between the different carbon top layers. The corrosion resistance of the coatings was studied via potentiodynamic polarization at room temperature and 80°C. Experiments showed that the coating with a carbon top layer deposited at 200°C, considerably reduces the current density and thus corrosion of the substrate is suppressed.

关键词： Bipolar Plate Corrosion Interfacial Contact Resistance Carbon Thin Film Physical Vapor Deposition

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Improving cycling performance of the NaNiO_(2)cathode in sodium-ion batteries by titanium substitution

Materials Futures

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Materials Futures 2024年第3期3卷 132-147页

作者： Siyu An Leonhard Karger Sören L Dreyer Yang Hu Eduardo Barbosa Ruizhuo Zhang Jing Lin maximilian Fichtner Aleksandr Kondrakov Jürgen Janek Torsten Brezesinski Battery and Electrochemistry Laboratory(BELLA) Institute of NanotechnologyKarlsruhe Institute of Technology(KIT)Kaiserstr.1276131 KarlsruheGermany Helmholtz Institute Ulm(HIU)Electrochemical Energy Storage Helmholtzstr.1189081 UlmGermany BASF SE Carl-Bosch-Str.3867056 LudwigshafenGermany Institute of Physical Chemistry&Center for Materials Research(ZfM/LaMa) Justus-Liebig-University GiessenHeinrich-Buff-Ring 1735392 GiessenGermany

O3-type layered oxide cathodes,such as NaNi_(0.5)Mn_(0.5)O_(2),have garnered significant attention due to their high theoretical specific capacity while using abundant and low-cost sodium as intercalation *** the lithium analog(LiNiO_(2)),NaNiO_(2)(NNO)exhibits poor electrochemical performance resulting from structural instability and inferior Coulomb *** enhance its cyclability for practical application,NNO was modified by titanium substitution to yield the O3-type NaNi_(0.9)Ti_(0.1)O_(2)(NNTO),which was successfully synthesized for the first time via a solid-state *** mechanism behind its superior performance in comparison to that of similar materials is examined in detail using a variety of characterization *** delivers a specific discharge capacity of∼190 mAh g^(−1)and exhibits good reversibility,even in the presence of multiple phase transitions during cycling in a potential window of 2.0−4.2 V ***^(+)/*** behavior can be attributed to the substituent,which helps maintain a larger interslab distance in the Na-deficient phases and to mitigate Jahn–Teller activity by reducing the average oxidation state of ***,volume collapse at high potentials and irreversible lattice oxygen loss are still detrimental to the ***,the performance can be further enhanced through coating and doping *** not only positions NNTO as a promising next-generation cathode material,but also serves as inspiration for future research directions in the field of high-energy-density Na-ion batteries.

关键词： Ni-rich layered oxide cathode material substitution doping electro-chemo-mechanical degradation Na-ion battery

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Intraprosthetic fixation techniques in the treatment of periprosthetic fractures: A biomechanical study

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World Journal of Orthopedics 2012年第10期3卷 162-166页

作者： Stephan Brand Johannes Klotz Thomas Hassel maximilian Petri Carl Haasper Friedrich-Wilhelm Bach Christian Krettek Thomas Goesling Department of Trauma Medical School Hannover (MHH) D-30625 Hannover Germany Department of Material Sciences Leibniz University Hannover D-30625 Hannover Germany

AIM: To develop new fixation techniques for the treatment of periprosthetic fractures using intraprosthetic screw fixation with inserted threaded liners. METHODS: A Vancouver B1 periprosthetic fracture was simulated in femur prosthesis constructs using sawbones and cemented regular straight hip stems. Fixation was then performed with either unicortical locked-screw plating using the less invasive stabilization system-plate or with intraprosthetic screw fixation using inserted liners. Two experimental groups were formed using either prostheses made of titanium alloy or prostheses made of cobalt chrome alloy. Fixation stability was compared in an axial load-to-failure model. Drilling was performed using a specially invented prosthesis drill with constantly applied internal ***: The intraprosthetic fixation model with titanium prostheses was superior to the unicortical lockedscrew fixation in all tested devices. The intraprosthetic fixation model required 10 456 N ± 1892 N for failure and the unicortical locked-screw plating required 7649 N ± 653 N(P < 0.05). There was no significant difference between the second experimental group and the control ***: Intraprosthetic screw anchorage with special threaded liners enhances the primary stability in treating periprosthetic fractures by internal fixation.

关键词： Periprosthetic fracture Less invasive stabilization system Plate fixation Intraprosthetic screw fixation Material science Biomechanical testing Axial load-to-failure

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Injury patterns of seniors in traffic accidents: A technical and medical analysis

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World Journal of Orthopedics 2012年第9期3卷 151-155页

作者： Stephan Brand Dietmar Otte Christian Walter Mueller maximilian Petri Philipp Haas Timo Stuebig Christian Krettek Carl Haasper Accident Research Unit Trauma Department Medical School Hannover (MHH) D-30625 Hannover Germany

AIM:To investigate the actual injury situation of seniors in traffic accidents and to evaluate the different injury ***:Injury data,environmental circumstances and crash circumstances of accidents were collected shortly after the accident event at the *** these data,a technical and medical analysis was performed,including Injury Severity Score,Abbreviated Injury Scale and Maximum Abbreviated Injury *** method of data collection is named the German InDepth Accident Study and can be seen as ***:A total of 4430 injured seniors in traffic accidents were *** incidence of sustaining severe injuries to extremities,head and maxillofacial region was significantly higher in the group of elderly people compared to a younger age(P<0.05).The number of accident-related injuries was higher in the group of seniors compared to other ***:Seniors are more likely to be involved in traffic injuries and to sustain serious to severe injuries compared to other groups.

关键词： Traffic accidents Seniors Head injury Injury severity score Abbreviated injury scale

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