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IR-transparent MgO-Gd_(2)O_(3) composite ceramics produced by self-propagating high-temperature synthesis and spark plasma sintering

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Journal of Advanced Ceramics 2021年第2期10卷 237-246页

作者： Dmitry A.Permin Maksim S.Boldin Alexander V.Belyaev Stanislav S.Balabanov Vitaly a.koshkin Atrem A.Murashov Igor V.Ladenkov Evgeny A.Lantsev Ksenia E.Smetanina Nadia M.Khamaletdinova G.G.Devyatykh institute of chemistry of high-purity substances of the ras nizhny novgorod603137russia Lobachevsky state university of nizhny novgorod nizhny novgorod603950russia “Joint-stock company”research and production enterprise“salut” nizhny novgorod603950russia G.A.Razuvaev institute of organometallic chemistry of the ras nizhny novgorod603137russia

A glycine–nitrate self-propagating high-temperature synthesis(SHS)was developed to produce composite MgO-Gd_(2)O_(3) *** X-ray powder diffraction(XRD)analysis confirmed the SHS-product consists of cubic MgO and Gd_(2)O_(3) phases with nanometer crystallite size and retains this structure after annealing at temperatures up to 1200℃.Near full dense high IR-transparent composite ceramics were fabricated by spark plasma sintering(SPS)at 1140℃and 60 *** in-line transmittance of 1 mm thick MgO-Gd_(2)O_(3) ceramics exceeded 70%in the range of 4–5 mm and reached a maximum of 77%at a wavelength of 5.3 *** measured microhardness HV0.5 of the MgO-Gd2O3 ceramics is 9.5±0.4 GPa,while the fracture toughness(KIC)amounted to 2.0±0.5МPa·m1/*** characteristics demonstrate that obtained composite MgO-Gd_(2)O_(3) ceramic is a promising material for protective infra-red(IR)windows.

关键词： MgO-Gd_(2)O_(3) self-propagating high-temperature synthesis(SHS) spark plasma sintering(SPS) optical properties infra-red(IR)ceramics

Measurement of AhR Ligands in the Tissues of Colon Cancer Patients with XRE Luciferase Reporter

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Journal of Oncology Research 2019年第1期1卷 3-9页

作者： Bystriakova Margarita.koshkin Sergei Tolkunova Elena Institute of Cytology of the Russian Academy of Science St-Petersburg 194064Russia

The Aryl hydrocarbon receptor(AhR)ligands exhibiting modulating activity represents a new class of anticancer agents that can be directed towards several *** have examined AhR expression in human colon cancer and adjacent non-tumor *** expression level was about 2-7 times higher in tumor tissue samples than in the adjacent non-tumor samples(in 82%of all the samples).We were unable to find any increase of ABCG2 expression on the level of the transcription,while the expression of MDR2 was increased in half of the tumors compared to the levels of expression in normal adjacent *** have used FICZ as a potent high affinity ligand of the AhR to calibrate the reporter cell line HEK293TAhR-luc as a potent high affinity ligand of the *** concentration of xenobiotic response element(XRE)ligands is higher,than in the blood of healthy people in 86%of the *** proposed test system will allow the use of the AhR ligand level as an additional diagnostic marker in the treatment of colon cancer.

关键词： Aryl hydrocarbon receptor Colon cancer HЕК293Т-AhR-luc Polycyclic aromatic hydrocarbon XRE luciferase reporter bioassay

Mechanisms of tyrosine kinase inhibitor resistance in renal cell carcinoma

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Cancer Drug Resistance 2023年第4期6卷 858-873页

作者： Patrick L.Sweeney Yash Suri Arnab Basu Vadim S.koshkin Arpita Desai Deming Department of Medicine Tulane University School of MedicineNew OrleansLA 70112USA University of Arizona College of Medicine TucsonAZ 85724USA Division of Hematology and Oncology Department of MedicineUniversity of Alabama at Birmingham Heersink School of MedicineBirminghamAL35233USA Division of Hematology and Oncology Department of MedicineUniversity of California at San Francisco School of MedicineSanFranciscoCA94143USA

Renal cell carcinoma(RCC),the most prevalent type of kidney cancer,is a significant cause of cancer morbidity and mortality *** tyrosine kinase inhibitors(TKls),in combination with immune checkpoint inhibitors(ICls),are among the first-line treatment options for patients with advanced *** therapies target the vascular endothelial growth factor receptor(VEGFR)tyrosine kinase pathway and other kinases crucial to cancer proliferation,survival,and *** have yielded substantial improvements in progression-free survival(PFS)and overall survival(OS)for patients with advanced ***,nearly all patients eventually progress on these drugs as resistance *** review provides an overview of TKl resistance in RCC and explores different mechanisms of resistance,including upregulation of alternative proangiogenic pathways,epithelial-mesenchymal transition(EMT),decreased intracellular drug concentrations due to efflux pumps and lysosomal sequestration,alterations in the tumor microenvironment including bone marrow-derived cells(BMDCs)and tumor-associated fibroblasts(TAFs),and genetic factors such as single nucleotide polymorphisms(SNPs).A comprehensive understanding of these mechanisms opens the door to the development of innovative therapeutic approaches that can effectively overcome TKl resistance,thereby improving outcomes for patients with advanced RCC.

关键词： Antiangiogenic tyrosine kinase inhibitors renal cell carcinoma acquired resistance sunitinib tumor microenvironment immune checkpoint inhibitors

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春小麦的产量与源/库关系

国外农学（麦类作物） 1991年第3期 34-36页

作者： E.I.koshkin 张怀渝

在开花期完全摘除穗一侧的小穗(处理穗),以测试新老春小麦品种对源库调控的不同反应,并提出了穗的生产潜力(处理穗的两倍产量)和其余一半穗的潜在蛋白质含量的概念。在系统选择中,现代品种的潜在产量和实际产量的改进是由于提高了茎叶... 详细信息

在开花期完全摘除穗一侧的小穗(处理穗),以测试新老春小麦品种对源库调控的不同反应,并提出了穗的生产潜力(处理穗的两倍产量)和其余一半穗的潜在蛋白质含量的概念。在系统选择中,现代品种的潜在产量和实际产量的改进是由于提高了茎叶重和叶面积持续期(L_(ado)),特别是在不利的灌浆环境条件下,叶面积持续期与实际籽粒产量的比率就会提高。已经确定,在新品种中,潜在的和实际的蛋白质含量有一致降低的倾向,而每株蛋白质总量则有增加的趋势。在老品种中,根对植株总呼吸作用的贡献较大。尽管产量不断改良,但维持呼吸作用与总呼吸作用的比率,以及在整个生育期中以产量为基础的呼吸损失却保持不变。在老品种中,以籽粒氮为基础的真呼吸碳损失(总呼吸减维持呼吸)较少,在其他品种之间没有一致的差异。

关键词：小麦产量源/库关系春小麦

Some aspects of simulating structural transformation in alloys based on immiscible components

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广东有色金属学报 2005年第2期15卷 217-217页

作者： koshkin Valery I.

The question has been studied of using the reversal monotectic reaction as technological mean for obtaining alloys based on immiscible components (IC).

关键词：合金物理模型金属材料熔炼工艺烧结工艺

Stromal and Tumor Glioma-derived Cells with Similar Characteristics Have Differences in α-Smooth Muscle Actin Expression and Localization

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Journal of Oncology Research 2021年第2期3卷 8-21页

作者： I.Gin I.Chistyakova V.Zenin S.koshkin A.Musorina Y.Lahina G.Timin V.Pospelov S.Prikhodko A.Petukhov E.Tolkunova Institute of Cytology Russian Academy of SciencesSt.Petersburg194064Russia Almazov National Medical Research Centre St.Petersburg197341Russia Peter the Great Saint-Petersburg Polytechnic University St.Petersburg195251Russia Scientific Technological University«Sirius» Sochi354340Russia

Gliomas are solid brain tumors composed of tumor cells and recruited heterogenic stromal *** study of the interactions between the perivascular niche and its surrounding cells is of great value in unraveling mechanisms of drug resistance in malignant *** this study,we isolated the stromal diploid cell population from oligodendroglioma and a mixed population of tumor aneuploid and stromal diploid cells from astrocytoma *** stromal cells expressed neural stem/progenitor and mesenchymal markers showing the same discordant phenotype that is typical for glioma ***,some of the stromal cells expressed *** the first time,we demonstrated that this type of stromal cells had the typical myofibroblastic phenotype as theα-SMA+cells formedα-SMA fibers and exhibited the specific function to deposit extracellular matrix(ECM)proteins at least in *** analysis showed diffuse or focalα-SMA staining in the cytoplasm of the astrocytoma-derived,A172,T98G,and U251MG glioma *** could suggest thatα-SMA may be one of the main molecules,bearing protective *** mechanisms and consequences ofα-SMA disruptions in gliomas are discussed.

关键词： Oligodendroglioma Astrocytoma Primary cell cultures Tumor microenvironment Myofibroblasts Extracellular matrix